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Hepatoprotector Effect of Coconut Water (Cocos nucifera L.) and Folic Acid to the Liver Histopathological Desccription of Pregnant Wistar Female Rats (Rattus norvegicus) Induced by Carbamate Muhammad Rosyid Ridho; Aris Prasetyo; Hairrudin Hairrudin
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.10758

Abstract

Abstract Carbamate is an insecticide with a working mechanism that inhibits the enzyme acetylcholineestrase (AChE). Obstacles to AChE will cause the formation of excessive free radicals in the body causing oxidative stress and causing lipid peroxidation in body cells, including hepatocyte cells in the liver. Pregnant women have a change in detoxification activity in the liver due to exposure to xenobiotic substances during pregnancy causing a decrease in cytochrome P450 1A2 (CYP1A2) which will cause an increase in free radicals and can damage liver cells. Coconut water contains antioxidants that can neutralize free radicals in the body. While folic acid can encourage improvement in morphology of liver cells. The purpose of this study was to determine the hepatoprotector effect of coconut water and folic acid on the histopathology of the liver of pregnant female wistar rats induced by carbamate. The design of this study is true experimental with a post test only control group design. The sampling method used is simple random sampling. The number of samples in this study were 28 rats divided into 4 groups K (aquades), P1 (carbamate), P2 (carbamate and coconut water), and P3 (carbamate and folic acid). At the end of the study rat liver was taken to then become histological preparations. The One Way ANOVA test results showed a significant difference between groups compared (p <0.05). Post hoc LSD test results showed that group P1 had damaged liver histopathology, there were significant differences with group K and P3 (p <0.05), but there were no significant differences when compared with group P2 (p = 0.826). Meanwhile, the P3 group had significant differences when compared with all groups (p <0.05). The conclusion of this study is that giving coconut water cannot prevent liver damage due to carbamate induction, while folic acid has been shown to prevent liver damage due to carbamate induction, from liver histopathology. Keywords: carbamate, coconut water, folic acid, liver histopathology
The Analysis of Osteoblast Cell Number on Femur Fractures Provided Red Spinach Extract (Amaranthus tricolor L.) Ferdian Nugroho; Aris Prasetyo; Muhammad Hasan
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.7461

Abstract

Bone fracture is a musculoskeletal injury with a high incidence rate. The healing process of the fracture can be inhibited by oxidative stress, which occurs due to Reactive Oxygen Species (ROS) that exceeds the antioxidant capacity in the body that neutralizes it. Antioxidants that have red spinach have the potential to suppress the level of oxidative stress. This study aims to determine the effect of red spinach ethanol extract on the healing process of fracture in male Wistar rats through osteoblast cell count. A sample of 30 male Wistar rats was divided into five groups; negative control group, positive control group, and three groups of red spinach ethanol treatment with doses of 35.4 mg / 150 g body weight (BW), 70.8 mg / 150 gBW, and 141.6 mg / 150gBW induced fracture, splinted, then treated for one week. One Way Anova test results showed a significance of 0.000 (p <0.05) in which there was a significant difference in the osteoblast level between the treatment group and the control group. The result of LSD test between P1 group and P3 group showed significantly different result where the increase of osteoblast cell number was in line with the increase of the dose of red spinach ethanol extract. The conclusion is that red spinach ethanol extract has a positive impact during the fracture healing process with osteoblast cell number parameters. Keywords: Red spinach ethanolic extract, fracture healing process, osteoblast, oxidative stress
The Effect of Red Spinach Extract (Amaranthus tricolor L.) on Serum Malondialdehyde of Male Rattus Novergicus Fracture Model Aris Prasetyo; Ahmad Baihaqi; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.6838

Abstract

Fracture is a musculoskeletal injury with a high incidence rate. The healing process of fracture is disturbed by the oxidative stress, because of imbalance quantity of Reactive Oxygen Species (ROS) and antioxidant capacity in the body that neutralizes it. Antioxidants in red spinach have the potential to suppress the level of oxidative stress. The study aimed to determinate the effect of red spinach ethanolic extract on decreasing oxidative stress by measuring malonaldialdehyde (MDA) concentration in fracture healing process. The study used thirty rats and divided into five groups; negative control group, positive control group,and three treatment groups of red spinach ethanolic extract in a dose of 35,4 mg/150gBB, 70,8 mg/150gBB, and 141,6 mg/150gBB manually fractured on right femur under anaesthesia and immobilized by leucodur plaster. Each group was treated orally respectively one week. The result of One Way Anova showed a significance of 0,000 (p<0,05) in which there was a significant difference in serum MDA levels between the treatment groups and the control groups. The result of LSD test between P1 group and P3 group showed significantly different in which decreased serum MDA levels were consistent with increasing doses of red spinach ethanolic extract. The study concluded that red spinach ethanolic extract had a positive effect on supression of oxidative stress in fracture healing process. Keywords: Red spinach ethanolic extract, fracture healing process, MDA, ROS
APLIKASI SATULINK SOLUSI UNTUK PELAYANAN PERBANKAN TANPA KANTOR Dermawan Suprihatin; Aris Prasetyo; Sarwati Rahayu
Jurnal Cendikia Vol 17 No 1 April (2019)
Publisher : LPPM AMIK Dian Cipta Cendikia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.317 KB)

Abstract

Indonesia adalah negara yang besar dengan lebih dari 17.000 pulau dari sabang sampai merauk dan memiliki jumlah penduduk lebih dari 250 juta jiwa. Namun dari jumlah tersebut ada hamper 100 juta penduduk tidak memiliki rekening di bank. Hal ini disebabkan oleh beberapa factor salah satunya adalah kurang meratanya pelayanan perbankan untuk setiap daerah, besarnya biaya pembukaan kantor cabang bank. Oleh karena itu OJK selaku regulator meluncurkan program LAKU PANDAI yaitu Layanan Keuangan Tanpa Kantor Dalam Rangka Keuangan Inklusif. Dengan adanya program ini diharapkan bank dapat memperluas jangkauan pelayanannya dan juga diharapkan masyarakat dapat mengakses layanan ini dengan mudah dan murah. Dalam penerapannya program ini menggunakan pihak ketiga yaitu agen bank yang akan menjadi pengubung atau perpanjangan tangan dari bank dimana setiap transaksi yang biasa dilakukan di kantor cabang bank dapat dilayani melalui agen bank tersebut. Dengan adanya program ini diharapkan bank dapat lebih optimal melayani nasabah, mengurangi biaya operasional bank, menambah jumlah transaksi dan nasabah bank, meningkatkan perekonomian masyarakat, memperluas daerah pelayanan bank, menyediakan produk perbankan yang sederhana mudah dipahami dan sesuai kebutuhan masyarakat
Effect of Vitamin C to Malondialdehyde (MDA) Level in Medical Students Jember University with Psychological Stress Rahmad Adi Prasetyo; Laksmi Indreswari; Aris Prasetyo
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6423

Abstract

Medical students may to receive excessive psychological stressors during their education. The response of stress experienced by the body can activate the sympathetic neuron pathways and complex system hypothalamic pituitary-adrenal (HPA) axis. This can lead to a state of oxidative stress in the body through an increase of metabolism, mitochondrial oxidation, neutrophil activity, glycolysis and lipolysis processes. The level of malondialdehyde (MDA) is the most frequently used parameter for assessing oxidative stress conditions in the body. Vitamin C is an antioxidant that can neutralize the effects of free radicals through electron transfer mechanisms. This study aims to determine the effect of vitamin C on MDA levels in medical students of Jember University who experienced psychological stress. This is clinical test study with Quasi Experimental approach that used Pretest - Posttest Control Group Design with 32 sample of medical students Jember University who experienced psychological stress. The level of psychological stress was determined through questionnaire of Depression Anxiety Stress Scale (DASS) version Damanic Indonesian while the examination of MDA levels by the TBARs test. The result of T test analysis between MDA level at pretest and posttest is p= 0,000. It shows that there is effect of vitamin C consumption to the malondialdehyde (MDA) level in medical students Jember University with psychological stress. Keywords: Psychological stress, Malondialdehyde, Vitamin C