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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Amalee: Indonesian Journal of Community Research & Engagement
Indarini Indarini
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Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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CASPASE-3 AKTIF DI LEUKEMIA MIELOSITIK AKUT (LMA) DAN LEUKEMIA LIMFOBLASTIK AKUT (LLA) Agus Setiawan; Indarini Indarini; Lyana Setiawan; Siti Boedina Kresno; Nugroho Prayogo; Arini Setiawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.411

Abstract

Dysregulation of apoptosis plays an essential role either in leukemogenesis or treatment response. Caspase-3 is a cysteine protease that functions as the final common mediator of apoptosis. The expression of the active caspase-3 is presumed as a predictor of prognosis and is able to predict the chemotherapy sensitivity. The aim of this study is to identify and to know the profile of active caspase-3 in Acute Myeloid Leukaemia (AML) and Acute Lymphoblastic Leukaemia (ALL), to correlate its expression in marrow and peripheral blood mononuclear cells, and to verify the extent of its use as a complete remission predictor after induction treatment. The study subjects consisted of patients who were diagnosed as AML and ALL with marrow and peripheral blood examination performed at the Department of Clinical Pathology Dharmais Cancer Hospital and CiptoMangunkusumo Hospital. Based on this study, it is revealed that the active caspase-3 expression in mononuclear marrow cells was higher in AML compared to ALL (p=0.033), active caspase-3 expression in marrow showed a strong correlation (r=0.764; p=0.001) to peripheral blood mononuclear cells in ALL and a medium correlation (r=0.594; p=0.042) in AML. The expression of the active caspase-3 in ALL patients was lower in complete remission patients compared to the non-complete remission patients. Regarding to this study it is recommended to measure the active caspase-3 along with molecules integrating in apoptosis signaling pathways such as cytochrome-c and in the formation of apoptosome.
Penguatan Usaha Mandiri Diversifikasi Produk Jahe melalui Penyuluhan Pemilihan Kemasan Pemasaran Digital dan Perizinan Produk Vendra Setiawan; Alfian Hendra Krisnawan; Indarini Indarini
Amalee: Indonesian Journal of Community Research and Engagement Vol 4 No 1 (2023): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v4i1.2624

Abstract

To survive the Covid-19 epidemic, businesses must employ innovative and important methods, one of which is functional food diversification for product expansion and higher selling value. However, some beginner entrepreneurs still do not understand this strategy, which causes the business to not develop, including what is experienced by partners. The goal of this community service project is to expand partners' knowledge of the marketing of diverse functional food products made from ginger, which was previously done in product production training. Marketing knowledge was provided through counseling methods related to digital marketing, packaging selection, and product licensing. The partners of this activity are the PKK group of RW 06 Rungkut Lor, Rungkut District, Surabaya. Participatory Action Research (PAR) with a counseling mechanism is the community service strategy adopted. Evaluation of increased knowledge using the pretest and posttest methods. The questions' components include the marketing process, marketing mix, digital marketing, general understanding of product licensing, and information related to NIB, PIRT permits, halal certificates, and BPOM food permits. According to the evaluation findings, there was a 9.59% gain in expertise in digital marketing outreach efforts and a 33.33% rise in product licensing outreach activities. It is envisaged that this increase in learning would aid in the resolution of partner product marketing issues and boost partner economic welfare.
Co-Authors Arini Setiawati Krisnawan, Alfian Hendra Laksono Trisnantoro Lyana Setiawan Nugroho Prayogo Siti Boedina Kresno Vendra Setiawan