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All Journal Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Cancer

Bidasari Lubis

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Author-ID : 3453496

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Parental knowledge, attitude and practice on malaria in Mandailing Natal district Syafruddin Haris; Sri Sofyani; Bidasari Lubis; Munar Lubis; Syahril Pasaribu; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Background Malaria is still considered to be an important healthproblem in Indonesia. Malaria has been found in islands withdifferent degree of endemicity. Behavior of the community isone of the factors affecting the incidence of malaria in MandailingNatal district.Objective To know the parental knowledge, attitude, and practiceamong parents whose children suffered from malaria or not.Methods A cross sectional study was conducted in six primaryschools and one health centre in October 2004. Subjects wereparents whose children were malaria positive and malaria negativebased on laboratory examination. Sample size was 85 parents foreach group. Selected respondents were interviewed usingstructured questionnaire. Degree of knowledge, attitude, andpractice on malaria were established using scoring system withinthree categories: good, less, and poor. Data were collected andpresented using chi-square and P<0.05 was considered as a levelof significant.Results The mean age of 85 parents whose children were positivemalaria, was 38.47 years (SD 6.67) and the mean age of thosewhose children were negative malaria was 40.41 years (SD 8.05).Parentâ€™s education level was 62.9% primary school and 90% oftheir children were school-aged. There were significant differenceson parental knowledge, attitude and practice in each group(P<0.05). There was also a significant correlation betweenoccupation and knowledge, but not between parental educationlevel and parental age. Parental knowledge and attitude on theincidence of malaria in Mandailing Natal district were good,though their practice were poor.Conclusion There are significant differences on parentalknowledge, attitude and practice, between parents whose childrenwere positive and negative for malaria.

Effect of iron and zinc supplementation in the treatment of malaria in children Danny Dasraf; Bugis Mardina Lubis; Bidasari Lubis; Nelly Rosdiana; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Background Iron and zinc administration for children withmalaria in endemic area were known to decrease parasitemia butdata on their effectiveness when given together to increasereticulocytes as erythropoiesis parameter and hemoglobin isinsufficient.Objective To determine the effect of zinc to increase ironabsorption in the treatment of Plasmodium falciparum malaria inchildren.Methods Children with positive Plasmodium falciparum on theirblood smear (n=86) examination were randomly assigned to dailysupplementation of iron 6 mg per kg body weight per day plusplacebo or iron plus zinc 10 mg per day for 30 days. Venous bloodspecimens were collected at the start and at the end of the study.Results Sixty-nine children completed the supplementations andhad both baseline and follow-up blood specimen study. After 30-day supplementation, the iron plus placebo and iron plus zincgroups showed significant difference on hemoglobin concentration(0.58 and 0.09 g/dl; P<0.05). There was no significant differencein reticulocyte production index and reticulocyte count beforeand after intervention in both groups. There was only significantdifference in red blood cells concentration after supplementationof iron plus placebo and iron plus zinc (4.7 in 4.5 million/Î¼l;P<0.05).Conclusions Iron supplementation with or without zinc showssignificant increase of hemoglobin concentration. It is slightlyhigher in iron plus placebo group.

Comparison of once a day and three times a day iron treatment in 9-12 year old elementary school children with iron deficiency anemia Dedy Gunadi; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Background The compliance of iron deficiency anemia treatmentthat is administered three times daily in children is low. Thecompliance will be better if therapy is administered once daily.Objective To compare the iron therapy response of once per dayvs. three times a day administration in 9-12 year old children withiron deficiency anemia.Methods Children with iron deficiency anemia were randomlyallocated into a ferrous sulfate once-daily group or a ferrous sulfatethree times-daily group with the same dose of 5 mg/kg /day ofelemental iron for 30 days. Iron deficiency anemia was definedas Hb < 12 g/dL (World Health Organization criteria), MCV< 70 fl, RDW > 16 %, Mentzer index > 13 and RDW index >220. Iron treatment response was characterized by the increase inHb level 30 days after treatment. Peripheral blood samples werecollected at the start and end of the study.Results Ninety seven children were enrolled. There weresignificant increases in Hb levels in both groups after 30 days ofiron therapy, but there was no significant difference in Hb levelbetween the two groups (P=0.55).Conclusion The administration of a once daily dose of ferroussulfate did not show a significant difference in the increase ofHblevels compared to a three times daily dose.

Effect of iron treatment on nutritional status of children with iron deficiency anemia Leon Agustian; Tiangsa Sembiring; Ani Ariani; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Background Iron has been shown to improve growth in childrenwith iron deficiency anemia (IDA), as indicted by increases inheight and weight. Frequently, malnutrition and iron deficiencycoexist.Objective To determine the effect of iron treatment on nutritionalstatus in children with IDA.Methods A randomized placebo-controlled clinical trial wasconducted at Bilah Hulu, a subdistrict of Labuhan Batu, NorthSumatera, Indonesia, between November 2006 and February2007. Iron deficiency anemia was diagnosed if there anemiawas present along with MCHC <31%, RDW index >220 andMentzer index> 13. Elementary school children (8-12 years old)with IDA were randomly assigned to either receive a daily therapyof 6 mg iron/kg/day or a placebo for three months. Nutritionalstatus was evaluated by anthropometric assessment before andafter intervention.Results From 300 subjects recruited, there were 111 (3 7 .2%)with iron deficiency anemia; 108 of them completed the therapy.After intervention, the iron and placebo groups had differentmean hemoglobin concentrations (P <0.05), but there was nosignificant difference in mean weight and height gain betweenthe two groups.Conclusion A significant increase in hemoglobin concentrationwas seen when iron was given, but did not affect weight and height increase in the subjects.

Impact of iron therapy on Mentzer index and red cell distribution width index in primary school children with iron deficiency anemia Budi Andri Ferdian; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 4 (2009): July 2009
Publisher : Indonesian Pediatric Society

Background Iron deficiency anemia (IDA) remains a commonnutritional problem, especially in school-age children. Due tothe many examinations that are needed to be performed and the invasive gold standard procedure, an easy and simple alternative examination to diagnose IDA is needed.Objective To determine the impact of iron therapy on Mentzerand red cell distribution width (RDW) indexes of children withIDA.Methods A randomized open clinical trial was conducted inprimary school aged children in North Aek Nabara, betweenNovember 2006 and November 2007. IDA was determined basedon WHO criteria. Subjects with severe anemia were excluded.Subjects were randomly assigned to groups that received eitheriron therapy or a placebo.Results Three-hundred subjects from aged 9 to 12 years oldwere recruited and 104 subjects completed the study. The meanRDW index of the iron and placebo groups after three monthsobservation were 239.96 (SD 39.25) and 235.17 (SD 31.77),respectively. The mean Mentzer index mean for the iron therapyand placebo groups after three months observation were 16.08(SD 1.98) and 16.20 (SD 2.27), respectively.Conclusion After therapy, there are no significant differences ineither the Mentzer or RDW indexes between the therapy andplacebo groups.

Growth velocity in elementary school children with iron deficiency anemia after iron therapy Dina Lyfia; Melda Deliana; Hakimi Hakimi; Nelly Rosdiana; Bidasari Lubis
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Background Iron supplementation in children with iron deficiencyanemia could decrease the incidence of stunting.Objective To study the effect of iron therapy on growth velocityin children with iron deficiency anemia.Methods A randomized clinical trial study was conducted atLabuhan Batu on November 2006 to May 2007. Iron deficiencyanemia was diagnosed if there were anemia, with mean corpuscular hemoglobin concentration <31 %, red cell distribution width index > 220, and Mentzer index> 13. Elementary school children (6-12 year old) with iron deficiency anemia were randomly assigned either to iron therapy group (children were given 6 mg iron/kg/day) or to placebo group for 3 months.Results Among 300 children recruited, there were 125 children,who suffered from iron deficiency anemia. After one month ofiron therapy, means of hemoglobin concentration were 12.4 g/dl in iron group and 11.7 g/dl in placebo group. There was a significant increase of height in iron group (129.9 (SD 7.58) em vs. 132.2 (SD 7.23) em) and in placebo (130.8 (SD 8.78) em vs. 128.7 (SD 8. 79) em), However, no significant difference was found in the mean of growth velocity between placebo and iron groups (2.1 (SD 0.01) em vs. 2.0 (SD 0.9) em.Conclusion There is a significant increase in height, but nosignificant difference between both groups in growth velocity.

Behavior of elementary schoolchildren with iron deficiency anemia after iron therapy Rina A.C. Saragih; T. Mirda Zulaicha; Sri Sofyani; Bidasari Lubis; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 49 No 5 (2009): September 2009
Publisher : Indonesian Pediatric Society

Background Some studies had been performed to determine theassociation between iron status and children's behavior yet it isstill controversial.Objective To investigate whether iron therapy has an effect onthe behavior of children with iron deficiency anemia (IDA).Method A randomized placebo-controlled clinical trial wasconducted in Labuhan Batu on November 2006-April2007. IDAwas defined as Hb < 12 g/dl, MCHC< 31%, ROW index > 220and Mentzer index> 13. Elementary school children (6-12 yearsold) with IDA were randomly assigned to the treatment groupwith a daily therapy of 6 mg iron/kg/day or placebo group for three months. The subjects' behavior was evaluated with child behavior check list (CBCL) before and six months after intervention.Results After six months, 110 subjects completed the therapy.Scores of CBCL in iron group after intervention were internalizing42.64 (SO 9.95), externalizing 37.13 (SO 9.04) & total score 38.24 (SO 10.20). There was significant decreased on externalizing and total problems score in the treatment group after intervention (P< 0.05). However, there was no significant difference on scores between groups.Conclusion Iron therapy had significantly decrease CBCL scoreon externalizing and total problems in the treatment group,however there was no significant difference on scores if comparedwith placebo group.

Liver dysfunction in children with hematologic malignancy or solid tumor Rita Carmelia; Bidasari Lubis; Adi Sutjipto; Trie Hariweni
Paediatrica Indonesiana Vol 43 No 4 (2003): July 2003
Publisher : Indonesian Pediatric Society

Background Deficiencies in liver synthetic function can only bedetected if the damage is severe, which are more often due to nonhepatic factors such as malignancies, both hematologic and solidtumor.Objective To assess liver function in children with either hemato-logic malignancy or solid tumor and to find out which one of themmostly affects liver function.Methods A retrospective study was conducted on 125 childrenwith malignancies in the Sub division of Hemato-Oncology De-partment of Child Health, Adam Malik Hospital, Medan, from Janu-ary 1999 until May 2000. The inclusion criteria included all pa-tients who were younger than 15 years and had not received anytreatment yet. The differences between prevalent liver dysfunctionin both groups were assessed by using chi-square test; Fisherâ€™sexact test was used to know the type of liver cell damage.Results Liver dysfunction occurred in both types of malignancies. Adecrease of albumin level was not significant in both groups. Therewas a statistically significant difference between the prolongedprothrombine time (PT) in hematologic malignancy (26.4%) and thatin solid tumor (10.4%) with p=0.03. There was no significant differ-ence in the elevation of serum transaminase concentration, totalbilirubin, and alkaline phosphatase. Based on aspartate aminotrans-ferase (AST) and alanine aminotransferase (ALT) ratio, we foundthat the type of liver cell damages was infiltrative disorders, occurred13 out of 20 cases with elevated AST and ALT.Conclusion Liver dysfunction occurred in both types of malig-nancy; it occurred more frequently in hematologic malignancy thanin solid tumors

The relation of BCG vaccination and severe malnutrition with the occurrence of tuberculous meningitis Nofareni Nofareni; Bistok Saing; Ridwan M. Daulay; Bidasari Lubis
Paediatrica Indonesiana Vol 44 No 1 (2004): January 2004
Publisher : Indonesian Pediatric Society

Objectives To assess BCG vaccination and nutritional states inchildren with tuberculous meningitis and their relations with theoccurrence of tuberculous meningitis.Methods A case-control study was conducted at the Divisionof Neurology, Department of Child Health, Adam Malik Hospi-tal, Medan, from January 1997 to December 2000. Subjects ofthis study were all tuberculous meningitis patients and primarytuberculosis patients as the control group. Odds ratio (OR) wasused to assess the risk of tuberculous meningitis in patientswith positive BCG vaccination and (1-OR) was used to assessthe efficacy of BCG to prevent tuberculous meningitis.Results Four out of sixteen tuberculous meningitis patients werevaccinated, while 10 of 16 primary tuberculosis patients were vac-cinated (p=0.03). OR of vaccinated patients to get tuberculousmeningitis was 0.2 (95%CI 0.04;0.91). The efficacy of BCG vacci-nation to prevent tuberculous meningitis was 1-0.2 = 0.8. The riskof severe malnourished patients to get tuberculous meningitis was2.33 (95%CI 0.52;10.48; p=0.26).Conclusion Most tuberculous meningitis patients were not BCGvaccinated. Severe malnutrition did not play role in the occurrenceof this disease

The effectiveness of chloroquine compared to Fansidar in treating falciparum malaria Emil Azlin; Ichwan HH Batubara; Wisman Dalimunte; Charles Siregar; Bidasari Lubis; Munar Lubis; Syahril Pasaribu
Paediatrica Indonesiana Vol 44 No 1 (2004): January 2004
Publisher : Indonesian Pediatric Society

Background The most difficult problem in eradicating malaria isthe resistance of P. falciparum to drugs. Mandailing Natal has thehighest malaria incidence in North Sumatera.Objective This study aimed to investigate the efficacy of chloro-quine and Fansidar in treating falciparum malaria.Methods A randomized double-blind study was done from April toMay 2001. Eighty-three patients with acute uncomplicated P.falciparum malaria infection were randomized into two groups.Group I (35 patients) received chloroquine and group II (48 pa-tients) received Fansidar. Blood examinations were performed onthe 1 st , 2 nd , 7 th , and 28 th days.Results The resistance of P. falciparum to drugs in the chloro-quine group were found in 10 patients with R II and 1 patients withR III, while in the Fansidar group, there were 14 patients with R II.Conclusion The efficacy of chloroquine and Fansidar in treatingfalciparum malaria was not significantly different

Co-Authors Adi Sutjipto Adillida Adillida Ahmad Faisal Ani Ariani Bebi Trianita Sari Bistok Saing Budi Andri Ferdian Bugis Mardina Lubis Chairuddin P Lubis Charles Siregar Dachrul Aldy Danny Dasraf Dedy Gunadi Dina Lyfia Dini Lailani Emil Azlin Guslihan D Tjipta Hakimi Hakimi Ichwan HH Batubara Iskandar Z. Lubis Leon Agustian Melda Deliana Munar Lubis Nelly Rosdiana Nofareni Nofareni Ridwan M. Daulay Rina A.C. Saragih Rita Angraini Rita Carmelia Saur L Margaretha Sisca Silvana Sri Sofyani Syafruddin Haris Syahril Pasaribu T. Mirda Zulaicha Tiangsa Sembiring Trie Hariweni Wisman Dalimunte Y Dimyati Yoyoh Yusroh

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