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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Buletin Kimia VALENSI Jurnal Veteriner Jurnal Natur Indonesia JURNAL SAINS DAN TEKNOLOGI INDONESIA JURNAL TEKNOLOGI LINGKUNGAN Jurnal Penelitian Hasil Hutan The Journal of Pure and Applied Chemistry Research EduChemia (Jurnal Kimia dan Pendidikan) Indonesian Journal of Chemistry Marinade EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Molekul: Jurnal Ilmiah Kimia Jurnal Jamu Indonesia Asian Journal of Aquatic Sciences Jurnal Penelitian Hasil Hutan Makara Journal of Science Jurnal Kedokteran Hewan

Purwantiningsih Sugita

Departemen Kimia, Fakultas MIPA, IPB University

Author-ID : 349897

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Veterinary Other

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Characterization and Bioactive Compound Analysis of Meretrix meretrix Linnaeus Apriandi, Azwin; Tarman, Kustiariyah; Sugita, Purwantiningsih
Marinade Vol 1 No 01 (2018): Marinade
Publisher : Fisheries Product Technology Department, Faculty of Marine Science and Fisheries, Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3345/marinade.v1i01.784

Meretrix meretrix was one of gastropods seawater has been used by people as a food. These shells are still categorized of bycatch and have not explored the benefits. This study aimed to characterize and analyze the content of bioactive Meretrix meretrix. This research was conducted morphological characterization shellfish sensory, measurement of yield, the content of the proximate analysis, heavy metals, and analysis of bioactive compounds from the extracts of water and methanol. Observation found that the Meretrix meretrix has a yellowish white color with black bars at the end of the shell and the white meat and chewy with a yield of meat and shells of 11.09% and 69.85%. Analysis of water content, ash, fat, protein, and carbohydrates respectively by 79.99%, 1.50%, 0.22%, 9.42% and 8.81%. Heavy metal obtained  8x10-4 ppm Hg content, 13x10-4 ppm Pb, Cd, and Cu 45x10-4 and 88x10-4 ppm. Bioactive compounds in water and methanol extract of shellfish Lamis including alkaloids, steroids, and saponins.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3345/marinade.v1i01.826

Meretrix meretrix was one of gastropods seawater has been used by people as a food. These shells are still categorized of bycatch and have not explored the benefits. This study aimed to characterize and analyze the content of bioactive Meretrix meretrix. This research was conducted morphological characterization shellfish sensory, measurement of yield, the content of the proximate analysis, heavy metals and analysis of bioactive compounds from the extracts of water and methanol. Observation found that the Meretrix meretrix has a yellowish white color with black bars at the end of the shell and the white meat and chewy with a yield of meat and shells of 11.09% and 69.85%. Analysis of water content, ash, fat, protein, and carbohydrates respectively by 79.99%, 1.50%, 0.22%, 9.42%, and 8.81%. Heavy metal obtained  8x10-4 ppm Hg content, 13x10-4 ppm Pb, Cd, and Cu 45x10-4 and 88x10-4 ppm. Bioactive compounds in water and methanol extract of shellfish Lamis including alkaloids, steroids, and saponins.

Perilaku Disolusi Ketoprofen Tersalut Gel Kitosan-Karboksimetilselulosa (CMC) Sugita, Purwantiningsih; Achmadi, Suminar Setiati; Yundhana, Yuyu
Jurnal Natur Indonesia Vol 13, No 1 (2010)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Study dissolution behaviour of ketoprofen through optimum chitosan-CMC microcapsule has been carried out. Into228.6 ml of 1.0% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 ml of CMC solution was added with concentrationvariation of 0.075; 0.0875; and 0.10% (w/v). Afterwards, 7.62 mL of glu was added slowly under stirring, withconcentrations varied: 3; 4.5; and 6% (v/v). All mixtures were shaked for 20 minutes for homogenization. Into eachmicrocapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Everymixture was then added with 5 ml of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature.Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Thedissolution behaviour of optimum ketoprofen microcapsules were investigated in gastric and intestinal medium.Microcapsule morphology before and after dissolution as well as empty microcapsule (blank) were observed withSEM. Spray drying process had successfully coated ketoprofen in chitosan-CMC microcapsule. Optimization byusing Minitab Release 14 software showed that among the microcapsule compositions studied, CMC and glu of0.0925% (w/v) and 3.01% (v/v), respectively, optimum to coat ketoprofen at constant chitosan concentration 1.0%(w/v). Result of SEM morphology and In vitro dissolution profile showed that ketoprofen in chitosan-CMCmicrocapsule was relatively well than chitosan-guar gum microcapsule. Kinetically, dissolution of ketoprofen frommicrocapsule in intestinal pH condition was first order with release rate constant, k, of 7.285 ï‚´ 10-4 % min-1 andrelease half-time, t1/2, of approximately 15 hours.

SINTESIS DAN OPTIMALISASI GEL KITOSAN-ALGINAT Sugita, Purwantiningsih; Sjachriza, Achmad; wahyono, dwi
Jurnal Sains dan Teknologi Indonesia Vol. 9 No. 1 (2007)
Publisher : Badan Pengkajian dan Penerapan Teknologi

Shrimp shell can be used to make chitosan. The objective of this work is to sythesis and optimize chitosan-alginate gel by comparing its rheological properties. Rheological properties of chitosan were improved by gelation using glutaraldehyde as cross linker and natural hydrocolloids such as alginate. Rheological properties measured were strength, break point, rigidity, swelling and shrinking gel. The gel was made by mixing chitosan solution 2.5% (w/v), glutaraldehyde 4%, 5%, and 6% (v/v), and alginate 0%, 0.75%, and 1.0%. According Modde 5, the optimum gel happened at glutaraldehyde and alginateconcentration are 4.0% and 0.82%, respectively. This optimalization to adsorp metal ions gave gel strength, break point, pembengkakan, rigidity and shrinking properties are 881,4385 g cm-2, 1,0267 cm, 4,5313 g, 8,5179 g cm-1 and 1,6280 g, respectively.

PERILAKU DISOLUSI KETOPROFEN DAN INDOMETASIN FARNESIL TERSALUT GEL KITOSAN-GOM GUAR Sugita, Purwantiningsih; Srijanto, Bambang; arifin, budi; amelia, fithri; mubarok, mahdi
Jurnal Sains dan Teknologi Indonesia Vol. 12 No. 1 (2010)
Publisher : Badan Pengkajian dan Penerapan Teknologi

Chitosan, a modification of shrimp-shell waste, has been utilized as microcapsule. However, it’s fragile gel property needs to be strengthened by adding glutaraldehyde (glu) and natural hydrocolloid guar gum (gg). This research’s purposes were to study dissolution behaviour of ketoprofen and infar through optimum chitosan-guar gum microcapsule. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid,38.1 mL of gg solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules and 0.05, 0.19, and 0.33% (w/v) for infar microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62mL of glu was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v) for ketoprofen microcapsules, and 4, 4.5, and 5% (v/v) for infar microcapsules. All mixtures were shaked for 20 minutes for homogenization. All mixtures wereshaked for 20 minutes for homogenization. Into each microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added, whereas solution of 100 mg of in 250 mL of 96% ethanol was added into each microcapsule mixture for infar. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Everymixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. The data of [gg], [glu], and medicine’s content from each microcapsule were treated with Minitab 14 software to obtain optimum [gg] and [glu] for microencapsulation. The dissolution behaviour of optimum ketoprofen and infar microcapsules were investigated. The result of optimization by using Minitab Release 14 software showed that among the microcapsule compositions of [gg] and [glu] were 0.35% (w/v) and 3.75% (v/v), respectively, optimum to coat ketoprofen, whereas [gg] and [glu] of 0.05% (w/v) and4.00% (v/v), respectively, optimum to coat infar, at constant chitosan concentration (1.75% [w/v]). In vitro dissolution profile showed that chitosan-guar gum gel microcapsule was more resistant in intestinal pH condition (rather basic) compared with that in gastric pH (very acidic).

PENGARUH IRADIASI GAMMA TERHADAP DEGRADASI ZAT WARNA DIRECT ORANGE 34 DALAM AIR Sugita, Purwantiningsih; Winarno, Ermin Katrin; Anriani, Lia
Jurnal Teknologi Lingkungan Vol. 1 No. 2 (2000): JURNAL TEKNOLOGI LINGKUNGAN
Publisher : Center for Environmental Technology - Agency for Assessment and Application of Technology

The aim of this experiment is study on technique of gamma irradiaton in analyzing dying agent direct orange 34 in waste water. Direct orange 34 was dispersed to oxalic and malic acids when the 60Co irradiated. The result showed that dose and dose rate of 60Co were less than 10 kGy and 7.57 kGy/hour, respectively. While, the pH of the first solution was 7.0. The technique showed that the chemical oxygen demand of dye solution was decreased from 60.38 to 4.90 ppm.

Perilaku Disolusi Ketoprofen dan Indometasin Farnesil Tersalut Gel Kitosan-GG Purwantiningsih Sugita; Achmad Sjahriza; Bambang Srijanto; Budi Arifin
Jurnal Ilmu Pertanian Indonesia Vol. 13 No. 2 (2008): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.004 KB)

Chitosan, a modification of shrimp-shell waste, has been utilized as microcapsule. However, it's fragile gel property needs to be strengthened by adding glutaraldehyde (glu) and natural hydrocolloid guar gum (gg). This research's purposes were to determine rheological properties of chitosan-guar gum gel, to study diffusion and dissolution behaviour of ketoprofen and infar through optimum chitosan-guar gum gel membrane and microcapsule, respectively, and to test the coating stability of both medicines by the gel microcapsules, which are new drug's preparation, to determine their shelf lives and to predict the degradation mechanisms. This research was designed in six (6) steps: (1) chitin isolation and chitosan synthesis; (2) synthesis and optimization of chitosan-guar gum gel membrane; (3) in vitro study of ketoprofen and infar diffusion behaviour through the optimum membrane; (4) synthesis and optimization of chitosan-guar gum gel microcapsule to coat ketoprofen and infar; (5) in vitro study of ketoprofen and infar dissolution behaviour from the optimum microcapsule; and (6) physical and chemical microcapsule stability test using relative humidity (RH) and temperature controlled climatic chamber method. Studies on ketoprofen diffusion through chitosan-guar gum membrane showed that the formation of membrane small pores were appeared to be caused by membrane swelling, which was supported by the forcing force resulted from the difference of ketoprofen concentrations in the diffusion cells and from the temperature increase. This unique pore opening process is excellent for drug delivery process as a microcapsule. Spray drying process had successfully coated ketoprofen and infar in chitosan-guar gum microcapsule. Optimization by using Minitab Release 14 software showed that among the microcapsule compositions studied, [gg] and [glu] of 0.35% (w/v) and 3.75% (v/v), respectively were optimum to coat ketoprofen, whereas [gg] and [glu] of 0.05% (w/v) and 4.00% (v/v), respectively were optimum to coat infar, at constant chitosan concentration (1.75% [w/v]). In vitro dissolution profile showed that chitosan-guar gum gel microcapsule was more resistant in intestinal pH condition (rather basic) compared with that in gastric pH (very acidic). From stability test, formulation of ketoprofen preparation composed of 1.75% (w/v) chitosan, 0.35% (w/v) gg, and 3.50% (v/v) glu, was relatively the best, ·with ketoprofen percentage left in microcapsule after 3 months, degradation rate constant, and shelf life of of 80.33%, 0.0351 % week-1 and 18.92 months, respectively. The degradation of ketoprofen was seem to follow autocatalytic reaction mechanism controlled by the formation and growth of reaction core. In the other hand, the formulation with composition of 1.75% (w/v) chitosan, 0.19% (w/v) gg, and 5.00% (v/v) glu, was relatively the best microcapsule, with infar percentage left in microcapsule after 3 months, degradation rate constant, and shelf life of 77.67%, 0.0008 %-2 week-1 , and 4.28 week or about 30 days, respectively. The degradation of infar was presumably caused by hydrolysis. Keywords: Chitosan-guar gum, diffusion, dissolution, stability

Ekstrak Metanol Cengkeh (Syzygium Aromaticum (L.) Merry & Perry) Varietas Tuni Buru Selatan sebagai Antimalaria Dharmawaty M Taher; Dedi Duryadi Solihin; Umi Cahyaningsih; Purwantiningsih Sugita
Acta VETERINARIA Indonesiana Vol. 6 No. 2 (2018): Juli 2018
Publisher : IPB University

Malaria masih menjadi salah satu masalah kesehatan di dunia dan Indonesia. Cengkeh (Syzygium aromaticum (L.) Merry & Perry) adalah tanaman asli Indonesia yang berpotensi sebagai fitofarmaka. Tujuan penelitian ini adalah untuk menganalisis aktivitas antimalaria in vitro, uji toksisitas, dan uji penghambatan secara in vivo ekstrak metanol cengkeh varietas Tuni Buru Selatan. Konsentrasi uji in vitro bunga, tangkai bunga, dan daun cengkeh masing-masing adalah 0,01, 0,1, 1, 10, dan 100 μg/mL duplo. Dosis uji toksisitas bunga cengkeh dan tangkai bunga cengkeh masing-masing 625, 1250, 2500, 5000, dan 10000 mg/kg BB dan lima ulangan. Uji in vivo dengan menggunakan tiga dosis perlakuan bunga cengkeh dan tangkai bunga cengkeh masing-masing 25, 50, dan 100 mg/kg BB dan 5 ulangan. Hasil uji in vitro menunjukkan 50% Inhibition Concentration (IC50) bunga cengkeh 1,25 μg/mL; tangkai bunga cengkeh 7,89 μg/mL dan daun cengkeh 11,42 μg/mL; 50% Lethal doses (LD50) bunga cengkeh 19743,327 dan tangkai bunga cengkeh 47304,436 mg/kg BB; Persentase penghambatan rata-rata uji in vivo bunga cengkeh 94,19; 95,81; 78,28% dan tangkai bunga cengkeh 90,48; 80,43; 74,14%. Ekstrak metanol cengkeh varietas Tuni Buru Selatan berpotensi sebagai antimalaria dan tidak toksik.

Toxicity Sub chronic Water Extract Meretrix meretrix Linnaeus In Vivo on Sprague dawley Rats Azwin Apriandi; Kustiariyah Tarman; Purwantiningsih Sugita
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 19 No 2 (2016): Jurnal Pengolahan Hasil Perikanan Indonesia
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Meretrix meretrix is one of the shells of sea water are widely utilized by people as food. This clamalso has many properties and benefits, so in this study tested the effect of the water extract of Meretrixmeretrix against blood chemistry profile Sprague Dawley rats with the method (OECD 413: 2009). Based onobservations obtained growth, feed intake, weight of liver and kidney in normal conditions. Levels of urea,creatinine, cholesterol between the control mice treated with A/0.1 and A/1 were not significantly different(p> 0.05) while the levels of bilirubin and albumin between control mice treated with A/0.1 and A/1 resultssignificantly different (p<0.05), but all blood chemistry parameters tested is still in the normal category.

Analisis Artemisinin Pada Tanaman Artemisia sacrorum, Ledeb dengan Metode Kromatografi Purwatiningsih Sugita
Indonesian Chemistry Letter Vol 1 No 1 (2001): Buletin Kimia
Publisher : Department of Chemistry

Artemisinin, a potent antimalarial sesquiterpene endoperoxide. From the leave parts of the medicinal plant Artemisia sacforum, Ledeb were investigated artemisinin by chromatography. The result were compared with standard artemisinin.

Co-Authors Achmad Sjachriza Achmad Sjahriza Ade Heri Mulyati Adi Santoso ADI SANTOSO Asep Hidayat Asep Hidayat Asep Saefurohman Auliya Ilmiawati Azwin Apriandi Azwin Apriandi Azwin Apriandi Bambang Srijanto Bambang Srijanto Bambang Srijanto Budi Arifin Cahyaningsih, Umi Cece Sumantri Dedi Duryadi Solihin Dian Susanthy Diana Widiastuti Dita Ariyanti dwi wahyono Dyah Iswantini Dyah Utami Cahyaning Rahayu Ellin Vina Setyowati Epi Taufik Ermin Katrin Winarno Ermin Katrin Winarno Fifia Zulti fithri amelia Ghozali, Ali Aulia Gustini Syahbirin Hanhan Dianhar Harjono - Hefni Effendi HENNY PURWANINGSIH Herdini . Irmanida Batubara Jaya Hardi Kiagus Dahlan Kurniawan, Yehezkiel Steven Kustiariyah Tarman LAKSMI AMBARSARI Latifah K. Darusman Lia Anriani Luthfan Irfana mahdi mubarok Mela Faradika Mersi Kurniati Muhamad Rifai Muhammad Fathurrahman Napthaleni , Novik Nurhidayat Nur Qadri Rasyid Okti Rachmawati Okti Rachmawati Pujiyati Pujiyati Pujiyati, Puspita Sari Rarah Ratih Adjie Maheswari Rini Siswati Asnel Siti Warnasih Sri Sugiarti Suminar S Achmadi Suminar Setiati Achmadi SUMINAR SETIATI ACHMADI Taher, Dharmawaty M. Tiltje Andretha Ransaleleh Tuti Wukirsari Tuti Wukirsari Uswatun Hasanah Wasmen Manalu Yuyu Yundhana Zainal Alim Masâ€™ud Zuniar Subastian Zuraida Hanum Zuraida Hanum

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