Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Jurnal Farmasi Klinik Indonesia
Irwan Ramli
Department of Radiology, Faculty of Medicine, Universitas Indonesia, Jakarta
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Hospital based cancer registry in Cipto Mangunkusumo hospital Jakarta Sibuea, Wilfried H.; Mangunkusumo, R. R.; Akbar, Nurul; Widjanarko, Abidin; Gatot, Djajadiman; Windiastuti, Endang; Hamzah, Mochtar; Panigoro, Sonar S.; Prihartono, Joedo; Krisnuhono, Ening; Lisnawati, Lisnawati; Utami, Sri M.S.; Ramli, Irwan; Roezin, Averdi; Pribadi, Sigit; Wilarso, Iik; Nasar, I Made; Cornain, Santoso
Medical Journal of Indonesia Vol 9, No 3 (2000): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.738 KB) | DOI: 10.13181/mji.v9i3.634

Abstract

[no abstract available]
Studi Nilai AgNOR dan MIB-1 pada Kanker Payudara yang Ditangani dengan Operasi Kurnia, Iin; Soetrisno, Esti; Yulian, Erwin D.; Ramli, Irwan; Alatas, Zubaidah
Indonesian Journal of Clinical Pharmacy Vol 1, No 3 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1011.587 KB)

Abstract

AgNOR dan MIB-1 adalah marker proliferasi sel kanker payudara yang berguna sebagai dasar pemberian radioterapi setelah operasi. Penetapan nilai AgNOR dan indeks MIB-1 dilakukan dengan teknik pewarnaan dan teknik pewarnaan imunohistokimia MIB-1 terhadap 25 sediaan mikroskopik jaringan kanker payudara dari penderita hasil operasi, dan dikelompokkan berdasarkan derajat diferensiasinya menjadi 3 kelompok sediaan berderajat diferensiasi baik (G1), 16 sediaan berderajat diferensiasi menengah (G2), dan 6 sediaan berderajat diferensiasi buruk (antara G2 dan G3). Hasil penelitian menunjukkan nilai AgNOR dan indeks MIB-1 cenderung meningkat seiring dengan meningkatnya derajat diferensiasi. Terdapat pula kecendrungan korelasi positif antara nilai AgNOR dan indeks MIB-1 (r =0,21) pada seluruh derajat diferensiasi, terdapat korelasi negatif antara AgNOR dan MIB-1 pada G1 (r=-0,97), korelasi positif pada G2 (r=0,36) serta korelasi positif antara G2 dan G3 (r=0,33). Korelasi positif antara AgNOR dan MIB-1 terkait dengan peningkatan fase G1, S dan G2 pada sel yang berproliferasi dan peningkatan jumlah sel yang mengalami mitosis. Korelasi negatif disebabkan oleh perbedaan proporsi antara sel yang berada pada fase G1, S dan G2 dengan yang sedang bermitosisKata kunci: Kanker payudara, AgNOR, MIB-1, operasi Study of AgNOR Value and MIB-1 in Breast CancerTreated With Surgery AbstractAgNOR and MIB-1 are marker for breast cancer cell proliferation and can be use as based for radiotherapytreatment after surgery. Value of AgNOR and MIB-1 index were determined using staining and immunohistochemistry staining method respectively from 25 of microscopic slides of breast cancer tissue patients with surgery, and grouped based on degree of differentiation, 3 slides were good degree (G1), 16 slides were medium degree (G2) and 6 slides were poor degree (between G2 and G3). The result shown that the value of AgNOR and MIB-1 index were tended to increase with the increased differentiation degree. There was a positive correlation between the value of AgNOR and index of MIB-1 in all group of differentiation degree (r = 0.21), there is a negative correlation between AgNOR and MIB-1 on G1 (r =-0,97), positive correlation in G2 (r = 0.36) as well as positive correlation between G2 and G3 (r = 0.33). The positive correlation between AgNOR and MIB-1 were associated to the increased of G1, S and G2 phase in the proliferation cell and an increase of cells undergoing mitosis. The negative correlation were caused by the different cell proportion in G1, S and G2 phase, and undergoing mitotis.Key words: Breast cancer, AgNOR, MIB-1, surgery
Co-Authors Abidin Widjanarko Anak Agung Istri Sri Wiadnyani Averdi Roezin Djajadiman Gatot Endang Windiastuti Ening Krisnuhono Esti Soetrisno I Made Nasar Iik Wilarso Iin Kurnia Joedo Prihartono Mochtar Hamzah Nurul Akbar R. R. Mangunkusumo Santoso Cornain Sigit Pribadi Sonar S. Panigoro Sri M.S. Utami Wilfried H. Sibuea Yulian, Erwin D. Zubaidah Alatas