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All Journal Jurnal Respirologi Indonesia Jurnal Klinik dan Riset Kesehatan
Iin Noor Chozin
Departemen Pulmonologi Dan Kedokteran Respirasi, Fakultas Kedokteran, Universitas Brawijaya - RSUD Dr Saiful Anwar Malang
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Differences in the Expression of miRNA-126 and Interleukin (IL)-13 in Fully Controlled and Not Fully Controlled Asthma Patients Yulia Kartina; Susanthy Djajalaksana; Iin Noor Chozin; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.99

Abstract

Backgrounds: Important finding in the last decades in the field of biology and medicine are micro-RNA (miRNA), including miRNA-126 that are involved in the regulation of interleukin-13 (IL-13) and the T helper 2 cell (Th2) response, the key components of the asthmatic response. The aim of this study is to find the difference in the expression of miRNA-126 and IL-13 serum in fully controlled and not fully controlled groups of stable asthma patients and analyze the relationship between them. Methods: Case-control studies was conducted in 36 stable asthma patients who visited pulmonary outpatient clinic Saiful Anwar Hospital from September 2018 to March 2019. Subjects were divided into 2 groups, each group consisted of 18 fully controlled asthma and 18 not fully controlled asthma patients. The expression of miRNA-126 was measured by the quantitative polymerase chain reaction (q-PCR) and IL-13 using the enzyme-linked immunosorbent assay (ELISA) method. Results: The expression of miRNA-126 was higher in the control group (3.499±2.99) than case group (2.719±2.73), but the difference was not significant (P=0.273). The IL-13 levels were higher in the case group (17.285±9.37) than control group (11.681±5.22), and the difference was significant (P=0.009). However, there was no relationship between the expression of miRNA-126 and IL-13 levels in both groups. Conclusions: There were differences in IL-13 levels, but there were no differences in the expression of miRNA-126 in the two groups. There was no relationship between miRNA-126 expression and IL-13 levels in both groups. (J Respir Indo. 2020; 40(1): 24-32)
The Effect of Pulmonary Rehabilitation on The Duration of Antibiotic Switches, IL-10 Levels and PEFR Values in Hospitalized Community Pneumonia Patients Mariyatul Khiptiyah; Iin Noor Chozin; Suryanti Dwi Pratiwi; Rahmad Rahmad; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 40, No 4 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i4.129

Abstract

Background: Pneumonia is an acute inflammation of the lung parenchyma and ranked third of 30 causes of death in the world. WHO estimates the death caused by pneumonia is 1.6 million per year. Long duration of antibiotic switches is associated with increased morbidity, nosocomial infections and costs of healthcare. This study aims to assess the effect of pulmonary rehabilitation with the duration of antibiotic switches and interleukin-10 (IL-10) levels of pneumonia patients in non-intensive care thus pulmonary rehabilitation can be routinely use as adjuvant therapy. Methods: The study was conducted in May-November 2019 at Saiful Anwar Hospital Malang, with 40 pneumonia patients in the non-intensive care and divided in two groups which contains of 20 patients. This study uses consecutive simple random sampling. In treatment group, pulmonary rehabilitation consists of breathing exercise, effective cough techniques, clapping, postural drainage and breathing muscle exercises with spirometry incentive tools. The pulmonary rehabilitation treatment was done by Medical Rehabilitation Department of Saiful Anwar Malang Hospital. IL-10 levels and PEFR values on the zero and fifth days of treatment were measured. Results: The duration of antibiotic switches received pulmonary rehabilitation was shorter 5.05 days (P
Effect of Giving Polyphytopharmaca on Improvement in The Degree of Asthma Control through Reduction of Eosinophils and Interleukin-13 Uncontrolled Asthma Patients Aditya Sri Listyoko; Iin Noor Chozin; Susanthy Djajalaksana
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.109

Abstract

Backgrounds: Bronchial asthma is a heterogeneous disease characterized with chronic airway inflammation. The level of asthma control is an indicator of asthma management outcomes. It is influenced by a complex immunological mechanism, included the role of IL-13 as a key biomarker of inflammation. We investigate the effect of Poly-Phytopharm (Kleinhovia hospita 100 mg, Curcuma xanthorriza 75 mg, Nigella sativa 100 mg and Ophiocephalus striatus 100 mg) on the level of asthma control tests (ACT) score, blood eosinophils, and serum IL-13 on not fully controlled asthma stable patients. Methods: This study used quasi-experimental pre and post test methods, in 15 stable asthma patients who were not fully controlled at the pulmonary outpatient clinic of Dr. Saiful Anwar General Hospital, Malang. Assessment of ACT score, blood eosinophils, and serum IL-13 are carried out before and after supplementation of Poly-Phytopharm three times a day, two capsules respectively for 12 weeks. The ACT was scored by the investigator by direct questioning of patients, the blood eosinophil was measured with blood analysis, and the IL-13 in serum was detected with qPCR method. Results: There is significant increase of ACT score (18.07±2.57 to 22.06±1.83; P=0.001). In subject with baseline eosinophils ≥300 pg/mL (n=9), there were significant reduction in blood eosinophils (653.15±276.77/µL to 460.66±202.04/µL; P=0.038), and a decrease of serum IL-13 (17.69±9.901 pg/ml to 16.17±12.438 pg/ml; P=0.609). Conclusions: The administration of poly-phytopharm for 12 weeks improves ACT level, decreases blood eosinophils, and decrease serum IL-13 on not fully controlled asthma stable patients. (J Respir Indo. 2020; 40(3): 130-8)
Impact of Pulmonary Rehabilitation on Hospitalization Duration, IL-6 Levels, and Respiratory Muscle Power in Hospitalized Community-Acquired Pneumonia Patients Santony Santony; Iin Noor Chozin; Teguh Rahayu Sartono; Rahmad Rahmad; Harun Al Rasyid
Jurnal Respirologi Indonesia Vol 42, No 1 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i1.276

Abstract

Background: Pneumonia is acute inflammation of the lung parenchyma. The long duration of hospitalization is associated with increased morbidity, nosocomial infections and treatment costs. Methods: The study was conducted from May to November 2019 at Saiful Anwar Hospital, Malang, with 40 pneumonia patients in the non-intensive community inpatient room divided into 2 groups. The treatment group performed pulmonary rehabilitation measures consisting of breathing exercise, effective coughing techniques, clapping, postural drainage and respiratory muscle training using spirometry incentives. Results: The duration of hospitalization for the treatment group was 2.25 days shorter (p<0.001). The average IL-6 level in the 5th day of the treatment group was lower than without treatment, that was 54.43 pg/ml (p=0.221). The mean of pressure threshold loading in the group without treatment was 31.5 cmH2O on first day and 36.35 cmH2O on the 5th day (p <0.001) and on first day treatment group was 32.9 cmH2O and 39.35 cmH2O on the 5th day (p=0.001), and the mean value of the 5th day of the treatment group was higher than without treatment (P=0.015). the mean of the 5th day of the treatment group was higher than without treatment (p=0.06).Conclusion: Pulmonary rehabilitation as adjunctive therapy shortens the duration of hospitalization. In both groups there was a decrease in IL-6 levels on the 5th day compared to zero and the lower IL-6 levels were not significant in the treatment group. There was a significant increase in the value of pressure threshold loading inspiration and expiration day fivecompared to day zero in the two groups and there was a significant increase in the Pressure Threshold Loading Inspiration mean treatment group compared to no treatment on the 5th day, but the Pressure Threshold Loading Expiration rate showed no significant increase.
Poly-Phytopharm Increases Act Score and Serum miR-126 Relative Expressions, and Decreases Blood Eosinophil Levels in Asthma Patients I Dewa Putu Ardana; Susanthy Djajalaksana; Iin Noor Chozin; Alidha Nur Rakhmani
Jurnal Respirologi Indonesia Vol 39, No 4 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v39i4.77

Abstract

Background: The levels of asthma control is an indicator of asthma management outcomes. A complex immunological mechanism influences it. We aimed to investigate the effect of Poly-Phytopharm on the asthma control tests (ACT) score, blood eosinophil levels, and miR-126 relative expressions in asthma patients. Methods: Quasi experimental method is used in 15 stable asthma patients who were not fully controlled at the pulmonary outpatient clinic of Dr. Saiful Anwar General Hospital Malang. Assessment of ACT score, blood eosinophil levels, and miR-126 relative expressions are carried out before and after supplementation of Poly-Phytopharm that consist of Nigella sativa 100 mg, Kleinhovia hospita 100 mg, Curcuma xanthorrhiza 75 mg, and Ophiocephalus striatus 100 mg extract, three times a day, two capsules respectively for 12 weeks. The ACT was scored by the investigator by direct questioning of patients, the blood eosinophil level was measured with blood analysis, and the relative expressions of miR-126 was detected with qPCR. Results: There were significant increase of ACT score (18.07±2.57 to 22.06±1.83, P=0.001), decrease in blood eosinophil levels (653.15±276.15 pg/mL to 460.66±202.04 pg/mL, P=0.038), and enhancement of serum miR-126 relative expressions (1.83±1.89 to 5.89±1.34, P=0.038). Conclusion: The administration of Poly-Phytopharm increases ACT score, decreases blood eosinophil levels and increases serum miR-126 relative expressions in not fully controlled stable asthma patients. (J Respir Indo. 2019; 39(4): 231-7)
Hubungan Antara Status Kemoterapi , Jumlah Netrofil dengan IgM dan IgG Antimannan pada Pasien Kanker Paru yang Mengalami Kolonisasi Candida spp Iin Noor Chozin; Ungky Setyawan; Sastia Rakhma
Jurnal Klinik dan Riset Kesehatan Vol 1 No 2 (2022): Februari
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1446.317 KB) | DOI: 10.11594/jk-risk.01.2.3

Abstract

Latar Belakang: Diagnosis Candida spp yang menyebabkan kandidiasis pada pasien kanker paru masih sulit. Kondisi ini berhubungan dengan status immunocompromise pada pasien. Salah satu biomarker yang dapat membantu diagnosis adalah IgM dan IgG antimannan. Tujuan penelitian ini untuk menganalisis hubungan antara status kemoterapi, jumlah neutrophil absolut dengan IgM dan IgG antimannan. Metode: Design penelitian correlative analytic cross-sectional mengikutsertakan 37 pasien di ruang rawat inap RSUD Dr. Saiful Anwar Malang. Kriteria inklusi meliputi pasien berusia >18 tahun dengan kanker paru yang tegak secara patologi anatomi kanker paru bukan sel kecil maupun kanker paru sel kecil, kultur sputumnya tumbuh Candida spp dengan atau tanpa spesies jamur ataupun koloni bakteri. Kriteria eksklusi penelitian ini meliputi pasien kanker paru dengan infeksi HIV dan penyakit autoimun. Dari 37 pasien ada yang sudah menerima kemoterapi dan belum kemoterapi. Dilakukan pemeriksaan jumlah netrofil absolut dan antibodi antimannan IgM dan IgG. Data status kemoterapi, jumlah netrofil absolut dianalisis hubungannya dengan antibodi IgM dan IgG antimannan. Hasil: Hasil penelitian ini menunjukkan tidak ada korelasi antara status kemoterapi dengan kepositifan IgM antimannan (p=0.585;r=0.089) maupun IgG antimannan (p=0.124;r=0.245). Terdapat hubungan yang signifikan dengan arah positif dengan kekuatan cukup antara jumlah neutrophil absolut dengan antibodi IgM antimannan (p=0,042; r=0,362), namun tidak terdapat hubungan antara jumlah neutrophil absolut dengan antibodi IgG antimannan (p=0,094; r=0,277). Kesimpulan: Tidak terdapat hubungan antara status kemoterapi dengan IgM antimannan maupun IgG antimannan. Terdapat hubungan signifikan dengan kekuatan cukup, arah positif antara IgM antimannan dengan jumlah netrofil absolut, tetapi tidak ada hubungannya dengan IgG antimannan.
The Role of Chemotherapy Status, Absolute Lymphocyte Count and Neutrophil Lymphocyte Ratio as Biomarkers of Candidiasis in Lung Cancer Patients Muhamad Yusuf Musthafa; Iin Noor Chozin; Ungky Agus Setyawan; Teguh Wahyu Sardjono; Noorhamdani AS
Jurnal Respirologi Indonesia Vol 43, No 3 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i3.518

Abstract

Background: Gradually, fungal infections are growing and have become a medical concern. Candida species are one of the most common pathogens in immunocompromised patients, such as those with lung cancer causing invasive fungal disease. Early diagnosis of candidiasis is critical for patient care in lung cancer patients. Anti-mannan IgM and IgG biomarkers are used to diagnose candidiasis. This study aims to determine the relationship between chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio to antimannan IgM and IgG.Methods: A correlative analytic cross-sectional study was conducted on 37 lung cancer patients with positive candida sputum cultures in Dr. Saiful Anwar Malang Hospital. The 37 patients were examined for total lymphocyte level, neutrophil-lymphocyte ratio, anti-mannan IgM, and IgG. Data analysis used a contingency coefficient to determine the relationship between chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio to anti-mannan IgM and IgG.Results: This study showed a positive correlation between chemotherapy status with anti-mannan IgM and IgG, although insignificant (p>0.05). However, there was a significant correlation between total lymphocytes and anti-mannan IgG (p=0.000;α=0.05) and between neutrophil-lymphocyte ratio and antimannan IgM (p=0.004; α=0.05).Conclusion: The study revealed that chemotherapy status, absolute lymphocyte count, and neutrophil-lymphocyte ratio could be a biomarker of candidiasis, so lung cancer patients with a history of chemotherapy, lymphopenia, and increased neutrophil-lymphocyte ratio should consider receiving antifungals earlier. 
Co-Authors Aditya Sri Listyoko Harun Al Rasyid I Dewa Putu Ardana Mariyatul Khiptiyah Muhamad Yusuf Musthafa Noorhamdani AS Rahmad Rahmad Rakhmani, Alidha Nur Santony Santony Sastia Rakhma Setyawan, Ungky Agus Suryanti Dwi Pratiwi Susanthy Djajalaksana Teguh Rahayu Sartono Teguh Wahyu Sardjono Ungky Setyawan Yulia Kartina