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Uji Validitas dan Reliabilitas Kwesioner Etiologi dan Faktor Risiko Kanker Nasofaring Awal Prasetyo; Bambang Hariwiyanto; Mohammad Hakimi; Soenarto Sastrowijoto
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

ABSTRACT Validity and reliability tests on questionnaires designed for etiology and risk factors of nasopharynx cancerBackground: The etiology and risk factors of NPC is a combination of multi-risk factors of genetic history, lifestyle, environmental exposure, and EBV infection. Currently, there is no publication about NPC’s questionnaire. This study analyzed the reliability and validity of the questionnaire of NPC’s etiology and risk factors.Methods: The cross-sectional study of the questionnaires of NPC’s etiology and risk factors were filled by the used-tryout samples i.e NPC sufferers and their family members, in April to August 2012. The study were done at Anatomical Pathology Laboratory of Kariadi & St. Elisabeth Hospitals Semarang. There are three main constructs, namely; genetic, lifestyle, and environmental exposure. The 74 filled-questionnaires were tested by correlation analysis of product moment for the validity, and the reliability tests conducted with Cronbach's Alpha. The data were analyzed with SPSS for Windows version 17.0.Results: A test for risk family history constructs were valid (p>0.932) and reliabel (Cronbach's Alpha=0.864). A test for lifestyle with a Pearson Correlation were p>0.785 for smoking habit, eating salted fish p>0.793, eating grilled-fish p>0.862, eating pickled p>0.831, drinking alcohol p>0.760, instant noodle p>0.497, food preservation p>0.495, food contains MSG p>0.627, with Cronbach's Alpha>0.751. A test for environmental exposure risk were valid for the exposure to passive cigarette smoke (p>0.486) Cronbach's Alpha=0.789,the exposure of the home environment p>0.658 Cronbach's Alpha=0.832, exposure-related jobs p>0.373 Cronbach's Alpha=0.697, and chronic nasopharingitis are all valid (p>0.900) with Cronbach's Alpha=0851.Conclusions: The questionnaires designed as a tool of NPC’s etiology and risk factors are valid and reliable.Keywords: Validity, realibility, questionnaires, NPC’s etiology and risk factorsABSTRAKLatar belakang: Etiologi dan faktor risiko KNF merupakan kombinasi risiko riwayat genetik, gaya hidup, paparan lingkungan, dan infeksi EBV. Saat ini, belum ada publikasi tentang kwesioner KNF. Penelitian ini membuktikan validitas dan reliabilitas alat ukur kwesioner etiologi dan faktor risiko KNF.Metode: Penelitian cross-sectional terhadap hasil pengisian kwesioner etiologi dan faktor risiko KNF yang diisi oleh sampel tryout terpakai, yaitu penderita KNF dan anggota keluarganya, pada April - Agustus 2012, di Laboratorium Patologi Anatomi RSUP  Dr. Kariadi Semarang dan RS St. Elisabeth Semarang. Kwesioner berdasar pada tiga konstruk utama, yaitu risiko genetik, risiko kebiasaan/gaya hidup, dan risiko paparan lingkungan. Sebanyak 74 kwesioner dilakukan uji validitas dengan analisis korelasi product moment, serta uji reliabilitas Cronbach's Alpha. Data dianalisis dengan SPSS for Windows version 17.0.Hasil: Uji konstruk risiko riwayat keluarga didapatkan valid (p>0,932) dan reliabel (Cronbach's Alpha=0,864). Uji konstruk risiko gaya hidup dengan Pearson Correlation didapatkan p>0,785 untuk subkonstruk kebiasaan merokok, kebiasaan makan ikan asin p>0,793, kebiasaan makan ikan/daging asap/bakar p>0,862, kebiasaan makan asinan p>0,831, kebiasaan minum alkohol p>0,760, kebiasaan makan mie instan p>0,497, kebiasaan makan makanan awetan p>0,495, kebiasaan makanan mengandung MSG p>0,627, Cronbach's Alpha=0,751. Uji konstruk risiko paparan lingkungan didapatkan valid untuk subkonstruk paparan pasif asap rokok (p>0,486), Cronbach's Alpha=0,789, paparan lingkungan rumah p>0,380, Cronbach's Alpha=0,713, paparan yang berhubungan dengan pekerjaan p>0,373 Cronbach's Alpha=0,697, infeksi nasofaringitis kronik semuanya valid (p>0,900), Cronbach's Alpha=0,851.Simpulan: Kwesioner yang diuji sebagai alat ukur untuk menggali etiologi dan faktor risiko KNF layak dipergunakan karena valid dan reliabel
Granzyme-B Expression as a Predictor of Immune Surveillance (Correlation Study in Patient with Squamous Cell Carcinoma and Uterine Cervical Dysplasia) Apriana, Ledisda; Udadi Sadhana; Ika Pawitra Miranti; Awal Prasetyo; Dik Puspasari
Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i3.585

Abstract

Background: The most common histologic type of cervical cancer is squamous cell carcinoma (SCC), with the risk of recurrence depending on immune surveillance with granzyme-B markers, and tumor infiltrating lymphocytes (TIL) is an immunological determinant associated with a better prognosis. Granzyme-B is produced by TIL. The study was aimed to prove the difference in expression of granzyme-B in SCC epithelial cells with cervical dysplasia precancerous lesions as a predictor of immune surveillance. Methods: Correlation analytic study with cross-sectional design on paraffin block patients with SCC and cervical epithelial dysplasia at the Anatomical Pathology Laboratory, RSUP Dr. Kariadi, Semarang, during 2018 and 2019, using granzyme-B immunohistochemistry assays, assessed TIL activation. Results: Most cases of cervical SCC were 40 years old, 50% were stage IIIB, 20% with the final condition died on observation 1 year after the initial diagnosis was made. The uterine cervical SCC group expressed granzyme-B with a mean score of 5.81±1.17 (p=0.001) and the dysplastic epithelial lesion group with a mean score of 6.83±0.95 (p=022), the Mann-Whitney test showed p value = 0.009, so that the test results are statistically significant. Conclusion: Expression of granzyme-B in dysplasia is higher than in uterine cervical SCC.
Ekspresi EBER pada Berbagai Tipe Histopatologi Karsinoma Nasofaring Kenty Wantri Anita; Bambang Endro Putranto; Awal Prasetyo; Dewi Kartikawati Paramita
Majalah Patologi Indonesia Vol 24 No 1 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

ABSTRAK Latar belakang Etiologi kanker nasofaring (KNF) sudah terbukti merupakan interaksi dari infeksi Epstein-Barr Virus (EBV), paparan lingkungan dan kerentanan genetik. Infeksi EBV mendominasi etiopatogenesis KNF terutama untuk tipe WHO-3. Di Indonesia, saat ini belum ada publikasi tentang ekspresi Epstein-Barr-virus-encoded small nuclear RNA (EBER) yang dikaitkan dengan klasifikasi histopatologi KNF. Tujuan penelitian ini menganalisis ekspresi EBER pada berbagai tipe histopatologi KNF untuk menambah informasi dalam diagnosis etiologi KNF, sehingga bermanfaat dalam strategi terapi. Metode Penelitian dengan desain cross sectional ini menggunakan sampel biopsi nasofaring yang didiagnosis sebagai KNF antara tahun 2009 sampai 2012 di Laboratorium Patologi Anatomik Fakultas Kedokteran Universitas Diponegoro/RSUP. Dr. Kariadi dan RS. St. Elisabeth Semarang. Sediaan dievaluasi ulang dan dilakukan in situ hybridization dengan probe fluorescein-conjugated peptide nucleic acid (PNA) pada jaringan blok parafin. Hasil Sebanyak 29 dari 31 kasus (93,5%) KNF tipe WHO-3 mengeskpresikan EBER positif dan terdapat perbedaaan bermakna (p=0,024) dengan KNF tipe WHO-1 dan 2. Uji korelasi antara ekspresi EBER dengan tipe histopatologi KNF positif kuat (koefisien korelasi Lambda = 0,667, p=0,034). Kesimpulan Ekspresi EBER terdapat lebih banyak pada KNF WHO tipe 3 yang berarti EBV lebih sering ditemukan pada KNF WHO tipe 3. Kata kunci: EBER, hibridisasi in situ, karsinoma nasofaring, virus Epstein-Barr. ABSTRACT Background The factors contributing nasopharingeal carcinoma (NPC) has been proven to be the interaction of viral, environmental and genetic factors. Etiopathogenesis of NPC is dominated by Epstein-Barr virus (EBV) infection, especially for WHO type 3. In Indonesia, there has been no publication about the expression of Epstein-Barr-virus-encoded small nuclear RNA (EBER) associated with histopathological classification. The aim of this study is to analyze the expression of EBER in various histopathological types of NPC and provide information onetiological diagnosis ofNPC that can be useful for therapeutic strategies. Methods This study was an descriptive designed as cross sectional study. Nasopharyngeal biopsies that were diagnosed as nasopharyngeal carcinoma, between the year 2009 and 2012, in Dr. Kariadi Hospital and St. Elisabeth Hospital Semarang were reevaluated. In situ hybridization with fluorescein-conjugated peptide nucleic acid (PNA) probe was performed on paraffin embedded tissue sections. Results This study found that 29 of 31 (93.5%) WHO-3 type NPC cases were EBER positif that significantly differed from WHO-1 and WHO-2 type NPC (p=0.024). There were strong positive correlation between histopathological types of NPC and expression of EBER (Lambda coefficient correlation=0.667, p=0.034). Conclusion EBER expressions found more in NPC WHO type 3 which mean EBV is often found in NPC WHO type 3. Key words: EBER, Epstein-Barr- virus, in situ hybridization, nasopharyngeal carcinoma.
EFFECT OF MINDFULNESS INTERVENTION ON THE INTENSITY OF PAIN IN NASOPHARYNGEAL CANCER PATIENTS UNDERGOING RADIATION TREATMENT Anna Jumatul Laely; Awal Prasetyo; Chandra Bagus Ropyanto
Belitung Nursing Journal Vol. 4 No. 2 (2018): March - April
Publisher : Belitung Raya Foundation, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.065 KB) | DOI: 10.33546/bnj.128

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Background: Physical responses that occur in patients with nasopharyngeal cancer are the emergence of pain due to the effects of treatment. The problem of pain in these patients at the stage of treatment remains critical to solve because it can cause comorbidity, psychological trauma and mortality. Mindfulness intervention is considered useful in transforming consciousness into the stage of acceptance. Objective: This study aims to determine the effect of mindfulness intervention on the intensity of pain in nasopharyngeal cancer patients undergoing radiation treatment. Methods: This was a quasi-experimental study with pretest posttest control group design. Thirty patients were selected using consecutive sampling, which divided into experiment and control group. Visual Analogue Scale (VAS) was used to measure pain. Each respondent received mindfulness intervention for six sessions, divided into three meetings. Paired t-test was used for data analysis. Results: The results showed a significant reduction of pain from 4.12 (moderate pain) to 3.06 (mild pain) in the experiment group. There was a significant difference in pain level before and after mindfulness intervention (p= 0.001). Conclusion: Mindfulness is effective in reducing pain intensity level in nasopharyngeal cancer patients undergoing radiation therapy.
Sensitivity and Specificity of the Comfort Scale to Assess Pain in Ventilated Critically Ill Adult Patients in Intensive Care Unit Wahyuningsih, Indah S; Prasetyo, Awal; Utami, Reni Sulung
Nurse Media Journal of Nursing Vol 7, No 1 (2017): (JUNE 2017)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.895 KB) | DOI: 10.14710/nmjn.v7i1.15126

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Background: Pain is a common phenomenon experienced by ventilated and critically ill adult patients. It is urgent to measure the pain among these patients since they are unable to report their pain verbally. Comfort Scale is one of the instruments used to measure pain in adult patients. The scale is used to measure pain among children patients with fairly high sensitivity and specificity.Purpose: This study aimed to examine the sensitivity and specificity of the Comfort Scale to measure pain in the ventilated critically ill adult patients in the ICU.Methods: This study employed a cross-sectional design with 66 ventilated adult patients in the ICUs of two hospitals in Semarang. The pain assessment was administered to the patients in 2 duplo periods by two observers comparing with the Comfort Scale and Critical Care Pain Observational Tool (CPOT) as a gold standard instrument during the pre and post positioning procedures. The data were analyzed using the receiver operating curve (ROC).Result: The results showed that in the pre-positioning procedure, the Comfort Scale had the sensitivity value of 69% and the specificity value of 81%. Meanwhile, in the post-positioning procedure, the values were decreasing (the sensitivity of 45%, the specificity of 67%). This indicated that the sensitivity value of the comfort scale decreased and could be interpreted that the ability of the instrument to detect pain remained low. Meanwhile, the decrease of the specificity value of the instrument between the pre and post administration was not far different, so it could be interpreted that the instrument can correctly identify the patient without pain.Conclusion: The Comfort Scale had a lower value of sensitivity and specificity in the post-positioning than that in the pre-positioning procedure. It is recommended that further studies should focus on the relationship between sedation and pain by using instruments of pain studies for adult patients (CPOT). Additionally, the hospital policy makers, that is Pain Task Force is expected to give education and training through workshops and seminars about the nurse skills in pain management on critical areas as part of the multidisciplinary team.
PENGARUH EKSTRAK KULIT BUAH NAGA MERAH TERHADAP KADAR AST DAN ALT DARAH TIKUS SETELAH AKTIFITAS FISIK MAKSIMAL Siahaan, Johanna; Tjahjono, Kusmiyati; Prasetyo, Awal
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 8, No 3 (2019): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.079 KB) | DOI: 10.14710/dmj.v8i3.24493

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Latar Belakang: Aktivitas fisik maksimal dapat menyebabkan terjadinya stres oksidatif, yang  kemudian merusak sel hepar. Salah satu penanda adanya kerusakan sel hepar adalah kadar AST dan ALT. Pemberian ekstrak kulit buah naga merah dapat berfungsi sebagai anti stres oksidatif. Kulit buah naga merah merupakan salah sumber antioksidan karena mengandung antosianin, betalain, vitamin C dan E. Tujuan: Mengetahui pengaruh ekstrak kulit buah naga merah terhadap kadar AST dan ALT tikus setelah aktivitas fisik maksimal. Metode: Penelitian true experimental dengan desain post test only control group design pada tikus jantan. Sampel penelitian sebanyak 18 tikus dibagi 3 kelompok dengan perlakuan yang berbeda. Kelompok K1 diberikan pakan standar dan aktifitas fisik maksimal, K2 diberikan pakan standar dan ekstrak kulit buah naga merah, dan P diberikan pakan standar, ekstrak kulit buah naga merah dan aktivitas fisik maksimal.  Hasil: Uji beda Post Hoc Bonferroni pada ALT berdasarkan kelompok perlakuan didapatkan bahwa antara perlakuan K1 terhadap K2 didapatkan nilai P = 1,000, K1 terhadap P nilai P = 0,031 dan K2 terhadap P nilai P= 0,093, sehingga dapat disimpulkan antara kelompok K1 terhadap K2 tidak berbeda bermakna (P > 0,05), begitu juga antara kelompok K2 terhadap P tidak berbeda bermakna (P> 0,05), sedangkan antara kelompok K1 terhadap P terdapat perbedaan bermakna (P< 0,05).Tidak terdapat penurunan kadar AST dan ALT pada semua kelompok . Terdapat peningkatan kadar AST dan ALT pada K1, K2, P. Kesimpulan: Ektrak kulit buah naga merah tidak yang diberikan sebagai antioksidan eksogen tidak dapat menurunkan kadar AST dan ALT darah tikus secara  bermakna setelah aktivitas fisik maksimal.Kata Kunci: Ekstrak kulit buah naga merah, AST, ALT, aktivitas fisik maksimal
LAJU TRANSPOR MUKOSILIAR MUKOSA NASAL PADA PETUGAS SPBU Darryl Samuel Salim; Awal Prasetyo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.867 KB) | DOI: 10.14710/dmj.v5i4.14260

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Latar Belakang : Uap BBM mengandung benzena, toluen, etilbenzena, xylene (BTEX) yang merupakan zat-zat iritan. Paparan zat iritan pada mukosa hidung akan menyebabkan kerusakan pada sistem trampor mukosiliar hidung. Petugas SPBU di Indonesia terpapar zat-zat iritan tersebut selama mereka bekerja. Pengaruh pekerjaan sebagai operator SBPU serta pengaruh lama bekerja terhadap sistem transpor mukosiliar hidung belum diketahui.Tujuan : Mengetahui perbedaan kecepatan TMSH (transpor mukosiliar hidung) antara pekerjaan sebagai petugas SPBU dan lama bekerja.Metode : Penelitian ini merupakan penelitian observasional dengan rancangan age matched case control. Sampel penelitian adalah 18 orang petugas SPBU di sekitar Tembalang Semarang dan 18 orang mahasiswa dan petugas di FK Undip Tembalang Semarang sebagai kelompok kontrol. Waktu TMSH diukur dengan menggunakan uji sakarin. Normalitas data diuji dengan Saphiro-Wilk. Data dianalisis dengan uji Mann-Whitney.Hasil : Rata-rata waktu TMSH pada petugas SPBU adalah 1222.56 detik dan pada bukan petugas SPBU adalah 892.33 detik. Pada uji Mann-Whitney waktu TMSH pada petugas dan bukan petugas didapatkan perbedaan bermakna (p=0.001), sedangkan tidak didapatkan perbedaan bermakna (p=0.075) pada waktu TMSH dibandingkan dengan lama bekerja.Kesimpulan : Terdapat perbedaan waktu TMSH pada petugas SPBU dan tidak terdapat perbedaan laju TMSH dibandingkan dengan lama bekerja.
Pengaruh Intervensi Mindfulness Terhadap Intensitas Kecemasan pada Pasien Kanker Nasopharal dengan Radiasi Jumatul Laely, Anna; Prasetyo, Awal; Bagus Ropyanto, Chandra
Journal Center of Research Publication in Midwifery and Nursing Vol 1 No 2 (2017): Journal Center of Research Publication in Midwifery and Nursing
Publisher : STIKES Bina Usada Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36474/caring.v1i2.2

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Kecemasan yang terjadi pada pasien kanker nasofaring pada masa radioterapi terutama disebabkan karena efek dari radiasi tersebut. Kecemasan pada tahap pengobatan menjadi sangat penting untuk diatasi karena dapat menyebabkan komorbiditas, trauma psikologis dan peningkatan mortalitas. Mindfulness merupakan psikoterapi yang efektif digunakan untuk mengurangi kecemasan pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh intervensi mindfulness terhadap intensitas kecemasan pada pasien kanker nasofaring yang sedang menjalani pengobatan radiasi. Metode penelitian yang digunakan pada penelitian ini adalah quasy eksperiment pre-post control trial design. Tigapuluh tiga responden dipilh dengan consecutive sampling dan terbagi dalam dua kelompok yaitu kelompok perlakuan dan kelompok kontrol. Pengukuran intensitas kecemasan dilakukan sebelum dan sesudah diberikan mindfulness selama 6 sesi menggunakan instrument Hamilton rating scale for anxiety (HAM-A). Uji hipotesis dilakukan untuk melihat pengaruh mindfulness dengan membedakan hasil sebelum dan sesudah dilakukannya intervensi pada kedua kelompok. Hasil Penelitian menunjukkan terjadi penurunan rata-rata tingkat kecemasan pada kelompok perlakuan setelah diberikan intervensi mindfulness dibandingkan dengan kelompok kontrol. Terdapat perbedaan signifikan tingkat kecemasan sebelum dan sesudah dilakukan mindfulness pada kelompok perlakuan dengan nilai P =0,001 (P<0,005).
Tingkat Ketahanan Hidup Penderita Kanker Nasofaring pada Berbagai Modalitas Terapi Studi Kasus yang Menjalani Terapi Konvensional dan Pengobatan Komplementer Alternatif Jessica Christanti; Awal Prasetyo
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

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Abstract

Survival rate of patients with nasopharyngeal cancer on various modalitie: Case study of patients on conventional therapy and Indonesian complementary and alternative medicineBackground: There are no data on survival rate of patients with nasopharyngeal cancer (NPC) on complementary alternative medicine in Indonesia. The aim of this study was to analyze the survival rate of patients with nasopharyngeal cancer (NPC) on conventional (modern) and complementary and alternative medicine (CAM) treatments.Methods: A cross-sectional observational study of 33 NPC patients from each conventional (modern) treatment and CAM group was performed. The guided intervews were conducted to describe CAM treatment in NPC patients by using a validated questionnaire based CAM therapies of California Health Interview Survey 2001. Survival analysis was conducted by the Kaplan-Meir method.Results: Most patients (52.3%) used CAM treatments.Multivitamin and herbal medicines were among the commonly used CAM (52.8%). Kaplan-Meier analysis showed no significant results (p=0.444) between groups. The first and second year of survival rate was comparable between groups (66.6% vs. 54.5%; 45.5% vs 33.3%). Furthermore, the median overall survival (OS) was shown (16; 95% CI: 1.58-8.90) in CAM treatment patients and conventional (modern) treatment (12; 95% CI: 8.477-0.00). The prevalenceratio (PR) obtained in this study was 1.2 (95% CI: 0.79-1.69).Conclusion: CAM treatment on NPC patients had no effect on survival rate compared with conventional (modern) treatment.Keywords: NPC, CAM, survival rateABSTRAKLatar belakang: Saat ini, belum ada data tingkat ketahanan hidup penderita kanker nasofaring (KNF) yang menjalani pengobatan komplementer alternatif di Indonesia. Fakta menunjukkan bahwa pengobatan komplementer alternatif di Indonesia merupakan bagian aktivitas sosial budaya. Penelitian ini menganalisis tingkat ketahanan hidup penderita KNF yang memperoleh pengobatan modern konvensional disertai pengobatan komplementer dan alternatif (PKA).Metode: Penelitian cross sectional dilakukan pada 33 penderita KNF di tiap kelompok yang menjalani PKA dan kelompok yang menggunakan pengobatan modern konvensional di wilayah Semarang dan sekitarnya. Wawancara terpimpin untuk terapi PKA dengan menggunakan California Health Interview Survey 2001 yang telah divalidasi. Tingkat ketahanan hidup dianalisis dengan uji Kaplan Meier.Hasil: Sebanyak (52,3%) penderita menjalani PKA, dimana yang tersering adalah dengan multivitamin dan jamu (52,8%). Tingkat ketahanan hidup kelompok PKA di tahun pertama (66,6%) dan tahun ke-2 (45,4%). Tingkat ketahanan hidup tahun pertama dan kedua kelompok obat konvensional 54,5% dan 33,3%. Analisis Kaplan Meier menunjukkan hasil yang tidak bermakna (p=0,444). Analisis median tingkat ketahanan hidup, penderita kelompok PKA didapatkan nilai 16 (CI 95%:1,581-8,900), dan pada kelompok pengobatan modern konvensional didapatkan nilai 12 (CI 95%: 8,477-0,00). Nilai PR didapatkan 1,158 (CI 95%: 0,792-1,692).Simpulan: Penggunaan PKA dan terapi modern konvensional tidak mempengaruhi tingkat ketahanan hidup penderita KNF.
The Effect of Hypnotherapy on Anticipatory Nausea in Head and Neck Cancer Patients Undergoing Chemotherapy Hamdani, Dadi; Prasetyo, Awal; Anggorowati, Anggorowati
Nurse Media Journal of Nursing Vol 10, No 3 (2020): (December 2020)
Publisher : Department of Nursing, Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v10i3.26027

Abstract

Background: One of the chemotherapy side effects on head and neck cancer patients is anticipatory nausea. However, the anticipatory nausea problem has not been properly resolved. Nausea might be psychologically reduced by hypnotherapy. There only have been very few studies conducted to examine the effects of hypnotherapy in alleviating anticipatory nausea.Purpose: This study aimed to determine the effect of hypnotherapy using Hanung induction technique on anticipatory nausea in head and neck cancer patients undergoing chemotherapy.Methods: This research employed a pre-post test of quasi-experiment with control group design. Consecutive sampling technique was used to obtain 64 subjects who met inclusion and exclusion criteria and were equally divided into the intervention and control groups. Hypnotherapy as the intervention was carried out in two sessions, each of which lasted for 20 minutes, with a week distance between sessions. The data were collected using a visual analog scale (VAS), which was used twice to measure anticipatory nausea and analyzed using the paired and independent-sample t-test.Result: The results showed that the mean score of anticipatory nausea in the intervention group reduced from 7.6±1.4 to 2.3 ±1.2 after hypnotherapy, while the mean in the control group increased from 6.4±1.6 to 6.7±1.4. There was a significant difference in the score of anticipatory nausea after the implementation of hypnotherapy between the intervention and the control group (p<0.001).Conclusion: The study concluded that hypnotherapy is effective in reducing the intensity of anticipatory nausea in head and neck cancer patients undergoing chemotherapy. Therefore, hypnotherapy can be applied by oncology nurses as an intervention in treating anticipatory nausea.