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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Darwati Muhadi
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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DIAGNOSTIC VALUE OF NEUTROPHIL-LYMPHOCYTE RATIO TO DIFFERENTIATE ISCHEMIC AND HEMORRHAGIC STROKE Martina Rentauli; Liong Boy Kurniawan; Darwati Muhadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1446

Abstract

IntroductionStroke is a neurologic emergency disease and the main cause of high mortality. Inflammatory process in stroke due to cell and tissue damage causes increase of leucocyte prominently neutrophil. Neutrophil Limphocyte Ratio is an easy-to-measure inflammatory marker. There is only few data of RNL in Indonesia.MethodsThis was a retrospective cross-sectional study using secondary data from Medical Record RSUP Wahidin Sudirohusodo, Makassar. Leucocyte, neutrophil and lymphocyte first data were taken from adult  stroke diagnosed patients. Data statistically analyzed and diagnostic value of  NLR was determined by ROC curve analysis.Results dan DiscussionTotal of 402 patients were enrolled, 214 (54.72%) with ischemic stroke and 182 (46.8) with hemorrhagic stroke. There was a significant RNL difference between ischemic stroke (median 7.23) and hemorrhage stroke (median 3.65) (p<0.001). Using cut off 5.18, ROC curve showed of AUC 0.730 which had weak perfomance to differentiate ischemic and hemorrhagic stroke with sensitivity 67.8% and specificity 68.6%.Conclusion and SuggestionNLR in hemorrhagic stroke is higher than ischemic stroke. We suggest further studies with larger and more evenly distributed samples and consideration of sampling time. 
ZAT BESI DI PENDONOR TERATUR DAN YANG TIDAK TERATUR (Iron in Regular and NonRegular Donors) Irna Diyana Kartika; Lince Wijoyo; Syahraswati Syahraswati; Rachmawati Muhiddin; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1277

Abstract

Blood donation is a process of taking blood from someone, either voluntarily or as a replacement donor blood banked for later usein blood transfusions. Regular donors are donors who regularly donate blood between 3−4 times a year. Nonregular donors are thosewho do not routinely donate blood in a year. Each donor donating one bag of blood, suffered a loss of approximately 200 mg of iron.The purpose of this study was to know the differences in the levels of iron profiles in regular and nonregular donors. The study wasconducted cross sectional on 65 samples of blood from the UPTD Transfusi Darah South Sulawesi Provincial Health Office, consisting of34 regular donors and 31 nonregular donors. Serum iron and TIBC levels were examined using ABX Pentra 400 with colorimetric andimmunoturbidimetry method. Ferritin level was examined using Elecsys with ECLIA principle. The data were then analyzed by unpairedT test. In this study, the regular donors showed an average serum iron level of 87.09 μg/dL, TIBC level 255.41 μg/dL and ferritin level121.27 μg/dL. The nonregular donors, showed an average serum iron level of 83.26 μg/dL, TIBC level was 261.80 μg/dL and ferritinlevel was 158.62 μg/dL. The results showed no significant differences between the levels of iron profiles in regular and nonregulardonors. Based on this study, it can be concluded that regular and nonregular blood donation did not affect the levels of iron profiles. Itis recommended to conduct a further cohort research to know the levels of iron profiles in blood donors by comparing before and afterdonating blood.
HITUNG TROMBOSIT DI SINDROM KORONER AKUT TERKAIT LOW MOLECULAR WEIGHT HEPARIN (LMWH) Cyntia Kornelius; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 3 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i3.376

Abstract

Heparin and Low molecular weight heparin (LMWH) had been used widely for prevention and treatment of thrombosis in the patients with acute coronary syndrome (ACS). Actually, the administration of heparin may caused some adverse effect, such as heparin inducedthrombocytopenia (HIT). This study was aimed to reveal thrombocytes count in patients with ACS who underwent LMWH therapy. An observational study with cohort prospective design was performed in 30 patients with ACS. The thrombocytes count was obtained from complete blood count (CBC) by using haematology analyzer (Sysmex XT 2000i) that performed at Clinical Pathology Laboratory, Dr. Wahidin Sudirohusodo Hospital, Makassar. The obtained data was analyzed with Wilcoxon test. The mean thrombocytes count before the administration of LMWH was 236.800/μL, while mean thrombocytes count after the administration of LMWH was 280.270/μL. Suprisingly this data showed that in general thrombocytes count was increased significantly (P=0.004) five day after starting LMWH therapy. In this study only one (3.3%) of 30 patients who received LMWH had trombocytes count less than 150.000/μL. Based on this study an antibody test to PF4-heparin complex was needed to determined occurance of HIT in this patient. The thrombocytes count was increased significantly (P=0.004) in patients with ACS who had given LMWH therapy.
UJI HEMATOLOGI PASIEN TERDUGA DEMAM BERDARAH DENGUE INDIKASI RAWAT INAP Juranah .; Darwati Muhadi; Mansyur Arif; Burhanuddin Bahar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1169

Abstract

Indonesia is an endemic area of Dengue Hemorrhagic Fever (DHF). The clinical symptoms of this disease varies; it can beasymptomatic or atypical fever. Therefore, the early detection of Dengue virus is important to reduce the incidence of new victims fromhis infection. The aim of this study was to find out the haematological features of DHF suspected patients indicated for hospitalization. Aross-sectional study was done on DHF suspected patients indicated for hospitalization. The data were obtained from the Medical Recordat Wahidin Sudirohusodo Hospital from January-July 2009. The data were presented in the form of table. The results showed that themean leukocyte counts was 5.138 103/µL ranging from 2.10–16.70 103/µL, the mean erythrocyte count was 5.136 106/µL rangingrom 3.2–6.40 106/µL, the mean platelet count was 111.27 103/µL ranging from 11.40–260 103/µL. The DHF patients at admissionwho had leucositopenia, thrombocytopenia, and monocytosis were 54.30%, 71.40%, and 51.40%, respectively. Based on the result itan be concluded, that the most common haematological abnormality in DHF suspected patients whom indicated for hospitalizationwere thrombo cytopenia, leucocytopenia and monocytosis.
EOSINOFIL PASCA MENGEROK MUKOSA HIDUNG DAN PEMERIKSAAN DARAH RUTIN DI RINITIS ALERGI Rima Yuliati Muin; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.995

Abstract

Diagnostic of rhinitis allergy was based on anamnesis, physical examinations. Examine including anterior rhinoscopy, nasal endoscope, skin test and laboratory assay of nasal cytology, eosinofil count in the blood. Eosinofil mucosal nasal brushing assay andeosinofil routine hematology can be used as other examination to diagnose rhinitis allergy and to evaluate therapy response. The aimof the study was to know the correlation between eosinofil level on mucosal nasal brushing and routine hematology in suspect allergyrhinitis. The study used cross sectional methods, and was done among 37 suspected Rhinitis Allergy patients in the Clinical PathologyLaboratory, and the Clinic of Ears, Nose and Throat at Wahidin Sudirohusodo hospital Makasar, during the period of March - August2008. Eosinofil mucosal nasal brushing assay used Hansel stain and routine hematology assay used automatic blood cell counter Sysmex1800i. The data were analyzed with Pearson Correlation test using SPSS for Windows version 12,0. In the results were found from the37 samples by a correlation test the mean eosinofil level of mucosal nasal brushing. In men was 12.9/HPF and in women was 5/HPF.While eosinofil in routine hematology in men was 1595/µl and in women was 551/µl, with p < 0.000 and r = 0.930. The conclusionso far from this study that the correlation of eosinofil count between mucosal nasal brushing and hematology routine in those patients suspect rhinitis allergy was very strong. So this test can be used as an alternative examination to diagnose rhinitis allergy.
Co-Authors Burhanuddin Bahar Cyntia Kornelius Irna Diyana Kartika Juranah . Lince Wijoyo Liong Boy Kurniawan, Liong Boy Mansyur Arif Martina Rentauli Rachmawati Muhiddin Rima Yuliati Muin Syahraswati Syahraswati