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UJI DAYA HAMBAT FRAKSI N-HEKSAN, KLOROFORM, DAN ETANOL EKSTRAK DAUN KITOLOD (Isotoma longiflora (Wild.) Presl.) TERHADAP BAKTERI Shigella sonnei Muthiah Rabbaniyyah; Solikah Ana Estikomah; Lija Oktya Artanti
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 1 (2021): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i1.5631

Bakteri Shigella sonnei (golongan Shigella sp) merupakan bakteri patogen penyebab penyakit disentri basiler (shigellosis). Penyakit infeksi saluran pencernaan umumnya diobati antibiotik, tetapi seiring berjalannya waktu resistensi terhadap antibiotik sintesis ditemukan. Hal ini membuat pencarian bahan alam dengan efek antibakteri sebagai alternatif mulai dikembangkan. Salah satu bahan alam yang memiliki senyawa metabolit sekunder dengan efek antibakteri adalah daun kitolod (Isotoma longiflora (Wild.) Presl.). Tujuan dari penelitian ini adalah untuk mengetahui daya hambat fraksi n-heksan, fraksi kloroform, dan fraksi etanol ekstrak daun kitolod terhadap bakteri Shigella sonnei. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%, dan selanjutnya dilakukan fraksinasi dengan metode ekstraksi cair-cair menggunakan ketiga pelarut dengan konsentrasi 10% v/v, 20% v/v, 30% v/v, dan 40% v/v. Pengujian daya hambat dilakukan dengan metode difusi sumuran pada media MHA, serta diukur zona hambat yang terbentuk. Skrining senyawa metabolit sekunder dilakukan dengan metode KLT . Hasil penelitian diketahui bahwa seluruh fraksi dari ekstrak daun kitolod memiliki potensi dalam menghambat pertumbuhan bakteri Shigella sonnei, sedangkan fraksi teraktif didapatkan dari fraksi etanol dengan konsentrasi 40% v/v. Uji skrining menyatakan ekstrak daun kitolod mengandung senyawa alkaloid, flavonoid, saponin, dan steroid.

Pengaruh Jenis Pelarut pada Ekstraksi Daun Kumis Kucing (Orthosiphon stamineus Benth) terhadap Kadar Kalium Janugraheni Prasetya Ningrum; Fitria Susilowati; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Indonesia has a variety of biological resources in various regions. One of the plants that can be used as medicine is Orthosiphon stamineus Benth. Orthosiphon stamineus Benth has several secondary metabolites, one of them is Potassium that has diuretic function. This study aims to know the effect of the solvent type to the level of Pottasium on the extraction of Orthosiphon stamineus Benth. The research method was done using atomic absorption spectrophotometry instrument. Samples were obtained and identified from UPT Materia Medica Batu Malang, East Java, sample was extracted by percolation method and infusion. The sample was the destructed then was destructied using HNO3 to transform organic metal into inorganic, then measured the absorbance using atomic absorption spectrophotometry at wavelength 766,5. The result showed that the concentration of potassium in Orthosiphon stamineus Benth in water solvent, ethanol 70%, ethanol 96%, and methanol were (29,256 ± 1,581) mg/L, (51,294 ± 5,028) mg/L, (31,406 ± 2.777) mg/L, (58.351 ± 2.925) mg/L. The method had in standard deviation value of each solvent is; water solvent 0,005, ethanol 70% 0,017, ethanol 96% 0,009, and methanol 0,001. Based on statistical test calculations using different test calculations over two samples there was a difference in average of Potassium level between each solvent, with the highest Potassium content found in methanol solvent.

Pengaruh Perbedaan Bahan Pengikat yang dikombinasikan dengan Bahan Penghancur dalam SediaanTabletHisap Ekstrak Habbatus Sauda' (Nigella sativa L.) Anugerah Suciati; Andi Sri Suriati Amal; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 2 (2019): September
Publisher : University Of Darussalam Gontor

Habbatus sauda ' (Nigella sativa L.) have been examined have the content of flavonoid compounds that act as antioxidants. In order to be utilized more effectively and efficiently, it needs to be made innovation preparations with active substances habbatus sauda '. One of the innovations of preparations that can apply habbatus sauda ' as the active substance is troches. This research was conducted to find out the influence incurred due to the difference in binders combined with disintegrant on troches dosage habbatus sauda' extract. Binders used are amylum manihot and PVP while disintegrant used is Avicel PH 102. Troches’ made in four different formulas. The method used in the manufacture of troches is wet granulation with 70% ethanol spraying. On the stage of preformulation, carried out an analysis of halal ingredients. The analysis shows the critical point of halal ingredients used in the formulation is not found. The results of the evaluation of physical properties of granule and tablet indicates that the difference in binders combined with disintegrant affect the physical properties of granule and tablet. The best formula is the Formula 3 with an average value of hardness 8,69 kg/cm3 and the fragility of 0,54%.

Tingkat Pengetahuan Pasien dan Rasionalitas Swamedikasi di Apotek Kecamatan Colomadu Sulfiatus Sholiha; Amal Fadholah; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 2 (2019): September
Publisher : University Of Darussalam Gontor

Self-medication is a part of the community's efforts to deal with minor illnesses by using over-thecounter drugs, limited over-the-counter drugs, and mandatory drug medicines without consulting a doctor first. This study was conducted to analyze the level of knowledge and rationality of the use of self-medication. Respondents had the aged in the range of 18-60 years at five Colomadu district drug stores. The retrieval data were done by interviewing used a questionnaire that had tested for validity and reliability. The respondents 110 with consecutive sampling method from five drug stores in Colomadu District. Data were analyzed by Chi-square test using Statistical Product and Servicer Solution (SPSS) version 17. The results showed that the level of knowledge of patients 37.3% wasclassified as poor, 39.1% classified as moderate and 23.6% classified as good. The use of selfmedication was 17.3% irrational and 82.7% rational. Based on the results of the chi-square test, the level of knowledge and rationality of self-medication was not influenced by gender, age, last education, and occupational factors. Based on the results of the study it was found that the level of knowledge of patients classified as moderate with a percentage of 39.1%. The rationality of selfmedication classified as rational with a percentage of 82.7%.

Penerapan Model Pembelajaran Two Stay Two Stray (TSTS) pada Mahasiswa Farmasi Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1119

This research aims to increase the ability of scientific work and the learning achievement of Basic Physics Course Pharmacy Students UNIDA Gontor through the implementation of cooperative learning model Two Stay Two Stray (TSTS) based on practicum. The approach used in this study is a qualitative approach that displays everything that happens naturally, is without any manipulation. This study includes classroom action research (PTK). Subject research is pharmacy students the first semester Class A Academic Year 2016/2017 totaling 30 students. Data collection techniques used in this study includes written tests, observation, interviews, and documentation. The stages of data analysis in this study consisted of three phases: (1) data reduction, (2) display data, and (3) conclusion. The results showed that the implementation of cooperative learning model of Two Stay Two Stray (TSTS) based practicum conducted in the Course of Basic Physics class A in Study program Pharmaceutical UNIDA Gontor can improve the ability of scientific work and achievement of learning physics. The ability of students overall scientific work has increased in the first cycle to the second cycle of 25.72%. The learning achievement increased in the first cycle to the second cycle of 20%.

Analisis Kadar Garam Aluminium pada Beberapa Merek Deodorant Stick dengan Metode Spektrofotometri Serapan Atom (SSA) Khamidah Fajri; Fitria Susilawati; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 2 (2019): September
Publisher : University Of Darussalam Gontor

Deodorant is a product created with the goal of reducing also covering body odor especially at the armpit through work against antimicrobial organisms cause the onset of smell. Aluminum is the active substances in the deodorant that is antibacterial and capable of reducing the amount of transpiration with underarm pores to clog. The threshold for the levels of aluminum in deodorant according to BPOM is 20%. This research was conducted to analyze the levels of aluminum salts contained in the deodorant stick which has been circulating widely in the community. Deodorant stick didestruksi using aqua regia (a mixture of HCl and HNO3), conc. For 2.5 hours. Aluminum Metal absorbance was measured using atomic absorption spectrophotometry (SSA) at a specific wavelength. The results showed that the average aluminum levels on all three samples in sequence is, sample A 1123.77 mg/L, the sample B 1.714 mg/L, and sample C 1157.13 mg/l. While the rate of percent aluminum obtained in three sample test, sample A 2.25%, sample B 0.003%, and sample C 4.63%. All three sample test have fulfilled the BPOM standard requirements about the use of aluminium in deodorants,which is no more than 20%.

ISOLASI DAN IDENTIFIKASI KITIN DAN KITOSAN DARI CANGKANG SUSUH KURA (Sulcospira testudinaria) Alam Maya Silalahi; Amal Fadholah; Lija Oktya Artanti
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 1 (2020): Maret
Publisher : University Of Darussalam Gontor

Susuh kura (Sulcospira testudinaria) merupakan golongan hewan yang termasuk dalam filum moluska kelas gastropoda yang hidup baik di perairan tawar. Saat ini pemanfaatan hewan susuh kura dalam pemenuhan kebutuhan manusia masih sangat sedikit terutama di daerah komoditas utamanya, penelitian ini bertujuan untuk mengisolasi kitin dan kitosan dari cangkang susuh kura (Sulcospira testudinaria) yang diharapkan mampu meningkatkan potensi hayati Indonesia. Kitosan merupakan polisakarida alami hasil modifikasi dari proses deasetilasi senyawa kitin yang banyak terkandung pada kelompok hewan crustacea, arthropoda, moluska, insekta dan fungi. Kitosan dapat dimanfaatkan dalam berbagai bidang kehidupan; bidang kedoteran/kesehatan, pangan, bioteknologi, pertanian dan lain sebagainya. Hasil penelitian menunjukkan bahwa kitin hasil isolasi cangkang susuh kura (Sulcospira testudinaria) dapat digunakan sebagai bahan dasar dalam pembentukan kitosan melalui tahap deproteinasi, demineralisasi dan deasetilasi. Karakterisasi fisika kitosan yang dihasilkan meliputi rendemen, kadar air, kadar abu dan kelarutan kitosan yang masing-masing diperoleh 20%; 0,247%; dan 0,0128% serta larut dalam asam asetat 2%. Karakterisasi kimia kitosan meliputi derajat deasetilasi kitosan yaitu sebesar 63%.

ANALISIS FAKTOR FAKTOR DALAM MENGGUNAKAN OBAT HERBAL DI LINGKUNGAN KAMPUS UNIDA GONTOR Amal Fadholah; Lija Oktya Artanti; Solikah Ana Estikomah
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 1 (2021): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i1.5706

Herbal asli Indonesia adalah tanaman obat yang tumbuh dan dibudidayakan di Indonesia dan digunakan secara turun temurun untuk tujuan kesehatan. Obat herbal yang beredar di Indonesia aman dikonsumsi dengan catatan bahwa produk tersebut sudah terdaftar di BPOM dan tidak mengandung bahan kimia obat (BKO) karena dapat membahayakan kesehatan dan berakibat fatal. Efektifitas obat herbal secara klinis masih belum didukung oleh bukti yang kuat dan konsisten. Tujuan penelitian ini untuk menganalisis faktor-faktor (feature, benefit dan function) yang mempengaruhi penggunaan produk herbal di lingkungan keluarga kampus UNIDA Gontor. Identifikasi obat herbal yang digunakan sesuai dengan keamanan produk dan manfaat yang diperoleh. Metode penelitian ini adalah mix method yaitu campuran kuantitatif dan kualitatif dengan pendekatan survey rapid assessment. Pengambilan sampel meggunakan metode purpossive sampling dan alat ukur berupa kuesioner dan panduan wawancara singkat dengan atribut features, benefit dan function. Hasil penelitian ditemukan penyebab pemilihan obat herbal alasan terbanyak yaitu alasan aman terhadap efek samping 25 orang, sunnah Rasul 20 orang, minim efek samping 20 orang, dan alasan lain 33 orang. Alasan berdasarkan persentase mengobati 18% dan mencegah penyakit 82%. Identifikasi terkait tingkat pemahaman responden tentang features antara lain: kemasan yang tidak layak digunakan berjumlah 64 orang dengan persentase 72%, dosis penggunaan 54%, kandungan bahan alam 67%, kemasan produk yang menarik 71%, label halal MUI 72%, serta label tanggal kadaluarsa 67%. Pemahaman benefit terkait obat yang efektif 62%, obat yang berkualitas 49%; rasa, bau dan warna obat herbal yang baik 48%, bentuk obat 70%, kemasan yang layak digunakan 71%, dan penyimpanan obat herbal 71%. Pemahaman function terkait komposisi obat herbal 11%, ketertarikan memahami cara kerja obat herbal 52%, kesesuaian indikasi obat herbal 31%, dan adanya efek samping 25%.

Formulasi Sediaan Tablet Hisap Ekstrak Kering Habbatus Sauda' (Nigella Sativa L.) dengan Kombinasi Sukrosa-Manitol sebagai Bahan Pengisi Yulisa Raras Dewi; Andi Sri Suriati Amal; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 3, No 1 (2019): Maret
Publisher : University Of Darussalam Gontor

Habbatus sauda' (Nigella sativa L) has been widely used by Indonesian people with capsule dosage form. In this study the researcher choose the form of suction tablets that aims to provide a form of treatment that can be given easily to children or elderly who are difficult to swallow the drug. This study aims to determine the physical characteristics of dry sucking tablets of habbatus sauda’ extracts with a combination of sucrose - mannitol as a filler material. Habbatus sauda' dried extract is made by water solvent and dried with freeze dryer. Habbatus sauda' dried extract tablet is made in 3 formulations with a combination of sucrose and mannitol namely FI (sucrose 1: manitol 5), FII (sucrose 1: manitol 6) and FIII (sucrose 1: manitol 7). The method of wet granulation is used in the production of dry sucking tablet of habbatus sauda’ dried extract. Granules tested include flow time test, silent angle, compressibility and moisture test. The habbatus sauda' dried extract suction tablets were tested for physical properties including weight uniformity, hardness, friability and tablet disolue time test. Data of granule test result and test of physical properties of tablet were compared with research, while granule flow time test and tablet hardness test were analyzed statistically using One Way ANOVA test with 95% confidence level. The results showed that there was an influence on the hardness and taste of suction tablets of habbatus sauda’ dried extract with a combination of sucrose-mannitol. From the result of the research, it can be concluded that the suction tablet of Habbatus sauda extract with sucrose concentration (1): mannitol (5) has good criteria as suction tablet with tablet hardness 8,57/kg, soluble time 13.27 / minute and 0,12% friability

Profil Kasus Tuberkulosis Resisten Obat di RSUP Dr. Soeradji Tirtonegoro Klaten Periode Tahun 2012-2017 Alifia Rimadhani Yuwono; Surya Amal; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 2 (2018): September
Publisher : University Of Darussalam Gontor

DR TB (Drug Resistance Tuberculosis) is the resistance of Micobacterium tuberculosis to anti-tuberculosis drugs. These study aims are to observe and identify the case profile of drug-resistant tuberculosis, which includes patient characteristics and resistance patterns of Micobacterium tuberculosis against ATD at dr. Soeradji Tirtonegoro Klaten. The type of research is descriptive-retrospective based on secondary data from laboratory data and medical records in the period 2012-2017. Sampling was done by total sampling technique. Obtained a total population of TB patients resistant was 15 patients with 10 patients who met the inclusion criteria expressed in the study sample. Characteristics of patients with drug-resistant tuberculosis, mostly found were female (60%) with an age range of 60-70 years (40%). Mostly origins of Klaten (central region) (90%). The educational status was high school graduated (50%), not working (60%), comorbidities were bronchiectasis (15.4%), the nutritional status was underweight (60%), and suffering the pulmonary TB (70%). The result of this study showed the resistance patterns were primary resistance (50%) and secondary resistance (50%). Resistant to 1 ATD (60%), 2 ATD (30%), 3 ATD (10%). The highest resistance was monoresistant streptomycin (20%), ethambutol (20%), rifampicin (10%), Isoniazid(10%). Polyresistant found was the combination of ethambutol and streptomycin (30%). MDR TB incidence (10%) was the combination of rifampicin + ethambutol + streptomycin. The highest sensitivity

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