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PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING UNTUK MENINGKATKAN SIKAP KERJA SAMA DAN HASIL BELAJAR SISWA PADA PEMBELAJARAN TEMATIK DI SDN KENCANA INDAH II Rahayu, Ika; Yulistiani, Irna
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 1 No. 2 (2016): Vol. 1 No. 2, Juni 2016
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.183 KB) | DOI: 10.36989/didaktik.v1i2.28

Abstract

The problem of this research is to increase cooperation attitude and student learning outcomes through the implementation model of Problem Based Learning on thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency. This study aims to determine the attitude of cooperation and improvement of student learning outcomes through the implementation model of Problem Based Learning in Scene 1 Indahnya Mutual Subtheme 1 Nation Cultural Diversity in Class IV. As the subjects in this study is the fourth grade students of SDN Kencana Indah 2 as a single class of 33 students. The research object of this class action is the improvement of the attitude of cooperation and student learning outcomes at 1 beauty togetherness theme of cultural diversity subtema one nation by using model Problem Based Learning. Implementation of a class action (PTK) was done 2 cycles and each cycle is done with 2 meetings and at the end of each cycle of observation to determine the result of increased cooperation attitude and student learning outcomes. The results of the research can be argued that the percentage of category cooperative attitude of students the observation of the first cycle of the first meeting included the category "Not Visible" reached 57.7%; category "Start Invisible" reached 72.7%; category "Start Developing" reached 39.4%; and the category "have been entrenched" reached 15.2%, while in the second cycle in the category "Not Visible" reached 15.2%; category "Start Invisible" reached 42.4%; category "Start Developing" reached 33.3%; and the category "have been entrenched" reached 93.9%. Besides the increase occurred in student learning outcomes of the first cycle that 45.5% to 84.8% in the second cycle. Thus it can be argued conclusion that the application of the model of Problem Based Learning can improve the attitude of cooperation and student learning outcomes in thematic learning themes subthemes 1 1 wonderful togetherness nation of cultural diversity in the class IV SDN Kencana Indah 2 Rancaekek District of Bandung regency.
Low level of plasma VEGF-A and C allele of -2578*C/A polymorphism in the VEGF-A gene are risk factors of diabetic foot ulcer in Javanese ethnic Rahayu, Ika; Sinorita, Hemi; Timotius, Kris Herawan; Sadewa, Ahmad Hamim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 2 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.404 KB) | DOI: 10.19106/JMedSci005302202106

Abstract

Diabetes mellitus (DM) is caused by abnormal insulin secretion, impairedinsulin action, or both. Approximately 12-25% of type 2 diabetes mellitus(T2DM) patients will develop diabetic foot ulcers (DFU). Vascular endothelialgrowth factor (VEGF) is a group of platelet-derived growth factors (PDGF)which have a potential role in angiogenesis. Low levels of VEGF-A can causeinsufficient angiogenesis leading to wound healing inhibition. The 2578*C/Apolymorphism of VEGF-A gene has been reported as a candidate markerfor the DFU development. However, the variant role in the development ofDFU in Javanese ethnic needs to be clarified. This study was conducted tocompare VEGF-A levels and the -2578*C/A polymorphism of the VEGF geneamong diabetic patients with and without DFU in Javanese ethnic. In thiscase-control study, the T2DM individuals with DFU as case group (n=19) andwithout DFU as control group (n=41) were recruited. The VEGF-A levelsweredetermined by ELISA. The ARMS-PCR technique was applied to investigate thepresence of -2578*C/A polymorphism of the VEGF gene. Data were analyzedwith independent t, Mann-Whitney, Chi-square, and Kruskal-Wallis tests withsignificance level of p<0.05. The median of plasma VEGF-A level was significantlydifferent between case and control groups (p=0.001). The genotype frequencyof -2578*C/A polymorphism of VEGF gene was no difference between case andcontrol groups. However, individuals with C allele have a higher risk factor todevelop DFU than A allele (CC+CA vs AA;p=0.042; OR=2.5). The plasma VEGF-Alevels were lower in T2DM subjects with DFU than those without DFU. Inconclusion,individuals with C allele of -2578*C/A polymorphism of VEGF geneare more susceptible to have DFU than individuals with A allele in Javaneseethnic with T2DM.
Hubungan antara Polimorfisme Gen VEGF-A dengan Perkembangan Ulkus Diabetika Ika Rahayu
Jurnal Kedokteran Meditek VOL. 24 NO. 66 APRIL-JUNI 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i66.1642

Abstract

Diabetes melitus (DM) merupakan suatu gangguan metabolik yang ditandai oleh hiperglikemia kronik. Hal ini disebabkan oleh kelainan sekresi insulin, gangguan kerja insulin atau gangguan keduanya. Sebanyak 12-25% pasien DM memunyai risiko untuk mengalami ulkus diabetika. Ulkus diabetika merupakan komplikasi yang sering terjadi pada pasien DM tipe 1 dan 2.Diabetes melitus merupakan suatu model prototopikal pada kejadian gangguan penyembuhan luka. Individu dengan DM menunjukkan kemampuan angiogenesis abnormal pada beberapa organ. Gen Vascular Endothelial Growth Factor-A (VEGF), merupakan gen yang menyandi polipeptida VEGF. Studi fungsional yang telah dilakukan mengindikasikan bahwa polimorfisme pada gen ini memengaruhi ekspresi mRNA. Ekspresi mRNA memunyai peranan penting pada proses penyembuhan luka.Kata Kunci : Diabetes melitus, ulkus diabetika, polimorfisme gen VEGF, VEGF-A
Evaluasi Antioksidan dan Antidiabetik Infusa Daun Karamunting (Rhodomyrtus tomentosa) pada Ikan Zebra (Danio rerio) Susana Elya Sudradjat; Ika Rahayu
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 2 (2022): Herb-Medicine Journal April 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.12317

Abstract

Background: Karamunting (Rhodomyrtus tomentosa) is a potential herbal plant that can be found in Kalimantan, Indonesia. This plant is widely used because of its benefits for health. Several studies show its ability as anti-inflammatory, anti-bacterial, anti-fungal, and anti-diabetic.Objective: This study aimed to evaluate the chemical content, antioxidant and anti-diabetic activity of the infusion of karamunting leaves.Methods: Liquid Chromatography-Mass Spectrometry (LCMS) was used for the phytochemical analysis of karamunting leaf infusion. Total phenolic content was calculated using Folin Ciocalteu's reagent. Antioxidant activity test using DPPH free radicals. An anti-diabetic activity test was performed using hyperglycemic-induced zebrafish.Results: There were 14 active compounds detected. There are three main fragments, namely Tectoridin, Engeletin, and Rhamnetin-3-O rhamnoside, in the infusion of karamunting leaves. The total phenolic content of the infusion of karamunting leaves was 288±5.94 g GAE/g. The antioxidant activity of karamunting leaf infusion was more potent than that of BHT (IC50 infusion 0.79±0.33 g/mL, BHT 13.5±2.5 g/mL). Karamunting leaf infusion has an ability that can be compared with metformin in lowering glucose levels in zebrafish blood.Conclusions: The main bioactive compounds in the infusion of karamunting leaves are Tectoridin, Engeletin, and Rhamnetin-3-O rhamnoside. The antioxidant activity of karamunting leaf infusion is powerful. Karamunting leaf infusion has the potential as an antihyperglycemic agent.
Profil fitokimia dan aktivitas antioksidan dari minyak atsiri kulit buah Jeruk Pontianak (Citrus nobilis lour. var. Microcarpa): Profil fitokimia dan aktivitas antioksidan dari minyak atsiri C.nobilis Farianti Wiranda; Ika Rahayu; agus Limanto
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract. Citrus nobilis lour fruit. var. microcarpa (C. nobilis) or Pontianak Orange is a food source with good vitamins and antioxidants, while the peel was considered as waste. Along with technological development, people processed it by utilizing its essential oil. Research showed that the essential oil of Pontianak orange peel (C. nobilis) could inhibit the growth of some gram-positive and -negative bacteria. Still, the compounds' composition and antioxidant and anti-inflammatory properties have not been studied much. Therefore, this study aimed to determine the active compound composition, antioxidant, and anti-inflammatory activity of C. nobilis essential oil. The essential oil from C. nobilis peel was extracted using the clavenger method. The GCMS methods was used for active compound profiling. The antioxidant activity of essential oils was examined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. The dominant active compound components in C. nobilis essential oil were limonene, β-myrcene, and linalool. The essential oil of C. nobilis had robust antioxidant activity (IC50 13.114 µg/mL) compared to BHT. The content of the dominant active compound in the essential oil supported this activity.
An Analysis of Simple Past Tense Errors in the Soul Sense with Silkina Podcast by Using the Surface Strategy Taxonomy Ela Nurmala; Ika Rahayu; Gingin Ginanjar Sapari; Rahmayanti Rahayu
Jurnal Bahasa Inggris Terapan Vol 9 No 1 (2023): April 2023
Publisher : Jurusan Bahasa Inggris - Politeknik Negeri Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35313/jbit.v9i1.4698

Abstract

The purpose of this study is to investigate the simple past tense errors found in the Soul Sense with Silkina Podcast. The study employed qualitative method with descriptive analysis. The data were collected from a podcast entitled Soul Sense with Silkina Podcast which consists 10 episodes of Soul Sense with Silkina Podcast. The data were analysed by applying the Surface Strategy Taxonomy proposed by Dulay. The result shows that there were four types of errors committed by the podcasters in using Simple Past Tense. Those types were Omission, Addition, Mis-formation and Mis-ordering. The total numbers of errors were 120 divided into Omission (23 errors), Addition (11 error), Mis-formation (82 errors), and Mis-ordering (4 errors). In other words, the highest amount of errors was Mis-formation with the percentage of 68.34%, while the omission was in the second place with the percentage around 19.17%. The third place was addition with the percentage around 9.16%, and the last was mis-ordering with the percentage around 3.33%.