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Cherry Azaria
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Effect of Jati Belanda Leaves (Guazuma ulmifolia Lamk.) Ethanol Extract on Microscopic Features of Atherosclerotic Animal Model’s Aorta Ryan J. Permana; Cherry Azaria; Rosnaeni Rosnaeni
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.68 KB) | DOI: 10.28932/jmh.v1i4.527

Abstract

“Jati Belanda” leaves (Guazuma ulmifolia Lamk.) possesses antidyslipidemia effect and in this study we assessed the effect of "Jati Belanda” leaves ethanol extract in delaying the progression of atherosclerosis in aorta of the rats.Thirty atherosclerosis animal models were divided into six groups, which are three variant dose of “Jati Belanda” leaves (EEDJB 1-2-3), standard control (SC), negative control (NC) and Comparative control/ CC (simvastatin). The parameters measured were the wall thickness and lumen diameter (both in mm), and the amount of foam cells. The result for Kruskal Wallis test showed highly significant differences (p=0.00) of wall thickness Dose2 (0.056 mm) and Dose3 (0.056 mm) compared to NC (0.075 mm) and non-significant compared to CC (0.055 mm). ANOVA result for lumen diameter, p=0.773.  ANOVA result for foam cells amount, p=0.000, Duncan test showed significantly different between EEDJB and NC group.It is concluded that “Jati Belanda” leaves ethanol extract reduced aortic wall thickness and the amount of foam cells, but did not increase lumen diameter on the athersclerotic aorta, and had an equal therapeutic effect compared to simvastatin in delaying the progression of atherosclerosis. Keywords: atherosclerosis, Jati Belanda, wall thickness, lumen diameter, foam cell
Topical Effect of Pinneaple (Ananas comosus) Juice in Combustio Healing Process Measured by Granulation Process, Reepitelialisation and Angiogenesis Cherry Azaria; Achadiyani Achadiyani; Reni Farenia
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.844 KB) | DOI: 10.28932/jmh.v1i5.539

Abstract

Skin protects the body from various trauma, such as high temperature trauma known ascombustio. Pineapple (Ananas comosus) contains lots of substances such as bromelain,antioxidants, and zinc shown to accelerated healing process in previous experiments. Aim ofthis research was to analize the effect of topical pinneaple juice application in combustiohealing process. The method was true experimental laboratory. Wistar rats’ back skin wereinduced by 100 o C iron plat untill 2 nd degree combustio occured, then divided into two groups(n=20). The treatment group were given topical application of pinneaple juice, then the healingprocess were observed macroscopically and microscopically on day 0, 3, 7, and 14. The resultshowed better wound healing in treatment group on day 14. MANOVA test showed topicalapplication of pinneaple juice accelerated healing process (p=0.001). Treatment group showedbetter histological structure changes, as seen from better granulation tissue formed (p=0.003)and reepithelization (p=0,000), but not from angiogenesis (p=0.733). Conclusion, topicalapplication of pinneaple (Ananas comosus) juice accelerated healing process in 2 nd grade ofcombustio animal model measured by granulation maturation process and reepithelizationprocess, but has no effect on angiogenesis.Keywords : Ananas comosus juice, 2 nd degree combustio, granulation tissue, reepitelisation,angiogenesis.
Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level Imelda Imelda; Cherry Azaria; Teresa Lucretia
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.598 KB) | DOI: 10.28932/jmh.v1i6.555

Abstract

Acute renal injury is characterized by decrement of glomerular filtration rate (GFR), resulting in nitrogen metabolic end product retention such as blood ureum. Aminoglycoside nephrotoxic injuries are common in elderly, with mortality rate 50-70%. Tempuyung has been empirically used in relieving renal problems as it contains several active antioxidants. This study aimed to analyze the protective effect of ethanol extract tempuyung leaf (EET) against gentamicin induced renal injury viewed from blood ureum level. The method used was true experimental laboratory, 16 wistar male rats, divided into 4 groups (n=4): negative control group (CMC), positive control group (Gentamicin 80 mg/kgBW), 1st treatment group (EET 100 mg/kgBW + Gentamicin), 2nd treatment group (EET 200 mg/kgBW + Gentamicin) for ten days. On the 11th day, blood serum were taken and the ureum level were analyzed. Data was analyzed by ANOVA and post hoc LSD test. Result showed positive control group had the highest blood ureum level (29.50  1.29 mg/dL) compared to negative control group (14.25  1.26 mg/dL), 1st treatment group (26.50  0.58 mg/dL), and 2nd treatment group (22.25  1.26 mg/dL) with significance difference (p<0,001). In conclusion, the result suggested the protective effect of EET against gentamicin induced renal injury.Keywords: acute renal injury, gentamicin, glomerular filtration rate, tempuyung, ureum
Co-Authors Achadiyani Imelda Imelda Reni Farenia Rosnaeni Rosnaeni Ryan J. Permana Teresa Lucretia