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All Journal JIMR - Journal of Islamic Medicine Research
Helmin Elyani
Faculty of Medicine Islamic Malang University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology

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Ekstraksi Senyawa Bioaktif dari Cladophora sp. Dengan Metode Solvent Free Microwave Assisted Extraction (SFMAE) Yoni Rina Bintari; Helmin Elyani
JIMR - Journal of Islamic Medicine Research Vol 1, No 1 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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Abstract

Introduction: Extraction stages is important, in order to discovery of bioactive compounds that have pharmalogical effects. Solvent Free Microwave Assisted Extraction (SFMAE) is alternative procedure with criteria of green chemistry and sustainability. Methods: In order the examine the effect of microwave power, six power level 0%, 20%, 40%, 60%, 80%, and 100% (0 W, 200 W, 400 W, 600 W, 800 W and 1000 W) were studied. The variation of adding water 10 ml/g, 15 ml/g, 20 ml/g and 30 ml/g were studied. Optimum condition of extraction from the highest yield. Phytochemichal screening using specific reagent to know bioactive compounds group.Results: The result obtained is the highest yield of 3,7333% with 400 W microwave power and 30 ml/g adding water in 360 seconds. The results of phytochemical screening of Cladophora Sp extract contain secondary metabolites of alkaloid, phenolic, terpenoid and saponin groups.Conclusion: From phytochemical screening, Cladophora sp. has potential of antioxidant and antibacterial activity, so the next research focus to antioxidant and antibacterial activity.Keywords: Extraction, SFMAE, Cladophora sp., Phytochemical 
Antibacterial potential of four herbal plants (Syzygium cumini, Piper ornatum, Anredera cordifolia, and Alpinia galangan) against Staphylococcus aureus and Escherichia coli Helmin Elyani; Rio Risandiansyah
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

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ABSTRACTIntroduction: The lack of new antibiotics and the increasing rate of resistance on pathogens requires the discovery of bioactive compounds with antibacterial activity. Using etnopharmacology knowledge, several Indonesian herbs, in particular Juwet (Syzygium cumini), Sirih merah (Piper ornatum), Binahong (Anredera cordifolia) and Laos (Alpinia galangan) had been shown possess wound-healing, anti-inflammatory and gastroprotective activities. It was postulated that these plants would also have antibacterial activity. Method: This study aims to assess the potential for antibacterial activity of these plants, in which decoctation, methanolic and choloroform extraction was used against Staphylococcus aureus and Escherichia coli growth by measuring and comparing zone of inhibition (ZOI), minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Results: All plants tested had some activity against S. aureus, but none were found to be active against E. coli. Furthermore, various extraction methods of S. cumini and A. galangan had antibacterial activity against S. aureus with a ZOI of 10 15 mm and 12 25 mm, respectively, with increased antibacterial activity found in non-polar extracts. Methanolic extract of S. cumini acts as a bactericidal at 0.391 mg/ml, whilst other extracts had a bactericidal activity at 6.25 mg/ml.Conclusion: From four plants tested, methanolic extracts of S. cumini and A. galangan has medium to strong antibacterial activity against clinical S. aureus strains.Keywords: Juwet, Sirih Merah, Binahong, Laos, Antibacterial, Antibiotic
Co-Authors Risandiansyah, Rio Yoni Rina Bintari