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Quantitative Analysis of Multi-components in Curcuma xanthorrhiza by Single Marker Badrunanto Badrunanto; Wulan Tri Wahyuni; Hera Nirwati; Mohamad Rafi
Indonesian Journal of Pharmacy Vol 30 No 4, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (936.617 KB) | DOI: 10.14499/indonesianjpharm30iss4pp301

Abstract

A new simple and effective routine analytical method for quantification of curcuminoids in Curcuma xanthorrhiza was developed by high-performance liquid chromatography. This method based on chromatographic fingerprint combined with a quantitative analysis of multi-components by single marker (QAMS). Curcumin was selected as an internal marker for the determination of two other similar compounds, i.e. bisdemethoxycurcumin and demethoxycurcumin, by using the relative coefficient factor (RCF). Excellent linearity was obtained for each component (r2 > 0.9998), and the recovery of extraction methods were within 100.23-103.95%. The precision of the method was good at inter-day and intra-day analysis (RSD < 4.0%). The stability of RCFs was good under various chromatographic conditions with RSD < 1%, and the ratio of retention time was used to locate each compound. The quantification of curcuminoids between QAMS and external standard method (ESM) proved the consistency and similarity of the two method (RSD < 2%). This study demonstrated that QAMS could be used as a routine method for quality control of curcuminoids in C. xanthorrhiza. This method successfully proved accurate, stable, more effective and simple than external standard method.
The Role of Social Media for Disasters in The Era of Disruption (Analysis of Responsiveness to COVID-19 Pandemics on Twitter) Rahmanto, Fajar; Rafi, Muhammad
Komunitas Vol 12, No 2 (2020): September 2020
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/komunitas.v12i2.25062

Abstract

Social media has become the choice as a means to access various information related to disasters. This article aims to determine the level of public responsiveness to the COVID-19 pandemic disaster through social media Twitter. The research method uses descriptive qualitative with a literature study approach. Sources of information were collected from Twitter using N-Capture regarding the COVID-19 pandemic in March 2020. For data analysis techniques using the NVivo12 Plus software with a query analysis approach. The results showed the community's responsiveness to the COVID-19 pandemic disaster since the advent of the COVID-19 outbreak in Indonesia in early March was enlivened with hashtags (# lawancovid19) of 14,930 counts. Through hashtag # lawancovid19, the bnpb-Indonesia account with (35.24%) and the ministry of health ministry account (20.68%) are the two twitter accounts used most the taggar. The #lawancovid19 narrative on Twitter developed by the Government is a form of information and education communication (IEC) actions regarding the COVID-19 pandemic as part of a preventive effort to prevent the spread of an increasingly widespread pandemic outbreak. Thus, social media can be utilized by the Government and the community to increase effectiveness and efficiency in disseminating disaster information.
PUTUSAN SENGKETA LAUT CHINA SELATAN SERTA IMPLIKASI HUKUMNYA TERHADAP NEGARA DISEKITAR KAWASAN TERSEBUT Darajati, Muhammad Rafi; Adolf, Huala; -, Idris
Jurnal Hukum & Pembangunan
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of interesting developments about the global security is the issue of territorial disputes in the South China Sea between Philippines and China. Philippines has brought the dispute to the Permanent Court of Arbitration. The ruling from Permanent Court of Arbitration said that China’s claim about a nine-dash line does not have a legal basis. However, China rejects the ruling and remains aggressive which might cause instability in South China Sea region. This research aims to look at the implications of the ruling of the Permanent Court of Arbitration for State Parties and states around the South China Sea region. Authors use juridical normative research method with literature studies. This research shows that States Parties have to implement and respect the ruling because it has already become the source of international law. For the states that located around the region, the ruling also has an effect to facing China’s aggressiveness and rules handling maritime claims in the South China Sea region.