Lukmantya Lukmantya
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Kadar reseptor glukokortikoid α dan β pada polip hidung tipe eosinofilik dan tipe neutrofilik Moch Mundir Arif; Rus Suheryanto; Lukmantya Lukmantya; Kenty Wantri Anita
Oto Rhino Laryngologica Indonesiana Vol 44, No 2 (2014): Volume 44, No. 2 July - December 2014
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (631.345 KB) | DOI: 10.32637/orli.v44i2.92

Abstract

Latar Belakang: Penatalaksanaan polip hidung banyak didasarkan pada tipe histopatologinya. Polip hidung tipe eosinofilik lebih sensitif terhadap pemberian kortikosteroid sedang tipe neutrofilik lebih resisten. Hasil pengobatan dengan kortikosteroid juga dipengaruhi oleh reseptor glukokortikoid (GR). Kadar reseptor glukokortikoid β yang tinggi  akan lebih resisten dibanding yang rendah. Rasio kadar reseptor glukokortikoid α dan β lebih berperan karena GR β bekerja menghambat GR α. Tujuan: Penelitian ini bertujuan mengetahui hubungan kadar reseptor glukokortikoid α dan β pada polip hidung tipe eosinofilik dan tipe neutrofilik. Metode: Penelitian observasional analitik dengan desain crosssectional. Hasil: Penelitian inimelibatkan 20 penderita polip hidung yang dilakukan biopsi atau operasi. Hasil biopsi atau operasi diperiksa jenis histopatologinya dan dihitung kadar reseptor glukokortikoid α dan β dengan pemeriksaan imunohistokimia. Data penelitian dianalisa dengan uji sampel t tidak berpasangan. Kadar reseptor glukokortikoid α pada polip hidung tipe eosinofilik didapatkan sama dengantipe neutrofilik. Kadar reseptor glukokortikoid β didapatkan lebih tinggi secara bermakna pada polip hidung tipe neutrofilik dibanding tipe eosinofilik. Rasio kadar GRα/GRβ lebih tinggi pada polip hidung tipe eosinofilik dibanding tipe eosinofilik tetapi perbedaannya tidak bermakna. Kesimpulan: penelitian ini kadar reseptor β lebih tinggi pada polip tipe neutrofilik dengan rasio kadar GRα/GRβ lebih tinggi pada polip hidung tipe eosinofilik. Penelitian lebih lanjut diperlukan menghitung kadar reseptor glukokortikoid α dan β lebih akurat dengan menggunakan teknik ELISA (RT-PCR).Kata kunci: Tipe polip hidung, reseptor glukokortikoid, imunohistokimia.ABSTRACTIntroduction: Management of nasal polyps is commonly based on its histopathologic type. Eosinophilic nasal polyps are more sensitive to corticosteroid administration, where as neutrophilic types are more resistant. Results of treatment with corticosteroid were also influenced by glucocorticoid receptor. Higher β Glucocorticoid Receptor (β GR) concentration render more resistency compared with lower one. Ratio of α and β GR was more meaningful because β GR acts to inhibit α GR. Purpose: This study aims todetermine relationship between α and β GR concentration in eosinophilic and neutrophilic nasal polyps. Methods: This is an observational analytic study with cross sectional design. Result: This study involves 20 patients with nasal polyp who underwent biopsy or operation. The biopsy or operation specimenswere then evaluated for its histopathologic type. The concentration of α and β GR was counted by immunohistochemistry. Data was analyzed with unpaired T-test. Concentration of α GR in eosinophilic nasal polyps was similar with neutrophilic type. Concentration of β GR in neutrophilic nasal polyps was significantly higher compared with neutrophilic type. Ratio of α GR/β GR concentration was higher in eosinophilic nasal polyps than eosinophilic, but insignificant. Conclusion: β GR concentration is higher in neutrophilic nasal polyps and ratio of α GR/β GR concentration is higher in eosinophilic nasal polyps. Further study is required to count α GR and β GR concentration more accurately using ELISA (RT-PCR).Keywords: Nasal polyps types, glucocorticoids receptors, immunohistochemistry.
Pengaruh kedalaman dan lama menyelam terhadap ambang-dengar penyelam tradisional dengan barotrauma telinga Arief Tjatur Prasetyo; Joseph Bambang Soemantri; Lukmantya Lukmantya
Oto Rhino Laryngologica Indonesiana Vol 42, No 2 (2012): Volume 42, No. 2 July - December 2012
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.957 KB) | DOI: 10.32637/orli.v42i2.21

Abstract

Background: Ear barotrauma is ear tissue damage resulted by the inability to equalize pressure in the middle ear space with the ambient pressure. The greatest relative change in pressure during diving,is near the surface. Ear barotrauma can occur when diving done without equalizing middle ear pressurewith proper procedures. Recurrent ear barotrauma in a long time period can use damage of elastic fibersrecoiling capacity of the tympanic membrane to be irreversible, so it can cause hearing loss. Suddenpressure changes in middle ear space, can be forwarded to the inner ear so it can cause inner eardamage, even deafness. Purpose: This study aims to determine the effect of depth and diving durationto hearing threshold in the traditional divers (divers with diving air compressor tools), who experienced ear barotrauma, and to know the incidence of ear barotrauma. Method: This was an observational analytic study with cross sectional data collection. Data analysis used the cross table, ChiSquare(X2), Spearman correlation and logistic regression test. Result: On October 8 - December 18, 2011 has been conducted a study in traditional divers. 24 samples from 74 population were found. 50 persons with noear barotrauma founds no significant statistic differences with characteristic samples. The results ofChi - Square and Spearman correlationthe showed p=0.350, p=0.382 and p=0.372, p=0.281, which are>a(0.05). The result of logistic regression test showed significancy values were 0.771 and 0.610, whichwere >a(0.05). Ear barotrauma incidence is 32.4%. Conclusion: There is no significant effect of depthand duration of diving to hearing threshold in the traditional divers who experienced ear barotrauma.Ear barotrauma incidence is 32.4%. Keywords:  ear barotrauma, diving depth, diving duration, hearing threshold. Abstrak :  Latar belakang: Barotrauma telinga adalah kerusakan jaringan telinga akibat ketidak-mampuanmenyamakan tekanan ruang telinga tengah dengan lingkungan. Perubahan tekanan relatif terbesar selamamenyelam terdapat di dekat permukaan. Barotrauma telinga dapat terjadi apabila penyelaman tanpamelaksanakan ekualisasi tekanan telinga tengah dengan cara yang benar. Barotrauma telinga berulangdalam periode lama dapat menyebabkan gangguan kapasitas recoiling serabut elastis membran timpanimenjadi irreversible, sehingga dapat menyebabkan gangguan pendengaran. Perubahan tekanan mendadakdi ruang telinga tengah dapat diteruskan ke telinga dalam sehingga dapat menyebabkan kerusakan telingadalam, bahkan ketulian. Tujuan: Mengetahui pengaruh kedalaman dan lama menyelam terhadap perubahanpendengaran pada penyelam tradisional (penyelam dengan alat bantu selam kompresor udara) yangmengalami barotrauma telinga, serta angka kejadian barotrauma telinga. Metode: Merupakan penelitianobservasional analitik, dengan pengambilan data secara cross sectional. Analisis data menggunakan tabelsilang, uji Chi-Square (X), korelasi Spearman dan regresi logistik. Hasil: Pada Oktober - Desember 2011telah dilakukan penelitian pada penyelam tradisional. Didapatkan 24 sampel dari 74 populasi. Terdapat50 orang tidak mengalami barotrauma telinga, yang tidak terdapat perbedaan statistik signifikan dengankarakteristik sampel. Hasil uji Chi-Square dan korelasi Spearman menunjukkan nilai p=0,350, p=0,382, danp=0,372, p=0,281, yang >a(0,05). Uji regresi logistik menunjukan nilai signifikansi 0,771 dan 0,610, yang>a(0,05). Angka kejadian barotrauma telinga sebesar 32,4%. Kesimpulan: Tidak terdapat pengaruh yangsignifikan kedalaman dan lama menyelam terhadap perubahan pendengaran pada penyelam tradisionalyang mengalami barotrauma telinga. Angka kejadian barotrauma telinga sebesar 32,4%.2 Kata kunci: barotrauma telinga, kedalaman menyelam, lama menyelam, ambang dengar