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Hubungan antara Polimorfisme Gen VEGF-A dengan Perkembangan Ulkus Diabetika Ika Rahayu
Jurnal Kedokteran Meditek VOL. 24 NO. 66 APRIL-JUNI 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i66.1642

Abstract

Diabetes melitus (DM) merupakan suatu gangguan metabolik yang ditandai oleh hiperglikemia kronik. Hal ini disebabkan oleh kelainan sekresi insulin, gangguan kerja insulin atau gangguan keduanya. Sebanyak 12-25% pasien DM memunyai risiko untuk mengalami ulkus diabetika. Ulkus diabetika merupakan komplikasi yang sering terjadi pada pasien DM tipe 1 dan 2.Diabetes melitus merupakan suatu model prototopikal pada kejadian gangguan penyembuhan luka. Individu dengan DM menunjukkan kemampuan angiogenesis abnormal pada beberapa organ. Gen Vascular Endothelial Growth Factor-A (VEGF), merupakan gen yang menyandi polipeptida VEGF. Studi fungsional yang telah dilakukan mengindikasikan bahwa polimorfisme pada gen ini memengaruhi ekspresi mRNA. Ekspresi mRNA memunyai peranan penting pada proses penyembuhan luka.Kata Kunci : Diabetes melitus, ulkus diabetika, polimorfisme gen VEGF, VEGF-A
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN SIKAP KERJA SAMA DAN HASIL BELAJAR SISWA PADA PEMBELAJARAN TEMATIK DI SDN KENCANA INDAH II Rahayu, Ika; Yulistiani, Irna
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 1 No. 2 (2016): Vol. 1 No. 2, Juni 2016
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.183 KB) | DOI: 10.36989/didaktik.v1i2.28

Abstract

The problem of this research is to increase cooperation attitude and student learning outcomes through the implementation model of Problem Based Learning on thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency. This study aims to determine the attitude of cooperation and improvement of student learning outcomes through the implementation model of Problem Based Learning in Scene 1 Indahnya Mutual Subtheme 1 Nation Cultural Diversity in Class IV. As the subjects in this study is the fourth grade students of SDN Kencana Indah 2 as a single class of 33 students. The research object of this class action is the improvement of the attitude of cooperation and student learning outcomes at 1 beauty togetherness theme of cultural diversity subtema one nation by using model Problem Based Learning. Implementation of a class action (PTK) was done 2 cycles and each cycle is done with 2 meetings and at the end of each cycle of observation to determine the result of increased cooperation attitude and student learning outcomes. The results of the research can be argued that the percentage of category cooperative attitude of students the observation of the first cycle of the first meeting included the category "Not Visible" reached 57.7%; category "Start Invisible" reached 72.7%; category "Start Developing" reached 39.4%; and the category "have been entrenched" reached 15.2%, while in the second cycle in the category "Not Visible" reached 15.2%; category "Start Invisible" reached 42.4%; category "Start Developing" reached 33.3%; and the category "have been entrenched" reached 93.9%. Besides the increase occurred in student learning outcomes of the first cycle that 45.5% to 84.8% in the second cycle. Thus it can be argued conclusion that the application of the model of Problem Based Learning can improve the attitude of cooperation and student learning outcomes in thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency.
Low level of plasma VEGF-A and C allele of -2578*C/A polymorphism in the VEGF-A gene are risk factors of diabetic foot ulcer in Javanese ethnic Rahayu, Ika; Sinorita, Hemi; Timotius, Kris Herawan; Sadewa, Ahmad Hamim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.404 KB) | DOI: 10.19106/JMedSci005302202106

Abstract

Diabetes mellitus (DM) is caused by abnormal insulin secretion, impairedinsulin action, or both. Approximately 12-25% of type 2 diabetes mellitus(T2DM) patients will develop diabetic foot ulcers (DFU). Vascular endothelialgrowth factor (VEGF) is a group of platelet-derived growth factors (PDGF)which have a potential role in angiogenesis. Low levels of VEGF-A can causeinsufficient angiogenesis leading to wound healing inhibition. The 2578*C/Apolymorphism of VEGF-A gene has been reported as a candidate markerfor the DFU development. However, the variant role in the development ofDFU in Javanese ethnic needs to be clarified. This study was conducted tocompare VEGF-A levels and the -2578*C/A polymorphism of the VEGF geneamong diabetic patients with and without DFU in Javanese ethnic. In thiscase-control study, the T2DM individuals with DFU as case group (n=19) andwithout DFU as control group (n=41) were recruited. The VEGF-A levelsweredetermined by ELISA. The ARMS-PCR technique was applied to investigate thepresence of -2578*C/A polymorphism of the VEGF gene. Data were analyzedwith independent t, Mann-Whitney, Chi-square, and Kruskal-Wallis tests withsignificance level of p<0.05. The median of plasma VEGF-A level was significantlydifferent between case and control groups (p=0.001). The genotype frequencyof -2578*C/A polymorphism of VEGF gene was no difference between case andcontrol groups. However, individuals with C allele have a higher risk factor todevelop DFU than A allele (CC+CA vs AA;p=0.042; OR=2.5). The plasma VEGF-Alevels were lower in T2DM subjects with DFU than those without DFU. Inconclusion,individuals with C allele of -2578*C/A polymorphism of VEGF geneare more susceptible to have DFU than individuals with A allele in Javaneseethnic with T2DM.