Muhammad Alief Abdul ‘Aziiz
Medical Undergraduate Study Program, Faculty of Medicine, Universitas Islam Bandung, Bandung

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Folic Acid Usual Doses Decrease the Buccal Micronucleus Frequency on Smokers Yuktiana Kharisma; Meta Maulida Damayanti; Fajar Awalia Yulianto; Santun Bhekti Rahimah; Winni Maharani; Meike Rachmawati; Herri S. Sastramihardja; Muhammad Alief Abdul ‘Aziiz; Muhammad Ilham Halim
Global Medical & Health Communication (GMHC) Vol 7, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.007 KB) | DOI: 10.29313/gmhc.v7i2.4414

Abstract

Cigarette contains toxic chemical compounds that trigger DNA instability. Initial genotoxic oral cavity characterized by the appearance of micronucleus (MN) in the buccal mucosa. Folate is needed in maintaining DNA stability. This study aimed to compare the effects of folic acid usual doses (400 mcg and 1.000 mcg) on the MN frequency of buccal mucosa in active smokers. It is a clinical trial conducted in November 2018 in the Laboratory of the Faculty of Medicine, Universitas Islam Bandung of 53 active smokers who divided into two treatment groups. Group A was administered by 400 mcg and group B 1,000 mcg folic acid supplementation within three weeks. The buccal mucosa smear stained with hematoxylin-eosin (HE) and observed through a light microscope with 100× and 400× magnification. Data were analyzed by the Wilcoxon test statistically. The results showed that there was a significant decrease (p=0.00) in MN frequency in folic acid supplementation for three weeks, namely group A=6.39±3.92 and group B=6.93±5.82 in pre-supplementation, and group A=3.80±2.66 and group B=3.31±2.71 post-supplementation of folic acid. Giving a dose of 400 mcg and 1,000 mcg for three weeks did not provide significant results (p=0.94) with Kruskal-Wallis test. In conclusion, administration of folic acid at usual dose give results to a decrease in the buccal mucosa MN frequency in active smokers. ASAM FOLAT DOSIS LAZIM MENURUNKAN FREKUENSI MIKRONUKLEUS MUKOSA BUKAL PADA PEROKOKAsap rokok mengandung senyawa kimia toksik yang memicu ketidakstabilan DNA. Deteksi genotoksik awal  rongga mulut ditandai dengan kemunculan mikronukleus (MN) pada mukosa bukal. Folat diperlukan dalam menjaga kestabilan DNA. Penelitian ini bertujuan mengetahui efek asam folat dosis lazim (400 mcg dan 1.000 mcg) terhadap frekuensi MN mukosa bukal pada perokok aktif. Penelitian ini merupakan uji klinis yang dilakukan pada bulan November 2018 di Laboratorium Fakultas Kedokteran, Universitas Islam Bandung terhadap 53 perokok aktif yang dibagi ke dalam dua kelompok perlakuan. Kelompok A mendapatkan suplementasi asam folat 400 mcg dan kelompok B mendapatkan suplementasi asam folat 1.000 mcg selama tiga pekan. Apus mukosa bukal diwarnai dengan hematoxylin-eosin (HE) dan diamati melalui mikroskop cahaya dengan pembesaran 100× dan 400x. Data dianalisis dengan uji Wilcoxon secara statistik. Hasil penelitian menunjukkan bahwa terdapat penurunan frekuensi MN yang signifikan (p=0.00) terhadap suplementasi asam folat selama tiga minggu, yaitu kelompok A=3,80±2,66 dan kelompok B=3,31±2,71 pada pre-suplementasi, serta kelompok A=6,39±3,92 dan kelompok B=6,93±5,82 pascasuplementasi asam folat. Pemberian dosis 400 mcg dan 1.000 mcg selama tiga minggu tidak memberikan hasil yang bermakna (p=0,94) berdasar atas Uji Kruskal-Wallis. Simpulan, pemberian asam folat dosis lazim memberikan hasil baik terhadap penurunan frekuensi MN mukosa bukal pada perokok aktif.
A Comparative Evaluation of Community Periodontal Index (CPI) and the Presence of Nicotine Stomatitis among Smokers after Oral Hygiene Instruction Meta Maulida Damayanti; Yuktiana Kharisma; Fajar Awalia Yulianto; Santun Bhekti Rahimah; Winni Maharani; Meike Rachmawati; Herri S. Sastramihardja; Muhammad Alief Abdul ‘Aziiz; Muhammad Ilham Halim
Global Medical & Health Communication (GMHC) Vol 8, No 1 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1150.723 KB) | DOI: 10.29313/gmhc.v8i1.5915

Abstract

Smoking can cause periodontal disease as well as lesions in the oral mucosa. Nicotine stomatitis is inflammation caused by heat stimuli injury on the hard and soft palate of the oral cavity; smokers commonly suffer from this condition. Knowledge of how oral hygiene affects the health of dental and oral cavity. The purpose of this study was to describe the differences in community periodontal index (CPI) and nicotine stomatitis in smokers after oral hygiene instruction. The study subjects were 54 men who have a history of active smoking for more than five years. The experiment was carried out in the Biomedical Laboratory of Faculty of Medicine Universitas Islam Bandung in September 2018–January 2019. Dental examination initiated before and after dental health instructions. CPI and nicotine stomatitis tests performed on all subjects by dentists using dental instruments. After six weeks of information about oral hygiene, all subjects re-examined. The results show that there is a statistically significant difference in the average CPI value in smokers before and after dental instruction with a p value<0.001 (p≤0.05). In contrast, the condition of nicotine stomatitis remains the same. CPI value influenced by oral and dental hygiene showed that dental health instruction is very effective. However, stomatitis has not healed as long as the cause is not eliminated. EVALUASI KOMPARATIF COMMUNITY PERIODONTAL INDEX (CPI) DAN STOMATITIS NIKOTIN DI KALANGAN PEROKOK SETELAH INSTRUKSI KEBERSIHAN MULUTMerokok dapat menyebabkan penyakit pada periodontal maupun lesi pada mukosa mulut. Stomatitis nikotin merupakan inflamasi yang disebabkan oleh panas yang terdapat pada palatum keras dan lunak; perokok umumnya menderita kondisi ini. Pengetahuan mengenai tata cara kebersihan mulut memengaruhi kesehatan gigi dan rongga mulut. Tujuan penelitian ini menilai perbedaan community periodontal index (CPI) dan stomatitis nikotin pada perokok setelah instruksi kebersihan mulut. Subjek penelitian adalah 54 pria yang memiliki riwayat merokok aktif selama lebih dari lima tahun. Penelitian dilakukan di Laboratorium Biomedik, Fakultas Kedokteran, Universitas Islam Bandung pada bulan September 2018–Januari 2019. Pemeriksaan dental dilakukan sebelum dan setelah instruksi kesehatan gigi. Pemeriksaan CPI dan stomatitis nikotin dilakukan kepada seluruh subjek oleh dokter gigi menggunakan instrumen gigi. Setelah enam minggu mendapatkan penyuluhan mengenai kebersihan mulut, seluruh subjek diperiksa kembali. Hasil penelitian menunjukkan bahwa terdapat perbedaan bermakna secara statistik nilai CPI rerata pada perokok sebelum dengan setelah dilakukan instruksi kesehatan gigi dengan p<0,001 (p≤0,05). Sebaliknya, kondisi stomatitis nikotin tetap sama. Nilai CPI dipengaruhi oleh kebersihan gigi dan mulut sehingga instruksi kesehatan gigi sangat efektif. Akan tetapi, stomatitis tidak dapat sembuh selama penyebabnya tidak dihentikan.