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Novi I. Fauzi
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Medicine & Pharmacology

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Anti-Hyperglycemic Activity of Phyllanthus emblica Leaves and Bark in Alloxan-Induced Diabetic Rats Maria Ulfah; Novi I. Fauzi; Nela Simanjuntak; Anastasia Sinuraya
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.403 KB) | DOI: 10.15416/pcpr.v4i2.24524

Abstract

Phyllanthus emblica is empirically used to treat various diseases. Chemical compounds in this plant includes benzene derivatives, diterpen and monoterpen, furanolacton, flavonoids and sterols. The purpose of this research is to investigate anti-hyperglycemic activity of P. emblica. The diabetic animal model was obtained by administration of alloxan 120 mg/kg BW intraperitonial. The rats were divided into 9 groups, i.e., normal group, negative control (1% CMC), positive control (glibenclamide 0.5 mg/kg BW) and P. emblica leaves and bark ethanol extract at the dose of 500, 750, and 1000 mg/kg BW. Determination of flavonoid content was performed through colorimetric method using UV-Vis spectrophotometer at 425 nm. After 7 days of induction, the entire group was treated for 21 days, fasting blood glucose was performed on days 0, 1, 8, 15 and 22. Then the data of fasting blood glucose level in mice was treated with one way ANOVA analysis and advanced test with post hoc Least Significant Differences (LSD) method. The percentage of the blood glucose decrease from the animal treated with leaves extract at doses of 500, 750 and 1000 mg/kg BW, respectively, were 22.47%; 21.03%; and 24.52%, while those of bark extract were 32.19%; 31.61%; and 37.24%, respectively. Determination of total flavonoid level showed that the highest amount of flavonoids was observed in leaves (35.838 mg/g Quercetin). In conclusion, P. emblica bark and leaves showed anti-hyperglycemic activity.  Keywords: anti-hyperglycemic,  alloxan, Phyllanthus emblica, Wistar 
In Vitro Inhibition of α-Amylase and α-Glucosidase by Different Parts of Amla Plant (Phyllanthus emblica L) Novi I. Fauzi; Maria Ulfah; Syarif Hamdani; Saeful Hidayat
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.883 KB) | DOI: 10.15416/pcpr.v3i3.19980

Abstract

Amla plant (Phyllanthus emblica L) has been empirically used to treat diabetes. The aim of this study was to determine the most potential part of amla plant that can be used as α-glucosidase and α-amylase inhibitors. The fruit was subjected to cold extraction method, while the stem underwent soxhlet extraction process. Ethanol was used as solvent for both extracts. In-vitro inhibiton against α-glucosidase and α-amylase enzyme was measured by calculating IC50 of water fractions of stem and fruits. Fruit fraction exhibited the highest percentage of inhibitory activity on α-amylase (IC50=5.68% w/v), while the strongest inhibition against α-glucosidase was shown by leaves fraction (IC50=0.87% w/v). In conclusion, the stem of P. emblica L was potential inhibitor of α-amylase , while the leaves was potential α-glucosidase inhibitor.Keywords: Phyllanthus emblica, α-glucosidase inhibitor, α-amylase inhibitor, fruit, leaves
Co-Authors Anastasia Sinuraya Hamdani, Syarif Nela Simanjuntak Saeful Hidayat TATI NURHAYATI