Laksmi Indreswari
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The Effect of Red Spinach Extract (Amaranthus tricolor L.) on Serum Malondialdehyde of Male Rattus Novergicus Fracture Model Aris Prasetyo; Ahmad Baihaqi; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.6838

Abstract

Fracture is a musculoskeletal injury with a high incidence rate. The healing process of fracture is disturbed by the oxidative stress, because of imbalance quantity of Reactive Oxygen Species (ROS) and antioxidant capacity in the body that neutralizes it. Antioxidants in red spinach have the potential to suppress the level of oxidative stress. The study aimed to determinate the effect of red spinach ethanolic extract on decreasing oxidative stress by measuring malonaldialdehyde (MDA) concentration in fracture healing process. The study used thirty rats and divided into five groups; negative control group, positive control group,and three treatment groups of red spinach ethanolic extract in a dose of 35,4 mg/150gBB, 70,8 mg/150gBB, and 141,6 mg/150gBB manually fractured on right femur under anaesthesia and immobilized by leucodur plaster. Each group was treated orally respectively one week. The result of One Way Anova showed a significance of 0,000 (p<0,05) in which there was a significant difference in serum MDA levels between the treatment groups and the control groups. The result of LSD test between P1 group and P3 group showed significantly different in which decreased serum MDA levels were consistent with increasing doses of red spinach ethanolic extract. The study concluded that red spinach ethanolic extract had a positive effect on supression of oxidative stress in fracture healing process. Keywords: Red spinach ethanolic extract, fracture healing process, MDA, ROS
Potential of Cocoa Extract (Theobroma cacao) in Inhibiting Erythrocyte Damage Induced by Physalia utriculus Venom Adinningtyas Intansari; Al Munawir; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 6 No 3 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i3.9661

Abstract

Physalia utriculus is one of the invertebrate marine biota that is often found in Indonesia. Some symptoms of venoming due to jellyfish stings cause pain, itching, and hemolysis. In Indonesia, 13 cases of jellyfish stings were reported in 2005-2009 with three people dying in Java, Bali, and Bangka. Cocoa beans (Theobroma cacao L.) contain fat, carbohydrates, proteins, and polyphenol compounds that are useful as antioxidants. Polyphenols in the form of epicathechins, catechins, and procyanidins serve to provide protection to hemolysis. The purpose of this study was to determine the potential of ethanol extract of cacao (Theobroma cacao L.) in inhibiting the damage of erythrocyte induced by Physalia utriculus in vitro. This study used 28 samples of erythrocytes divided into seven groups, namely the normal control group, negative controls, and treatment with cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02%. Each subsequent group induced venom Physalia utriculus. The results showed that the average speed of erythrocyte lysis in the treatment group by giving cocoa ethanol extract 0.2%, 0.1%, 0.04%, and 0.02% respectively (seconds ± standard deviation) was 858,25 ± 94,44; 1.000,5 ± 159,93; 678,5 ± 19,71; and 1.006 ± 159,50. The mean speed of erythrocyte lysis in the negative control group was 1,025 ± 164.63 and the positive control group with the administration of N-Acetylcystein can last up to one hour after administration of venoms. Test for normality and homogeneity shows that data is normally distributed and homogeneous. One Way Annova analysis shows the significance value of p <0.05, then a post hoc analysis test was performed with the Bonferoni method to find out the differences in significance in each group. In this study it can be concluded that the administration of cocoa ethanol extract has no potential to inhibit erythrocyte damage that has been venomed by Physalia utriculus in vitro. Keywords: Physalia utriculus, cacao, erythrocyte damage
Tetraciclyne Resistance Eschericia coli Isolated From Broiler Chicken Meat Anisa Rizca Putri; Enny Suswati; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6402

Abstract

Antibiotic resistance is a serious health problem that have ben uneffective therapy. The cause of antibiotic resistance 80% comes from food of animal origin such as Broiler Chicken. E. coli contamination in antibiotic resistant chicken has been shown to transfer genetic factors between bacteria in the human intestinal system. Almost all broiler breeders use commercial feed containing tetracycline antibiotics. The use of antibiotics in the feed mixture is one of the risk factors for resistance. The aim of this study was to get an information of antibiotic resistance E. coli which isolated from broiler meat. Identification test of E. coli used two phase, presumtive test and confirmed test. Sensitivity test for E. coli to antibiotic by disc diffusion Kirby Bauer method. This study used 6 sample of upper thigh broiler meat, the antibiotic use tetracycline. The data were analyzed descriptively. The results of this study show that from 6 isolate sample, there are 4 isolate identificated as E. coli and 2 isolate show resistance to the tetracycline antibiotic. The conclusion of this study showed resistance has occurred on 50% sample.
The Effect of Zumba Exercise to Women's Waist Hip Ratio Laksmi Indreswari; Yunita Dewi Anggraeni; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.17449

Abstract

Abdominal obesity is a global public health problem. The high prevalence of abdominal obesity triggers an increase in morbidity and mortality in chronic diseases such as diabetes mellitus, cardiovascular, and cancer. One of the causes of the high prevalence of abdominal obesity is the lack of physical activity. Prevention efforts are needed through the identification of risk factors such as measurement of waist hip ratios. The respondents of this study were divided into two groups: 28 respondents who did zumba exercise for four weeks and 28 control respondents. The statistical test performed was a paired t-test comparison test. The results of this study indicate the value of t-count > t-table value (7.184 > 2.052) and the significance of 0.000 < 0.05. These results indicate that there is a decrease in the waist hip ratio after doing zumba exercise for four weeks.
Analysis Of Rat Platelet Count After Electrical Exposure In Acute And Subacute Phase Of Burn Injury Fransiska Nooril F P H; Ulfa Elfiah; Laksmi Indreswari; Desie Dwi Wisudanti
Jurnal Rekonstruksi dan Estetik Vol. 4 No. 1 (2019): Jurnal Rekonstruksi dan Estetik, Juni 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.759 KB) | DOI: 10.20473/jre.v4i1.24347

Abstract

Electrical burns are one of the causes of important health burdens throughout the world with incidences varying between 4 – 18% of all burns. In electrical burns, blood vessels are the heavily damaged tissue characterized by endothelial erosion, followed by adhesion and aggregation of platelet to form hemostatic plug. The screening test for assesing the formation of a hemostatic plug is platelet count. Platelet count monitoring is very important during the resuscitation phase and treatment periods in severe burns, namely in acute and subacute phase of burns. The purpose of this study is to determine and to analyze about the changes in platelet count of rat after electrical exposure in acute and subacute phase of burns. The control group in this study was not given electrical exposure and rat’s blood was taken directly after the adaptation process. In the other five groups, P1, P2, P3, P4 and P5 were exposed to 140 V for 17 seconds, then their blood was taken for platelet counts on days 0, 3, 7, 10 and 14 post-exposure. The result of this study based on Post Hoc LSD test showed that there was a change of platelet platelet number after exposure in acute phase of burn injury and there was no change of platelet platelet number after exposure in burning subacute phase.
Effect of Vitamin C to Malondialdehyde (MDA) Level in Medical Students Jember University with Psychological Stress Rahmad Adi Prasetyo; Laksmi Indreswari; Aris Prasetyo
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6423

Abstract

Medical students may to receive excessive psychological stressors during their education. The response of stress experienced by the body can activate the sympathetic neuron pathways and complex system hypothalamic pituitary-adrenal (HPA) axis. This can lead to a state of oxidative stress in the body through an increase of metabolism, mitochondrial oxidation, neutrophil activity, glycolysis and lipolysis processes. The level of malondialdehyde (MDA) is the most frequently used parameter for assessing oxidative stress conditions in the body. Vitamin C is an antioxidant that can neutralize the effects of free radicals through electron transfer mechanisms. This study aims to determine the effect of vitamin C on MDA levels in medical students of Jember University who experienced psychological stress. This is clinical test study with Quasi Experimental approach that used Pretest - Posttest Control Group Design with 32 sample of medical students Jember University who experienced psychological stress. The level of psychological stress was determined through questionnaire of Depression Anxiety Stress Scale (DASS) version Damanic Indonesian while the examination of MDA levels by the TBARs test. The result of T test analysis between MDA level at pretest and posttest is p= 0,000. It shows that there is effect of vitamin C consumption to the malondialdehyde (MDA) level in medical students Jember University with psychological stress. Keywords: Psychological stress, Malondialdehyde, Vitamin C
The Correlation between Noise in Workplace and Sleep Quality in Workers at PT. Muroco Jember Wood Processing Factory Lathifa Rusyda Gani; Dwita Aryadina Rachmawati; Laksmi Indreswari; Alif Mardijana; Yudha Nurdian
Journal of Agromedicine and Medical Sciences Vol 4 No 2 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i2.6790

Abstract

Noise is a problem that can’t be resolved properly until now because it is one of the factors that sometimes is neglected from the work environment, so it can be a serious threat to the health of workers. The production tools and engines in the factory as the result of technology development produce a sound that can cause noise and interfere with health. Noise can also cause a variety of other disorders such as physiological, psychological, and communication disorders. Psychological disorders can include discomfort, lack of concentration, insomnia, and irritability. Sleep disorders can be associated with 13% of occupational hazards. Workers who have sleep disorders have a 1.62 times higher risk of experiencing work accidents compared with workers who do not have sleep disorders. The aim of this study is to determine the correlation between noise in workplace and sleep quality in workers at PT. Muroco Jember wood processing factory. This is an analytical observational study with cross sectional study design using workers of the factory who meet inclusion and exclusion criteria. Noise in the workplace was measured with sound level meter and sleep quality of the workers was measured with Pittsburgh Sleep Quality Index Questionnaire. Spearman correlation test result between these variables is p= 0,899. That result indicates that there is no significant correlation between noise in workplace and sleep quality in workers at PT. Muroco Jember wood processing factory. Keywords: Noise, Sleep Quality, Worker
Analysis of Personal Protective Equipments Pesticides Usage Effects on Health Complaints of Farmers in Pringgondani Village Sumberjambe District Jember Regency BJ Azmy As'ady; Supangat Supangat; Laksmi Indreswari
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.7901

Abstract

Jember is one of the districts in East Java Province with the majority of its population working as farmers. Pringgondani Village Farmers in Jember use pesticides when farming. Pesticides contain harmful chemicals. Use of PPE (Personal Protective Equipments) can protect farmers when mixing and spraying pesticides. This study aims to analyze correlation between PPE pesticides usage and health complaints of farmers in Pringgondani Village Sumberjambe District Jember Regency. Cross sectional surveys were conducted on 50 samples. Data were collected by interview using questionnaire. Data were analyzed by chi square test to know correlation between PPE pesticides use (protective clothing, head protection, mask, gloves and boots) and health complaints (headache, increased fatigue, itching and nausea). Chi square test result showed significance 0,043 (p <0,05) where there was a correlation between head protector use and health complaint of respondent with contingency coefficient (r) equal to 0,318. The conclusion is that there is a correlation between the head protection use and health complaints of farmers in Pringgondani Village Sumberjambe District Jember Regency with sufficient correlation. Keywords: PPE, pesticides, health complaints, Farmers, Pringgondani, Jember