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Erna Kristiani
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Characteristic of Central Nervous System Tumours from 2011-2015: A Single Institution Study Febrihardita Dwinovitch; Nadya Aisyah Widowati; Erna Kristiani
Medicinus Vol 6, No 2 (2017): February 2017 - May 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i2.1142

Abstract

Background: Central nervous system (CNS) tumours affect the quality of life of patients since its neurological deficits. Data from Globocan 2012 reveals that there are 256,000 cases of CNS tumour. Epidemiology of the CNS tumours is very important for diagnosis and treatment, but data in Indonesia is still not fully reported.Objective: The aim of this study was to determine the exact amount of the incidence, histologic type of the tumour and the characteristic of patient in our institution.Methods: This is an observational study, all pathology report of CNS tumours that underwent surgery at Siloam Hospitals Lippo Village from 2011 until 2015. We classified based on gender, age, location of the tumour, and the histologic type according to WHO Classification of CNS tumour 2007.Results and Discussion: There were 913 patients of CNS tumours from 2011 until 2015. The most common tumours were meningioma (32.96%) followed by glioma (21.35%) and pituitary adenoma (16.10%). In meningioma, most occur in women, 41 - 50 years old, located in the frontal region and the most common subtype is transitional meningioma. In glioma, most occur in men, 31 - 40 years old, located in the frontal region and the most common subtype is glioblastoma. In adenoma hipofisis, most occur in men, 41 - 50 years old.Conclusion: The result of this study was accordance with the literature so this data could be a reference for further research.
GAMBARAN KLINIKOPATOLOGIK ASTROSITOMA HIGH GRADE Erna Kristiani
Medicinus Vol 4, No 9 (2015): June 2015 - September 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i9.1190

Abstract

Astrositoma merupakan glioma tersering. Tumor ini bisa mengenaiĀ  dewasa dan anak-anak.World Health Organization (WHO) mengelompokkan astrositoma menjadi 4 grade berdasarkan karakteristik histologik. Astrositoma high grade terdiri atas astrositoma anaplastik (grade III) dan glioblastoma (grade IV).Data Departemen Patologi Anatomik Rumah Sakit Cipto Mangunkusumo (RSCM) tahun 2001-2010 melaporkan kejadian astrositoma sebanyak 179 kasus atau sekitar 20% dari seluruh tumor intrakranial, astrositoma anaplastik ditemukan sebanyak 12 kasus, danĀ  glioblastoma 42 kasus.Seperti pada tumor otak lain, astrositoma high grade mengakibatkan gejala dan tanda gangguan neurologik fokal dan umum. Pemeriksaan radiologik pilihan adalah dengan Magnetic Resonance Imaging (MRI). Astrositoma anaplastik memberikan gambaran hypointense pada T1 dan hyperintense pada T2 dengan efek massa yang bervariasi. Karakteristik glioblastoma pada MRI berupa lesi iregular menyangat kontras di sekeliling nekrosis sentral (ring enhancement) dan edema vasogenik luas di sekitar tumor.Astrositoma anaplastik secara histopatologik dicirikan dengan atipia inti, peningkatan selularitas, serta aktivitas proliferasi yang nyata. Glioblastoma secara histopatologik serupa dengan astrositoma anaplastik, disertai adanya proliferasi vaskular dan/atau nekrosis. Astrositoma anaplastik dan khususnya glioblastoma mempunyai variasi gambaran histologik yang beragam, antara lain varian small cell, granular cell, giant cell, dan gliosarcoma.
BRAF V600E Immunoexpression in Papillary Thyroid Carcinoma and Its Association with Prognostic Factors and Histopathologic Variant Erna Kristiani; Endang SR Hardjolukito; Agnes S Harahap; Benyamin Makes
Medicinus Vol 8, No 1 (2020): February 2020 - May 2020
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v8i1.3120

Abstract

Aim: to provide additional information regarding the clinicopathological characteristics of Papillary Thyroid Carcinoma (PTC). Methods: Fifty patient with PTC were reviewed to determine prognostic factors such as age, gender, size of tumor and histologic variant. BRAF V600E mutation was detected by immunohistochemical staining and assessed with H score. Result: BRAF V600E mutations were detected in 17 (34%) cases. There were seven cases with extrathyroidal extension (ETE) p 0,04, 11 cases with lymph node metastasis (LNM) p < 0,001, and 8 cases with tall cell variant p 0,047.The cases with positive BRAF V600E mutation had mean age of 44.71 years, and the size of the tumor between 0.1-4cm. Six cases of them are male and 11 female.Conclusion: There were significant relationships between BRAF V600E mutation with ETE, LNM, and tall cell variant. There was no significant relationship between BRAF V600E mutation, either with age, gender, or size of the tumor. BRAF V600E immunohistochemical examination can be performed as additional investigation for PTC patients.
Peritoneal (Paraovarian) Malignant Mesothelioma Erna Kristiani; Stephanie Marisca
Medicinus Vol 6, No 3 (2017): June 2017 - September 2017
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v6i3.1149

Abstract

Peritoneal Malignant Mesothelioma (PMM) is uncommon disease, but increasing in frequency nowadays. This highly aggressive malignancy occurs most commonly in older men and has a strong association with asbestos exposure. It manifests most often as diffuse sheet-like or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. The very large variations of its clinical features and its histological appearance mimicking adenocarcinoma make this tumor is difficult to diagnose.We report a case of PMM that previously diagnose as adenocarcinoma of the ovary. A 29 year-old female came to gynecology clinic with para-ovarian mass. She had no history of asbestos exposure. The mass was oval 9x6x6 cm in size, whitish and firm. Microscopic features showed papillary dense structure with desmoplastic stroma, covered by a layer of cuboidal to columnar cells. The cells with mild pleomorphism and hyperchromatic nuclei, mitotic figures were minimal. The immunohistochemistry tests revealed positive for D2-40, Calretinin, CK8 and CK 18, weakly positive for Inhibin and EMA, and negative for CEA and AFP. Patient had been received chemotherapy, there were no metastasis.