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KORELASI ANTARA MODIFICATION OF DIET IN RENAL DISEASE (MDRD) DAN CYSTATIN C SERUM PADA USIA 40–70 TAHUN Jus, Jason; Irwanto, Ronald; Pusparini, Pusparini
Majalah Kedokteran Bandung Vol 48, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (60.104 KB) | DOI: 10.15395/mkb.v48n3.605

Abstract

Pelaporan estimasi laju filtrasi glomerulus (eLFG) pada setiap hasil pemeriksaan kreatinin dianjurkan, walaupun saat ini tidak semua laboratorium mencantumkan pada hasil pemeriksaan. Modification of Diet in Renal Disease (MDRD) merupakan formula yang digunakan untuk mengestimasi laju filtrasi glomerulus menggunakan kreatinin serum. Cystatin C serum merupakan pemeriksaan yang relatif baru dan petanda yang baik untuk menilai fungsi ginjal. Penelitian ini bertujuan mengetahui korelasi antara MDRD dan cystatin C serum. Penelitian ini menggunakan data sekunder dari 260 subjek penelitian usia 40?70 tahun yang memeriksakan kreatinin serum dan cystatin C serum selama periode Januari 2013?September 2014 di laboratorium klinik swasta di Jakarta Barat dengan desain potong lintang. Hasil penelitian menunjukkan bahwa usia rata-rata subjek 55,7+7,8 tahun. Kadar cystatin C serum rata-rata 0,99 + 0,6 mg/L, MDRD 80,24±28,1 mL/min/1,73m2. Terdapat korelasi negatif antara MDRD dan cystatin C serum dengan r=-0,767, p=0,001 (uji Pearson). Disimpulkan bahwa semakin tinggi nilai MDRD, nilai cystatin C serum semakin rendah. MDRD dapat digunakan sebagai alternatif uji fungsi ginjal bila pemeriksaan cystatin C serum tidak tersedia. [MKB. 2016;48(3):129?34]Kata kunci: Cystatin C, eLFG, kreatinin, MDRD Correlation between Modification of Diet in Renal Disease (MDRD) and Serum Cystatin C in 40?70 Years Old Reporting of the estimated glomerular filtration rate (GFR) in every creatinine test is suggested, despite the fact that every laboratory reports it in their result. Modification of Diet in Renal Disease (MDRD) is a formula that is used to estimate the GFR using serum creatinine. Serum cystatin C is a relatively new test and superior for assessing kidney functions. The purpose of this study was to show the correlation between MDRD and serum cystatin C. A cross-sectional study was conducted using secondary data from 260 subjects, aged 40?70 years old to assess serum creatinine and serum cystatin C at a private laboratory in West Jakarta, during the period of January 2013?September 2014. The result of the study showed that the mean age of subjects was 55.7+7.8 years old, the mean serum cystatin C level was 0.99 + 0.6 mg/L, and the mean MDRD was 80.24±28.1 mL/min/1.73 m2. Pearson correlation analysis showed a negative correlation between MDRD and serum cystatin C with r = -0.767 and p =0.001. In conclusion, higher MDRD presents lower cystatin C serum; hence,  MDRD can be used as an alternative renal function test when serum cystatin C is not available. [MKB. 2016;48(3):129?34] 
Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D Pusparini, Pusparini; Merijanti, Lie Tanu; Sudharma, Novia I.
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.171-180

Abstract

Background One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The purpose of the present study was to determine the concentrations of 25(OH) vitamin D [25(OH)D] in an elderly population and to find any association between 25(OH)D and MMP-9 concentrations.MethodsThis study was of cross-sectional design involving 160 male and female subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9 and 25(OH)D concentrations was done concurrently on subjects who met the inclusion and exclusion criteria after all study subjects had been selected. 25(OH)D and MMP-9 concentrations were assessed by direct competitive chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Statistical analysis used chi square and t tests.ResultsMean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with 25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects (p=0.809).ConclusionThe MMP-9 concentration was increased among male subjects with low level of (OH)D. This study confirmed that 25(OH)D concentration may have a potential role in endothelial function.
Heavy mental workload increase poor sleep quality in informal garment workers Merijanti, Lie T; Pusparini, Pusparini; Meiyanti, Meiyanti; Alvina, Alvina; Sudharma, Novia I; Tjahjadi, Muljadi
Universa Medicina Vol 38, No 3 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.632 KB) | DOI: 10.18051/UnivMed.2019.v38.202-208

Abstract

Background Sleep is needed by the human body so that the performance of body remains optimal when the body is awake, especially during work. Informal workers often work without clear regulations, with inadequate equipment and poor work environment, and pay little attention to occupational health and safety factors. The existence of large work demands with unclear work system arrangements will certainly result in a mental workload in these workers. The objective of this study was to determine the relationship between mental workload and sleep patterns of workers in the informal garment sector. MethodsA cross-sectional study involving 225 informal garment workers was conducted between December 2018 and May 2019. Data collection included respondents’ demographics, job characteristics, measurement of mental burden and disturbances in sleep patterns. The sleep pattern used the PSQI (Pittsburgh Sleep Quality Index) instrument and the mental burden used the Rating Scale Mental Effort (RSME). A multiple linear regression analysis was used to analyze the data. ResultsThe mean sleep quality was 5.40 ± 2.54. Multiple linear regression test found that mental workload correlated significantly with sleep quality of workers (β=0.016, p=0.012).ConclusionThis study demonstrated that heavy mental workload decreases the quality of sleep in informal garment workers. A good work system management is required so that workers are assigned that portion of the task that is commensurate with their capacity.
Homocysteine and cognitive function in the elderly Pusparini, Pusparini
Universa Medicina Vol 28, No 2 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.106-116

Abstract

Dementia is prevalent among elderly people, and projections show that the number of affected might triple over the next 50 years, because of a large increase in the oldest segment of the population. The objective of this study was to investigate the relationship between cognitive function and serum homocysteine level. This study was a cross-sectional study carried out in Mampang district, South Jakarta. A total of 94 elderly people was recruited for this study consisting of 44 females and 50 males. In this study serum homocysteine level was assessed by fluorescent polarization immunoassay and cognitive function with the mini mental state examination (MMSE). In elderly women MMSE scores for plasma homocysteine concentrations of <11.7 mmol/L, 11.7-14.9 mmol/L and >14.9 mmol/L were 24.00 ± 3.68, 23.80 ± 6.51, and 20.80 ± 9.00 respectively, with p=0.000. In elderly men the MMSE scores for plasma homocysteine concentrations of <11.7 mmol/L, 11.7-14.9 mmol/L and >14.9 mmol/L were respectively 27.66 ± 2.06, 26.33 ± 3.79 and 24.03 ± 5.52 with p=0.008. Homocysteine concentrations of >14.9 mmol/L were more commonly found in males (66%) than in females (22.70%). The results of a regression analysis indicated that the factors influencing cognitive function were level of education (p=0.001) and age (p=0.035), whereas gender and homocysteine concentration did not affect cognitive function (p=0.554 and p=0.714, respectively). Plasma homocysteine concentration was inversely related to cognitive function. The most important factors affecting cognitive function were level of education and age.
Obesitas sentral, sindroma metabolik dan diabetes melitus tipe dua Pusparini, Pusparini
Universa Medicina Vol 26, No 4 (2007)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2007.v26.195-204

Abstract

Sudah diketahui secara luas bahwa seseorang dengan obesitas mempunyai risiko tinggi untuk mengalami resistensi insulin dan komplikasi metaboliknya seperti diabetes melitus tipe 2 (T2DM), hipertrigliseridemia, penurunan kolesterol high density lipoprotein, hipertensi dan penyakit kardiovaskuler. Akumulasi jaringan adiposa pada bagian tertentu di tubuh seperti di rongga perut menyebabkan peningkatan risiko terjadinya resistensi insulin sampai terjadinya sindroma metabolik. Sindroma metabolik merupakan suatu abnormalitas metabolik yang melibatkan berbagai faktor yang saling berkaitan serta merupakan faktor risiko penyakit jantung koroner yang paling penting pada populasi modern. Pengaturan produksi adipositokin berperan penting pada homeostasis metabolisme glukosa dan lipid. Disregulasi produksi adipositokin pada obesitas sentral terlibat langsung pada patogenesis sindroma metabolik. Penurunan berat badan atau pencegahan peningkatan berat badan merupakan cara terbaik mencegah terjadinya obesitas terutama obesitas sentral yang juga merupakan suatu cara mencegah terjadinya T2DM. Edukasi mengenai komplikasi obesitas dan keterlibatan keluarga dalam pengobatan T2DM sangat penting.
Blood transfusion: is it safe for users? Pusparini, Pusparini
Universa Medicina Vol 29, No 1 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.i-iii

Abstract

Blood transfusion is a long-known life-saving procedure for patients in need of blood, as its history can be traced to about 200 years ago. The first successful blood transfusion performed from one human to another was pioneered by James Blundell, an obstetrician who in 1818 succeeded in transfusing 227 mL of blood to a patient with postpartum hemorrhage
Low density lipoprotein cholesterol decreases vascular cell adhesion molecule-1 in postmenopausal women Pusparini, Pusparini; Wiradharma, Danny; Herwana, Elly
Universa Medicina Vol 30, No 3 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.146-154

Abstract

In premenopausal women cardiovascular disease is rarely encountered, but after menopause the prevalence of cardiovascular disease increases drastically. There are several risk factors for cardiovascular disease, known as traditional risk factors, among others body fat concentration, age, duration of menopause, body mass index (BMI), and estradiol concentration. Cardiovascular disease is considered as an inflammatory disorder, in which adhesion molecules play an important role. Vascular cell adhesion molecule-1 (VCAM-1) is one of the adhesion molecules with an important role in the atherosclerotic process. The aim of this study was to determine the relationship of risk factors affecting the expression of VCAM-1 in postmenopausal women. This study was a cross-sectional study involving 182 postmenopausal women in the age range of 47- 60 years, who were residents of Mampang Prapatan subdistrict, South Jakarta. Venous blood samples were obtained for laboratory investigations, viz. fasting blood glucose, total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, creatinine, serum glutamic oxaloacetic transamirase (SGOT), serum glutamic pyruvic transmirasi (SGPT), bilirubin, total protein, albumin, estradiol and vascular cell adhesion molecule-1 (VCAM-1).A multiple regression analysis was performed on traditional risk factors and their relationship with VCAM-1 concentration. The results showed there were five traditional risk factors influencing VCAM-1 concentration, viz. duration of menopause, BMI, estradiol concentration, HDL cholesterol, and LDL cholesterol. Among these five factors, LDL cholesterol had the greatest influence on VCAM-1 expression (beta coefficient = -0.253 and p=0.001). In conclusion, LDL cholesterol concentration decreased VCAM-1 expression in postmenopausal women.
Glycemic control for prevention vascular complication in diabetic patient Pusparini, Pusparini
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.77-79

Abstract

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Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level Pusparini, Pusparini; Merijanti, Lie Tanu; Lesmana, Alvina; Meiyanti, Meiyanti
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.205-213

Abstract

Background Vitamin D insufficiency is associated with obesity and central obesity, which is in turn associated with the accumulation of visceral fat. Visceral fat secretes adiponectin which has a role in the pathogenesis of the metabolic syndrome, diabetes mellitus and cerebrovascular disease. The aim of this study was to determine the relationship between serum 25-hydroxy vitamin D [25(OH)D] level and adiponectin level in adults with central obesity. Methods This study was a cross sectional study with 80 subjects with central obesity and 80 healthy subjects as controls. The age of the subjects ranged from 55 to 65 years. The data collection included anthropometry and blood biochemistry (lipid profile, fasting blood glucose, 25(OH)D, and adiponectin). The data were analyzed using independent t test with p <0.05.Results Mean waist circumference and 25(OH)D level in the central obesity group were 94.9 ± 7.8 cm and 14.3 ± 6.6 ng/mL, respectively, and in the control group 72.4 ± 5.0 cm and 19.2 ± 8.6 ng/mL respectively. There were significant differences in adiponectin level between the central obesity group and the control group at the 25(OH)D level of <20 ng/mL (p=0.001), but no significant differences between the two groups at the 25(OH)D level of ³20 ng/mL (p=0.538).Conclusion The central obesity subgroup with 25(OH)D level of <20 ng/mL have lower adiponectin levels compared with the control group. This study demonstrates the role of adiponectin as a link between insulin resistance and vitamin D status in adults.
Hypoglycemic effect of Phaleria macrocarpa (Scheff.) Boerl dry extract in healthy adults Meiyanti, Meiyanti; Margo, Eveline; Pusparini, Pusparini; Merijanti, Lie Tanu; Lesmana, Alvina
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (828.359 KB) | DOI: 10.18051/UnivMed.2018.v37.195-202

Abstract

BackgroundThe prevalence of diabetes in Indonesia continues to increase and causes many complications. Fruits of Phaleria macrocarpa (Scheff.) Boerl. (PM) are used in the traditional health system of the Indonesians, as effective remedy in the management of diabetes mellitus. The aim of this study was to evaluate the effect and magnitude of doses of PM dry fruit extract (PME) on blood glucose levels in healthy adults.MethodsThis research was of pre-posttest design involving 30 healthy volunteer subjects aged 20-55 years receiving glucose loads. At pre-test the subjects were given orally 75 g glucose, and at post-test they were given PME at doses of 125 mg and 250 mg. Data collection included anthropometric examination and blood glucose level. The area under the curve (AUC) of blood glucose levels was measured at 0, 15, 30, 60, 120 and 180 minutes. Data analysis was performed using paired t-test with p <0.05.ResultsThe percentage of reduction in AUC between pre- and post-test after administration of PME 125 mg was 12.1% and significant (p=0.000). But the percentage of reduction in AUC between pre- and post-test after administration of PME 250 mg was 4.07% and not significant (p=0.06). The reduction in AUC between post-test PME 125 mg vs PME 250 mg showed significant results (p=0.011).Conclusion This study demonstrated that a dose of 125 mg Phaleria macrocarpa (Scheff.) Boerl. dry extract has a hypoglycemic effect in healthy adults, and may therefore be suitable for use as traditional anti-diabetic drug.