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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Clinical Pharmacy and Pharmaceutical Science
Fef Rukminingsih
Politeknik Katolik Mangunwijaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Sand Granules Ekstrak Biji Alpukat (Persea Americana Seed Extract) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue : Sand Granules of Avocado Seed Extract (Persea Americana Seed Extract) as Natural Larvaside of Dengue Fever Fef Rukminingsih; Anasthasia Pujiastuti
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.362 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13607

Abstract

Dengue hemorrhagic fever (DHF) threatens people in the rainy season. DHF is one of the major public health problems in Indonesia. These problems encourage an effort to eradicate Ae. aegypti larvae by using natural larvicide. One of the plants that can be used as natural larvicides is avocado seeds (Persea americana Seed) which contain saponin. This study aims to determine the larvacidal activity of avocado seed extract sandgranules with LC50 of 8.87 mg.mL-1 against Ae. aegypti larvae. This study is an experimental research with a complete random design in a unidirectional pattern. The independent variable in this study is the variation concentration of Explotab as a disintegrant agent ie 2, 3, and 4%. Sand granules of avocado seed extract are made by wet granulation method. Results of the larvacidal activity test of avocado seed extract sand granules were analyzed by calculating the percentage of larvae mortality and statistical analysis using SPSS. The results of this study is the larvacidal activity of pure avocado seed extract with LC50 8.87 mg. L-1 is greater than the avocado seed extract sand granules. The addition of Explotab did not affect the total larvae mortality, but there was a significant difference in larvae mortality at 5 hours of sand granules exposure with explotab concentration of 3% and 4% (a significance value <0.05).
Monitoring Tekanan Darah Pada Pasien Diabetes Melitus Tipe Dengan Hipertensi Di Puskesmas Tlogosari Kulon Kota Semarang Fef Rukminingsih; Putri Sri Wahyuni
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 2 No. 2 (2023): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v2i2.38

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action, or both. DM is a risk factor for hypertension. Hypertension in DM increases the risk of complications so it is necessary to monitor whether blood pressure targets are achieved. This study aims to determine the achievement of blood pressure targets in type 2 DM patients with hypertension at the Tlogosari Kulon Health Center, Semarang City. This research is a descriptive observational study. Data collection uses purposive sampling technique. Data were obtained from medical records of type 2 DM patients with hypertension aged ≥ 45 years, who had blood pressure examination results on 2 consecutive visits in September 2022 – February 2023, use antihypertensives for at least 1 year. It was found 47 patients, consisting of 25 male patients and 22 female patients. A total of 26 patients were aged between 60-69 years. A total of 36 patients (76.59%) had taken antihypertensives for 1-5 years and 42 patients (89.40%) received single therapy, namely amlodipine. Only 1 patient received combination therapy of 2 drugs (amlodipine and candesartan). There were 14 patients who achieved the target blood pressure <140/90 mmHg (29.78%).
Co-Authors Pujiastuti, Anasthasia Putri Sri Wahyuni