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Efek Jus Buah Naga Super Merah (Hylocereus costaricensis) dan Simvastatin terhadap Kadar Kolesterol Total Darah dan Bobot Badan Tikus Jantan Galur Wistar Hiperkolesterolemia Karimah, Fauziyyah; Achmad, Sadiah; Prawiradilaga, R. Rizky Suganda
Global Medical & Health Communication (GMHC) Vol 2, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstrak Penyakit kardiovaskular terjadi akibat beberapa faktor risiko dan di antaranya kadar kolesterol yang tinggi. Menurut survei WHO pada tahun 2008 sekitar 17,3 juta orang meninggal dunia karena penyakit kardiovaskular. Tujuan penelitian ini untuk mengetahui perbedaan efek pemberian jus buah naga super merah (Hylocereus costaricensis) sebagai terapi herbal dengan simvastatin sebagai obat standar yang telah digunakan dalam dunia medis terhadap kadar kolesterol total darah dan bobot badan tikus jantan galur Wistar hiperkolesterolemia.Penelitian dilakukan di Laboratorium Biomedik Universitas Islam Bandung pada bulan AprilËMei 2014 dengan menggunakan metode eksperimental laboratorik pada 20 ekor tikus hiperkolesterolemia dengan memberi diet tinggi lipid dan Propil Tiourasil (PTU) selama 14 hari. Jus buah naga super merah (Hylocereus costaricensis) diberikan secara oral dengan dosis 3,6 g; 7,2 g; dan 10,8 g. Simvastatin sebagai kontrol positif diberikan dengan dosis 0,18 mg. Kontrol negatif dan kontrol normal tanpa pemberian intervensi. Data penelitian dianalisis dengan uji Analysis of Variance (ANOVA) dan dilanjutkan uji Posthoc. Hasil penelitian dengan uji beda terhadap kelompok jus buah naga super merah dosis 3,6 g dan 7,2 g berturut-turut menurunkan kadar kolesterol total sebesar 42,45 mg/dL dan 41,96 mg/dL (p=0,001), sementara dosis 10,8 g cenderung tidak berubah walaupun terjadi kenaikan hanya 1,22 mg/dL (p=0,535). Kelompok kontrol positif menunjukkan penurunan kadar kolesterol total sebesar 21,32 mg/dL (p=0,001). Perubahan bobot badan tikus pada pemberian jus buah naga super merah dosis 3,6 g; 7,2 g; dan 10,8 g dan simvastatin berturut-turut 1,75 g; 22,16 g; 19,5 g; dan 34,75 g yang tidak berbeda secara bermakna (p=0,823). Simpulan, jus buah naga super merah menurunkan kadar kolesterol total lebih tinggi daripada simvastatin, sedangkan bobot badan tikus jantan tidak berbeda. Â Kata kunci: Bobot badan tikus, jus buah naga, kolesterol, simvastatinÂ The Effect of Super Red Dragon Fruit Juice (Hylocereus costaricensis) and Simvastatin to TotalBlood Cholesterol and Body Weight of Male Wistar Rats Induced Hypercholesterolemia Â Abstract Cardiovascular disease occurs due to several factors including high cholesterol level. According to a survey conducted by WHO in 2008 around 17.3 million people died because of cardiovascular disease. The purpose of this research is to compare the effect of super red dragon fruit juice as herbal therapy and simvastatin as standard drug that have been used in the medical therapy to decrease total blood cholesterol and body weight of male Wistar rats induced hypercholesterolemia. This research was conducted at the Biomedical Laboratory Bandung Islamic University in 2014 AprilËMei used laboratoric experiment methods using 20 rats that was induced hypercholesterolemia with high-fat feeding and Propil Tiourasil (PTU) for 14 days. Super red dragon fruit (Hylocereus costaricensis) juice given orally at doses 3.6 g; 7.2 g; and 10.8 g. Simvastatin as a positive control was given at a dose of 0.18 mg. Negative control and normal control without intervention. Research data were analyzed by Analysis of Variance (ANOVA) test and Post Hoc test. The results of this research with the different test groups of super red dragon fruit juice dose of 3.6 g and 7.2 g respectively lower total cholesterol by 42.45 mg/dL and 41.96 mg/dL (p=0.001), while 10.8 g doses are unlikely to change despite an increase of only 1.22 mg/dL (p=0.535). Positive control group showed a decrease in total cholesterol levels by 21.32 mg/dL (p=0.001). Changes in body weight of rats in the provision of super red dragon fruit juice dose of 3.6Â g; 7.2 g; 10.8 g; and simvastatin were 1.75 g; 22.16 g; 19.5 g; and 34.75 g respectively and were not significantly different (p=0.823). Conclusion, super red dragon fruit juice lowers total cholesterol levels higher than simvastatin, while the body weight of male rats did not differ. Â Keywords: Body weight, dragon fruit juice, cholesterol, simvastatinÂ

Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY Triyani, Yani; Herliani, Irna; Patrisia, Nurul; Achmad, Sadiah; Hendyanny, Eka; Hartati, Julia
Global Medical & Health Communication (GMHC) Vol 3, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak Angka kejadian penyakit infeksi di Indonesia masih tinggi, dengan angka mortalitas 230 kematian per 100.000 populasi. Dampak hal tersebut adalah penggunaan antibiotik yang tidak terkendali menyebabkan resistensi obat dan multidrug resistant bahkan extensive drug resistant. Konsumsi substansi yang berfungsi imunomodulator menjadi salah satu alternatif pemecahan. Tujuan penelitian ini untuk mengetahui apakah ekstrak etanol ceplukan (Physalis angulata) yang memiliki efek imunomodulator berpengaruh pada aktivitas fagositosis makrofag intraperitoneal mencit jantan galur DDY, serta menilai optimasi dosis ekstrak etanol ceplukan dan membandingkan efeknya dengan obat herbal imunomodulator terstandar. Penelitian ini merupakan eksperimental laboratorik dengan subjek 25 ekor mencit jantan galur DDY yang dibagi lima kelompok. Setiap kelompok diberi perlakuan yang sama selama tujuh hari. Kelompok I (kontrol negatif) tidak diberikan ekstrak etanol ceplukan, kelompok II, III, dan IV diberikan ekstrak etanol ceplukan dengan dosis 12,5%, 25%, dan 50%, serta kelompok V (kontrol positif) diberikan obat herbal imunomodulator terstandar dosis 50 ÂµL. Pada hari ke-8, dilakukan pengukuran aktivitas fagositosis makrofag intraperitoneal dengan melihat jumlah makrofag yang memfagosit biji lateks. Uji statistik yang digunakan adalah Kruskal-Wallis, Mann-Whitney, dan independent t-test. Hasil penelitian ini menunjukkan bahwa ekstrak etanol ceplukan dosis 12,5% (rata-rata: 10, SD: 11,5) dan 25% (rata-rata: 14, SD: 8,5) secara signifikan meningkatkan aktivitas fagositosis makrofag dibanding dengan kontrol negatif. Ekstrak etanol ceplukan dosis 25% tidak berbeda bermakna dibanding dengan obat imunomodulator (rata-rata: 13, SD: 8,26) (p=0,05). Simpulan, ekstrak etanol ceplukan meningkatkan aktivitas fagositosis makrofag intraperitoneal dengan dosis optimum 25% dan memiliki efek yang sama dengan obat herbalÂ imunomodulator terstandar. Â Kata kunci: Aktivitas fagositosis, biji lateks, ekstrak etanol ceplukan, mencit jantan galur DDY Â Dossage Optimation and Comparison of Ethanol Extract of Ceplukan (Physalis angulata) to Standardized Immunomodulator Herbal Medicine on Intraperitoneal Macrophage of Male Mice DDY Strain Â Abstract Number of infection disease are still in Indonesia. There were 230 people died from 100,000 population. The impact is Indonesia still face uncontrolled use of antibiotic which cause multidrug resistant even Â extensive drug resistant. The use of immunomodulator became the alternative solutions. This study aims was to describe whether there were an ability of Physalis angulata as an immunomodulator for the activity in macropag phagocytosis in DDY male rats. It also aim to identify extract optimation and compare it with the standard herbal immunomodulator. This was an experimental study with 25 male DDY rats divided into 5 groups. Group I as control negative was not given any ceplukan ethanol extract, group II, III and IV were given ceplukan ethanol extract with 12.5%, 25% and 50% dosage respectively and group V acted as positive control fed by standard herbal immunomodulator. On the 8th day intraperitoneal macrophage phagocytosis were measured by counting the number of macrophage which consumed the latex seeds. Statistical analysis used was Kruskal-Wallis, Mann-Whitney, and independent t-test.The resuts from this study showed that ceplukan ethanol extracts with the dosage of 12.5% (mean: 10, SD: 11.5) and 25% (mean: 14; SD: 8.5) significantly increased the phagocyte activity of macrophage compared to negative control. However 25% ceplukan ethanol extracts had no significant difference compared to standar herbal immunomodulator (mean: 13; SD: 8.25, p>0.05). The conclusions are ceplukan ethanol extract increases the phagocyte activity of macrophage with optimum dosage of 25% and possess the same effect with standard herbal immunomodulator. Key words: Latex seeds, male DDY rats, phagocytes activities, physalis angulata

Efek Jus Buah Naga Super Merah (Hylocereus costaricensis) dan Simvastatin terhadap Kadar Kolesterol Total Darah dan Bobot Badan Tikus Jantan Galur Wistar Hiperkolesterolemia Fauziyyah Karimah; Sadiah Achmad; Rizky Suganda Prawiradilaga
Global Medical & Health Communication (GMHC) Vol 2, No 2 (2014)
Publisher : Universitas Islam Bandung

Penyakit kardiovaskular terjadi akibat beberapa faktor risiko dan di antaranya kadar kolesterol yang tinggi. Menurut survei WHO pada tahun 2008 sekitar 17,3 juta orang meninggal dunia karena penyakit kardiovaskular. Tujuan penelitian ini untuk mengetahui perbedaan efek pemberian jus buah naga super merah (Hylocereus costaricensis) sebagai terapi herbal dengan simvastatin sebagai obat standar yang telah digunakan dalam dunia medis terhadap kadar kolesterol total darah dan bobot badan tikus jantan galur Wistar hiperkolesterolemia. Penelitian dilakukan di Laboratorium Biomedik Universitas Islam Bandung pada bulan April–Mei 2014 dengan menggunakan metode eksperimental laboratorik pada 20 ekor tikus hiperkolesterolemia dengan memberi diet tinggi lipid dan propil tiourasil (PTU) selama 14 hari. Jus buah naga super merah (Hylocereus costaricensis) diberikan secara oral dengan dosis 3,6 g; 7,2 g; dan 10,8 g. Simvastatin sebagai kontrol positif diberikan dengan dosis 0,18 mg. Kontrol negatif dan kontrol normal tanpa pemberian intervensi. Data penelitian dianalisis dengan uji analysis of variance (ANOVA) dan dilanjutkan uji posthoc. Hasil penelitian dengan uji beda terhadap kelompok jus buah naga super merah dosis 3,6 g dan 7,2 g berturut-turut menurunkan kadar kolesterol total sebesar 42,45 mg/dL dan 41,96 mg/dL (p=0,001), sementara dosis 10,8 g cenderung tidak berubah walaupun terjadi kenaikan hanya 1,22 mg/dL (p=0,535). Kelompok kontrol positif menunjukkan penurunan kadar kolesterol total sebesar 21,32 mg/dL (p=0,001). Perubahan bobot badan tikus pada pemberian jus buah naga super merah dosis 3,6 g; 7,2 g; dan 10,8 g dan simvastatin berturut-turut 1,75 g; 22,16 g; 19,5 g; dan 34,75 g yang tidak berbeda secara bermakna (p=0,823). Simpulan, jus buah naga super merah menurunkan kadar kolesterol total lebih tinggi daripada simvastatin, sedangkan bobot badan tikus jantan tidak berbeda. THE EFFECT OF SUPER RED DRAGON FRUIT JUICE (HYLOCEREUS COSTARICENSIS) AND SIMVASTATIN TO TOTAL BLOOD CHOLESTEROL AND BODY WEIGHT OF MALE WISTAR RATS INDUCED HYPERCHOLESTEROLEMIACardiovascular disease occurs due to several factors including high cholesterol level. According to a survey conducted by WHO in 2008 around 17.3 million people died because of cardiovascular disease. The purpose of this research is to compare the effect of super red dragon fruit juice as herbal therapy and simvastatin as standard drug that have been used in the medical therapy to decrease total blood cholesterol and body weight of male Wistar rats induced hypercholesterolemia. This research was conducted at the Biomedical Laboratory Bandung Islamic University in 2014 Apri–Mei used laboratoric experiment methods using 20 rats that was induced hypercholesterolemia with high-fat feeding and propil tiourasil (PTU) for 14 days. Super red dragon fruit (Hylocereus costaricensis) juice given orally at doses 3.6 g; 7.2 g; and 10.8 g. Simvastatin as a positive control was given at a dose of 0.18 mg. Negative control and normal control without intervention. Research data were analyzed by analysis of variance (ANOVA) test and post hoc test. The results of this research with the different test groups of super red dragon fruit juice dose of 3.6 g and 7.2 g respectively lower total cholesterol by 42.45 mg/dL and 41.96 mg/dL (p=0.001), while 10.8 g doses are unlikely to change despite an increase of only 1.22 mg/dL (p=0.535). Positive control group showed a decrease in total cholesterol levels by 21.32 mg/dL (p=0.001). Changes in body weight of rats in the provision of super red dragon fruit juice dose of 3.6 g; 7.2 g; 10.8 g; and simvastatin were 1.75 g; 22.16 g; 19.5 g; and 34.75 g respectively and were not significantly different (p=0.823). Conclusion, super red dragon fruit juice lowers total cholesterol levels higher than simvastatin, while the body weight of male rats did not differ.

Optimasi Dosis dan Perbandingan Efek Ekstrak Etanol Ceplukan (Physalis angulata) dengan Obat Herbal Imunomodulator Terstandar terhadap Aktivitas Makrofag Intraperitoneal Mencit Jantan Galur DDY Yani Triyani; Irna Herliani; Nurul Patrisia; Sadiah Achmad; Eka Hendyanny; Julia Hartati
Global Medical & Health Communication (GMHC) Vol 3, No 1 (2015)
Publisher : Universitas Islam Bandung

Angka kejadian penyakit infeksi di Indonesia masih tinggi, dengan angka mortalitas 230 kematian per 100.000 populasi. Dampak hal tersebut adalah penggunaan antibiotik yang tidak terkendali menyebabkan resistensi obat dan multidrug resistant bahkan extensive drug resistant. Konsumsi substansi yang berfungsi imunomodulator menjadi salah satu alternatif pemecahan. Tujuan penelitian ini untuk mengetahui apakah ekstrak etanol ceplukan (Physalis angulata) yang memiliki efek imunomodulator berpengaruh pada aktivitas fagositosis makrofag intraperitoneal mencit jantan galur DDY, serta menilai optimasi dosis ekstrak etanol ceplukan dan membandingkan efeknya dengan obat herbal imunomodulator terstandar. Penelitian ini merupakan eksperimental laboratorik dengan subjek 25 ekor mencit jantan galur DDY yang dibagi lima kelompok. Setiap kelompok diberi perlakuan yang sama selama tujuh hari. Kelompok I (kontrol negatif) tidak diberikan ekstrak etanol ceplukan, kelompok II, III, dan IV diberikan ekstrak etanol ceplukan dengan dosis 12,5%, 25%, dan 50%, serta kelompok V (kontrol positif) diberikan obat herbal imunomodulator terstandar dosis 50 µL. Pada hari ke-8, dilakukan pengukuran aktivitas fagositosis makrofag intraperitoneal dengan melihat jumlah makrofag yang memfagosit biji lateks. Uji statistik yang digunakan adalah Kruskal-Wallis, Mann-Whitney, dan independent t-test. Hasil penelitian ini menunjukkan bahwa ekstrak etanol ceplukan dosis 12,5% (rata-rata: 10, SD: 11,5) dan 25% (rata-rata: 14, SD: 8,5) secara signifikan meningkatkan aktivitas fagositosis makrofag dibanding dengan kontrol negatif. Ekstrak etanol ceplukan dosis 25% tidak berbeda bermakna dibanding dengan obat imunomodulator (rata-rata: 13, SD: 8,26) (p=0,05). Simpulan, ekstrak etanol ceplukan meningkatkan aktivitas fagositosis makrofag intraperitoneal dengan dosis optimum 25% dan memiliki efek yang sama dengan obat herbal imunomodulator terstandar. DOSSAGE OPTIMATION AND COMPARISON OF ETHANOL EXTRACT OF CEPLUKAN (PHYSALIS ANGULATA) TO STANDARDIZED IMMUNOMODULATOR HERBAL MEDICINE ON INTRAPERITONEAL MACROPHAGE OF MALE MICE DDY STRAINNumber of infection disease are still in Indonesia. There were 230 people died from 100,000 population. The impact is Indonesia still face uncontrolled use of antibiotic which cause multidrug resistant even extensive drug resistant. The use of immunomodulator became the alternative solutions. This study aims was to describe whether there were an ability of Physalis angulata as an immunomodulator for the activity in macropag phagocytosis in DDY male rats. It also aim to identify extract optimation and compare it with the standard herbal immunomodulator. This was an experimental study with 25 male DDY rats divided into 5 groups. Group I as control negative was not given any ceplukan ethanol extract, group II, III and IV were given ceplukan ethanol extract with 12.5%, 25% and 50% dosage respectively and group V acted as positive control fed by standard herbal immunomodulator. On the 8th day intraperitoneal macrophage phagocytosis were measured by counting the number of macrophage which consumed the latex seeds. Statistical analysis used was Kruskal-Wallis, Mann-Whitney, and independent t-test.The resuts from this study showed that ceplukan ethanol extracts with the dosage of 12.5% (mean: 10, SD: 11.5) and 25% (mean: 14; SD: 8.5) significantly increased the phagocyte activity of macrophage compared to negative control. However 25% ceplukan ethanol extracts had no significant difference compared to standar herbal immunomodulator (mean: 13; SD: 8.25, p>0.05). The conclusions are ceplukan ethanol extract increases the phagocyte activity of macrophage with optimum dosage of 25% and possess the same effect with standard herbal immunomodulator.

Nyeri Punggung Bawah serta Kebiasaan Merokok, Indeks Massa Tubuh, Masa Kerja, dan Beban Kerja pada Pengumpul Sampah Ida Astuti; Dony Septriana Rosady; Nurul Romadhona; Sadiah Achmad; Mia Kusmiati
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 1 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i1.4326

Kejadian nyeri punggung bawah (NPB) di Indonesia bervariasi antara 7,6% sampai 37%, umumnya terjadi pada usia 45–60 tahun. NPB merupakan nyeri yang dirasakan daerah punggung bawah dan dapat terasa nyeri yang lokal maupun nyeri radikuler yang terasa di daerah lumbar atau lumbo-sakral. Tujuan penelitian ini mengidentifikasi faktor risiko keluhan nyeri punggung pada petugas pengumpul sampah di Kecamatan Bandung Wetan periode Maret–Juli 2018. Jumlah sampel 84 responden yang diambil dengan menggunakan teknik simple random sampling. Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross sectional dan analisis data menggunakan chi square. Hasil penelitian ini didapatkan bahwa sebagian besar responden memiliki keluhan NPB sebanyak 75%. Kebiasaan merokok sedang 64%, indeks massa tubuh (IMT) normal 62%, masa kerja baru 99%, dan responden dengan beban kerja yang ringan 99%. Tidak terdapat hubungan kebiasaan merokok (p=0,811), IMT (p=0,735), beban kerja (p=0,081), dan masa kerja (p= 0,561) dengan keluhan nyeri punggung bawah. Simpulan, tidak terdapat hubungan kebiasaan merokok, IMT, beban kerja, dan masa kerja dengan keluhan nyeri punggung bawah pada petugas pengumpul sampah di Kecamatan Bandung Wetan. Terdapat faktor lain yang lebih berpengaruh terhadap NPB seperti posisi kerja dan lama kerja. LOW BACK PAIN AND SMOKING HABITS, BODY MASS INDEX, WORKING PERIOD AND WORKLOAD ON GARBAGE COLLECTORSIncidence low back pain (LBP) in Indonesia are varies between 7.6% to 37%, generally occurs at the age of 45–60 years. LBP is a pain that is felt in the low back area. It could felt local and radicular pain in lumbar or lumbo-sacral area. The objectives of the study was to identify the risk factors of back pain complaints on garbage collectors in Bandung Wetan sub-district during March to June 2018. The subjects were 84 respondents and used simple random sampling technique. This research used observational analytical method with cross sectional approach and data analysis used chi square. The results of this study reveald that most respondents had 75% LBP complaints. Respondents with moderate smoking habits were 64%, respondents with normal body mass index (BMI) of 62%, respondents with a new work period of 99%, and respondents with a light workload of 99%. The results of statistical analysis showed that there were no correlation between smoking habits (p=0.811), BMI (p=0.735), workload (p=0.081) and years of work (p=0.561) with complaints of low back pain. Conclusions, there are no relationship between smoking habits, BMI, workload, and years of service with complaints of low back pain in officers of garbage collectors in Bandung Wetan Subdistrict. There are other factors that have more influence on LBP such as work position and duration of work.

Identifikasi Senyawa Alkaloid dari Akar Piper sarmentosum Roxb. Ex Hunter dan Uji Aktivitasnya terhadap Jamur Candida albicans Hartiwi Diastuti; Sadiah Achmad; Enny Ratnaningsih
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 22, No 2 (2005)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2005.22.2.96

Piper sarmentosum Roxb. Ex Hunter or “Sirih duduk” has long been used for traditional medicine to cure various diseases, such as fungus infections. The investigation of the bioactive compounds of P. sarmentosum roots has not been carried out. This research was aimed to isolate the bioactive compounds from P. sarmentosum roots. The results showed that methanol extracts of P. sarmentosum roots have an activity on Candida albicans. The separation a bioactive compounds from methanol extracts of P. sarmentosum roots was performed by column chromatography, thin layer chromatography and recrystalizations. The identifications of the bioactive compounds were carried out using ultra violet spectrometry, infrared spectrometry, gas chromatography-mass spectrometry and nuclear magnetic resonance spectrometry. The results indicated that from methanol extracts, an alkaloid compound of piperoylpyrol derivative was 5-hydroxy-5- (3,4-methylenedioxyphenyl)-2-pentenoyl pyrol, could be purely isolated. Examination of bioactivity at concentration 0.10-2.50 mg/ml showed that this compound had an activity on C. albicans.

Karakteristik Kejadian Gagal Jantung Kongesti (GJK) pada Pasien Diabetes Mellitus Tipe 2 (DM tipe 2) di RSUD Al-Ihsan Bandung Tahun 2019-2020 Muhammad Rifqi Khairul Ummam; Sadiah Achmad; Ratna Dewi Indiastuti
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.670

Abstract. Congestive heart failure (CHF) is a functional or structural heart disorder that interferes with ventricular filling or ejection of blood into the systemic circulation. The risk factors for CHF are age and gender. The purpose of this study was to analyze the incidence of congestive heart failure in type 2 DM patients at the outpatient polyclinic of Al-Ihsan Hospital, Bandung. This study is an analytic observational with a cross-sectional approach. The sampling technique used was purposive sampling from medical record data with a total sample of 80 people who entered the inclusive criteria. Data analysis using Chi-square test. The results of the study described CHF patients as 22.5%. Type 2 DM patients experienced CHF 16.25%, and male 6.25%. The age of type 2 DM patients who experienced the most CHF was in the range of 55-64 as much as 10.00%. From this study, it was concluded that the characteristics of type 2 DM patients at the Al-Ihsan outpatient polyclinic who experienced CHF were women experiencing CHF more than men and the age of type 2 DM patients who experienced CHF was mostly in the range of 55-64 years. Abstrak. Gagal jantung kongesti (GJK) adalah gangguan fungsional atau struktural jantung yang mengganggu pengisian ventrikel atau ejeksi darah ke sirkulasi sistemik. Faktor risiko terjadinya GJK adalah usia dan jenis kelamin. Tujuan penelitian ini adalah untuk menganalisis kejadian gagal jantung kongesti pada pasien DM tipe 2 di poliklinik rawat jalan RSUD Al-Ihsan, Bandung. Penelitian ini merupakan observasinal analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan Purposive Sampling dari data rekam medik dengan jumlah sampel sebanyak 80 orang yang masuk kriteria inklusif. Analisis data menggunakan uji Chi-square. Hasil penelitian menggambarkan pasien GJK 22.5%. Pasien DM tipe 2 perempuan yang mengalami GJK 16.25%, dan laki-laki 6.25%. Usia pasien DM tipe 2 yang terbanyakmmengalami GJK pada rentang 55-64 sebanyak 10.00%. Dari penelitian ini didapatkan kesimpulan bahwa karakteristik pasien DM tipe 2 di poliklinik rawat jalan Al-Ihsan yang mengalami GJK adalah perempuan lebih banyak mengalami GJK daripada laki-laki dan usia penderita DM tipe 2 yang mengalami GJK terbanyak pada rentang 55-64 tahun.

Hubungan Positif COVID-19 pada Wanita Hamil dengan Kejadian Persalinan Bayi Prematur di Rumah Sakit Umum Daerah Al-Ihsan Jawa Barat Yora Ordellia Budiawati; Sadiah Achmad; Ferry Achmad Firdaus Mansoer
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1187

Abstract. Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the virus SARS COV-2. This disease spreads very quickly and brings its concerns to pregnant women because it can cause very serious complications, among others is premature delivery, This study aims to see whether there is a relationship between COVID-19 and preterm labor. The research design used is a Cross-Sectional Comparative design, using secondary data from medical records with a total of 196 mothers giving birth and the data were tested by Chi-Square test. This study showed that 20.41% of COVID-19 positive pregnant women gave birth to premature babies while COVID-19 negative pregnant women gave birth to 12.24% of premature babies with a P-Value of 0.164 (P>0.05). There is no relationship between COVID-19 and preterm labor in pregnant women at Al-Ihsan Hospital West Java. This result was obtained because many maternity mothers chose to give birth outside the hospital such as independent practice midwives or maternity clinics as well as PONED and other primary health facilities. Abstrak. Corona Virus Disease 2019 (COVID-19) adalah penyakit infeksi yang diakibatkan oleh virus SARS COV-2. Penyakit ini menyebar luas dengan sangat cepat dan membawa kekhawatiran tersendiri bagi ibu hamil karena dapat menyebabkan komplikasi yang sangat serius antara lain persalinan prematur. Penelitian ini bertujuan untuk melihat ada tidaknya hubungan antara COVID-19 dengan persalinan prematur. Rancangan penelitian yang digunakan adalah disain Cross Sectional Comparative, data yang digunakan adalah data sekunder dari rekam medik dengan total 196 ibu bersalin dan data diuji dengan uji Chi Square. Di dapatkan wanita hamil COVID-19 positif melahirkan sebanyak 20.41% bayi prematur sedangkan wanita hamil negatif COVID-19 melahirkan sebanyak 12.24% bayi prematur dengan hasil P Value 0,164 (P>0,05). Tidak terdapat hubungan antara COVID-19 dengan persalinan prematur pada wanita hamil di RSUD Al-Ihsan Jawa Barat. Hasil ini didapatkan karena banyak ibu bersalin yang memilih untuk bersalin di luar RS seperti bidan praktik mandiri atau klinik bersalin maupun PONED serta fasilitas Kesehatan primer yang lain.

Pengaruh Kepatuhan Minum Obat Kelasi Besi dengan Kadar Ferritin pada Pasien Thalassemia di RSUD Al-Ihsan Bandung Tahun 2021/2022 Raihan Saparizki; Agung Firmansyah Sumantri; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.5824

Abstract. Thalassemia is a hereditary blood disorder that is commonly found in the world. One of the reasons for the decreased quality of life of patients is the high level of serum ferritin in the body. Ferritin levels can affect various things, one of which is patient compliance with taking iron chelation drugs. This study aims to determine the relationship between the level of compliance with iron chelation drug consumption and serum ferritin levels in thalassemia patients at Al-Ihsan Hospital, Bandung. The sample in this study was 59 patients with thalassemia children to adolescents aged 1 to 18 years. This study used a purposive sampling technique and an analytic observational method with a cross-sectional study design. Adherence level data were measured using the MMAS 8 questionnaire, while data on serum ferritin levels were obtained from the patient's medical record. Data collection was carried out in 2021 – 2022. The results of this study indicate that the majority of thalassemia patients (58%) have a low level of adherence to taking iron chelating drugs and most have serum ferritin levels >2,500 ng/mL (56%). There was a statistically significant relationship between the level of adherence to taking iron-chelating drugs and serum ferritin levels in thalassemia patients at Al-Ihsan Hospital in Bandung (p=0.00). In this study there was a moderate level of compliance with ferritin levels > 2,500 because there were other factors that affected ferritin levels, therefore future researchers are expected to be able to study other factors that affect ferritin levels. Abstrak. Thalasemia merupakan kelainan darah herediter yang banyak ditemukan di dunia. Salah satu alasan menurunnya kualitas hidup pasien ialah tingginya kadar feritin serum pada tubuh. Kadar feritin tersebut dapat dipengaruhi berbagai hal, salah satunya ialah kepatuhan pasien dalam mengonsumsi obat kelasi besi. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kepatuhan konsumsi obat kelasi besi dengan kadar feritin serum pada penderita thalassemia di RSUD Al – Ihsan Bandung. Sampel pada penelitian ini adalah pasien thalassemia anak sampai remaja berusia 1 sampai 18 tahun sebanyak 59 pasien. Penelitian ini menggunakan teknik purposive sampling dan metode analitik observasional dengan design penelitian cross-sectional. Data tingkat kepatuhan diukur dengan kuesioner Morisky Medication Adherence Scale-8 (MMAS-8) yang diisi dipandu oleh peneliti, sedangkan data kadar feritin serum didapatkan dari rekam medis pasien. Pengambilan data dilakukan pada tahun 2021 – 2022, Pengumpulan data dilakukan dengan pemeriksaan langsung, menggunakan uji chi – square, dan dianalisis dengan software SPSS. Hasil penelitian ini menunjukan bahwa mayoritas penderita thalassemia di RSUD Al – Ihsan Bandung (58%) memiliki tingkat kepatuhan rendah dalam konsumsi obat kelasi besi dan sebagian besar memiliki kadar feritin serum >2.500 ng/mL (56%). Terdapat hubungan bermakna secara statistik antara tingkat kepatuhan konsumsi obat kelasi besi dan kadar feritin serum pada penderita talasemia di RSUD Al-Ihsan Bandung (p=0,00). Pada penelitian ini terdapat tingkat kepatuhan sedang dengan kadar feritin >2.500 karena hal tersebut terdapat faktor faktor lain yang mempengaruhi kadar feritin, oleh karena itu peneliti selanjutnya diharapkan dapat meneliti faktor faktor lain yang mempengaruhi kadar feritin.

Diabetes Melitus sebagai Komorbiditas Utama terhadap Mortalitas Pasien COVID-19 Zahra Salsabila; Yani Triyani; Sadiah Achmad
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6721

Abstract. Cases of COVID-19 are rapidly increasing and spreading throughout Indonesia and have an impact on the degree of severity and the number of deaths in the population that are affected by the presence of comorbidities. The purpose of this study was to analyze the relationship between comorbidities and mortality in COVID-19 patients. This study uses analytic methods with a cross-sectional research design. Data were obtained from the medical records of inpatients with confirmed COVID-19 at Al-Islam Hospital Bandung for the 2021 period. The statistical test used a univariate data test by looking at the characteristics of COVID-19 patients based on age, sex, and length of stay and using the Chi test -Square to analyze whether there is a relationship between the independent and dependent variables. The number of respondents in this study was 2,047 people, with the most age being ≥60 years (39.5%), male sex (51.3%), with the highest comorbidity diabetes mellitus (41.9%), followed by hypertension (35.7%) and renal disease (12.4%) which have CFR values of 10.1%, 5.9%, and 5.2% respectively. Patients with comorbid diseases have a decreased immune response and the location of ACE-2 receptors is found not only in the respiratory tract but also in other organs such as the pancreas and kidneys. The conclusion shows that there is a relationship between comorbidities and mortality of COVID-19 patients at Al-Islam Hospital Bandung in 2021 with a p-value <0.001 (p <0.05) Abstrak. Kasus COVID-19 dengan cepat meningkat dan menyebar ke seluruh Indonesia serta berdampak pada derajat keparahan dan jumlah kematian populasi yang dipengaruhi oleh adanya komorbiditas. Tujuan penelitian ini adalah menganalisis hubungan komorbiditas dengan mortalitas pasien COVID-19. Penelitian ini menggunakan metode analitik dengan rancangan penelitian cross sectional. Data diperoleh dari rekam medis pasien rawat inap yang terkonfirmasi COVID-19 di Rumah Sakit Al-Islam Bandung Periode 2021. Uji Statistik menggunakan uji data univariat dengan melihat karakteristik pasien COVID-19 berdasarkan usia, jenis kelamin, dan lama rawat inap serta menggunakan uji Chi-Square untuk menganalisis ada tidaknya hubungan antara variable bebas dan terikat. Jumlah responden pada penelitian ini sebanyak 2.047 orang, dengan usia yang paling banyak ≥60 tahun (39,5%), jenis kelamin laki-laki (51,3%), dengan komorbiditas tertinggi diabetes melitus (41,9%), disusul dengan hipertensi (35,7%) dan renal disease (12,4%) yang memiliki nilai CFR berturut-turut 10,1%, 5,9%, dan 5,2%. Pasien dengan penyakit komorbid berada dalam penurunan respon imun serta lokasi reseptor ACE-2 yang ditemukan tidak hanya di saluran respirasi, tetapi juga didapatkan di organ lain seperti pankreas dan ginjal. Kesimpulan menunjukkan terdapat hubungan komorbiditas dengan mortalitas pasien COVID-19 di RS Al-Islam Bandung tahun 2021 dengan nilai p <0.001 (p<0.05)

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