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All Journal Global Medical and Health Communication Jurnal Integrasi Kesehatan dan Sains Journal of Health and Dental Sciences Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Yuke Andriane
Bagian Farmakologi, Fakultas Kedokteran, Universitas Islam Bandung
Humanities Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Pengetahuan dan Perilaku Swamedikasi oleh Ibu-Ibu di Kelurahan Tamansari Kota Bandung Putri Anggraini Aswad; Yuktiana Kharisma; Yuke Andriane; Titik Respati; Eka Nurhayati
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 2 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i2.4462

Abstract

Swamedikasi merupakan upaya individu untuk mengobati penyakit atau gejala yang dikenali sendiri. Swamedikasi dapat menjadi permasalahan kesehatan akibat keterbatasan pengetahuan mengenai obat sehingga akan memengaruhi perilaku seseorang. Tujuan penelitian ini adalah mendeskripsikan pengetahuan dan perilaku swamedikasi oleh ibu-ibu di Kelurahan Tamansari Kota Bandung. Rancangan penelitian observasional deskriptif dengan metode cross sectional. Jumlah sampel 50 orang dengan teknik consecutive sampling. Pengambilan data melalui kuesioner. Hasil penelitian menunjukkan pengetahuan responden tentang definisi swamedikasi (54%), penggolongan obat berdasar atas logo (64%), makna logo obat dibeli tanpa resep dokter (46%), makna logo obat bebas terbatas (52%), definisi aturan pakai obat 3x sehari (56%), interval waktu penggunaan obat (68%), perbedaan dosis obat dewasa dengan anak (88%), definisi efek samping obat (80%), menanggulangi efek samping (98%), definisi kontraindikasi obat (86%), definisi interaksi obat (62%), dan penyimpanan obat (86%). Prevalensi perilaku swamedikasi pada responden (60%), obat modern lebih mendominasi (64%), pemilihan obat modern untuk swamedikasi didasarkan atas keinginan sendiri (38%), warung kelontong sebagai tempat mendapatkan obat (48%), informasi swamedikasi diperoleh melalui media elektronik dan media cetak (36%), kebiasaan membaca kandungan obat (64%) dan tanggal kadaluarsa obat (86%), serta menyimpan obat di rak obat (50%). Simpulan penelitian ini, pengetahuan swamedikasi pada masyarakat secara umun cukup baik. Terdapat upaya untuk mengatasi masalah kesehatan dengan melakukan swamedikasi. SELF-MEDICATION KNOWLEDGE AND BEHAVIOR BY MOTHERS IN TAMANSARI VILLAGE OF BANDUNGSelf-medication is an individual effort to treat a disease or symptom that is recognized by itself. Self-medication can be a health problem due to limited knowledge about drugs which will affect a person’s behavior. The aim of this study was to describe the self-medication knowledge and behavior of mothers in Tamansari village of Bandung. Descriptive observational study design with cross-sectional method. The number of samples were 50 people with consecutive sampling technique. Data was collected by using questionnaire. The research showed that respondent’s knowledge of definition of self-medication (54%), classification of drugs based on logos (64%), meaning of over the counter drug (46%), limited free drug logos meaning (52%), definition of drug use rules 3x a day (56%), time interval for drug use (68%), difference in drug dosage between adults and children (88%), definition of drug side effects (80%), overcoming side effects (98%), definition of contraindications (86%), definition of drug interactions (62%), and drug storage (86%). The prevalence of self-medication behavior in respondent’s (60%), modern medicine dominates (64%), the selection of modern drugs for self-medication are based on their own desires (38%), grocery stalls as places to get medicine (48%), self-administered information obtained through electronic media and printed (36%), habit of reading drug content (64%) and drug expiration dates (86%), and storing drugs on drug racks (50%). The conclusion of this study that level knowledge by mothers is generally quite good. There are efforts to overcome health problem with self-medication.
RELATIONSHIP BETWEEN BLOOD PRESSURE AND BLOOD GLUCOSE ON VASCULAR BLOOD FUNCTION AND AEROBIC WORKING CAPACITY IN FEMALE NURSE'S SHIFT WORK Ike Rahmawaty Alie; Yuke Andriane; Rizki Perdana; Doni Septiadi Rosady; Ieva B Akbar
Journal of Health and Dental Sciences Vol. 2 No. 1 (2022): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Shift work is a rotating work time outside regular working hours, either rotating with the shift work method. Shift work can cause changes in metabolism, immunological status, and oxidative status that cause inflammation due to changes in circadian rhythm. Nurses, primarily female, in provide 24-hour services also have to do shift work. This study aimed to see the relationship between blood pressure and blood glucose to vascular function and aerobic capacity in female nurses working in hospitals. The research method was descriptive-analytic to know the relationship between blood pressure and glucose to blood vessel function as measured by cGMP and aerobic capacity. Through VO2max, the research sample was selected purposively with inclusion criteria of having worked as female nurses who had worked for at least six months and were aged 20-40 years. The results show that the fasting blood glucose value had more influence on the cGMP value than the MABP value (r= 0.204 vs. 0.034), although the relationship was weak and very weak. The correlation analysis between fasting Blood Glucose and VO2max and Blood Pressure with VO2max shows blood pressure is more significant than fasting Blood Glucose on VO2max (0.105 vs. 0.083) even though the correlation between the two is very weak. It may be because many other factors can influence blood vascular function and aerobic functional capacity. DOI : 10.54052/jhds.v2n1.p1-14
Sediaan Nanopartikel Alginat Ekstrak Etanol Daun Sirsak (Annona muricata Linn) Memiliki Efek Antikanker pada Kultur Sel Kanker Paru (HTB183) Neng Resa Aulia Tulloh; Yuke Andriane
Jurnal Riset Kedokteran Volume 1, No.2, Desember 2021, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.989 KB) | DOI: 10.29313/jrk.v1i2.565

Abstract

Abstract. Introduction: Lung cancer is the second most common cancer in the world with the highest mortality rate. Chemotherapy is a method that has a high modality in the management of lung cancer. The disadvantage of chemotherapy is that it has a high level of resistance and side effects. One strategy to overcome these deficiencies in the development of phytopharmaceuticals. The purpose of this study was to examine the anticancer effect of alginate nanoparticles of soursop leaf ethanol extract (NPS) and its combination on HTB183 lung cancer cell culture. Methods: This research is a pure experimental study in vitro on HTB183 lung cancer cell culture which was carried out at the UGM Laboratory in March-December. Toxicity test was carried out using the MTT method to obtain the ICvalue50 and analyzed using probit regression calculation using software SPSS. Results: The results of this study showed that the IC50 alginate nanoparticles of soursop leaf ethanol extract on lung cancer cell culture were 31,261 (±4.4) g/mL. Conclusion: Alginate nanoparticles from soursop leaf ethanol extract had a moderate anticancer effect on HTB183 lung cancer cell culture. The anticancer effect of soursop leaf preparations is caused by alginate nanoparticles that can bind the content of soursop leaf extract stably. Abstrak. Pendahuluan: Kanker paru merupakan kanker ke dua paling sering terjadi di dunia dengan angka kematian tertinggi. Kemoterapi menjadi salah satu metode pengobatan yang memiliki modalitas tinggi dalam penatalaksanaan kanker paru. Kekurangan dari kemoterapi adalah tingkat resistensi dan efek samping yang tinggi. Salah satu strategi untuk mengatasi kekurangan tersebut dengan mengembangkan obat antikanker bahan alam. Tujuan penelitian ini adalah menguji efek antikanker nanopartikel alginat ekstrak etanol daun sirsak (NPS) dan kombinasinya pada kultur sel kanker paru HTB183. Metode: Penelitian ini merupakan penelitian eksperimental murni in vitro pada sel kultur kanker paru HTB183 yang dilaksanakan di Laboratorium UGM pada bulan Maret−Desember. Uji toksisitas dilakukan menggunakan metode MTT untuk mendapatkan nilai IC50 dan dianalisis menggunakan penghitungan regresi probit melalui software SPSS. Hasil: Hasil penelitian ini menunjukkan IC50 nanopartikel alginat ekstrak etanol daun sirsak terhadap kultur sel kanker paru sebesar 31,261 (±4,4) μg/mL. Simpulan: nanopartikel alginat ekstrak etanol daun sirsak memiliki efek antikanker sedang pada kultur sel kanker paru HTB183. Efek antikanker sediaan daun sirsak disebabkan oleh nanopartikel alginate dapat mengikat kandungan ekstrak daun sirsak secara stabil.
Semaglutide Oral (Rybelsus) pada Diabetes Melitus Tipe 2 di Ras Asia: Tinjauan Pustaka Ghilda Ainun Nisaa S; Santun Bhekti Rahimah; Yuke Andriane
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.546

Abstract

Abstract. Oral semaglutide is a GLP-1 receptor agonist (GLP-1 RA) which activates the GLP-1 receptor and causes increased control of blood glucose, through increased insulin secretion by pancreatic beta cells, decreased glucagon secretion by pancreatic alpha cells, and decreased emptying rate. stomach. The hormone GLP-1 can have an incretin effect, namely the production of more insulin due to high glucose levels. The effect of increasing in patients with DM(T)2 decreased as active GLP-1 levels also decreased. GLP-1 can also regulate pancreatic beta cell genes by inhibiting their apoptosis, preventing glucolipotoxicity, and enhancing beta cell function. The administration of oral semaglutide drug in DM(T)2 patients with Asian race is also superior because the drug can suppress appetite and make weight loss which will control DM(T)2 in Asian races who have adiposity/fat content and waist circumference is higher. higher than other races, and had a higher decrease in HbA1c levels. Abstrak. Semaglutide oral merupakan GLP-1 receptor agonist (GLP-1 RA) yang akan mengaktifkan reseptor GLP-1 dan menyebabkan peningkatan kontrol dari glukosa darah, melalui peningkatan sekresi insulin oleh sel beta pankreas, penurunan sekresi glukagon oleh sel alfa pankreas, dan penurunan laju pengosongan lambung. Hormon GLP-1 dapat memberikan efek incretin, yaitu pengeluaran insulin yang lebih banyak karena kadar glukosa yang tinggi. Efek incretin pada pasien DM(T)2 mengalami penurunan seiring dengan kadar GLP-1 aktif yang juga menurun. GLP-1 juga dapat mengatur gen sel beta pankreas dengan menghambat apoptosisnya, mencegah glukolipotoksisitas, dan meningkatkan fungsi sel beta. Pemberian obat semaglutide oral pada pasien DM(T)2 dengan ras Asia juga lebih unggul karena obat tersebut dapat menekan nafsu makan dan membuat penurunan berat badan yang akan mengendalikan DM(T)2 pada ras Asia yang memiliki adipositas/ kandungan lemak dan lingkar pinggang lebih tinggi dibandingkan ras lain, serta memiliki penurunan kadar HbA1c yang lebih tinggi.
Teh Hijau (Camellia Sinensis) dapat Menurunkan Profil Lipid pada Pasien Dislipidemia: Kajian Pustaka Gita Puspa Mahardhika; Yuke Andriane; Riri Risanti
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1533

Abstract

Abstract. Dyslipidemia is a lipid metabolism disorder that causes an increase or decrease in the lipid fraction of the plasma. Dyslipidemia is a risk factor for diseases with high mortality rates, such as cardiovascular disease. World Health Organization (WHO) stated there are 2.6 million deaths due to dyslipidemia per year. Fifty-three percent of dyslipidemic patients did not comply with treatment due to fear of side effects. Non-adherence to hypolipidemic drugs causes an increase in cardiovascular events and mortality, hence alternative therapy needs to be considered. Green tea contains epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC), and epicatechin (EC) which can lower lipid profiles by various mechanisms. Catechins with gallate esters in green tea decrease the synthesis of cholesterol and triglycerides by interfering with emulsification, hydrolysis, micelle formation, and lipid absorption in the intestinal lumen. EGCG can lower LDL by increasing LDL-R expression. Abstrak. Dislipidemia merupakan kelainan metabolisme lipid yang menyebabkan adanya peningkatan atau penurunan fraksi lipid dalam plasma. Dislipidemia menjadi faktor risiko dari penyakit – penyakit dengan tingkat mortalitas tinggi, seperti penyakit kardiovaskular. Berdasar atas data dari Organisasi Kesehatan Dunia (WHO) mengatakan terdapat 2,6 juta kematian akibat dislipidemia per tahunnya. Terdapat 53% pasien dislipidemia yang tidak patuh menjalani pengobatan karena takut akan efek samping yang ditimbulkan. Ketidakpatuhan penggunaan obat dislipidemia ini menyebabkan peningkatan kejadian kardiovaskular dan kematian sehingga terapi alternatif perlu dipertimbangkan. Teh hijau mengandung epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC), dan epicatechin (EC) yang dapat menurunkan profil lipid dengan berbagai mekanisme. Catechin dengan ester gallate pada teh hijau dapat mengganggu proses emulsifikasi, hidrolisis, pembentukan misel, dan penyerapan lipid di lumen usus sehingga sintesis kolesterol dan trigliserid menurun. EGCG dapat menurunkan LDL dengan meningkatkan ekspresi LDL-R.
Scoping Review: Efek Daun Belalai Gajah (Clinacanthus nutans) terhadap Penurunan Kadar Glukosa Darah pada Tikus Model Diabetes Rifqy Zidane El-Fariq Nizar; Yuke Andriane; Saleh Trisnadi
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1749

Abstract

Abstract. Diabetes Mellitus (DM) is a chronic disease caused by a decrease in the activity of the pancreas in producing insulin or when the body cannot use the insulin it produces effectively. The body of people with diabetes is unable to absorb glucose properly, causing hyperglycemia conditions which can lead to life-threatening complications. The prevalence and cases of DM in the world increased continuously over the last few decades. Non-compliance to the use of antidiabetic drugs can cause disruption of body functions and mortality, hence alternative therapies need to be considered. The compounds in belalai gajah leaves that have been tested to have antihyperglycemic effects include flavonoids, saponins, and tannins with various mechanisms.. The purpose of this study was to determine the effect of belalai gajah leaves (Clinacanthus nutans) on reducing blood glucose levels in diabetic rats. This research method is scoping review, by searching for articles published in 2011-2021 on the Google Scholar, Proquest, Springer Link, and Science Direct databases. The sample in this study is research articles in international journals that meet the inclusion, exclusion and feasibility criteria based on PICOS, totaling three articles. The results of this study showed that belalai gajah leaves (Clinacanthus nutans) could significantly reduce blood glucose levels (p≤0.05) compared to the control group. Flavonoid, saponins, and tannins play a role in the repair of pancreatic beta cells, inhibition of glucose release, and increase insulin activity and GLUT-4 translocation through the P13K and MAPK pathways. This mechanism can reduce blood glucose levels in diabetic rats. Abstrak. Diabetes Melitus (DM) merupakan suatu penyakit kronis yang diakibatkan oleh penurunan aktivitas pankreas dalam memproduksi insulin atau saat tubuh tidak dapat menggunakan insulin yang dihasilkannya secara efektif. Tubuh penderita DM tidak mampu menyerap glukosa dengan baik sehingga menimbulkan kondisi hiperglikemia yang menyebabkan komplikasi yang dapat mengancam jiwa. Jumlah prevalensi dan kasus DM di dunia terus mengalami peningkatan selama beberapa dekade terakhir. Ketidakpatuhan penggunaan obat antidiabetes dapat menyebabkan terganggunya fungsi tubuh dan kematian sehingga terapi alternatif perlu dipertimbangkan. Kandungan senyawa dalam ekstrak daun belalai gajah yang telah teruji memiliki efek antihiperglikemik di antaranya flavonoid, saponin, dan tanin dengan berbagai mekanisme. Tujuan penelitian ini adalah untuk mengetahui efek daun belalai gajah (Clinacanthus nutans) terhadap penurunan kadar glukosa darah pada tikus model diabetes. Metode penelitian ini adalah scoping review, dengan mencari artikel yang dipublikasikan tahun 2011-2021 pada database Google Scholar, Proquest, Springer Link, dan Science Direct. Sampel dalam penelitian ini berupa artikel penelitian pada jurnal internasional yang memenuhi kriteria inklusi, eksklusi dan uji kelayakan berdasarkan PICOS berjumlah tiga artikel. Hasil penelitian ini menunjukkan daun belalai gajah (Clinacanthus nutans) dapat menurunkan kadar glukosa darah dengan signifikan (p≤0,05) dibandingkan dengan kelompok kontrol. Senyawa flavonoid, saponin, dan tanin berperan dalam perbaikan sel beta pankreas, inhibisi pengeluaran glukosa, serta meningkatkan aktivitas insulin dan translokasi GLUT-4 melalui jalur P13K dan MAPK. Mekanisme tersebut dapat menurunkan kadar glukosa darah pada tikus model diabetes.
Histopathology of Nephrotoxicity Associated with Administered Water Extract Purple Sweet Potato (Ipomoea batatas) in Mice (Mus musculus) in Stratified Phases of Dose Meta Maulida Damayanti; Raden Anita Indriyanti; Yuktiana Kharisma; Yuke Andriane; Uci Ari Lantika; Ratna Damailia; Meike Rachmawati
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9662

Abstract

The main aim of the registered purple sweet potato (Ipomoea batatas) is to provide minimize the adverse chemical drugs, in addition to its anti-inflammatory, antioxidant, and antimicrobial effects. Potentially adverse effects may be observed in laboratory animals in particular, the extent to which this administration can cause toxicity. This study aimed to examine the histopathology of nephrotoxicity associated with administered water extracts of purple sweet potato in mice with stratified doses. The study was conducted at the Biomedical Laboratory, Faculty of Medicine, Universitas Islam Bandung on September 2019. Female mice (Mus musculus) strain Swiss Webster, aged between 6–8 weeks weighing 25 to 30 g, were obtained from Biopharma Laboratory, Bandung. The animal was acclimatized for seven days before being administered water extract purple sweet potato: eleven mice, one control group, and ten treatment groups underwent toxicity doses of purple sweet potato water extract administration. Purple sweet potato variant of Ayamurasaki prepared in various oral doses. The results show in the control group there were no histopathological changes, but in the group administered water extract purple sweet potato from the first phase seems in a mild grade of macrophage accumulation, mild vacuolization of tubular epithelial cells, mild vascular dilatation, and mild hydrophilic degeneration. In the second phase, macrophage accumulation was visible in moderate grades. The LD50 of purple sweet potato extract is greater than 5,000 mg/kgBW. The findings of this study indicate that registration of purple sweet potato extract in confirmatory doses is safe to administer and did not exhibit any mortality. The toxicity test of purple sweet potato water extracts in the kidney exhibits minimal chemical effects.
Efek Antikanker dan Ko-Kemoterapi Nanopartikel Alginat Ekstrak Etanol Daun Sirsak (Annona Muricata) dengan Doxorubicin pada Kultur Sel Kanker Serviks Uteri (HeLa) Revina Mayra Salsabila Hasyim; Lelly Yuniarti; Yuke Andriane
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5741

Abstract

Abstract. Uterine cervical cancer ranks fourth in the world and Asia and second in Indonesia. Cervical uteri cancer chemotherapy with doxorubicin still has high side effects. To reduce these side effects, combination therapy can be carried out between standard drugs and drugs from natural ingredients, one of which is soursop leaf in the form of nanoparticles which can increase the delivery of compounds. The purpose of this study was to analyze the anticancer effect of alginate nanoparticles of soursop leaf ethanol extract and its combination with doxorubicin on cervical uteri cancer (HeLa) cells. This research is a pure in vitro experimental study on cervical uteri cancer cell culture (HeLa). The cytotoxicity test was carried out using the microtetrazolium method and analyzed using the SPSS software probit regression. The combination test was carried out with concentrations of 1/2 IC50, 3/8 IC50, 1/4 IC50, 1/8 IC50 and analyzed using CompuSyn software to obtain a CI value indicating the synergy of the preparations. This study had an IC50 of soursop leaf extract nanoparticles of 52.0825 (±24.26) µg/mL (moderate effect) and doxorubicin which had an IC50 of 4.8 (±0.10) µg/mL (strong effect). The lowest CI value obtained was 0.04106. The conclusion of this study is that soursop leaf extract nanoparticles have a moderate anticancer effect and are highly synergistic with eight combinations of doxorubicin. Abstrak. Kanker serviks uteri menempati urutan keempat di dunia dan Asia serta kedua di Indonesia. Kemoterapi kanker serviks uteri dengan doxorubicin masih memiliki efek samping yang tinggi. Untuk menurunkan efek samping tersebut, dapat dilakukan terapi kombinasi antara obat standar dengan obat dari bahan alam, salah satunya adalah daun sirsak dalam bentuk nanopartikel yang dapat meningkatkan penghantaran senyawa. Tujuan penelitian ini adalah untuk menganalisis efek antikanker sediaan nanopartikel alginat ekstrak etanol daun sirsak dan kombinasinya dengan doxorubicin pada sel kanker serviks uteri (HeLa). Penelitian ini merupakan penelitian eksperimental murni in vitro pada kultur sel kanker serviks uteri (HeLa). Uji sitotoksisitas dilakukan menggunakan metode microtetrazolium dan dianalisis melalui regresi probit software SPSS. Uji kombinasi dilakukan dengan konsentrasi 1/2 IC50, 3/8 IC50, 1/4 IC50, 1/8 IC50 dan dianalisis menggunakan software CompuSyn hingga didapatkan nilai CI yang menunjukkan sinergitas sediaan. Penelitian ini memiliki hasil IC50 nanopartikel ekstrak daun sirsak sebesar 52,0825 (±24,26) µg/mL (efek sedang) dan doxorubicin yang memiliki IC50 sebesar 4,8 (±0,10) µg/mL (efek kuat). Nilai CI terendah yang didapatkan adalah sebesar 0,04106. Kesimpulan penelitian ini adalah nanopartikel ekstrak daun sirsak memiliki efek antikanker sedang dan bersifat sinergis sangat kuat dengan doxorubicin sebanyak delapan kombinasi.
Hubungan Penyakit Ginjal Kronik dengan Derajat Klinis Covid-19 di Ruang Rawat Inap RSUD Al-Ihsan Bandung Tahun 2021 Tasya Sherina; Yuke Andriane; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6710

Abstract

Abstract. Chronic kidney disease can increase the risk of death due to COVID-19 infection. It is caused by changes in the immune system, including persistent systemic inflammation and immunosuppression. Apart from respiratory cells, SARS-Cov-2 also attacks other organs, including the kidney where there are proximal renal tubular epithelial cells, glomerular mesangial cells, and podocytes that express ACE2 receptors on their surface which are the targets of COVID-19. This study uses an observational analytic design through a cross-sectional approach. The sampling technique used simple random sampling which met the inclusion and exclusion criteria, with a total sample of 60 taken from secondary data in the form of inpatient medical records. Bivariate analysis was carried out to analyze the relationship between chronic kidney disease and the clinical degree of COVID-19 using the chi-square test. Univariate data analysis showed that the number of Covid-19 sufferers who experienced chronic kidney disease was 30 people (50.0%), Covid-19 sufferers who did not experience chronic kidney disease were 30 people (50.0%) and the clinical degree of Covid-19 was without symptoms and mild symptoms none (0%), moderate symptoms 37 people (61.7%), severe symptoms 9 people (15.0%) and critical symptoms 14 people (23.3%). The results of bivariate data analysis obtained 0.596 (p> 0.05) so that it can be concluded that there is no relationship between chronic kidney disease and the degree of clinical symptoms in Covid-19 patients at Al Ihsan Hospital in Bandung. Abstrak. Penyakit ginjal kronik dapat meningkatkan risiko kematian karena infeksi COVID-19. Hal ini disebabkan oleh perubahan sistem kekebalan, termasuk inflamasi sistemik persisten dan terjadi imunosupresi. Selain sel pernapasan, SARS-Cov-2 juga menyerang organ lain, termasuk ginjal yang dimana terdapat sel epitel tubulus ginjal proksimal, sel mesangial glomerulus, dan podosit yang mengekspresikan reseptor ACE2 pada permukaannya yang menjadi target COVID-19. Penelitian ini menggunakan desain analitik observasional melalui pendekatan cross-sectional. Teknik pengambilan sampel menggunakan simple random sampling yang memenuhi kriteria inklusi dan eksklusi, dengan jumlah sampel 60 yang di ambil dari data sekunder berupa rekam medis pasien rawat inap. Analisis bivariat di lakukan untuk menganalisis hubungan penyakit ginjal kronik dengan derajat klinis COVID-19 menggunakan uji chi-square. Analisis data univariat menunjukan jumlah penderita Covid-19 yang mengalami penyakit ginjal kronik sebanyak 30 orang (50.0%), penderita Covid-19 yang tidak mengalami penyakit ginjal kronik sebanyak 30 orang (50.0%) dan derajat klinis Covid-19 tanpa gejala dan gejala ringan tidak ada (0%), gejala sedang 37 orang (61.7%), gejala berat 9 orang (15.0%) dan gejala kritis 14 orang (23.3%). Hasil analisis data bivariat diperoleh 0.596 (p>0,05) sehingga dapat disimpulkan tidak terdapat hubungan antara penyakit ginjal kronik dengan derajat gejala klinis pada pasien covid-19 di RSUD Al Ihsan Bandung.
Kebersihan Tangan dan Infeksi Cacing Enterobius Vermicularis pada Anak Sekolah Dasar Ahmad Heru Sopyan; Yuke Andriane; Ismet Muchtar Nur
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6138

Abstract

Abstract. Enterobiasis is an infection with the worm Enterobius vermicularis which is still a global public health problem in both developed and developing countries. One of the factors that increases the risk of Enterobiasis is poor hand hygiene. The purpose of this study was to find out whether there is a relationship between hand hygiene and Enterobiasis in grade 6 students at SDN Jayamakmur 1 Karawang, West Java, in 2022. The type of research was analytic observational with a cross sectional research design. The research population was 6th grade students at SDN Jayamakmur 1 Karawang, West Java, with a total sample of 32 people. Data collection was carried out using a hand hygiene questionnaire and anal swab examination and analyzed using the Chi-square test. The results of the study showed that the number of students who had good hand hygiene and those who had poor hand hygiene were almost the same and the frequency distribution of Enterobiasis examinations showed that most of the respondents did not experience Enterobiasis. The results showed that there was a relationship between hand hygiene and Enterobiasis in grade 6 students at SDN Jayamakmur 1 Karawang, West Java, in 2022 (P-value = 0.006). Hand hygiene is important in everyday life because hands are the first medium that is very often contaminated with parasites, especially Enterobius vermicularis, which can cause Enterobiasis. Abstrak. Enterobiasis merupakan infeksi cacing Enterobius vermicularis yang masih menjadi masalah kesehatan masyarakat global baik di negara maju maupun berkembang. Salah satu faktor yang meningkatkan risiko Enterobiasis adalah kebersihan tangan yang kurang baik. Tujuan penelitian ini untuk mengetahui apakah terdapat hubungan kebersihan tangan dengan Enterobiasis pada siswa kelas 6 SDN jayamakmur 1 Karawang Jawa Barat tahun 2022. Jenis penelitian adalah analitik observasional dengan desain penelitian cross sectional. Populasi penelitian adalah siswa kelas 6 di SDN Jayamakmur 1 Karawang Jawa Barat dengan jumlah sampel sebanyak 32 orang. Pengumpulan data dilakukan dengan kuesioner kebersihan tangan dan pemeriksaan anal swab serta dianalisis dengan uji Chi-square. Hasil penerlitian menunjukan jumlah siswa yang memiliki kebersihan tangan yang baik dengan yang memiliki kebersihan tangan yang buruk hampir sama banyak dan distribusi frekuensi pemeriksaan Enterobiasis sebagian besar responden tidak mengalami Enterobiasis. Hasil penelitian menunjukan terdapat hubungan antara kebersihan tangan dengan Enterobiasis pada siswa kelas 6 SDN Jayamakmur 1 Karawang Jawa Barat tahun 2022 (P-value = 0,006). Kebersihan tangan merupakan hal penting dalam kehidupan sehari-hari karena tangan merupakan perantara pertama yang sangat sering terkontaminasi parasit khususnya Enterobius vermicularis sehingga dapat menyebabkan Enterobiasis.
Co-Authors Abdul Hadi Hassan Ahmad Heru Sopyan Alfiani Triamullah Annisa Rahmah Furqaani Asep Saefulloh Astuti, Ratna Dewi Indi Caecielia Wagiono Doni Septiadi Rosady Eka Nurhayati Endang Suherian Fajar Awalia Yulianto Ghaliby Ardhia Ramli Ghilda Ainun Nisaa S Gita Puspa Mahardhika Hendryanny, Eka Herry Garna Herry S. Sastramihardja Ieva B Akbar Ike Rahmawaty Alie Ismet Muchtar Nur Lelly Yuniarti Mas Rizky A. A. Syamsunarno Meike Rachmawati Meita Nurfitriani Saefulloh Meta Maulida Damayanti Mia Kusmiati Miranti Kania Dewi Neng Resa Aulia Tulloh Neni Anggraeni Nugraha Sutadipura Oky Haribudiman Perdana, Rizki Putri Anggraini Aswad Qyana Al Farisi R. Ruslami Raden Aliya Tresna M. D. Raden Anita Indriyanti Raden Sarah Azzahra Nur Arofah Rahma Ratu Halima Ratna Damailia Retno Ekowati Revina Mayra Salsabila Hasyim Rifqy Zidane El-Fariq Nizar Rina Permatasari Riri Risanti Sadiah Achmad Saleh Trisnadi Santun Bhekti Rahimah Silmi Hizba Hunafa Syahrir Zein Rumatumia Tasya Sherina Titik Respati Gilarsi Uci Ari Lantika Waya Nurruhyuliawati, Siti Aminah, Uni Gamayani, Eddy Fadlyana Yuktiana Kharisma