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Polimorfisme COX-1 terhadap Agregasi Platelet pada Pasien Penyakit Jantung Koroner Wahab, Charliandri Saputra; Putranto, J. Nugroho Eko; Rochmawati, Ike Dhiah
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.203

Polimorfisme genetik COX-1 (Cyclooxygenase 1) menjadi salah satu faktor penyebab variasi respon terhadap agregasi platelet. Variasi tersebut dapat menimbulkan Coronary Arthery Disease (CAD) pada pasien penyakit jantung koroner (PJK). Penelitian ini dilakukan di RSUD Sidoarjo di Jawa Timur selama 1 bulan yaitu terhitung mulai bulan November hingga Desember 2017 dengan melibatkan 30 pasien. Metode penelitian yang digunakan yaitu Polymerase Chain Reaction (PCR) agar pemeriksaan polimorfisme COX-1 dan metode Light Transmittance Aggregometry (LTA) untuk pengukuran agregasi platelet. Dari 30 pasien yang terlibat dengan penelitian ini didapatkan jenis polimorfisme COX-1 homozygout (wild type) sebanyak 4 pasien dengan nilai bp pada kisaran rentang 233-243dan Heterozygot sebanyak 26 pasien dengan kisaran rentang 244-294. Analisis yang dilakukan agar mengetahui hubungan antara polimorfisme COX-1 terhadap agregasi platelet pada pasien PJK yaitu analisis inferensial, dimana diperoleh nilai p=0,423. Dari hasil uji analisis yang diperoleh, maka dapat diambil kesimpulan bahwa tidak hubungan antara polimorfisme COX-1 terhadap agrgasi platelet.

A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report Tutik Kusmiati; Ni Made Mertaniasih; Johanes Nugroho Eko Putranto; Budi Suprapti; Soedarsono; Abdul Rahman Bahmid
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17119

Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTcprolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-oldwoman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimenMDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurringat 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimentherapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimenMDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patientswith QTc prolongation before changing the regiment.

THE PROFILE OF CORONARY HEART DISEASE PATIENTS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA Ogiska Chaherfa Nadasya; Johanes Nugroho Eko Putranto; I Ketut Sudiana; Agus Subagjo
Majalah Biomorfologi Vol. 31 No. 1 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i1.2021.6-10

Background: Coronary heart disease is a deadly disease for human. The incidence of coronary heart disease is different, so that this research reported the profile of coronary heart disease patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Objective: To analyze the profile of CHD patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from February to September 2018. Materials and Methods: A descriptive research based on the medical records. Results: There were 65 male patients and 20 female patients. There were 58% patients aged 50-60 years old, 24% patients aged more than 60 years old, and 18% patients are under 50 years old. The patients’ occupations were as follows: 42% civil servants, 36% private employees, 9% housewives, 5% retirees, 3% entrepreneurs, 1% for teacher, driver, fisherman, priest, and merchant. The complaints included chest pain (40%), shortness of breath (23.5%), PCI (4.6%), thump chest (1.2%), lower right abdominal pain (1.2%), right leg pain (1.2%), nausea (1.2%), vomitting (1.2%), cough (1.2%), dysentry (1.2%), and no complaint (23.5%). CHD patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia had the history of hypertension (30.6%), heart disease (22.6%), diabetes mellitus (21.9%), smoking (5.6%), COPD (0.8%), and no history of disease (12.9%). Sixty-one percent of the patients had blood sugar level of ≥100 mg/dl, 19% patients had blood sugar level of <100 mg/dl, 20% patients did not have data. Conclusion: There were 85 patients, predominantly males of 50-60 years old. The most common occupation of the patients was civil servant and they came with major complaint of chest pain with the history of hypertension.

Correlation between Changes of NT-Pro BNP and HS-Troponin I Level with Cardiotoxicity in Locally Advanced Breast Cancer After Three Cycles of Neoadjuvant CAF Chemotherapy Cicilia Indriaty; Leonita Anniwati; J.Nugroho Eko Putranto; Desak Gede Agung Suprabawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1352

Chemotherapy with cyclophosphamide, adriamycin, and fluorouracil (CAF) regiment in patients with locally advanced breast cancer have a risk of cardiotoxicity. Cardiotoxicity examination standards using left ventricular ejection fraction (LVEF) by echocardiography are considered insensitive for detection of subclinical ventricular dysfunction. NT-pro BNP and Hs-Troponin I (hs-TnI) as cardiac biomarkers are expected to help detect early cardiotoxicity. This study intended to analyze the correlation between changes of NT-pro BNP and hs-TnI levels with cardiotoxicity in breast cancer after three cycles of chemotherapy.This was a cross-sectional observational study, conducted at the Dr. Soetomo General Hospital Surabaya. The subjects consisted of 23 breast cancer patients who underwent chemotherapy with CAF regiment. NT-proBNP and hs-TnI examination used CLIA methods (Immulite 1000, ADVIA Centaur TnI-Ultra). Cardiotoxicity based on decreased LVEF to more than 10% of the initial LVEF value using echocardiography. Significant increases in NT pro BNP and hs-TnI levels were obtained before and after treatment (p=0.000, p=0.002). A significant decrease in LVEF was obtained before and after treatment (p=0.000), but only 2 patients (8.7%) showed cardiotoxicity. There was no correlation between changes in NT-pro BNP and hs-TnI levels with changes in LVEF before and after chemotherapy (p=0.666 and r=0.095; p=0.254 and r=-0.28). There was no correlation between changes in NT-pro BNP and hs-TnI levels with cardiotoxicity, which was assessed based on LVEF reduction, in locally advanced breast cancer after three-cycles of chemotherapy with CAF regiment.

Moderate Cardiovascular Risk Factor among Indonesian: Do Carotid Intima-media Thickness (CIMT) Predict Further? Rina Mawarti; Denny Suwanto; Johanes Nugroho Eko Putranto; Djoko Soemantri
Cardiovascular and Cardiometabolic Journal Vol. 1 No. 2 (2020): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v1i2.2020.38-44

Background. Determining management strategies in an individual with intermediate cardiovascular risk represent a great challenge. The impact of increased CIMT to improve estimated cardiovascular disease (CVD) risk score in individual at intermediate cardiovascular risk has not yet been fully elucidated. Aims. For this reason, we sought to determine the association between CIMT increment and incident of CVD. Methods. We conducted a longitudinal retrospective cohort study involving 28 patients with intermediate cardiovascular risk (Framingham risk score 10% - 20%). Subjects with criteria fulfillment had their data collected through history taking, physical examination, and CIMT re-measurement using echocardiography. Results. Bivariate analysis with regression logistic showed significant correlation between increased CIMT with CVD event (p= 0.016). CIMT measurement is a plausible noninvasive method to predict subclinical cardiovascular disease to further promote more aggressive management.

The Correlation between Serum TG/HDL-c Ratio and Arterial Stiffness Using The Cardio-ankle Vascular Index in Overweight or Obese Patients Andrianus Oktovianto; Ni Putu Anggun Laksmi; Johanes Nugroho Eko Putranto; Raden Mohammad Yogiarto
Cardiovascular and Cardiometabolic Journal Vol. 1 No. 2 (2020): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v1i2.2020.31-37

Background. The effect of increasing TG/HDL-c serum ratio, as a result of insulin resistance, is considered to have an important role in the occurrence of arterial stiffness. Increased arterial stiffness is an important marker in the development of cardiovascular disease and is a predictor of heart attack and stroke. Aims. This research was conducted to determine the relationship between the arterial stiffness assessed through non-invasive cardio-ankle vascular index (CAVI) examination and the TG/HDL-c ratio in overweight and obese individuals. Cardio-Ankle Vascular Index (CAVI) is a non-invasive clinical measurement to evaluate arterial stiffness manner and independent of blood pressure. Methods. This study is considered as correlational study using purposive sampling as the technique. Thirty-two subjects participated in this research and each of them was subjected a CAVI examination to assess arterial stiffness. Their blood samples were collected for lipid profile measurement. The data were analyzed using Pearson Correlation Test. Results. The correlation between TG/HDL-c serum level and arterial stiffness using CardioAnkle Vascular Index (CAVI) in overweight or obese patients (p <0,01) proved to be positive and significant.

Faktor Risiko Pasien Acute Limb Ischemia Fhahira Rizkhika Admadiani; J Nugroho Ekoputranto; Heroe Soebroto; Agus Subagjo
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 4 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Acute Limb Ischemia (ALI) is a classification of peripheral arterial disease that causes decreased blood flow to the extremities, with onset within 2 weeks and characterized by 6 'P's, namely pallor, pain, perishing cold, pulseless, paralysis, and paresthesia. This can be identified through several risk factors, including: diabetes, smoking, gender, high blood pressure, age,hyperlipidemia, atrial fibrillation (AF) and diabetes. This study aims to identify risk factors in ALI patients. Hospital identification. Soetomo Surabaya Period January 2016 – March 2019. This study uses a total sampling technique. This study uses a descriptive cross sectional method with medical record instruments and direct interviews with patients. Twenty-five (25) patients were known to have ALI (14 males and 11 females), and the age of the patients ranged from 65 to 69 years (20%). The causes of risk included a history of smoking obtained from 10 subjects (40%), a history of hypertension in 7 subjects (28%), a history of stage 1 hypertension, a history of diabetes mellitus with the highest blood glucose test value > 126 mg/dl up to 10 people. . (62.5%), with a history of hyperlipidemia, with total cholesterol within normal limits of up to 4 (66.7%), LDL in the normal range of not more than 3 (60%), and HDL with 2 with low HDL values (40%). ), and the highest triglyceride levels were within the normal range. Electrocardiographic examination revealed 7 patients (28%) with atrial fibrillation. Most of the ALI patients in this study were aged between 65 and 69 years and were male. Most ALI patients in this study were 65-69 years old and males. The most common risk factors for ALI patients were hypertension, diabetes mellitus, and hypercholesterolemia.

Correlation between Changes of NT-Pro BNP and HS-Troponin I Level with Cardiotoxicity in Locally Advanced Breast Cancer After Three Cycles of Neoadjuvant CAF Chemotherapy Cicilia Indriaty; Leonita Anniwati; J.Nugroho Eko Putranto; Desak Gede Agung Suprabawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 1 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i1.1352

Chemotherapy with cyclophosphamide, adriamycin, and fluorouracil (CAF) regiment in patients with locally advanced breast cancer have a risk of cardiotoxicity. Cardiotoxicity examination standards using left ventricular ejection fraction (LVEF) by echocardiography are considered insensitive for detection of subclinical ventricular dysfunction. NT-pro BNP and Hs-Troponin I (hs-TnI) as cardiac biomarkers are expected to help detect early cardiotoxicity. This study intended to analyze the correlation between changes of NT-pro BNP and hs-TnI levels with cardiotoxicity in breast cancer after three cycles of chemotherapy.This was a cross-sectional observational study, conducted at the Dr. Soetomo General Hospital Surabaya. The subjects consisted of 23 breast cancer patients who underwent chemotherapy with CAF regiment. NT-proBNP and hs-TnI examination used CLIA methods (Immulite 1000, ADVIA Centaur TnI-Ultra). Cardiotoxicity based on decreased LVEF to more than 10% of the initial LVEF value using echocardiography. Significant increases in NT pro BNP and hs-TnI levels were obtained before and after treatment (p=0.000, p=0.002). A significant decrease in LVEF was obtained before and after treatment (p=0.000), but only 2 patients (8.7%) showed cardiotoxicity. There was no correlation between changes in NT-pro BNP and hs-TnI levels with changes in LVEF before and after chemotherapy (p=0.666 and r=0.095; p=0.254 and r=-0.28). There was no correlation between changes in NT-pro BNP and hs-TnI levels with cardiotoxicity, which was assessed based on LVEF reduction, in locally advanced breast cancer after three-cycles of chemotherapy with CAF regiment.

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