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All Journal Majalah Obat Tradisional
Indah Purwantini
Universitas Gadjah Mada, Jogjakarta
Health Professions Medicine & Pharmacology Public Health

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PENGARUH MEDIA PADA PERTUMBUHAN FUNGI ENDOFIT IP-2 DAN PRODUKSI METABOLIT AKTIF INHIBITOR POLIMERISASI HEM Purwantini, Indah; Wahyono, Wahyono; Mustofa, Mustofa; Susidarti, Ratna Asmah
Majalah Obat Tradisional Vol 20, No 1 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.469 KB) | DOI: 10.14499/mot-TradMedJ20iss1pp%p

Abstract

Endophytic fungus IP-2 is the endophytic fungus isolated from the plant Artemisia annua L. This fungus is known to have activity as an inhibitor of heme polymerization. The aim of this study is to examine the suitable medium for the growth and production of the active metabolite and to determine the appropriate time for harvesting the active metabolite. Endophytic fungus was fermented in 4 types of media for 14 days. Sampling was taken every day to obtain the weight of the dry cells which were used for analysis of growth. The media obtained is used to determine their activities as heme polymerization inhibitor. Tests were carried out using the method developed by Bassilico et al (1998). Data of dry cell weight and the percentage inhibition of heme polymerization were analyzed in order to obtain the curve of growth and metabolite production. Both curves will be used to determine the proper time to harvest the active metabolite. The results showed that the PDB was the best medium for endophytic fungus IP-2 growth and was able to produce the active metabolite higher than most other media. In the PDB media, at day-7 showed that active metabolite produced at most so that proper harvest time metabolite is on the 7th day of fermentation.
FORMULASI TABLET HISAP EKSTRAK KUNYIT (Curcuma domestica) DENGAN KOMBINASI BAHAN PENGISIMANITOL – AMILUM MANIHOT Sulaiman, T. Nanda Saifullah; Purwantini, Indah; Haryanti, Farida
Majalah Obat Tradisional Vol 17, No 3 (2012)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.864 KB) | DOI: 10.14499/mot-TradMedJ17iss3pp47-52

Abstract

Ekstrak hidroalkoholik kunyit direkomendasikan sebagai suplemen untuk prevensi atherosklerosis. Namun,penggunaannya dalam pengobatan tradisional dirasa kurang praktis dan kurang acceptable, sehingga perlu dibuat sediaan tablet hisap. Tujuan penelitian ini adalah untuk mengetahui pengaruh variasi kombinasi bahan pengisi manitol-amilum manihot terhadap sifat fisik granul, tablet dan rasa tablet.Formula optimum diperoleh dengan menggunakan metode simplex lattice design. Ekstrak air dibuat menggunakan penyari berupa akuades suhu 80OC sedangkan ekstrak alkohol menggunakan penyari etanol 96%. Kedua ekstrak dicampur  sehingga diperoleh ekstrak hidroalkoholik kunyit, kemudian digranul dengan metode granulasi basah, dibuat menjadi lima formula dengan kombinasi bahan pengisi manitol-amilum manihot. Hasil penelitian menunjukkan bahwa kombinasi bahan pengisi manitol-amilum manihot mampu mempengaruhi kekerasan tablet, waktu larut dan penerimaan rasa. Formula optimum yang didapat adalah campuran bahan pengisi manitol-amilum manihot dengan perbandingan 80% : 20%.
Co-Authors Djoko Santosa Endang Lukitaningsih Farida Haryanti, Farida Mustofa Mustofa Ratna Asmah Susidarti T. Nanda Saifullah Sulaiman, T. Nanda Saifullah Wahyono Wahyono Wiwik Supriati