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All Journal Health and Medical Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Scientific Journal

Nurwiyeni Nurwiyeni

Universitas Baiturrahmah

Author-ID : 3550924

Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Articles

The Profile of Patients with Appendicitis in Rsi Siti Rahmah Padang West Sumatra at The Period of 2016 - 2017 Annisa Didel; M. Nurhuda; Nurwiyeni Nurwiyeni
Scientific Journal Vol. 1 No. 1 (2022): SCIENA Volume I No 1, January 2022
Publisher : CV. AKBAR PUTRA MANDIRI

Appendicitis is a common cause of abdominal pain that requires emergency surgery in each age group and sex. The incidence of appendicitis in the world reaches 3442 million cases each year. The survey at 15 provinces of Indonesia in 2014 showed 4,351 cases of hospitalized appendicitis.This aims to obtain information about the profile of patients suffering from appendicitis at the Siti Rahmah Islamic Hospital Padang West Sumatra in the period of 2016 – 2017.The study is descriptive by using secondary data from patient’s medical record.This study was conducted from January to February 2019, the sample are 65 samples by simple random sampling technique.The results showed that the highest age group of incidences was in the young adults (17-45 years), which is 39 people (60%), and the highest sex group was male 36 people (55.4%), leukocytosis with 50 people (76.9%), classification was acute appendicitis with 42 people (64.6%), pain onset was 24-48 hours 33 people (50.8%). The highest age group of 42 patients with acute diagnosis was young adults (73.8%), four patients with the chronic diagnosis were highest at young adults group, and 19 patients (36.8%) with the diagnosis of perforation were highest at the older adults group.

Characteristics of Myopic Patients as a Guide for General Public at Rumah Sakit Islam Siti Rahmah Padang in 2021 Haves Ashan; Zikra Apriani; Nurwiyeni Nurwiyeni; Seres Triola
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.4274

Myopia is a form of refractive error in which rays parallel to the line of sight in the non-accommodating eye are focused in front of the retina. Refractive errors are one of the most common causes of visual impairment worldwide and the second leading cause of treatable blindness. Myopia as a refractive disorder, almost always occupies the top order compared to other refractive disorders. The purpose of this research is toknowing the characteristics of myopic patients at Siti Rahmah Hospital Padang in the period 2021. This study is descriptive with a case series design, the study population is myopia sufferers as many as 329 cases and the sample size is all of these cases.And the results of this study explain that the highest proportion of myopia sufferers is in the age group of 16 - 30 years, which is 165 people or 50.2%, myopia is mostly suffered by women, namely 185 people or 56.2%, while men 144 people or 43 ,8%, most of the patients examined were of the Karo ethnicity, amounting to 137 people (41.6%), that there were many myopia sufferers at the education level of Public High School which amounted to 157 people (47.7%), the percentage of myopia sufferers was The highest percentage was found in the sample who had a job as a student as many as 136 people (41.6%), and the highest percentage of myopia correction results was found in the sample with a full correction of 215 people (65.3%) while 114 people with a percentage of 34, 7% is the result of incomplete correction.

Gambaran Histopatologi Tumor Ganas Payudara di Laboratorium Patologi Anatomi RSUP M. Djamil Padang Tahun 2017 Ana Stesia Suarfi; Debie Anggraini; Nurwiyeni Nurwiyeni
Health and Medical Journal Vol 1, No 1 (2019): HEME January 2019
Publisher : Universitas Baiturrahmah

Pendahuluan: Tumor ganas payudara merupakan suatu penyakit dimana terjadi pertumbuhan berlebih atau perkembangan tidak terkontrol dari sel-sel jaringan payudara. Metode dalam mediagnosis tumor ganas payudara sampai sekarang yang menjadi gold standard adalah pemeriksaan histopatologi, dimana dalam pemeriksaan ini dapat menentukan jenis tumor payudara baik ganas maupun jinak. Pemeriksaan histopatologi jaringan payudara dibutuhkan sebagai diagnosis definitif dalam menentukan jenis tumor ganas payudara serta derajat histopatologinya. Tujuan penelitian untuk mengetahui gambaran histopatologi tumor ganas payudara di Laboratorium Patologi Anatomi RSUP. M. Djamil Padang tahun 2017. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional. Sampel penelitian ini adalah 47 orang penderita tumor ganas payudara di Laboratorium Patologi Anatomi RSUP.Dr.M.Djamil Padang tahun 2017 yang memenuhi kriteria inklusi dan eksklusi. Data penelitian diperoleh dari status laboaratorium Patologi Anatomi RSUP.DR.M.Djamil Padang tahun 2017. Hasil: Frekuensi penderita tumor ganas payudara tertinggi pada kelompok umur 26-65 tahun (95,7%), jenis kelamin wanita (100%), jenis histopatologi karsinoma duktal invasif (63,8%), derajat histopatologi (68,1%). Kesimpulan: Gambaran kejadian tumor ganas payudara di laboraorium RSUP.Dr.M.Djamil Padang tahun 2017 banyak terjadi pada usia 26 -65 tahun, berjenis kelamin wanita, jenis histopatologi karsinoma duktal invasif, derajat II.

Ekspresi Tinggi Androgen Receptor Sebagai Penentu Prognosis Adenokarsinoma Prostat di Sumatera Barat Anandia Putriyuni; Nurwiyeni Nurwiyeni
Health and Medical Journal Vol 4, No 1 (2022): HEME January 2022
Publisher : Universitas Baiturrahmah

Abstrak Pendahuluan: Adenokarsinoma adalah jenis kanker prostat terbanyak didiagnosis sampai saat ini. Androgen receptor (AR) berperan penting dalam inisiasi, pertumbuhan dan progresifitas adenokarsinoma prostat, tetapi mekanisme AR masih belum jelas. Analisa ekspresi AR sebagai biomarker prognosis adenokarsinoma prostat belum pernah dilakukan di Sumatera Barat. Tujuan penelitian: Untuk menganalisa ekspresi tinggi AR dalam penentuan prognosis adenokarsinoma prostat di Sumatera Barat. Metode: Rancangan penelitian analitik observasional dengan desain cross sectional. Penelitian dilakukan bulan November 2019 sampai Oktober 2020. Sampel digunakan sebanyak 56 kasus adenokarsinoma prostat secara consecutive sampling yang tersimpan di laboratorium Patologi Anatomik di Sumatera Barat. Slaid yang telah terwarnai hematoxyline dan eosin (HE) dan blok parafin dikumpulkan. Selanjutnya dilakukan review slaid untuk menentukan Gleason score berdasarkan International Society of Urological Pathology (ISUP) 2014/WHO edisi 2016. Metode pewarnaan imunohistokimia (IHK) pada AR untuk menganalisis ekspresi protein secara semikuantitatif. Ekspresi tinggi AR jika interpretasi yang ditemukan strong. Analisis data secara statistik menggunakan uji Chi-square. Hasil: Hasil penelitian mendapatkan kasus adenokarsinoma prostat terbanyak adalah high grade Gleason score (Gleason score 8-10) yaitu 43 (76,79%) kasus dan ekspresi tinggi AR 29 (51,80%) kasus. Adenokarsinoma prostat dengan high grade Gleason score ditemukan ekspresi tinggi AR lebih banyak dibandingkan ekspresi rendah AR. Secara statistik terdapat hubungan yang signifikan antara ekspresi tinggi AR dengan Gleason score (p=0,018). Kesimpulan: Ekspresi tinggi AR merupakan penanda penting untuk progresifitas tumor. Ekspresi AR sebaiknya diperiksa pada kasus adenokarsinoma prostat untuk menentukan prognosis pasien.Kata kunci -- Adenokarsinoma prostat, Androgen receptor, Gleason score, Prognosis Abstract Introduction: Adenocarcinoma is the most type of prostate cancer diagnosed until now. Androgen receptor (AR) plays important roles in initiation, growth and progression of prostate adenocarcinoma. However, the mechanism of AR is unclear. Analysis of AR expression as the prognostic biomarker in prostate adenocarcinoma has never been done in West Sumatera. Aims: To analyze high AR expression in determining the prognosis of prostate adenocarcinoma in West Sumatera. Method: The observational analytic study was done with cross sectional design. This study was conducted from November 2019 to October 2020. Samples of 56 prostate adenocarcinoma were collected by consecutive sampling stored in Anatomical Pathology Laboratories in West Sumatera. Hematoxylin and eosin (HE) stained slides and paraffin blocks were retrieved. Slides were evaluated to review Gleason score based on the International Society of Urological Pathology (ISUP) 2014/WHO 2016. Immunohistochemistry (IHC) staining method with AR antibody was performed to discover protein expression semiquantitatively. High AR expression was characterized by strong interpretation. Statistical data analysis used Chi-square test. Results: The results showed that the most prostate adenocarcinoma was high grade Gleason score (Gleason score 8-10) in 43 (76.79%) cases and high AR expression in 29 (51.79%) cases. High grade Gleason score of prostate adenocarcinoma showed high AR expression more than low AR expression. There was statistically significant correlation between AR expression and Gleason score (p=0.018). Conclusion: High AR expression is the important marker of tumor progression. We suggest that AR expression should be performed in patients of prostate adenocarcinoma for prognosis. Keywords -- Prostate adenocarcinoma, Androgen receptor, Gleason score, Prognosis

Co-Authors Ana Stesia Suarfi Anandia Putriyuni Annisa Didel Debie Anggraini Haves Ashan M. Nurhuda Seres Triola Zikra Apriani

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