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All Journal Perfecting a Video Game with Game Metrics Journal Of Syiah Kuala Dentistry Society Dental Journal (Majalah Kedokteran Gigi) Journal of Indonesian Dental Association MDJ (Makassar Dental Journal) Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Budapest International Research in Exact Sciences (BirEx Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian Masyarakat Indonesia
Eha Renwi Astuti
Department Of Dentomaxillofacial Radiology, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia, 60132
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Health Professions Medicine & Pharmacology Physics Public Health Social Sciences Transportation

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CBCT-3D Anthropometric Measurement of Mandibular Bone to Sex Determination in Surabaya Indonesia : a Pilot Study Riki Kristanto; Eha Renwi Astuti; Daniel Haryono Utomo; Mieke Sylvia Margaretha Amiatun Ruth
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15696

Abstract

Background : Identification of personal is one of important aspects in forensic odontology, because it is oneof the core aspect of forensic science. The one methode of sex determination is measurement of mandibular.The mandibular is a largest and most powerful facial bone in the skull, which is generally resistant topostmortem damage and an important source for personal identification. Previous studies have studiedgender and age prediction using CBCT reconstructive images in a different picture.The objective of thisstudy is to determine the sex determination of os.mandibular using CBCT anthropometric measurements.Materials and Methods : This study involved twenty subjects (10 male and 10 female) with age groupbetween 20 and 35 years. CBCT scans were performed on all subjects, and the data obtained is reconstructedfor 3D viewing. After getting a 3D CBCT scan, measurements were taken on six parameters.Results : The differential mean of male and female is 1,7 mm (Ramus-L), 2,1 mm (Con-Cor), 6,9 mm(BG-Br), 7,3 mm (BIC-Br), 3,5 mm (BH 1st molar) dan 3,8 mm (BH canine). The collected data wereanalyzed using SPSS statistical with Independent T-Test and Logistic Regression test and also DiscrimantFunction. The results showed that of the six parameters, BG-Br and BIC-Br showed 0,0 (P<0,05) statisticallysignificant differences, with the accuracy of the prediction of gender determination on BIC-Br 70% for maleand 80% for female and the overall BG-Br yield of 80% to both group.Conclusion : Sex determination using mandibular with 3D imaging methods can be used and helps in sexdetermination with 80% accuracy.
Automatic image slice marking propagation on segmentation of dental CBCT Agus Zainal Arifin; Evan Tanuwijaya; Baskoro Nugroho; Arif Mudi Priyatno; Rarasmaya Indraswari; Eha Renwi Astuti; Dini Adni Navastara
TELKOMNIKA (Telecommunication Computing Electronics and Control) Vol 17, No 6: December 2019
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/telkomnika.v17i6.13220

Abstract

Cone Beam Computed Tomography (CBCT) is a radiographic technique that has been commonly used to help doctors provide more detailed information for further examination. Teeth segmentation on CBCT image has many challenges such as low contrast, blurred teeth boundary and irregular contour of the teeth. In addition, because the CBCT produces a lot of slices, in which the neighboring slices have related information, the semi-automatic image segmentation method, that needs manual marking from the user, becomes exhaustive and inefficient. In this research, we propose an automatic image slice marking propagation on segmentation of dental CBCT. The segmentation result of the first slice will be propagated as the marker for the segmentation of the next slices. The experimental results show that the proposed method is successful in segmenting the teeth on CBCT images with the value of Misclassification Error (ME) and Relative Foreground Area Error (RAE) of 0.112 and 0.478, respectively.
AKTIVITAS SUPEROKSIDA DISMUTASE, KATALASE DAN KADAR MALONDIALDEHIDA KELENJAR SUBMANDIBULARIS TIKUS WISTAR SETELAH IRADIASI SINAR GAMMA Kemala Hayati; Eha Renwi Astuti; Tri Martini
Journal of Syiah Kuala Dentistry Society Vol 1, No 2 (2016): JULY
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (809.951 KB)

Abstract

AbstractA common side effect of radiotherapy used in the treatment of head and neck cancers is the occurrence of structural and physiological alteration of the salivary gland due to exposure to ionizing irradiation, as demonstrated by conditions such as decreased salivary flow. Ionizing irradiation cause burst of reactive oxygen species (ROS) such as superoxide, hydroxil and hidrogen peroxide which induce activation of self-defense system such as superoxide dismutase and catalase. If this defense system could not diminish the excessive amount of  ROS it would lead to oxidative stress which can be determined by rise of malondialdehide (MDA) levels. The aim of this research is to find out the influence of single and fractionated dose of gamma ray irradiation on superoxide dismutase and catalase activities and malondialdehide levels in rat submandibular glands at 24 hours, 3 weeks and 6 weeks after exposure of gamma ray irradiation. For this research, experimental laboratory was done. Sixty male Wistar rats aged 3-4 months (250-300 g) grouped into three. Group A (20 rats) as control group were not irradiated. Group B (20 rats) were irradiated with single dose (10 Gy) and group C were irradiated with fractionated dose (10 Gy in 5 fraction of 2 Gy/day) of Co60 Gamma ray, with their neck ventral surface exposed to the source. The rat submandibular glands were extirpated at 24 hours, 3 weeks and 6 weeks after irradiation and then analysed for superoxide dismutase and catalase activities using microreader and malondialdehide levels using spectrophotometer. There were significant differences (p:0,000) of superoxide dismutase and catalase activities and malondialdehide levels after gamma ray irradiation at evaluation time 24 hours, 3 weeks and 6 weeks. Superoxide dismutase activity in group B (10 Gy single dose irradiation) and group C (10 Gy fractionated dose irradiation) decreased in compare to group A (control). Catalase activity in group B decreased in compare to group A at 24 hours, in group C catalase activity increased in compare to group A. Malondialdehide levels increased in group B and C compare to group A at 24 hours, 3 weeks and 6 weeks after irradiation.
The role of heat shock protein (HSP ) as inhibitor apoptosis in hypoxic conditions of bone marrow stem cell culture Sri Wigati Mardi Mulyani; Ernie Maduratna Setiawati; Erma Safitri; Eha Renwi Astuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 1 (2014): March 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.11 KB) | DOI: 10.20473/j.djmkg.v47.i1.p41-44

Abstract

Background: The concept of stem cell therapy is one of the new hope as a medical therapy on salivary gland defect. However, the lack of viability of the transplanted stem cells survival rate led to the decrease of effectiveness of stem cell therapy. The underlying assumption in the decrease of viability and function of stem cells is an increase of apoptosis incidence. It suggests that the microenvironment in the area of damaged tissues is not conducive to support stem cell viability. One of the microenvironment is the hypoxia condition. Several scientific journals revealed that the administration of hypoxic cell culture can result in stress cells but on the other hand the stress condition of the cells also stimulates heat shock protein 27 (HSP 27) as antiapoptosis through inhibition of caspase 9. Purpose: The purpose of this study was to examine the role of heat shock protein 27 as inhibitor apoptosis in hypoxic conditions of bone marrow stem cell culture. Methods: Stem cell culture was performed in hypoxic conditions (O2 1%) and measured the resistance to apoptosis through HSP 27 and caspase 9 expression of bone marrow mesenchymal stem cells by using immunoflorecence and real time PCR. Results: The result of study showed that preconditioning hypoxia could inhibit apoptosis through increasing HSP 27 and decreasing level of caspase 9. Conclusion: The study suggested that hypoxic precondition could reduce apoptosis by increasing amount of heat shock protein 27 and decreasing caspase 9.Latar belakang: Konsep terapi stem cell merupakan salah satu harapan baru sebagai terapi medis kelainan kelenjar ludah. Namun, rendahnya viabilitas stem cell yang ditransplantasikan menyebabkan penurunan efektivitas terapi. Asumsi yang mendasari rendahnya viabilitas dan fungsi stem cell adalah tingginya kejadian apoptosis. Hal ini menunjukkan bahwa lingkungan mikro di daerah jaringan yang rusak tidak kondusif untuk mendukung viabilitas stem cell. Salah satu lingkungan mikro adalah kondisi hipoksia. Beberapa jurnal ilmiah mengungkapkan bahwa kondisi hipoksia pada kultur sel dapat menyebabkan sel-sel stres, namun di sisi lain kondisi stres sel juga merangsang heat shock protein 27 (HSP 27) sebagai antiapoptosis dengan menghambat ekspresi caspase 9. Tujuan: Tujuan penelitian ini adalah untuk meneliti peran protein heat shock 27 sebagai inhibitor apoptosis dalam kondisi hipoksia kultur stem cell sumsum tulang. Metode: Kultur stem sel dilakukan dalam kondisi hipoksia (O2 1%) dan mengukur resistensi terhadap apoptosis melalui ekspresi HSP 27 dan caspase 9 stem cell mesenchymal sumsum tulang dengan menggunakan immunoflorecence dan PCR real time. Hasil: Hasil penelitian menunjukkan bahwa prakondisi hipoksia dapat menghambat apoptosis melalui peningkatan HSP 27 dan penurunan tingkat Caspase 9. Simpulan: Studi ini menunjukkan bahwa prakondisi hipoksia dapat mengurangi apoptosis dengan meningkatkan jumlah protein heat shock 27 dan penurunan caspase 9.
VEGF expression and new blood vessel after dental X-ray irradiation on fractured tooth extraction wound Niluh Ringga Woroprobosari; Jenny Sunariani; Eha Renwi Astuti
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 3 (2015): September 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1668.229 KB) | DOI: 10.20473/j.djmkg.v48.i3.p159-164

Abstract

Background:Dental X-ray has an important role in dentistry. Complication case such as tooth fracture extraction requires this examination to determine the appropriate treatment measures. Dental X-ray can also cause a negative impact to the body at cellular and even molecular level. Purpose: The aim of this study was to evaluate the decrease of vascular endothelial growth factor (VEGF) expression and new blood vessels number caused by dental X-ray irradiation on fractured tooth extraction wound on day 3 and 7 after extraction. Method: We used 30 wistar rats which was randomly divided into 6 groups. Each rat’s central insisive of left mandible was fractured and then extracted after or without X-ray irradiation. Group KA and KB were control groups without irradiation. Group P1 A and P1 B were treatment groups with 0.08 mSv irradiation dose. Group P2 A and P2 B were treatment groups with 0.16 mSv irradiation dose. The subject from group KA, P1 A, and P2 A were sacrficed and sockets were collected at day 3. The subject from group KB, P1 B, and P2 B were sacrficed and sockets were collected at day 7. Socket were processed and painted with hematoxylin eosin and immunohistochemistry, then observed with a microscope. Data processing was performed with SPSS 16 through one way anova test and post hoc Tukey test HS. Result: The lowest means expression of VEGF and the number of new blood vessels on the day 3 was found in P2 A group, and the highest found in the KA group. The lowest means expression of VEGF and the number of new blood vessels on the day 7 was found in P2 B group, and the highest found in the KB group. Conclusion: Dental X-ray irradiation dose of 0.08 mSv and 0.16 mSv causes decrease of VEGF expression and new blood vessels in the wound fractured tooth extraction in day 3 and day 7 post-extraction.
Transforming growth factor beta 1 expression and inflammatory cells in tooth extraction socket after X-ray irradiation Ramadhan Hardani Putra; Eha Renwi Astuti; Rini Devijanti Ridwan
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 2 (2016): June 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (870.269 KB) | DOI: 10.20473/j.djmkg.v49.i2.p87-92

Abstract

Background: Radiographic examination is often used in dentistry to evaluate tooth extraction complications. X-ray used in radiographic examination, however, has negative effects, including damage to DNA and inflammatory response during wound healing process. Purpose: This study aimed to analyze the effects of X-ray irradiation on transforming growth factor beta 1 (TGF-ß1) expression and number of inflammatory cells in tooth extraction sockets. Method: Thirty rats were divided into three groups, which consist of control group (with a radiation of 0 mSv), treatment group 1 (with a radiation of 0.08 mSv), and treatment group 2 (with a radiation of 0.16 mSv). These rats in each group were sacrificed on days 3 and 5 after treatment. Inflammatory cells which were observed in this research were PMN, macrophages, and lymphocytes. Histopathological and immunohistochemical examinations were used to calculate the number of inflammatory cells and TGF-ß1 expression. Obtained data were analyzed using SPSS 16.0 software with one way ANOVA and Tukey’s HSD tests. Result: There was no significant decrease in the number of PMN. On the other hand, there were significant decreases in the number of macrophages and lymphocytes in the sacrificed group on day-5 with the radiation of 0.16 mSv. Similarly, the most significant decreased expression of TGF-ß1 was found in the group sacrificed on day 5 with the radiation of 0.16 mSv. Conclusion: X-ray irradiation with 0.08 mSv and 0.16 mSv doses can decrease TGF-ß1 expression and number of inflammatory cells in tooth extraction sockets on day 3 and 5 post extraction.
Changes in the number of macrophage and lymphocyte cells in chronic periodontitis due to dental X-ray exposure Alhidayati Asymal; Eha Renwi Astuti; Rini Devijanti
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 2 (2018): June 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v51.i2.p99-103

Abstract

Background: Periodontitis is an inflammatory disease caused by specific microorganisms that attacks tooth-supporting tissues, P. gingivalis bacteria are mostly found in patients suffering from chronic periodontitis which is usually diagnosed by means of clinical and radiographic examination. The latter play important roles in the management of periodontitis, including: establishing diagnosis, determining treatment plans and evaluating the results of treatment. Unfortunately, the use of X-rays to perform such radiographic examination has negative effects since the body’s various parts, especially the head, are not well protected from the effects of X-ray radiation. Purpose: This research aimed to analyze the effects of dental X-ray exposure on the number of macrophages and lymphocytes in experimental subjects suffering from periodontitis. Methods: 36 rats that had been diagnosed with chronic periodontitis were divided into three groups, namely: a control group, treatment group I (exposed to a 0.16 mSv dose of radiation) and treatment group II (exposed to a 0.32 mSv dose of radiation). These subjects were subsequently sacrificed on the third and fifth days after treatment. Thereafter, histopathological examination was performed to identify any changes in the number of macrophages and lymphocytes. Results: The results of an HSD test confirmed that, on the third day, there were significant differences in the number of lymphocytes between the control group and treatment group I, as well as between the control group and treatment group II. On the fifth day, there were also significant differences in the number of lymphocytes between the control group and treatment group I, as well as between treatment group I and treatment group II. Similarly, there was a significant difference in the number of macrophage cells on the third day between the control group and treatment group I. On the fifth day, there were also significant differences in the number of macrophage cells between the control group and treatment group I, as well as between treatment group I and treatment group II. Conclusion: Dental x-ray exposure at a dose of 0.16 mSv can elevate the number of macrophages and lymphocytes on the third and fifth days. On the other hand, dental x-ray radiation at a dose of 0.32 mSv can reduce the number of macrophages on day 3 as well as the number of lymphocytes on the third and fifth days.
The effect of X-ray irradiation to the formation of polychromatic erythrocyte cell micronucleus in Wistar rats (Rattus norvegicus) Eha Renwi Astuti; Hutojo Djajakusuma; Indeswati Diyatri; Nastiti Faradilla Ramadhani
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 3 (2021): September 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i3.p128-131

Abstract

Background: Panoramic and cephalometric radiography is very important for diagnosis, treatment plan, and evaluation of orthodontic treatment results. Panoramic and cephalometric radiography are frequently performed at the same time, causing DNA damage and chromosome aberration. Purpose: This study aims to analyse the effect of X-ray exposure in panoramic and cephalometric radiography on micronuclei cell numbers. Methods: Laboratory-based analytical study with 60 healthy-male Wistar rats weighing 200–300 grams divided into 6 treatment groups (n=10). The control group: without radiographic exposure, the treatment group 2: using panoramic radiographic exposure followed by cephalometric, and the treatment group 3: using panoramic radiographic exposure and 24 hours later performed cephalometric radiographic. The unit of analysis was the polychromatic erythrocytes of mice cell, were examined 24 hours and 48 hours after irradiation had been finished. The polychromatic erythrocytes were examined using May-Gruenwald-Giemsa staining and 100x magnification under a microscope with 2000 cells per view. Data obtained were analysed using the SPSS 20 version software. The mean and standard deviations were calculated for each clinical parameter, and a one‐way ANOVA statistical test of significance was used. Statistical significance was set at p<0.05. Results: The analysis showed a significant increase (p<0.05) in the number of micronucleus in groups that used panoramic radiographic exposure followed by cephalometric. Conclusion: X-ray radiation can increase the number of micronucleus in polychromatic erythrocyte cells in rats.
Interprocessus distances based on gender using panoramic radiographs Eha Renwi Astuti; Otty Ratna Wahyuni; Dina Karimah Putri; Nastiti Faradilla Ramadhani; Ramadhan Hardani Putra; Azifah Shafa Izdihar; Khusnul Rahmawati
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 6 No 1 (2022): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v6i1.748

Abstract

Objectives: This research is aimed to find out the differences of interprocessus distances between males and females using panoramic radiographs. Materials and Methods: This research is using observational analytic with cross sectional study design. Secondary data was taken from 96 panoramic radiographs consisting of 48 males and 48 females, from RSKGM-P Universitas Airlangga. Measurements were carried out using ImageJ Software by 3 observers. The measurement results were then analyzed by independent t-test and the inter-measuring reliability was tested using the Intraclass Correlation Coefficient (ICC) on IBM SPSS software. Results: The result showed that the significance value (2-tailed) of interprocessus distances measurement on males and females was <0.05 in both regions. Reliability test of inter-observer using ICC obtained the overall measurement results was more than 0.75 which means excellent reliability. Conclusion: There was a significant difference between the interprocessus distances on males and females as measured by panoramic radiographs.
Kelebihan dan kekurangan penggunaan radiasi dosis rendah (Low Doses Radiation: advantages and disadvantages) Lusi Epsilawati; Azhari Azhari; Bremmy Laksono; Haris Nasutianto; Eha Renwi Astuti
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Vol 4 No 3 (2020): Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI)
Publisher : Ikatan Radiologi Kedokteran Gigi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jrdi.v4i3.633

Abstract

Objectives: To inform and discuss the benefits and harms of low dose radiation. Literature Review: Low dose radiation (LDR) was often used, including for services in the field of dentistry. Several studies have studied this for a long time but the results are still not conclusively agreed. Some researchers found a variety of side effects that are not beneficial to the body, but some found no association with the body damage caused by this, and even some found that LDR has beneficial effects on the body. Conclusion: low doses of radiation cause significant changes in the body, although this condition is met with an adaptive reaction which is considered a beneficial response by the body. Therefore, no matter how small the radiation is given, it will still have an impact on the body so it is better to be wise in its use.
Co-Authors Adiningsih Adiningsih Aga Satria Nurrachman Agus Zainal Arifin Alhidayati Asymal Arif Mudi Priyatno Azhari Azhari Azifah Shafa Izdihar Baskoro Nugroho Berty Pramatika Bremmy Laksono Deny Saputra Diana Lilik Zainiyyah Dina Karimah Putri Dini Adni Navastara, Dini Adni Erma Safitri Ernie Maduratna Setiawati Evan Tanuwijaya Fadhlil Ulum Abdul Rahman Haris Nasutianto Haryono Utomo Hilda Majidah Hutojo Djajakusuma Indeswati Diyatri Jenny Sunariani Kemala Hayati Khusnul Rahmawati Lusi Epsilawati Mieke Sylvia Nastiti Faradilla Ramadhani Niluh Ringga Woroprobosari Norlaila Sarifah Nur Laili Izzatul Faikoh Putra, Ramadhan Hardani Rarasmaya Indraswari Ratu Sofia Nur Aini Ricardo Henrique Alves da Silva Riki Kristanto Rini Devijanti Rini Devijanti Ridwan Sarianoferni Sarianoferni . Sri Wigati Mardi Mulyani Tri Martini Umi Lutfiah Wahyuni, Otty Ratna Yunita Savitri