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Trie Hariweni

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Author-ID : 3462295

Health Professions Medicine & Pharmacology

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Liver dysfunction in children with hematologic malignancy or solid tumor Rita Carmelia; Bidasari Lubis; Adi Sutjipto; Trie Hariweni
Paediatrica Indonesiana Vol 43 No 4 (2003): July 2003
Publisher : Indonesian Pediatric Society

Background Deficiencies in liver synthetic function can only bedetected if the damage is severe, which are more often due to nonhepatic factors such as malignancies, both hematologic and solidtumor.Objective To assess liver function in children with either hemato-logic malignancy or solid tumor and to find out which one of themmostly affects liver function.Methods A retrospective study was conducted on 125 childrenwith malignancies in the Sub division of Hemato-Oncology De-partment of Child Health, Adam Malik Hospital, Medan, from Janu-ary 1999 until May 2000. The inclusion criteria included all pa-tients who were younger than 15 years and had not received anytreatment yet. The differences between prevalent liver dysfunctionin both groups were assessed by using chi-square test; Fisherâ€™sexact test was used to know the type of liver cell damage.Results Liver dysfunction occurred in both types of malignancies. Adecrease of albumin level was not significant in both groups. Therewas a statistically significant difference between the prolongedprothrombine time (PT) in hematologic malignancy (26.4%) and thatin solid tumor (10.4%) with p=0.03. There was no significant differ-ence in the elevation of serum transaminase concentration, totalbilirubin, and alkaline phosphatase. Based on aspartate aminotrans-ferase (AST) and alanine aminotransferase (ALT) ratio, we foundthat the type of liver cell damages was infiltrative disorders, occurred13 out of 20 cases with elevated AST and ALT.Conclusion Liver dysfunction occurred in both types of malig-nancy; it occurred more frequently in hematologic malignancy thanin solid tumors

Knowledge, attitude, and practice of underfive children stimulation of working and nonworking mothers Trie Hariweni; Muhammad Ali; Sri Sofyani; Iskandar Z Lubis
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Objective To assess and compare knowledge, attitude, and prac-tice of underfive children stimulation of working and nonworkingmothers and to determine the correlation between knowledge, at-titude, practice of stimulation and mothersâ€™ ages, educational level,number of children, and number of underfive children.Methods A cross-sectional study was performed in PT. IndofoodSukses Makmur, Tanjung Morawa, Medan from October 2002 un-til November 2002. Respondents were female workers havingunderfive children assigned as working mothers and wives of maleworkers (with similar inclusion criteria) assigned as nonworkingmothers. Selected respondents were interviewed using a struc-tured questionnaire. Sample size for each group was 58. Knowl-edge, attitude, and practice of stimulation were classified as good,less, and poor.Results There were 131 mothers interviewed. There were no sig-nificant differences in the ages, educational level, number of chil-dren, and number of underfive children. Good knowledge of stimu-lation of the working and nonworking mothers were 64.6% and97%, respectively; good attitude toward stimulation were 95.4%and 27.3%, respectively, while good practice of stimulation were58.5% and 22.7%, respectively. These differences were statisti-cally significant.Conclusion There were significant differences in knowledge, atti-tude, and practice of underfive children stimulation between work-ing and nonworking mothers. The knowledge of stimulation of theworking mothers was worse than that of the nonworking mothersand the attitude and practice of the working mothers were betterthan those of the nonworking mothers

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