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All Journal Jurnal Natur Indonesia e-Journal Pustaka Kesehatan Alchemy : Journal of Chemistry Biogenesis: Jurnal Ilmiah Biologi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY Pharmascience The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Kefarmasian Indonesia Nusantara Science and Technology Proceedings

Ari Satia Nugraha

Drug Utilisation And Discovery Research Group, Faculty Of Pharmacy, University Of Jember, Jember, Indonesia 68121

Author-ID : 332716

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Efek Hepatoprotektif Ekstrak Buah Merah (Pandanus conoideus Lam.) pada Hati Mencit Jantan Galur Swiss induksi dengan CCl4 Nugraha, Ari Satia; Hadi, Ninisita Sri; Siwi, Sri Untari
Jurnal Natur Indonesia Vol 11, No 1 (2008)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

A research on red fruit (Pandanus conoideus Lam.) has been conducted to determine its hepatoprotective effect.This research was concern on three group of treatments, a blank treatment (water), a standard drug (curcuminecontaining) and red fruit extract treatment group. The liver destruction was induced by CCl 4. The hepatoprotectiveeffect was illustrated by SGOT – SGPT level of activity and percentage of cell destruction obtained from histopatogolicanalysis. Compared to the blank group, which had level of SGOT-SGPT activity as 38224,40  2,92 U/L and SGPT of24128,00  5,22 U/L, the red fruit treatment group showed a lower SGOT – SGPT activity (20112,4  2,68 U/L and18923,0  2,77 U/L, respectively); while the standard drug treatment group showed level of SGOT and SGPT activityas 29732,4  1,85 U/L and 20640,8  3,78 U/L, respectively. The histopatologic evaluation also illustrated similaritythat the red fruit treatment group occupied the lowest percentage of hepatocyte destruction shown as percentageof cell degeneration and cell necrosis of 28,3% and 31,7%, respectively. The standard drug treatment showed78,3% of destruction based on degenerative cell destruction and 88,3% based on cell necrosis. Almost 100% of celldestruction was shown in the blank group. Based on these result, the red fruit extract possessed a liver cellprotection activity against cell destruction caused by CCl4 exposure and even more active than a standard drug.

Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak dan Fraksi Tumbuhan Anyang-Anyang (Elaeocarpus grandiflorus J. E. Smith.) terhadap Escherichia coli Savitri, Ganevi Resta; Triatmoko, Bawon; Nugraha, Ari Satia
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 5, No 1 (2020)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v5i1.32206

Pada saat ini sudah banyak dilakukan penelitian terhadap khasiat antibakteri suatu tanaman. Salah satu sumber alternatif antibakteri dari bahan alam adalah tumbuhan anyang-anyang. Penelitian potensi antibakteri tumbuhan anyang-anyang bertujuan untuk mengetahui nilai IC50 esktrak dan fraksi dari tumbuhan anyang-anyang (Elaeocarpus grandiflorus J. E. Smith) dalam menghambat pertumbuhan Escherichia coli (E. coli). Ekstraksi dilakukan secara maserasi dan fraksinasi secara partisi cair-cair. Uji aktivitas antibakteri yang dilakukan adalah metode mikrodilusi dengan mengacu pada protokol yang ditetapkan oleh Clinical and Laboratory Standard Institute (CLSI) M07-A9. Skrining fitokimia dilakukan dengan metode Kromatografi Lapis Tipis (KLT) untuk mengetahui golongan senyawa yang terdapat dalam ekstrak dan fraksi daun anyang-anyang. Nilai IC50 diperoleh dengan melakukan analisis probit terhadap masing-masing nilai persen penghambatan setelah pemberian 5 seri konsentrasi sampel ekstrak dan fraksi daun anyang-anyang. Kontrol positif menggunakan injeksi gentamisin 40.000 Âµg/mL dan kontrol negatif menggunakan dimetilsulfoksida (DMSO) 1%. Ekstrak daun anyang-anyang memiliki IC50 yang paling rendah yakni sebesar 360,969Â±10,542 Âµg/mL. Hasil skrining fitokimia menunjukkan sampel dan fraksi positif mengandung polifenol. Kesimpulan dari penelitianÂ ini adalah ekstrak methanol kasar daun anyang-anyang mempunyai potensi menghambat pertumbuhan bakteri E. coli.

Isolasi Fungi Tanah Muara dan Skrining Aktivitas Antibakteri Terhadap Staphylococcus aureus Afrian Rosyadi; Bawon Triatmoko; Ari Satia Nugraha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.28834

Penyakit infeksi merupakan salah satu penyebab kematian di dunia. Antibiotika sering digunakan dalam pengobatan infeksi bakteri namun saat ini mengalami resistensi. Berdasarkan hal tersebut, penelusuran alternatif antibiotika dari bahan alam perlu dilakukan, salah satunya dari fungi. Fungi merupakan mikrobe eukariotik sebagai sumber utama antibiotika yang tersedia saat ini termasuk penisilin. Penelitian ini dilakukan untuk mengetahui potensi aktivitas antibakteri ekstrak etil asetat hasil fermentasi isolat fungi tanah muara terhadap bakteri gram positif Staphylococcus aureus. Penapisan fitokimia ekstrak menggunakan metode KLT sedangkan pengujian aktivitas antibakteri penelitian ini menggunakan metode mikrodilusi. Aktivitas antibakteri dilaporkan dalam persen penghambatan. Hasil uji antibakteri ketujuh ekstrak memiliki aktivitas dengan persen penghambatan tertinggi dari kode isolate IS-IB-T2 sebesar 66,5 ± 1,1 % dan terendah dari kode isolate IS-IB-B2 sebesar 12,2 ± 0,7 % pada konsentrasi 100 μg/mL. Adanya terpenoid dalam tiap ekstrak diduga memiliki kontribusi dalam mekanisme antibakteri. Maka dari itu, fungi yang berasal dari tanah muara berpotensi untuk dieksplorasi senyawa antibiotiknya lebih jauh lagi.

Aplikasi Label Pintar Edible dari Ekstrak Antosianin Ubi Jalar Ungu (Ipamoea Batatas L.) untuk Monitoring Kesegaran Sayuran Cabai Hijau (Capsicum Annuum L.) Aissa Dinar Yanuariski; Bambang Kuswandi; Ari Satia Nugraha
Pustaka Kesehatan Vol 8 No 1 (2020): Volume 8 No. 1, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i1.12072

Vegetable products are foods that are popular with many people. One vegetable product such as green chili is a vegetable commodity that cannot be abandoned by society in daily life. This was followed by demands for quality of green chili products. so that an analytical tool is needed that can analyze the freshness of green chili easily and practically. This study aims to develop an edible freshness sensor based on anthocyanin indicators from purple sweet potato extract (Ipomoea batatas L.) with a membrane mixture of cassava starch and chitosan. The edible freshness sensor can be applied as a freshness sensor and know the freshness level of green chili with various parameters. Tests for green chili freshness test included pH test, weight loss, texture value, and sensory evaluation test. The color change of the edible freshness sensor was observed visually and tested using the ImageJ program to determine the mean green value. The results show the color change of the freshness sensor is dark purple when the green chili is fresh, the light purple is still fresh and the light green is no longer fresh or rotten. The mean value of the green sensor for edible freshness increased along with the decline in the quality of green chili in the packaging. Keywords: Anthocyanin, tapioca starch, chitosan, green chilli

Determination of Classification Model and Total Phenolic Content of Local Variety Soursop (Annona muricata L.) Leaf Powder in Different Altitudes Using NIR and FTIR Spectroscopy with Chemometrics Lestyo Wulandari; Ari Satia Nugraha; Yashinta Nirmala Siswanti
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Soursop (Annona muricata L.) leaves have been widely used traditionally to overcome health problems, this is related to its total phenolic content. This study was aimed to determine the classification model and total phenolic content of soursop leaf powder of local varieties, in different altitudes using NIR and FTIR spectroscopy with chemometrics. Local variety soursop leaf samples that have been collected from low land (0-200 meter above sea level (masl)), medium land (201-700 masl) and high land (>700 masl) are prepared, then scanned using NIR and FTIR spectroscopy. Furthermore, the NIR spectra data from the samples were used as predictors on the LDA classification model of local and queen varieties soursop leaves to identify sample varieties. Samples identified as local varieties, whose total phenolic content was determined using a comparative method (UV-Vis spectrophotometry). The highest mean of total phenolic content is owned by samples from medium land (Jember) of 5.72% w/w GAE, followed by low land (Bangkalan) 2.95% w/w GAE and high land (Batu) 1, 78% w/w GAE. NIR and FTIR spectra data belonging to the samples were analyzed by chemometrics qualitatively using LDA, SVM and SIMCA, and quantitatively using PLS, PCR and SVR. The best classification and calibration model are formed from the NIR spectra data, that are the LDA model with an accuracy of 100% and the PLS model with an R-square calibration value of 0.998071 and RMSEC of 1.2735631. The LDA and PLS models are applied to the real samples. The results of the sample's total phenolic content determination obtained from the NIR spectroscopy method and UV-Vis spectrophotometry method were then tested with Paired-Samples T Test and it can be concluded that the content obtained from the two methods did not have a significant difference.

Cytotoxic Potential of Flavonoid from Nicotiana tabacum Leaves on MCF-7 Human Breast Cancer Cells Banun Kusumawardani; Qonita Nafilah Febi; Malihatul Rosidah; Deri Abdul Azis; Endah Puspitasari; Ari Satia Nugraha
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp97-10

Flavonoid has potential bioactivity as anticancer agents. The flavonoid of cultivated tobacco (Nicotiana tabacum), locally known as “Kasturi”, leaves was screened for its cytotoxicity against MCF-7 human breast cancer cells and non-transformed Vero cells (African normal cell kidney line) in different concentrations. This study aimed to examine the cytotoxic potential of the flavonoid of Kasturi tobacco leaves against MCF-7 human breast cancer cells. Flavonoid obtained from methanolic extracts of Kasturi tobacco leaves, which have been purified from nicotine. The flavonoid of Kasturi tobacco leaves with concentrations of 20 to 640 μg/mL were exposed to MCF-7 and Vero cells for 24 h. Cell viability was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Flavonoid of Kasturi tobacco leaves with concentrations of 160 μg/mL decreased the MCF-7 cell viability more than 50%, with an inhibitory concentration 50 (IC50) value of 148.41 μg/mL. Meanwhile, it inhibited 50% of Vero cell viability at 255.35 μg/mL. The flavonoid of Kasturi tobacco leaves has cytotoxic activity on MCF-7 cells, and might be a potential alternative agent for human breast cancer therapy.Keywords: flavonoid, tobacco leaves, human breast cancer cells, anticancer activity

Isolasi Fungi Tanah Kabupaten Situbondo serta Skrining Aktivitas Antibakteri Terhadap Pseudomonas Aeruginosa Fawwas Batio Putra Pamungkas; Bawon Triatmoko; Ari Satia Nugraha
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.750

Bacterial resistance to antibiotics is a serious concern. The search for new antibacterial compoundsfrom medicinal plants can result in overexploitation of natural ingredients. Therefore, it is necessary to search for new alternative sources. This study was aimed to fi nd new antibacterial agents derived from soil fungi isolated from swampy soil in the Pasir Putih Beach area of Situbondo Regency in inhibiting Pseudomonas aeruginosa (P. aeruginosa). Isolation was carried out using Potato Dextrose Agar (PDA) dissolved in sea water. The isolation results showed that 5 isolates fungi. The fungi IS-STB-III-4 and IS-STB-III-5 have the potential to inhibit bacterial using antagonist tests. Potential soil fungi were fermented for 14 days and extracted with ethyl acetate as a solvent. The extraction results were dissolved in 10% DMSO with a concentration series of 1000 μg /mL, 2000 μg/mL, 4000 μg/mL, 6000 μg/mL, 8000 μg/mL which will be used for antibacterial activity test using the disc diff usion method. The extract activity test showed results that were directly proportional to the extract concentration. The analysis and profi ling of the extract using High Performance Liquid Chromatography (HPLC) instrument showed that the extract contained alkaloids which were then isolated and identifi ed by HPLC.

Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Kepundung (Baccaurea racemosa Muell.Arg.) secara In Vitro Lestyo Wulandari; Ari Satia Nugraha; Nuri Putri Azhari
Jurnal Sains Farmasi & Klinis Vol 7, No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Kepundung (Baccaurea racemosa Muell.Arg.) merupakan salah satu tanaman berkhasiat di Indonesia yang mengandung flavonoid, polifenol, tanin, dan terpenoid yang dapat berfungsi sebagai antioksidan. Kandungan senyawa dengan aktivitas antioksidan dapat dikaitkan dengan potensi aktivitas antidiabetes dari tanaman ini. Penelitian dilakukan untuk mengetahui aktivitas antioksidan dan antidiabetes ekstrak metanol, etanol, dan etil asetat dari daun kepundung. Ekstraksi dilakukan dengan metode ultrasonik. Pengujian aktivitas antioksidan dilakukan secara kuantitatif dengan metode DPPH, sedangkan pengujian aktivitas antidiabetes menggunakan metode penghambatan enzim α-amilase. Nilai IC50 pada penentuan aktivitas antioksidan dan antidiabetes ditentukan dengan menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum. Hasil penentuan antioksidan menunjukkan bahwa nilai IC50 ekstrak metanol, etanol, dan etil asetat masing-masing adalah 9,38 ± 0,15; 10,55 ± 0,09; dan 946,70 ± 2,31 ppm. Ini menunjukkan ekstrak metanol dan etanol memberikan hasil terbaik dalam aktivitas antioksidan. Nilai IC50 aktivitas antidiabetes in vitro ekstrak metanol, etanol, dan etil asetat masing-masing adalah 67,63 ± 0,36; 67,46 ± 0,23; dan 841,04 ± 1,52 ppm. Hasil ini juga menunjukkan bahwa ekstrak metanol dan etanol daun kepundung memiliki aktivitas antidiabetes yang hampir sama

Molecular Docking Analysis of Anti-malarial Compounds as Plasmepsin IV Inhibitor from Targeted Indonesian Medicinal Plants Arthur Hariyanto Prakoso; Muhammad Habiburrohman; Wilda Nur Rohmatillah; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0801

Malaria is one of the major causes of death in tropical and sub-tropical countries, caused by the infection of the protozoan parasite (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium knowlesi). As the prevalence of parasite drug-resistant strains increasing, alternative medicine to eliminate malaria is needed. In this study, a molecular docking protocol was employed to predict and select natural compounds from Indonesian medicinal plants as an antimalarial drug candidate. The docking protocol was validated by the RMSD value of crystal versus docking calculation. From 43 species of plants, 238 total compounds were collected and docked into Plasmepsin IV (PMIV) enzyme which plays a role in the nutrition uptake of Plasmodium in human blood circulation. This enzyme was collected from a protein database with codename 5I70. The protocol was produced an acceptable RMSD value of 1.435 ?. The docking experiment resulted in AM202 (Cassiamin B) from Cassia siamea as the best potent Plasmepsin IV inhibitor. This compound has the potential candidate for future anti-malarial drugs. Cassiamin B had an affinity value of -11.2 kcal/mol which was higher than PMIV’s native ligand (-3.8 kcal/mol).

Ethnopharmacology and Computer-Aided Tandem Protocol to Search for Antimalarial Agents from Indonesian Medicinal Plants: HAP Inhibitor Adinda Kusuma Pertiwi; Muhammad Habiburrohman; Yoshinta Debby; Bawon Triatmoko; Ari Satia Nugraha
Nusantara Science and Technology Proceedings International Conference on Life Sciences and Biotechnology (ICOLIB)
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2021.0802

The anti-malarial potency of Indonesian medicinal plants was evaluated through computational study. From 43 Indonesian medicinal plants, 238 previously reported compounds were carefully docked into HAP (histo-aspartic protease) with codename 3FNT in which the enzyme plays an important catalytic role in Plasmodium falciparum innate metabolism. Exhaustive docking experiments produced 6 best hits molecules including AM210 (4-hydroxy- 3-methoxy strychnine), AM213 (protostrychnine), and AM216 (pseudostrychnine) which have less free energy compared to HAP native ligand, 1,2-ethanediol. This study revealed the potency of Strychnos nux-vomica L. as a source for antimalaria and support its traditional claims.

Co-Authors Adinda Kusuma Pertiwi Afrian Rosyadi Aissa Dinar Yanuariski Amrina Rosyada Fajriyanti Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Asia Asia Asia Asia Bambang Kuswandi Bawon Triatmoko Deri Abdul Azis Dinar Mutia Rani Dwi Koko Pratoko Endah Puspitasari Fawwas Batio Putra Pamungkas Gani Asri Muharam Gani Asri Muharam Ifan Arif Maulana Indah Purnamasary Ita Husnul Chotimah Kartika Senjarini Larissa Tania Lestyo Wulandari Lestyo Wulandari Luh Putu Ratna Sundari Malihatul Rosidah Mariatul Kibthiyyah Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Muhammad Zainul Arifin Muhammad Zainul Arifin Nafa Rosyida Zanuba Naura Bathari Winarto Nimas Ayu Amanda Putri Ninisita Sri Hadi Nuri Putri Azhari Qonita Nafilah Febi Rike Oktarianti Rofiko Nuning Rahayu Saeful Akhmad Tauladani Savitri, Ganevi Resta Silvya Fitri Nur Azizah Sri Untari Siwi Syubbanul Wathon, Syubbanul Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yashinta Nirmala Siswanti Yoshinta Debby Ziyan Nihlatul Millah

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