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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Acta Biochimica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research Eureka Herba Indonesia Open Access Indonesian Journal of Medical Reviews Indonesian Community Empowerment Journal Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research
Lusia Hayati
Department Of Biology, Faculty Of Medicine, Sriwijaya University, Palembang
Religion Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PREVALENCE AND SENSITIVITY PATTERN OF GRAM-NEGATIVE BACILLI MULTIDRUG-RESISTANT (MDR) IN MOHAMMAD HOESIN HOSPITAL PALEMBANG Desi Oktariana; Vena Sabputri Sutrisno; Mastiar Endang Frida Siahaan; Phey Liana; Lusia Hayati
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.13796

Abstract

Increased Production of Freedia Herbal SME Hippocrates Medika Palembang with The Application of Extraction Machine Technology Rachmat Hidayat; Lusia Hayati; Nita Parisa; Septi Purnamasari; Rara Inggarsih
Indonesian Community Empowerment Journal Vol. 2 No. 1 (2022): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v2i1.17

Abstract

Indonesia is the second largest biodiversity-rich country in the world. Abundant biodiversity makes Indoensia rich in the potential of plants to be used as a variety of flavorful vegetables, dried fruit, medicine and medicinal plants packaged in the form of herbs. Freedia is the flagship product of this SME which is downstream from the innovation products of Rachmat Hidayat and the team. Freedia is an herb that is processed as a brew drink to overcome diabetes mellitus disorder. The implementation of this activity uses methods of observation, interview, design, manufacturing, trial, application and monitoring. Based on the results of the application of extraction machines in UKM Hippocrates Medika it can be concluded that the existence of these machines greatly supports the production process of freedia herbs to three times more than before.
Improving the Quality of Freedia Herbal Products SME Hippocrates Medika Palembang with the Application of Capsulation Technology Rachmat Hidayat; Lusia Hayati; Nita Parisa; Septi Purnamasari; Rara Inggarsih
Indonesian Community Empowerment Journal Vol. 2 No. 1 (2022): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v2i1.18

Abstract

Spices have been widely developed for herbal products because people believe that the product is safe without any side effects that are harmful to the health of the body. Herbal products are made from natural ingredients of plants or plants without a mixture of chemicals. One of the herbal product businesses in Palembang is SME Hippocrates Medika. SME Hippocrates Medika was established in 2019 as a komanditer snuffoying business. Freedia is the flagship product of this SME which is downstream from the innovation products of Rachmat Hidayat and the team. Freedia is an herb that is processed as a brew drink to overcome diabetes mellitus disorder. In an effort to improve the quality of Freedia products, efforts are made to carry out a capsulation process for the extract so that the discomfort of freedia extract can be minimized to the maximum. The application of capsulation technology greatly helps improve the quality of freedia herbal products. Where consumers feel very comfortable in the consumption of freedia herbs because there is no need to bother boiling herbs and do not need to feel bitter when consuming herbs.
The first investigation of AAC(6’)-Ib enzyme in carbapenem-resistant enterobacteriaceae isolated from Indonesian patients Beauty Novianty; Ella Amalia; Ziske Maritska; Yuwono; Lusia Hayati
Acta Biochimica Indonesiana Vol. 2 No. 1 (2019): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v2i1.32

Abstract

Background: Over the past decade, numbers of Carbapenemase Producing-Carbapenem Resistant Enterobacteriaceae (CP-CRE) has been increasing worldwide and it has been becoming a threat because of its resistance against carbapenem which is considered as the “last resort” antibiotic. Therapy options for its infection are still limited. Aminoglycoside serves as one of the most commonly used antibiotics, but the resistance against it has already been presented for a long time. Aminoglycoside Modifying Enzyme (AME) is the most important resistance mechanism against aminoglycoside. AAC(6’)-Ib enzyme is one of the most common AME produced by the gram-negative bacteria. Objectives: This study wished to identify the gene of this enzyme among CRE isolated from infected Indonesian patients in Dr. Mohammad Hoesin Hospital Palembang. Methods: Twenty-eight isolates collected from CRE-infected patients identified by Vitek 2 Compact (bioMerieux, USA) in dr. Mohammad Hoesin Hospital Palembang during September—November 2017. AAC(6’)-Ib gene was identified using PCR method, then visualize by electrophoresis. The result is then analyzed by comparing it with a susceptibility test. Results: Out of 28 samples, AAC(6’)-Ib is identified in 22 (78.57%) samples. Samples with AAC(6’)-Ib showed to be less resistant to various antibiotics, significantly to amikacin (p=0.023). Conclusion: AAC(6’)-Ib gene is found in most of samples implying its frequent occurrence in Indonesian patients.
Polymorphism of p53 Codon 72 Gene on Cervical Cancer Incidence in Malay Population Lusia Hayati; Siska Delvia
Archives of The Medicine and Case Reports Vol. 1 No. 1 (2020): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v1i1.5

Abstract

In Indonesia, the cases of cervical cancer are estimated at around 50 per 100.000 people. Itwas estimatedthattherearemore than 1 millionwomenworldwidewho have cervical cancer,and most of them have not been diagnosed yet or do not have access to screening and medicaltreatment. P53 codon 72 polymorphism can affect the risk of cervical cancer through theregulation of proliferationandcellapoptosis.The purpose of this research was to investigate theassociation between p53 codon 72 polymorphism and cases of cervical cancer. This researchwas observational analytic research. The research was done by examining in the laboratory ofMolecular Biology, Faculty of Medicine, Universitas Sriwijaya by using a case-control studyapproach.Thesampleoftheresearchconsistedof 70 subjects,and they were divided into twogroups:35 in case group and 35 in the control group. The determination of genotype andallotype was done by using PCR-RFLP technics. The results of the research showed there wasa significant difference between p53 codon 72 polymorphism between the case group andcontrol group. The results of genotypes of p53 codon 72 polymorphism in the case groupwere seven respondents (20.0%) with Pro/Pro genotype, five respondents (14.3%) withArg/Arg genotype, and 23 respondents (65.7%) with Pro/Arg. While in control group, there were28 respondents (80.0%) with Pro/Pro genotype, 0 respondent (0.0%) with Arg/Arg genotype,and 7 respondents (20%) with Pro/Arg. The frequency of the Prolin allele in case group was 37(52.9%), and the Arginin allele was 33 (47.1%), while the frequency of the Prolin allele in thecontrol group was 63 (90%), and the Arginin allele was 7 (10%). The Chi-Squareofgenotypewasvalued0.000,OR1,304andCI95%1,071-5,891,whiletheallelewas valued 0.000, OR 8.027 andCI 95% 3.228-19.962. There was anassociation between genotype and allele of p53 codon 72polymorphismandcases of cervicalcancer.
Dermatoglyphy in Breast Cancer Patients: A Systematic Review Rara Inggarsih; Akhyar Dyni Zakyah; Lusia Hayati; Joko Marwoto; Septi Purnamasari; Arwan Bin Laeto; Masayu Farah Diba
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.368

Abstract

Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.
The Effects of Sambiloto Leaf Extract (Andrographis paniculata) on Blood Sugar Regulation: An In Vivo Study Rachmat Hidayat; Lusia Hayati
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.1

Abstract

Sambiloto (Andrographis paniculata) is one of the most common plants in Indonesia. Sambiloto contains quite varied secondary metabolites, where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aims to assess the effect of Sambiloto (Andrographis paniculata) leaf extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which indicates the potential of the test extract's ability to improve blood glucose intake to cells so that it can maintain blood sugar regulation. The process of extracting sambiloto is carried out by maceration in which 500 grams of simplicia are macerated with 96% ethanol for 72 hours. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group (100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambiloto extract was able to reduce blood sugar levels significantly, were at the ES 100 and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach the target below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extract are believed to be responsible for the effect of blood glucose regulation. In conclusion, Sambiloto extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in Rat Muscle Tissue Induced Aloxan Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.4

Abstract

Diabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. Bay leaves contain entirely various secondary metabolites, and this plant is rich in flavonoids, alkaloids, terpenes, and glycosides. This study aims to assess the effect of bay leaf extract (Syzygium polyanthum) on blood sugar levels and the expression of GLUT4 protein in muscle tissue. A total of 30 white rats (Rattus norvegicus) Wistar strains were obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 – and 250 grams. Bay leaf Simplicia was obtained from the Tawangmangu Herbal Research Center, Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) and diabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly even though they had not reached the target blood glucose target of less than 200 mg / dL. The treatment with bay leaf extract was able to reduce blood sugar levels significantly. The administration of metformin drugs or bay leaf extract showed the ability to increase the level of GLUT4 protein. In conclusion, bay leaf extract affects reducing blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
The Effect of Bay Leaf Extract (Syzygium polianthum) Against Cholesterol Regulation in Hypercholesterolemic Rats Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.6

Abstract

Cholesterol is an important precursor that plays a role in the production and regulation of various sterol group compounds, especially steroid hormone compounds, androgen hormone compounds, cortisol compounds, and estrogen compounds. This herb is known to have the effect of improving glucose regulation by increasing glucose intake into cells and tissues. Its ability to improve cell and tissue metabolism is mediated by the content of secondary metabolite compounds. This ability is believed to have the potential to improve cholesterol regulation. Bay leaf extract is effective in lowering cholesterol levels through regulation of Acetyl CoA production.
Indonesian Plants with Potential as Anti-diabetes Mellitus Agent Rachmat Hidayat; Lusia Hayati; Nita Parisa
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.7

Abstract

Diabetes Mellitus (DM) is a degenerative disease that continues to increase in number in Indonesia and is a disease that is spread throughout the world due to unbalanced nutritional conditions. Treatment of diabetes mellitus is a chronic and lifelong treatment. Treatment of diabetes mellitus, such as the use of insulin and oral antihyperglycemia drugs, is relatively expensive, is used for a long time and can cause unwanted side effects. There are many plants that have potential as antihyperglycemia drugs. One of the active compounds that act as antihyperglycemia is flavonoids.Flavonoids derived from various types of plants studied are thought to act as antihyperglycemic agents. Flavonoids are known to have the ability to scavenge free radicals or act as natural antioxidants. The antioxidant activity of flavonoids is related to phenolic –OH groups which can capture or neutralize free radicals (such as ROS or RNS). Flavonoids can play a role in pancreatic tissue damage caused by DNA alkylation due to alloxan induction as a result of improving the morphology of the rat pancreas.
Co-Authors Akhyar Dyni Zakyah Arwan Bin Laeto Beauty Novianty Ella Amalia, Ella Joko Marwoto Masayu Farah Diba Mastiar Endang Frida Siahaan Nita Parisa Oktariana, Desi Phey Liana RACHMAT HIDAYAT Rara Inggarsih Septi Purnamasari Siska Delvia Vena Sabputri Sutrisno Yuwono Ziske Maritska