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All Journal MEDIA MEDIKA INDONESIANA Media Kesehatan Masyarakat Indonesia Nurse Media Journal of Nursing Jurnal Kedokteran Diponegoro Jurnal NERS Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Biomedical Journal of Indonesia Universa Medicina SPEKTRA: Jurnal Kajian Pendidikan Sains Belitung Nursing Journal IJEMS (Indonesian Journal of Environmental Management and Sustainability) CARING (Center of Publication in Midwifery and Nursing) : Jurnal Publikasi Penelitian Kebidanan dan Keperawatan Media Medika Muda Majalah Patologi Indonesia Jurnal Smart Keperawatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Life Science

Awal Prasetyo

Departemen Patologi Anatomik Fakultas Kedokteran Universitas Diponegoro

Author-ID : 345312

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Penghambatan aktivitas proliferasi sel dan perubahan histopatologik epitel mukosa nasofaring mencit C3H dengan pemberian ekstrak benalu teh Hidayat Sulistyo; Awal Prasetyo; Tjahjono
Majalah Patologi Indonesia Vol 19 No 1 (2010): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAKLatar belakangEfek scurrulla atropurpurea (SA) sebagai anti kanker telah banyak dibuktikan hingga tingkat molekuler, namunsebagaian besar dilakukan secara in vitro. Penelitian ini bertujuan untuk membuktikan inhibisi aktivitas proliferasisel dan perubahan histopatologik epitel mukosa nasofaring mencit C3H dengan pemberian ekstrak SA.MetodePenelitian eksperimental menggunakan 15 mencit C3H, dibagi menjadi tiga kelompok: kelompok kontrol (K)diinduksi dengan uap larutan formalin 10%, diberi diet standar AIN-93M mengandung 54 mg/kg BB formalinselama 9 minggu; kelompok P1 diinduksi uap formalin dan diet standar berformalin selama 6 minggu, lalu diberi1,5 g/kgBB ekstrak SA selama 3 minggu; kelompok P2 diberi ekstrak SA selama 3 minggu, kemudian diinduksiuap formalin dan diet standar mengandung formalin selama 6 minggu. Di akhir penelitian dilakukan pemeriksaanhistopatologik dan hitung AgNOR.HasilSkor perubahan histopatologik epitel nasofaring kelompok K (3,72±0,46), P1 (2,07±0,62), dan P2 (1,69±0,48).Rerata hitung AgNOR kelompok K (3±0,15), P1 (1,72±0,07), dan P2 (1,76±0,08). Uji Mann-Whitney terhadapvariabel perubahan histopatologik antara P1 vs P2, K vs P2, dan P2 vs P3 bermakna. Uji Mann-Whitneyterhadap variabel hitung AgNOR antara K vs P1 dan K vs P2 bermakna, namun antara P1 vs P2 tidakbermakna.KesimpulanEkstrak SA sebelum dan sesudah induksi formalin menimbulkan pengaruh berbeda bermakna pada perbaikanskor histopatologik dan aktivitas proliferasi sel epitel mukosa nasofaring mencit C3H

Metode Penyapihan Ventilasi Mekanik Di Intensive Care Unit: Studi Literatur Sarinti Sarinti; Reni Sulung Utami; Awal Prasetyo
Jurnal Smart Keperawatan Vol 3, No 1 (2016): Juni 2016
Publisher : Sekolah Tinggi Ilmu Kesehatan (STIKes) Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jskp.v3i1.463

Latar belakang : Pasien di ICU ( Intensive Care Unit ) yang membutuhkan bantuan ventilasi mekanik hampir mencapai 30% dari total pasien. Ventilasi mekanik yang digunakan dalam jangka panjang dapat meningkatkan resiko terjadinya mortalitas, dan ventilator associated pneumonia sehingga diperlukan perencanaan penyapihan yang tepat. Tujuan : Studi literatur ini bertujuan untuk mengidentifikasi metode penyapihan pasien dari ventilasi mekanik di ICU. Metode : Penelusuran literatur dilakukan melalui database Google scholar dan Google search dengan menggunakan kata kunci weaning mechanical ventilation, weaning protocol, critical care nursing. Literatur yang digunakan dari tahun 1997-2015 dalam bentuk full text. Literatur yang sesuai kriteria inklusi dan eksklusi dianalisis secara narasi. Hasil: Penelusuran mendapatkan 7 artikel penelitian yang menunjukkan metode penyapihan pasien dari ventilasi mekanik. Metode penyapihan dari ke 7 artikel tersebut adalah metode protokol dan non protokol. Metode non protokol misalnya physician direct weaning ( PDW ) dan collaboration weaning plan ( CWP ). Metode penyapihan dengan protokol antara lain : nurse` protokol directed weaning ( NPDW ) dan protokol base weaning ( PBW ). Kesimpulan : Metode penyapihan protokol menunjukkan hasil lebih efektif dibandingkan metode non protokol. Kata Kunci: Penyapihan Ventilasi Mekanik, Protokol Penyapihan, Keperawatan Kritis Methode of Weaning from Mechanical Ventilation in Intensive Care Unit : Study Literature ABSTRACT Back ground : patients in the ICU who require mechanical ventilation assistance almost 30% of the total patients. Mechanical ventilation is used in the long term can increase the risk of mortality and ventilator associated pneumonia so that proper planning is necessary weaning. Objectives : the literature study aims to identify methods of weaning patients from mechanical ventilation in the ICU. Methods : the literature study search pass through by Google scholar and Google search using keywords weaning mechanical ventilation, weaning protocol, critical care nursing. Literature is used from the year 1997-2015 in the form of full text. Appropriate literature inclusion and exclusion criteria were analyzed narrative. Results : search get 7 articles studies showing methods of weaning patients from mechanical ventilation. Method of weaning to the article 7 is the method protocol and non-protocol. Methods of non protocols eg physician-direct weaning ( PDW ) and collaboration weaning plan ( CWP ). Methods of weaning protocols include: nurse` protocol directed weaning (NPDW) and protocols base weaning ( PBW ). Conclusion : the method of weaning protocol shows the results more effective than non - protocol methods Key word : weaning mechanical ventilation; weaning protocol; critical care nursing

Tingkat Ketahanan Hidup Penderita Kanker Nasofaring pada Berbagai Modalitas Terapi Studi Kasus yang Menjalani Terapi Konvensional dan Pengobatan Komplementer Alternatif Jessica Christanti; Awal Prasetyo
MEDIA MEDIKA INDONESIANA 2012:MMI VOLUME 46 ISSUE 2 YEAR 2012
Publisher : MEDIA MEDIKA INDONESIANA

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Survival rate of patients with nasopharyngeal cancer on various modalitie: Case study of patients on conventional therapy and Indonesian complementary and alternative medicineBackground: There are no data on survival rate of patients with nasopharyngeal cancer (NPC) on complementary alternative medicine in Indonesia. The aim of this study was to analyze the survival rate of patients with nasopharyngeal cancer (NPC) on conventional (modern) and complementary and alternative medicine (CAM) treatments.Methods: A cross-sectional observational study of 33 NPC patients from each conventional (modern) treatment and CAM group was performed. The guided intervews were conducted to describe CAM treatment in NPC patients by using a validated questionnaire based CAM therapies of California Health Interview Survey 2001. Survival analysis was conducted by the Kaplan-Meir method.Results: Most patients (52.3%) used CAM treatments.Multivitamin and herbal medicines were among the commonly used CAM (52.8%). Kaplan-Meier analysis showed no significant results (p=0.444) between groups. The first and second year of survival rate was comparable between groups (66.6% vs. 54.5%; 45.5% vs 33.3%). Furthermore, the median overall survival (OS) was shown (16; 95% CI: 1.58-8.90) in CAM treatment patients and conventional (modern) treatment (12; 95% CI: 8.477-0.00). The prevalenceratio (PR) obtained in this study was 1.2 (95% CI: 0.79-1.69).Conclusion: CAM treatment on NPC patients had no effect on survival rate compared with conventional (modern) treatment.Keywords: NPC, CAM, survival rateABSTRAKLatar belakang: Saat ini, belum ada data tingkat ketahanan hidup penderita kanker nasofaring (KNF) yang menjalani pengobatan komplementer alternatif di Indonesia. Fakta menunjukkan bahwa pengobatan komplementer alternatif di Indonesia merupakan bagian aktivitas sosial budaya. Penelitian ini menganalisis tingkat ketahanan hidup penderita KNF yang memperoleh pengobatan modern konvensional disertai pengobatan komplementer dan alternatif (PKA).Metode: Penelitian cross sectional dilakukan pada 33 penderita KNF di tiap kelompok yang menjalani PKA dan kelompok yang menggunakan pengobatan modern konvensional di wilayah Semarang dan sekitarnya. Wawancara terpimpin untuk terapi PKA dengan menggunakan California Health Interview Survey 2001 yang telah divalidasi. Tingkat ketahanan hidup dianalisis dengan uji Kaplan Meier.Hasil: Sebanyak (52,3%) penderita menjalani PKA, dimana yang tersering adalah dengan multivitamin dan jamu (52,8%). Tingkat ketahanan hidup kelompok PKA di tahun pertama (66,6%) dan tahun ke-2 (45,4%). Tingkat ketahanan hidup tahun pertama dan kedua kelompok obat konvensional 54,5% dan 33,3%. Analisis Kaplan Meier menunjukkan hasil yang tidak bermakna (p=0,444). Analisis median tingkat ketahanan hidup, penderita kelompok PKA didapatkan nilai 16 (CI 95%:1,581-8,900), dan pada kelompok pengobatan modern konvensional didapatkan nilai 12 (CI 95%: 8,477-0,00). Nilai PR didapatkan 1,158 (CI 95%: 0,792-1,692).Simpulan: Penggunaan PKA dan terapi modern konvensional tidak mempengaruhi tingkat ketahanan hidup penderita KNF.

Uji Validitas dan Reliabilitas Kwesioner Etiologi dan Faktor Risiko Kanker Nasofaring Awal Prasetyo; Bambang Hariwiyanto; Mohammad Hakimi; Soenarto Sastrowijoto
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.307 KB)

ABSTRACT Validity and reliability tests on questionnaires designed for etiology and risk factors of nasopharynx cancerBackground: The etiology and risk factors of NPC is a combination of multi-risk factors of genetic history, lifestyle, environmental exposure, and EBV infection. Currently, there is no publication about NPC’s questionnaire. This study analyzed the reliability and validity of the questionnaire of NPC’s etiology and risk factors.Methods: The cross-sectional study of the questionnaires of NPC’s etiology and risk factors were filled by the used-tryout samples i.e NPC sufferers and their family members, in April to August 2012. The study were done at Anatomical Pathology Laboratory of Kariadi & St. Elisabeth Hospitals Semarang. There are three main constructs, namely; genetic, lifestyle, and environmental exposure. The 74 filled-questionnaires were tested by correlation analysis of product moment for the validity, and the reliability tests conducted with Cronbach's Alpha. The data were analyzed with SPSS for Windows version 17.0.Results: A test for risk family history constructs were valid (p>0.932) and reliabel (Cronbach's Alpha=0.864). A test for lifestyle with a Pearson Correlation were p>0.785 for smoking habit, eating salted fish p>0.793, eating grilled-fish p>0.862, eating pickled p>0.831, drinking alcohol p>0.760, instant noodle p>0.497, food preservation p>0.495, food contains MSG p>0.627, with Cronbach's Alpha>0.751. A test for environmental exposure risk were valid for the exposure to passive cigarette smoke (p>0.486) Cronbach's Alpha=0.789,the exposure of the home environment p>0.658 Cronbach's Alpha=0.832, exposure-related jobs p>0.373 Cronbach's Alpha=0.697, and chronic nasopharingitis are all valid (p>0.900) with Cronbach's Alpha=0851.Conclusions: The questionnaires designed as a tool of NPC’s etiology and risk factors are valid and reliable.Keywords: Validity, realibility, questionnaires, NPC’s etiology and risk factorsABSTRAKLatar belakang: Etiologi dan faktor risiko KNF merupakan kombinasi risiko riwayat genetik, gaya hidup, paparan lingkungan, dan infeksi EBV. Saat ini, belum ada publikasi tentang kwesioner KNF. Penelitian ini membuktikan validitas dan reliabilitas alat ukur kwesioner etiologi dan faktor risiko KNF.Metode: Penelitian cross-sectional terhadap hasil pengisian kwesioner etiologi dan faktor risiko KNF yang diisi oleh sampel tryout terpakai, yaitu penderita KNF dan anggota keluarganya, pada April - Agustus 2012, di Laboratorium Patologi Anatomi RSUP Dr. Kariadi Semarang dan RS St. Elisabeth Semarang. Kwesioner berdasar pada tiga konstruk utama, yaitu risiko genetik, risiko kebiasaan/gaya hidup, dan risiko paparan lingkungan. Sebanyak 74 kwesioner dilakukan uji validitas dengan analisis korelasi product moment, serta uji reliabilitas Cronbach's Alpha. Data dianalisis dengan SPSS for Windows version 17.0.Hasil: Uji konstruk risiko riwayat keluarga didapatkan valid (p>0,932) dan reliabel (Cronbach's Alpha=0,864). Uji konstruk risiko gaya hidup dengan Pearson Correlation didapatkan p>0,785 untuk subkonstruk kebiasaan merokok, kebiasaan makan ikan asin p>0,793, kebiasaan makan ikan/daging asap/bakar p>0,862, kebiasaan makan asinan p>0,831, kebiasaan minum alkohol p>0,760, kebiasaan makan mie instan p>0,497, kebiasaan makan makanan awetan p>0,495, kebiasaan makanan mengandung MSG p>0,627, Cronbach's Alpha=0,751. Uji konstruk risiko paparan lingkungan didapatkan valid untuk subkonstruk paparan pasif asap rokok (p>0,486), Cronbach's Alpha=0,789, paparan lingkungan rumah p>0,380, Cronbach's Alpha=0,713, paparan yang berhubungan dengan pekerjaan p>0,373 Cronbach's Alpha=0,697, infeksi nasofaringitis kronik semuanya valid (p>0,900), Cronbach's Alpha=0,851.Simpulan: Kwesioner yang diuji sebagai alat ukur untuk menggali etiologi dan faktor risiko KNF layak dipergunakan karena valid dan reliabel

LAJU TRANSPOR MUKOSILIAR MUKOSA NASAL PADA PETUGAS SPBU Darryl Samuel Salim; Awal Prasetyo
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 5, No 4 (2016): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar Belakang : Uap BBM mengandung benzena, toluen, etilbenzena, xylene (BTEX) yang merupakan zat-zat iritan. Paparan zat iritan pada mukosa hidung akan menyebabkan kerusakan pada sistem trampor mukosiliar hidung. Petugas SPBU di Indonesia terpapar zat-zat iritan tersebut selama mereka bekerja. Pengaruh pekerjaan sebagai operator SBPU serta pengaruh lama bekerja terhadap sistem transpor mukosiliar hidung belum diketahui.Tujuan : Mengetahui perbedaan kecepatan TMSH (transpor mukosiliar hidung) antara pekerjaan sebagai petugas SPBU dan lama bekerja.Metode : Penelitian ini merupakan penelitian observasional dengan rancangan age matched case control. Sampel penelitian adalah 18 orang petugas SPBU di sekitar Tembalang Semarang dan 18 orang mahasiswa dan petugas di FK Undip Tembalang Semarang sebagai kelompok kontrol. Waktu TMSH diukur dengan menggunakan uji sakarin. Normalitas data diuji dengan Saphiro-Wilk. Data dianalisis dengan uji Mann-Whitney.Hasil : Rata-rata waktu TMSH pada petugas SPBU adalah 1222.56 detik dan pada bukan petugas SPBU adalah 892.33 detik. Pada uji Mann-Whitney waktu TMSH pada petugas dan bukan petugas didapatkan perbedaan bermakna (p=0.001), sedangkan tidak didapatkan perbedaan bermakna (p=0.075) pada waktu TMSH dibandingkan dengan lama bekerja.Kesimpulan : Terdapat perbedaan waktu TMSH pada petugas SPBU dan tidak terdapat perbedaan laju TMSH dibandingkan dengan lama bekerja.

PERBEDAAN PROFIL SPIROMETRI PADA PETUGAS SPBU Redyaksa Drestanta Ariandoko; Awal Prasetyo
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 6, No 4 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

LATAR BELAKANG : Uap Bahan Bakar Minyak (BBM) mengandung bahan kimia beracun yang berpotensi menyebabkan kelainan patologi pada saluran nafas. Petugas SPBU di Indonesia tidak memakai masker untuk mengurangi atau menghilangkan efek paparan uap atau gas yang dihasilkan oleh BBM sehingga dapat mengganggu fisiologi paru yang diukur dengan spirometer.TUJUAN : Mengukur profil spirometri petugas SPBU (Vital Capacity, Forced Vital Capacity, Forced Expiratory Volume in One Second/VC, FVC, FEV1) dan membuktikan keterkaitannya dengan usia, jenis kelamin, dan lama kerja.METODE : Studi observasional analitik dengan rancangan cross sectional. Pada petugas SPBU sebanyak 32 orang dilakukan pengukuran spirometri meliputi VC, FVC, FEV1 dan dilakukan Mann-WhitneyHASIL : Terdapat hubungan bermakna antara VC dengan jenis kelamin (p=<0,05), antara VC dengan lama kerja (p<0,05). Tidak terdapat hubungan bermakna antara FVC dan FEV1 dengan usia, jenis kelamin, dan lama kerja (p>0,05). Tidak terdapat hubungan bermakna antara profil spirometri petugas SPBU dan non petugas SPBU.SIMPULAN : Jenis kelamin dan lama kerja memiliki hubungan bermakna dengan VC. Usia, jenis kelamin, dan lama kerja tidak memiliki hubungan bermakna dengan FVC dan FEV1.

COMPARISON OF THE EFFECTIVENESS OF CURCUMA DOMESTICA EXTRACT AND CURCUMA XANTHORRIZA EXTRACT AGAINST LIVER FUNCTION AND HEPATIC CELL INFLAMMATION ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS MICE Amira Naufal; Alfin Ihza Trimahendra; Astika Widy Utomo; Vega Karlowee; Awal Prasetyo; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Diabetes mellitus can cause complications including liver damage, which has an impact on increasing levels of SGOT and SGPT in the blood, as well as inflamation and hepatic steatosis. Turmeric (Curcuma domestica) and java turmeric (Curcuma xanthorizza) are known to have high levels of curcumin and xanthorizzol as an antioxidant and proven to improve liver function. Antioxidant therapy in patients with NAFLD is known to improve liver function and histopathological features. The effects of turmeric and java turmeric extract on liver function in streptozotocin-induced diabetes mellitus mice are still unknown. Objective: Comparing effects of administered turmeric and java turmeric extract on liver function and histopathologic features of streptozotocin-induced diabetes mellitus mice. Method: Research design Post Test Only Control Group Design are used. Male swiss mice around 25-30 gram are used. Streptozotocin-induced diabetes mellitus mice with a total samples (n = 20) divided into 4 groups, Control+PBS, Control+STZ, STZ+Turmeric, and STZ+Java Turmeric (an = 5). Blood glucose, weight, SGOT, SGPT levels and histopathologic features including percentage of inflamation and hepatic steatosis were examined at day 21. All the research data were analyzed using statistics program. Result: Turmeric and java turmeric extract cannot significantly reduce blood glucose level. Administration of java turmeric extract significantly reduce SGPT level against control+STZ group (84,12±17,53 vs. 36,3±27,4 u/L, p=0,018). Administration of turmeric extract significantly reduce hepatic cell inflamation against control+STZ group (30(26-68) vs. 20(15-30)%, p=0,035). Conclusion: Each turmeric and java turmeric extract can improve liver fuction and decreasing hepatic cell inflamation on streptozotocin-induced diabetes mellitus mice, but may not mediated by decreasing blood glucose level.

Nitric oxide (NO) level of the follicular fluid in endometriosis patients Cahyono Hadi; Djaswadi Dasuki; Ahmad Hamim Sadewa; Indwiani Astuti; Awal Prasetyo
Majalah Obstetri dan Ginekologi Vol. 26 No. 1 (2018): April
Publisher : Universitas Airlangga

Objectives: To ascertain the nitric oxide (NO) level of the follicular fluid of endometriosis sufferers compared with that of the non-endometriosis patients.Materials and Methods: Follicular fluid was taken from 64 women, but only 54 continued with further laboratory test. Women with endometriosis had their follicular fluid taken during laparoscopy, while the follicular fluid from non-endometriosis women was taken during tubectomy. Nitric Oxide level was analyzed using the PCR-RFLP method. Data were analyzed using software STATA Intercooled Version 11.Results: NO level in endometriosis is higher than that in non-endometriosis and has a significant relationship with all the variables (age, parity, dysmenorrhea, dyspareunia, types of endometriosis, and grade of endometriosis).Conclusion: The NO level in endometriosis is higher than that in non-endometriosis. The distribution of the polymorphism of allele GG is greater than that in non-endometriosis. The existence of polymorphism GG caused a higher eNOS, increasing NO level, causing a decrease in fertility which derived from the degenera-tive oocyte.

Higher IL-1beta level in the follicular liquid of endometriosis compared with non-endometriosis patients Cahyono Hadi; Djaswadi Dasuki; Ahmad Hamim Sadewa; Indwiani Astuti; Awal Prasetyo
Majalah Obstetri dan Ginekologi Vol. 28 No. 2 (2020): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V28I22020.59-66

Objective: To ascertain the IL-1b level in the follicular liquid of endometriosis sufferers compared with that of non-endometriosis sufferers.Materials and Methods: The ELISA method, for detecting the IL-1b, is taken from follicular fluid of endometriosis as well as non-endometriosis patients that diagnosed according to the ASRM criteria.Results: The 54 subjects were dominantly endometriosis <34 year old (88.9%). The IL-1b levels of endometriosis patients and non-endometriosis patients were 82.86 ± 30.15 and 56.05 ± 23.27 respectively (p=0.01). The ROC value of IL-1b was found at a cut-off point of 26 (with the IL-1b cut-off point of 65.16). The discriminating value of AUC (area under curve) was 59.3%.Conclusion: It was concluded that the IL-1b level in endometriosis is higher than that in non- endometriosis.

Artemisia annua Leaf Extract Increases GLUT-4 Expression in Type 2 Diabetes Mellitus Rat Arum Kartikadewi; Awal Prasetyo; Lisyani Budipradigdo; Heri Nugroho; Kusmiyati Tjahjono; Arthur Lelono
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.531

BACKGROUND: The depletion of glucose transporter 4 (GLUT-4) affects blood glucose level in the type 2 diabetes mellitus (T2DM) patient. Herbals supplementation such as Artemisia annua is known to posses an antidiabetic potency, but its effect on long term glucose control marker, glicated hemoglobin (HbA1C) and muscle GLUT-4 expression still has not been investigated.METHODS: Twenty Wistar rats were divided into four groups (five rats per group). The C1 group was consist of healthy control rats and C2 group was consist of diabetic control rats. Diabetic condition was induced by giving high lard fat diet for 28 days, followed with 30 mg/kgBW of Streptozotocin injection at the 29th day. Meanwhile, T1 and T2 group were consist of diabetic rats, which were supplemented with 50 mg/kgBW and 100 mg/kgBW of Artemisia annua leaf extract, respectively. GLUT-4 expression and HbA1C level were measured at the 14th day post-treatment.RESULTS: The GLUT-4 was expressed 1.8 and two times higher in T1 and T2 group, respectively, compared to C2 group. Meanwhile, HbA1C level in C2 group was two times higher than C1 group (11.95±2.52 compared to 5.61±2.69, p<0.01). Further, the administration of 100 mg/ kgBW Artemisia annua extract caused a slight reduction of HbA1C (11.95±2.52 compared to 8.18±3.53, p>0.05)CONCLUSION: Muscle cell’s GLUT-4 in T1 and T2 group was expressed increasingly and significantly different compared to the C2 group. HbA1C level in T2 was slightly reduced although no significant different compared to C2 group.KEYWORDS: Artemisia annua, GLUT-4, HbA1C, type 2 diabetes mellitus

Co-Authors - Anggorowati Aditya Purnama Ahmad Hamim Sadewa Alendra Chakramurty Alfin Ihza Trimahendra Amira Naufal Anisa Ell Raharyani Anna Jumatul Laely Antari, Arlita Leniseptaria Apriana, Ledisda Ariani, Resti Arthur Lelono Arum Kartikadewi Asri, Hairul Astika Widy Utomo Bagus Ropyanto, Chandra Bambang Endro Putranto Bambang Hariwiyanto Cahyono Hadi Cahyono Hadi Chandra Bagus Ropyanto Dadi Hamdani Darryl Samuel Salim Dewi Kartikawati Paramita Dik Puspasari Dik Puspasari Djaswadi Dasuki Djaswadi Dasuki Eriawan Agung Nugroho Franky Yusuf Hermawan Istiadi Heru Suwardianto Hidayat Sulistyo Ika Pawitra Miranti Ika Pawitra Miranti Indwiani Astuti Indwiani Astuti Jessica Christanti Jumatul Laely, Anna K. Heri Nugroho HS, K. Heri Kenty Wantri Anita, Kenty Wantri Kusmiyati Tjahjono Kusmiyati Tjahjono Lisyani Budipradigdo Meira Dewi Kusuma Astuti Meira Dewi Kusuma Astuti Mochamad Ali Sobirin Mohammad Hakimi Muniroh, Muflihatul Nani Maharani Neni Susilaningsih Nurjaya Adinugroho Rahajeng, Herera Redyaksa Drestanta Ariandoko Reni Sulung Utami Rizki Widya Nur Sarinti Sarinti Sarinti, Sarinti Selvia David Richard Siahaan, Johanna Soenarto Sastrowijoto Sony Noegroho Sri Jumini Taufiq R Nasihun Tjahjono Tjahjono Tjahjono Tri Nur Kristina Udadi Sadhana Udadi Sadhana, Udadi Vega Karlowee Vega Karlowee Veni, Rizka Wahyu Haris Prabowo Wahyuningsih, Indah S Wiratno Wiratno Yuriz Bakhtiar

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