Claim Missing Document
Check
Articles

Formulasi Sediaan Emulgel Untuk Penghantaran Transdermal Ketoprofen Priani, Sani Ega; Darijanto, Sasanti Tarini; Suciati, Tri; Iwo, Maria Immaculata
Acta Pharmaceutica Indonesia Vol 38, No 1 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.55 KB)

Abstract

Ketoprofen adalah obat golongan anti inflamasi non-steroid (AINS) yang banyak digunakan untuk mengobati nyeri dan inflamasi. Penggunaan oral ketoprofen dapat menimbulkan berbagai efek samping sistemik. Pemakaian transdermal diketahui mampu mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan oral, sehingga dapat mengurangi resiko efek samping sistemiknya. Penelitian ini bertujuan untuk membuat sediaan emulgel untuk penghantaran transdermal ketoprofen. Propilenglikol 10% dan menthol 3% digunakan sebagai peningkat penetrasi. Sediaan dievaluasi meliputi pengamatan organoleptik, pH, viskositas, serta pengujian stabilitas fisik menggunakan metode sentrifugasi dan freeze thaw. Selanjutnya dilakukan uji difusi in vitro dan uji iritasi kulit dan mata pada kelinci. Sediaan emulgel memenuhi kriteria stabilitas fisik berdasarkan uji sentrifugasi dan freeze thaw. Nilai pH dan viskositas sediaan relatif stabil selama kurun waktu penyimapanan 120 hari pada suhu kamar. Propilenglikol dan mentol dapat meningkatkan difusi perkutan ketoprofen, yang berbeda signifikan dibandingkan emulgel tanpat peningkat penetrasi (p<0,05). Formula emulgel bersifat sedikit mengiritasi kulit dengan nilai indeks iritasi kutan 0,83-1,17 (nilai maksimal 8), tetapi tidak mengiritasi mata.Kata kunci: Ketoprofen, transdermal, emulgel, peningkat penetrasi.AbstractKetoprofen as an non-steroidal anti-inflammatory drugs (NSAIDs) used for pain and inflamation treatment. However, there are some serious adverse effects associated with oral use of NSAIDs. Transdermal route is known to reach effective local concentration with low plasma concentration resulting in reduction systemic adverse effects. The objectives of this study was to formulate emulgel of ketoprofen for transdermal delivery. Ketoprofen emulgel was prepared using 10% of propilene glycol and 3% of menthol as penetrant enhancer. Evaluation of preparation included organoleptic evaluation, pH, viscocity, and physical stability test using centrifugation and freeze thaw method. Skin permeation was evaluated in vitro using spangler membrane and irritation effect test on rabbits. Emulgels were stable after centrifugation and freeze thaw test. The viscosity and pH of preparations were relatively stable during storage at room temperature for 120 days. Propylenglycol and menthol increased diffusion rate of ketoprofen, differ significantly from emulgel without enhancer (p<0.05). Emulgel preparation were slightly irritate to the skin with irritation index 0.83-1.17 (maximum value 8) but was not irritate to the eyes.Keywords: Ketoprofen, transdermal, emulgel, penetrant enhancer
Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Priani, Sani Ega; Nurrayyan, Nurrayyan; Darusman, Fitrianti
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.782 KB) | DOI: 10.12928/pharmaciana.v7i2.7387

Abstract

Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS  was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.
Formulasi dan Evaluasi Sediaan Mikroemulsi Untuk Penghantaran Transdermal Ketoprofen dengan Fasa Minyak Labrafil M1944CS Priani, Sani Ega; Darijanto, Sasanti Tarini; Suciati, Tri; Iwo, Maria Immaculata
Jurnal Matematika dan Sains Vol 19 No 3 (2014)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ketoprofen termasuk obat anti inflamasi non steroid (NSAIDs) untuk pengobatan simptomatik nyeri dan inflamasi. Pemakaian ketoprofen secara transdermal diketahui mampu menghantarkan zat aktif untuk mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan per oral, sehingga  mengurangi resiko efek samping sistemik. Penelitian ini bertujuan untuk mendapatkan mikroemulsi ketoprofen yang stabil secara fisik untuk penghantaran transdermal. Optimasi formula mikroemulsi dibuat menggunakan fasa minyak labrafil M 1944 CS, surfaktan Cremophor EL, serta kosurfaktan etanol, propilenglikol, dan gliserin. Evaluasi sediaan meliputi pengamatan organoleptik, pH, viskositas, dan  ukuran globul, serta pengujian stabilitas fisik menggunakan metode sentrifugasi dan freeze thaw. Selanjutnya dilakukan uji difusi in vitro dan uji iritasi kulit dan mata pada kelinci. Formula mikroemulsi optimum mengandung labrafil 15%, cremophor EL 30%, dan propilenglikol 10%. Sediaan mikroemulsi memenuhi kriteria stabilitas fisik berdasarkan uji sentrifugasi dan freeze thaw. Nilai pH dan viskositas sediaan relatif stabil selama 120 hari penyimpanan pada suhu kamar. Mikroemulsi ketoprofen memiliki ukuran globul rata-rata 29,3 nm. Jumlah ketoprofen terdifusi selama 180 menit pengujian adalah 386,6 ± 61,2 µg/cm2. Sediaan mikroemulsi mengiritasi ringan pada kulit tetapi tidak mengiritasi mata. Kata kunci: Ketoprofen, Mikroemulsi, Transdermal, Difusi.   Formulation and Evaluation of Microemulsion for Ketoprofen Transdermal Delivery Using Labrafil M1944CS as an Oil Phase Abstract Ketoprofen belongs to NSAIDs and is commonly applied  for symptomatic treatment of pain and inflamation. Transdermal route of ketoprofen application enables the delivery of this active substance to reach its effective concentration in target organ but with lower plasma concentration compared to that of per oral application and hence can reduce systemic side effects. The objectives of this study are to obtain microemulsion formulation of ketoprofen for transdermal delivery. Microemulsion was formulated using Labrafil M 1944 CS as an oil phase, cremophor EL as surfactant and etanol, propylene glycol, glycerin as cosurfactans. Evaluation of ketoprofen microemulsion included organoleptic evaluation, pH, viscocity, globul diameter, and physical stability test using centrifugation and freeze thaw methods. Skin permeation was evaluated in vitro using spangler membrane and irritation effect test on rabbits. The optimum formulation of microemulsion was labrafil 15%, cremophor EL 30%,and  propylene glycol 10%. Microemulsion of ketoprofen did not show any changes during freeze thaw and centrifugation tests which indicated its stability. The viscosity and pH of preparations were relatively stable for 120 days storage at room temperature. Average globule  diameter of microemulsion was 29.3 nm. The total ketoprofen diffused was 386.6 ± 61.2 µg/cm2 for 180 minutes of testing time. The microemulsion showed slight irritation effect on the skin but no irritation effect on the eyes. Keywords : Ketoprofen, Microemulsion, Transdermal, Diffusion.
Kajian Pengembangan Sediaan Nanosuspensi Untuk Penghantaran Intravena Obat Sukar Larut Air Sani Ega Priani
Majalah Farmasetika Vol 7, No 2 (2022): Vol. 7, No. 2, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i2.37343

Abstract

Pengembangan bentuk sediaan perlu dilakukan untuk penghantaran intravena senyawa aktif dengan kelarutan yang rendah dalam air. Nanosuspensi sebagai suatu produk nanoteknologi banyak diaplikasikan untuk tujuan tersebut. Penelitian ini bertujuan untuk mengkaji pengembangan sistem nanosuspensi untuk penghantaran intravena obat sukar larut air dalam hal jenis penstabil yang aman digunakan dan  mengkaji pengaruhnya terhadap disolusi,   pelepasan , dan profil farmakokinetika zat aktif  serta kajian keamanan penggunaan. Penelitian dilakukan dengan systematic literature review (SLR), menggunakan artikel ilmiah dari database bereputasi yang memenuhi kriteria inklusi dan eksklusi yang sudah ditetapkan. Hasil kajian menunjukkan bahan penstabil utama yang digunakan pada pengembangan nanosuspensi intravena  adalah poloxamer, lesitin, TPGS (D-a-tocopheryl polyethylene glycol 1000 succinate), dan BSA (bovine serum albumin) yang bersifat biokompatibel, non toksik, dengan harus memperhatikan kadar maksimal menurut  FDA’s Inactive Ingredient Database for IV route. Pengembangan nanosuspensi secara signifikan mampu meningkatkan disolusi dan pelepasan zat aktif dibandingkan dengan bentuk murni/suspensi. Pengembangan nanosuspensi pada beberapa bahan aktif mampu merubah profil farmakokinetika yang ditandai dengan peningkatan nilai AUC (area under curve), Cmax,  dan  MRT (mean residence time) dengan memberikan profil pelepasan diperlambat (sustained release). Pengembangan nanosuspensi pada beberapa bahan aktif terbukti aman digunakan secara intravena berdasarkan  uji hemolisis dan iritasi vaskular. Berdasarkan kajian yang telah dilakukan diketahui bahwa nanosuspensi sesuai dan potensial untuk diaplikasikan untuk penghantaran intravena obat sukar larut air.
The immunostimulant activity of Tibb an-Nabawi natural products: a literature review Sani Ega Priani
Jurnal Ilmiah Farmasi Vol. 17 No. 1 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss1.art5

Abstract

Abstract Background: Enhancing the immune system is very important during the Covid-19 pandemic to prevent infections and reduce the risk of disease severity. Therefore, it is necessary to use natural products with an immunostimulant effect. In Islam, there is a system of treatment or disease prevention based on Al-Quran and Hadith, which is called Tibb an-Nabawi or prophetic medicine. Objective: This research aims to conduct a literature study of Tibb an-Nabawi, which has proved to be able to increase the immune system, based on Islamic and scientific approaches.Method: The research was based on a systematic literature review using research articles from the last ten years. The inclusion criteria were articles discussing the immunostimulatory activity of Tibb an-Nabawi, while the exclusion criteria were immune system enhancing herbs that were not Tibb an-Nabawi.Results: Based on the literature studies, it is known that at least six natural products based on Tibb an-Nabawi have scientifically proved to increase the immune system, namely black cumin, honey, dates, ginger, garlic, and pumpkin. The mechanism of immune system enhancement is different in each substance, but in general, they can increase humoral or cellular immunity. The active compounds contained in each of these ingredients contribute to the resulting immunostimulant activity.Conclusion: Black cumin, honey, dates, ginger, garlic, and pumpkin are natural products based on Al-Quran and Hadith, which have scientifically proved to enhance the immune system.Keywords: Tibb an-Nabawi, Thibbun Nabawi, immune system, immunostimulant, pandemic Intisari  Latar belakang:  Peningkatan sistem imun sangat penting di masa pandemic Covid-19 untuk mencegah infeksi dan menurunkan resiko keparahan penyakit. Oleh karena itu, penggunaan bahan alam dengan efek meningkatkan aktivitas sistem imun perlu dilakukan. Dalam Islam dikenal istilah thibbun Nabawi yakni pengobatan atau pencegahan penyakit berbasis Al-Quran dan Hadist.Tujuan: Melakukan studi literatur tentang bahan thibbun Nabawi yang terbukti meningkatkan sistem imun disertai kajian dari sisi Islami dan juga ilmiahnya.Metode: Penelitian berbasis systematic literature review, dengan menggunakan artikel penelitian 10 tahun terakhir. Kriteria inklusi meliputi artikel-artikel membahas aktivitas imunostimulan dari bahan-bahan thibbun Nabawi dan kriteria eksklusi adalah bahan alami peningkat sistem imun yang bukan merupakan thibbun Nabawi. Hasil: Berdasarkan studi literatur diketahui bahwa sedikitnya ada 6 bahan thibbun Nabawi yang terbukti secara ilmiah mampu meningkatkan sistem imun yakni jintan hitam, madu, kurma, jahe, bawang putih, dan labu kuning. Mekanisme peningkatkan sistem imun berbeda beda untuk setiap bahan namun secara umum bahan bahan tersebut mampu meningkatkan imunitas humoral ataupun selular. Senyawa aktif yang terkandung dalam setiap bahan tersebut berkontribusi terhadap aktivitas immunostimulant yang dihasilkanKesimpulan: Jintan hitam, madu, kurma, jahe, bawang putih, dan labu kuning merupakan bahan alam berbasis thibbun Nabawi yang terbukti secara ilmiah mampu meningkatkan system imun.Kata kunci : Thibbun Nabawi, sistem imun, imunostimulan, pandemik
Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Sani Ega Priani; Nurrayyan Nurrayyan; Fitrianti Darusman
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.782 KB) | DOI: 10.12928/pharmaciana.v7i2.7387

Abstract

Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS  was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.
The development of antioxidant peel-off facial masks from cinnamon bark extract (Cinnamomum burmannii) Sani Ega Priani; Restianti Mutiara; Dina Mulyanti
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.902 KB) | DOI: 10.12928/pharmaciana.v10i1.14193

Abstract

The bark of cinnamon (Cinnamomum burmannii) contains cinnamaldehyde and other active substances with potent antioxidant properties. Antioxidants are effective at preventing and reducing UV-induced skin damages and skin aging. This study was intended to formulate and characterize the antioxidant peel-off facial masks containing cinnamon bark extract and the combination of polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) as gelling agents. The ethanol extract of cinnamon bark and the developed peel-off mask were evaluated for their antioxidant activities by the α,α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method and for their physical characteristics. The cinnamon bark extract exhibited a very strong antioxidant activity, as evidenced by IC50= 10.04 ± 0.08 ppm. As for the formulated peel-off mask, it had excellent physical characteristics, which were identified during organoleptic observations and pH, viscosity, spreadability, and film drying time evaluations. Similar to its constituent extract, this mask produced significantly potent antioxidant effects, with IC50= 47.31 ± 1.47 ppm. For these reasons, peel-off facial masks containing cinnamon bark extract have not only excellent physical characteristics but also powerful antioxidant properties.
In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel Fitrianti Darusman; Debby Prihasti Ayustine; Saadiya Noerman; Sani Ega Priani; Widad Aghnia Shalannandia
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.443 KB) | DOI: 10.12928/pharmaciana.v11i2.20024

Abstract

The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. The inclusion complex is formed by utilizing b-cyclodextrin as the host of the active compounds. The Ibuprofen (2-(4-isobutyl-phenyl)propionate) is a propionate acid derivative and classified in class II of the Biopharmaceutic Classification System, which has low dissolutions and high permeability. This study aims to develop a nanogel containing ibuprofen-β-cyclodextrin inclusion complex with the ratio of 1:1, 1:2 and 2:1; and to compare the in-vitro diffusion profile with pure ibuprofen gel. The inclusion complex of ibuprofen-β-cyclodextrin was prepared using the coprecipitation method with the three molar comparison ratio of 1:1, 1:2, and 2:1. The in-vitro study was performed using the gel-based viscolam, comparing the three formulas of ibuprofen-β-cyclodextrin with pure ibuprofen gel. The ibuprofen concentration of each gel tested in the experiment was 1%. The particle size characterization of ibuprofen-β-cyclodextrin inclusion complex gel resulted in having nanoparticle size (510 nm). This characteristic indicates that the inclusion complex gel could enhance the cumulative release amount of ibuprofen compared with pure ibuprofen gel with a relatively smaller particle size (156 nm). Pure ibuprofen and inclusion complex powder size measured to be 763 nm and 957 nm, respectively. The ibuprofen-b-cyclodextrin inclusion complex gel with a molar ratio of 2:1 demonstrated an increase in in-vitro diffusion profile of ibuprofen with a cumulative release amount of 740.3 µg.cm-2. Meanwhile, pure ibuprofen gel had the cumulative release amount of 294.74 µg.cm-2. The gel containing ibuprofen-β-cyclodextrin inclusion complex could enhance the cumulative release amount of ibuprofen compared to pure ibuprofen gel. The ibuprofen-β-cyclodextrin inclusion complex gel at a ratio of 2:1 exhibited an increase in the diffusion of ibuprofen in-vitro.
In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil Sani Ega Priani; Dinnanda Yussepina Wulansari; Fitrianti Darusman
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.671 KB) | DOI: 10.12928/pharmaciana.v11i1.18048

Abstract

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% of post-pubertal women. Caffeine and grape seed oil were known can be used as an anti-cellulite agent. Microemulsion systems are known could enhance the diffusion rate of drugs through the skin. This study was conducted to develop a microemulsion gel containing caffeine and grape seed oil and determine the effect of caffeine's in vitro diffusion profile. Microemulsion gel was prepared using tween 80 as a surfactant, glycerin as cosurfactant, viscolam mac 10 as a gelling agent. The preparations were evaluated by organoleptic, pH, viscosity, rheology, spreadability, globule size, and thermodynamic stability tests. In vitro diffusion tests were performed by Franz diffusion cell. The result showed that microemulsion containing 1 % of caffeine and 5% of grapeseed oil has good physical characteristics and stability with an average globule size 126 ±17 nm. Microemulsion gel system could enhance the cumulative release amount of caffeine through synthetic membrane compared with gel system. Drug release kinetics of caffeine from microemulsion gel system follows the Higuchi model.
Formulasi Sediaan Emulgel Untuk Penghantaran Transdermal Ketoprofen Sani Ega Priani; Sasanti Tarini Darijanto; Tri Suciati; Maria Immaculata Iwo
Acta Pharmaceutica Indonesia Vol. 38 No. 1 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ketoprofen adalah obat golongan anti inflamasi non-steroid (AINS) yang banyak digunakan untuk mengobati nyeri dan inflamasi. Penggunaan oral ketoprofen dapat menimbulkan berbagai efek samping sistemik. Pemakaian transdermal diketahui mampu mencapai konsentrasi efektif pada jaringan target, dengan konsentrasi plasma yang lebih rendah dibanding penggunaan oral, sehingga dapat mengurangi resiko efek samping sistemiknya. Penelitian ini bertujuan untuk membuat sediaan emulgel untuk penghantaran transdermal ketoprofen. Propilenglikol 10% dan menthol 3% digunakan sebagai peningkat penetrasi. Sediaan dievaluasi meliputi pengamatan organoleptik, pH, viskositas, serta pengujian stabilitas fisik menggunakan metode sentrifugasi dan freeze thaw. Selanjutnya dilakukan uji difusi in vitro dan uji iritasi kulit dan mata pada kelinci. Sediaan emulgel memenuhi kriteria stabilitas fisik berdasarkan uji sentrifugasi dan freeze thaw. Nilai pH dan viskositas sediaan relatif stabil selama kurun waktu penyimapanan 120 hari pada suhu kamar. Propilenglikol dan mentol dapat meningkatkan difusi perkutan ketoprofen, yang berbeda signifikan dibandingkan emulgel tanpat peningkat penetrasi (p<0,05). Formula emulgel bersifat sedikit mengiritasi kulit dengan nilai indeks iritasi kutan 0,83-1,17 (nilai maksimal 8), tetapi tidak mengiritasi mata.Kata kunci: Ketoprofen, transdermal, emulgel, peningkat penetrasi.AbstractKetoprofen as an non-steroidal anti-inflammatory drugs (NSAIDs) used for pain and inflamation treatment. However, there are some serious adverse effects associated with oral use of NSAIDs. Transdermal route is known to reach effective local concentration with low plasma concentration resulting in reduction systemic adverse effects. The objectives of this study was to formulate emulgel of ketoprofen for transdermal delivery. Ketoprofen emulgel was prepared using 10% of propilene glycol and 3% of menthol as penetrant enhancer. Evaluation of preparation included organoleptic evaluation, pH, viscocity, and physical stability test using centrifugation and freeze thaw method. Skin permeation was evaluated in vitro using spangler membrane and irritation effect test on rabbits. Emulgels were stable after centrifugation and freeze thaw test. The viscosity and pH of preparations were relatively stable during storage at room temperature for 120 days. Propylenglycol and menthol increased diffusion rate of ketoprofen, differ significantly from emulgel without enhancer (p<0.05). Emulgel preparation were slightly irritate to the skin with irritation index 0.83-1.17 (maximum value 8) but was not irritate to the eyes.Keywords: Ketoprofen, transdermal, emulgel, penetrant enhancer