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All Journal SANITAS: Jurnal Teknologi dan Seni Kesehatan AVICENNA
Leni Marlina
Poltekkes Kemenkes Bengkulu
Environmental Science Health Professions Medicine & Pharmacology Public Health

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Hubungan Kadar Trigliserida dengan Mahasiswa Obesitas Jon Farizal; Leni Marlina
Avicenna: Jurnal Ilmiah Vol. 14 No. 02 (2019): Jurnal Ilmiah Avicenna
Publisher : Public Health Department, Faculty of Health Science University Muhammadiyah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36085/avicenna.v14i02.391

Abstract

Obesitas dapat menjadi penyebab   meningkatnya kadar trigliserida dalam darah. Kadar trigliserida yang berlebihan dalam darah dapat meningkatkan resiko penumpukan atau mengendapnya trigliserida pada dinding pembuluh darah yang dapat menyebabkan terjadinya ateroskleresis. Tujuan penelitian mengetahui hubungan kadar trigliserida dengan mahasiswa yang mengalami overweight. Jenis penelitian ini adalah survei analitik dengan rancangan crossectional. Populasi pada penelitian ini sebanyak 40 responden dengan menggunakan metode total sampling. Sampel diukur dengan menggunakan alat Spektrofotometer UV-Vis metode Glycerol Posfat Oxidase-Para Amino Antipyrine (GPO-PAP). Hasil penelitian ini diketahui sebagian besar responden kadar trigliserida Normal (75%), sebagian kecil responden kadar trigliserida tidak normal (25%), sebagian besar responden jenis kelamin Laki-laki (60%), dan hampir sebagian responden jenis kelamin perempuan (40%). Uji kolerasi Spearman didapatkan nilai (p=0.433), p>0,05 maka tidak ada hubungan yang bermakna antara mahasiswa obesitas dengan kadar trigliserida.
Testing Effect Of Immunomodulator Ethanol Extract Of Mengkudu Leaves (Morinda Citrifolia) On Macrofag Cell Activities In Mencit Balb/C Infected Plasmodium Berghei Jon Farizal; Leni Marlina; Susiwati Susiwati; zamharira Muslim
SANITAS: Jurnal Teknologi dan Seni Kesehatan Vol 11 No 2 (2020): SANITAS Volume 11 Nomor 2 Tahun 2020
Publisher : Politeknik Kesehatan Kemenkes Jakarta II

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36525/sanitas.2020.23

Abstract

Background malaria fever is a disease that is still a problem in developing countries. Plasmodium bergheiis a facultative intracellular parasite, so the immune system that plays a role is the cellular system. Morinda citrifolia is a traditional medicinal plant that contains many active compounds that can reduce the number of malaria parasitemia. Proving the immunomodulatory effect of ethanol extract ofmorinda citrifolia on phagocytosis activity of Balb/c mice infected with Plasmodium berghei. The data were obtained from calculating the number of phagocytosis activity of macrophage cells in each field of view. A different test for macrophage phagocytosis using One Way ANOVA followed by Post Hoct Test. Method this type of research is experimental with the design of the post-test only control group design in experimental animals balb/c mice consisting of 24 male mice, divided into 4 groups. (K) is the control group given Aquabidest, and the treatment group (P1, P2, P3) which was given extract morinda citrifolia with stratified doses (0.64 mg / kgBb / day, 1.28 mg / kgBb / day, 2.56 mg / kgBb / day). The treatment process was given for 13 days and on the 6th day was infected with Plasmodium bergheias much as 0.1 ml x 106 intraperitoneally. On the 14th day, peritoneal fluid isolation was carried out followed by an examination of macrophage cell phagocytosis activity. Result ethanol extract Morinda citrifolia can increase macrophage phagocytosis, between control and treatment P1, P2, and P3 have significant differences, but between treatments, there is no significant difference. Conclusion. Ethanol extract of Morinda citrifolia in various doses can increase the phagocytosis of macrophages in Babl/c mice infected with Plasmodium berghei.
Co-Authors Jon Farizal Jon Farizal, Jon Susiwati Susiwati Zamharira Muslim