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All Journal Jurnal Kefarmasian Indonesia
Nanang Yunarto
Pusat Biomedis dan Teknologi Dasar Kesehatan, Badan Litbangkes, Kemenkes RI
Medicine & Pharmacology

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Prospek Tanaman Obat sebagai Antihepatitis Nanang Yunarto
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hepatitis remains a serious global health problem because of the potential impact to morbidity and mortality. Prevalence of hepatitis patients in Indonesia either by viral infection or noninfection increases rapidly. The high cost of treatment hepatitis resulted in the switch in the use medicinal plants to cope with this disease. Several types of medicinal plants were proven to be antihepatitis such as meniran, temulawak, mengkudu and pegagan. The objective of this paper is to provide scientific information study of medicinal plants useful as antihepatitis and their development prospect. The method used in this study is to review the relevant scientific articles in international and national journals. Based on reference studies it has been reported that meniran, temulawak, mengkudu and pegagan have a great potential and prospective as antihepatitis drugs. The important challenge in development of medicinal plants is a constant quality as well as, continuous supply of raw materials and effect assured.
Optimasi Formula Tablet Salut Enterik Natrium Diklofenak dengan Bahan Penyalut Kollicoat 30 D Nanang Yunarto
Jurnal Kefarmasian Indonesia VOLUME 4, NOMOR 2, AGUSTUS 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Diclofenac sodium is an analgetic and antiinflammation drug and commonly used by oral administration. Because of it’s side effects that can cause stomach irritation, nausea and vomiting, it’s made in the form of enteric-coated. Enteric-coated formulations developed used organic solvent having toxicity and flammability risks. The aim of this study is to develop diclofenac sodium enteric-coated tablets with a water-based coating material. Coating material used is Kollicoat 30 D which is a derivative of acrylic polymer that can dispersed in water. Optimalization of the formula is done by the weight gain 4%, 6% and 8%. The result showed that enteric coated tablets used coating material with weight gain 8% gave the best result with all parameters meet the requirements of the test, there was no change in acid medium for 2 hours and stable released active ingredient in alkaline medium.
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