Sita Laksmi Andarini
Universitas Indonesia

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Lung Diffusion Capacity of X Fighter Pilot in Madiun Ririn Astuty Ningsih; Faisal Yunus; Triya Damayanti; Flora Ekasari; Sita Laksmi Andarini; Dicky Soehardiman; Ratnawati Ratnawati; Fathiyah Isbaniah; Erlang Samoedro
Jurnal Respirologi Indonesia Vol 40, No 1 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1007.037 KB) | DOI: 10.36497/jri.v40i1.96

Abstract

Background: Pilot works in the high environment that exposed by G force. Increasing G force led to linear decreases in cardiac output and blood oxygenation of the brain. Thus, likely due to decreased lung gas exchange capacity in hypergravity. This study aims to investigate the pulmonary diffusing capacity test among Fighter pilots in Madiun. Methods: This study used cross sectional method conducted on February 2019 in Madiun. The total subjects consist of 44 Fighter pilots based on total sampling. Interview was done to fill out question about sociodemografic and smoking habit, flight hour data and physical fitness. Lung function measurement was done using portable spirometry and DLCO equipment (Easyone TM Pro Lab). Result: Spirometri result was found in the standard normal range in 41 subjects (93,2%) only 3 subject (6,8%) get obstruction abnormalities and none of them get restriction result. Average VEP1 prediction was 103,3±10,60 % and median range for VEP1/KVP was 84,5(63,5-92,5) %. Lung diffusion capacity measurement was found to be normal in 41 subject (93,2%) and to be deficient in 3 subject (6,8%) in smoker. Conclusion: This study demosntrated that diffusion capacity and spirometry test in Fighter pilots generally in normal range. Lung diffusion capacity has no association with age, BMI, flight hour, physical fitness, Brinkman index and spirometry parameters. (J Respir Indo. 2020; 40(1): 39-47)
Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta Astari Pranindya Sari; Ratnawati Ratnawati; Wahju Aniwidyaningsih; Sita Laksmi Andarini; Faisal Yunus
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.38

Abstract

Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status. Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed. Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation. Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.
Surfactant Protein D Level in Cement Workers Nurlinah Jalil; Sita Laksmi Andarini; Muhammad Ilyas; Feni Fitriani Taufik
Jurnal Respirologi Indonesia Vol 42, No 3 (2022)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v42i3.280

Abstract

Background: Pneumoconiosis occurs almost all in entire worldwide. Pneumoconiosis had threatened cement workers. Serologic abnormalities had found in pneumoconiosis. Surfactant Protein D (SP-D) levels increased in silica exposed workers. Surfactant Protein D (SP-D) may be useful biomarkers for early diagnosis of pneumoconiosis but it has not yet been studied in Indonesia.Method: This is a cross-sectional study and was done by consecutive sampling. The total subject was 61, consisting of 44 cement exposed workers and 17 control from September 2017–March 2018. Serum level of SP-D was measured by ELISA method. Cement exposed workers are a worker in the production area in workers in quarry areas.Results: This study found that total characteristic subjects were male 100% and mean of age was 42.5 years old, the youngest and oldest subject was 21 and 55 years old, respectively. Normal weight group's greatest number was found in 21 subjects (47.7%), followed by overweight 12 subjects (22.3%), obese 8 subjects (18.2%), and underweight 1 subject (2.3%). Based on a history of smoking, this study found that 26 subjects (59.1%) had never smoked, 12 subjects (27.3%) as smokers, and 6 subjects (13.6%) as former smokers. Duration of exposure <10 years was found in 9 subjects (20.5%) and duration of exposure ≥10 years was found in 35 subjects (79.5%) with using self-respiratory safety instrument as good categorical 5 subjects (11.4%), moderate categorical 36 subjects (81.8%) and poor in quality categorical 3 subjects were found (6.8%). Mean of serum SP-D levels in exposed group was found that 111.027 ng/ml and mean of serum SP-D levels in control group was found that 67.648 ng/ml. Levels of serum SP-D were significantly higher in exposed group than control group (p-value=0.014).Conclusion: Comparison serum SP-D levels between exposed group and control group statistically higher in exposed group than control group.