Ferry Safriadi
Sub Bagian Urologi, FK Universitas Padjadjaran/RS. Hasan Sadikin. Jl. Pasteur No. 38 Bandung.

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PENILE CANCER: A STUDY OF 9 CASES AT HASAN SADIKIN HOSPITAL BANDUNG BETWEEN JANUARY 2010 AND DECEMBER 2015 Firmansyah, Irfan; Safriadi, Ferry
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.468

Abstract

Objective: Penile cancer are the rarest carcinoma of the genitourinary system that are often devastating for the patient and frequently diagnostically and therapeutically challenging for the Urologist. In view of this, it would be interesting to study the incidence, demographics, presentation, and treatment of the patients. The aim of this study was to report the status of penile cancer at Hasan Sadikin Hospital Bandung. Material & Methods: This was a retrospective study of 9 patients. We study the incidence, demographics, presentation, and treatment of the patients at Hasan Sadikin Hospital Bandung between January 2010 and December 2015. Results: The mean age of the patients was 50.44 ± 12.09 years old. All patients had squamous cell carcinoma. Five patients underwent partial penectomy, 4 patients underwent total penectomy and perineostomy for urinary diversion. Four patients had lymph node localization. A Superficial lymph node dissection was performed in two patients. One of our patient was referred to hemato-oncologist for chemotherapy. Conclusion: Penile cancer seems rare in our hospital. General public should be educated about genital hygiene and early circumcision in male infant as a prophylactic measure. An understanding of the various operative procedures for treatment of the primary tumor and regional lymph nodes is therefore critical in the successful management of this condition.
THE INDONESIAN LINGUISTIC VALIDATION OF THE URETERAL STENT SYMPTOMS QUESTIONNAIRE Tansol, Christiano; Noegroho, Bambang Sasongko; Safriadi, Ferry; Sani, Wildan
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.454

Abstract

Objective: To validate the Indonesian version of the ureteral stent symptoms questionnaire (USSQ) for patients with indwelling ureteral stents. Material & Methods: The Indonesian version of the USSQ was developed following a well-established multistep process by two urologists and two independent translators. A total of 38 patients with indwelling temporary unilateral ureteral stents completed the Indonesian USSQ. Patients completed questionnaires at 1 week after stent insertion and 1 week after stent removal. The reliability of the Indonesian version was evaluated for internal consistency using Cronbach’s alpha test. Domain structures were examined by interdomain (section) associations using Spearman’s correlation coefficient (r). Sensitivity to change of each domain was assessed using Wilcoxon test. Results: Urinary, pain, general health, work performance and additional problem showed good internal consistency whereas sexual problem and global quality of life displayed low consistency. There were strong correlations of urinary symptoms with body pain (r=0.633) and general health (r=0.686), moderate correlation with work performance. In addition there was also strong correlation between body pain and general health (r=0.723). Sensitivity to change were significant to all domain except sexual matters domain. (p<0.001). Conclusion: The Indonesian USSQ is reliable and can be utilize as a tool to investigate symptoms and to assess quality of life related issues due to ureteral stents in Indonesian patient.
METASTASIS AND LOCAL INVASION PATTERN OF BLADDER CANCER IN HASAN SADIKIN HOSPITAL Mustafa, Akhmad; Safriadi, Ferry
Indonesian Journal of Urology Vol 25 No 2 (2018)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v25i2.428

Abstract

Objective: The aim of this study is to provide database about local invasion and metastasis pattern, as well as the disease characteristics of bladder cancer in Hasan Sadikin Hospital, Bandung. Material & Methods: Between January 2011 and December 2016 there were 321 cases of bladder cancer recorded in our hospital. Of all cases, 106 patients included in this study, with evident of local invasion or distant metastasis either radiologically (contrast abdominal pelvic CT scan) or pathologically. Results: The study group consist of 106 patients (86 men [81.7%], 20 women [28.3%]); with mean age of 56.78 ± 13.19 (4-76) years old. Histopathology findings of transitional cell carcinoma (TCC) consist of 82 (77.3%) patients and the atypical histology features group of 24 (22.7%) patients. Local invasion was found in 99 patients of 321 (30.8%), with the most common organ invasion to the prostate in male (n=38 [35.8%]). Lymph node metastasis were found in 47 patients (44.3%), with the most common nodal metastasis to obturator lymph nodes (n=21 [19.8%]). Distant metastasis was found in 24 patients (22.6%) with the most common site for distant metastasis was the liver (n=12 [11.3%]). In TCC group, 12 patients (63.1%) had a distant organ metastasis with nodal metastasis, whereas in atypical group, majority of the patients with distant organ metastasis (n=5 [83.3%]) had no lymph node involvement. Moreover, in transitional cell group, not all patient (n=17 [73.1%]) had local invasion of the tumor, while all patients with distant organ metastasis in atypical group (n=6 [100%]) had abdominal or pelvic wall invasion (cT4b). Conclusion: TCC is the most common pathology findings and with Prostate is the most common site for local tumor invasion. Obturator lymph nodes is the most common nodal metastasis and liver is the most common site for distant metastasis in bladder cancer. 
Prostatektomi Radikal: Morbiditas dan Mortalitas di RSUP dr. Hasan Sadikin, Bandung Safriadi, Ferry
Indonesian Journal of Cancer Vol 7, No 1 (2013): Jan - Mar 2013
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.169 KB)

Abstract

Kanker prostat merupakan salah satu jenis keganasan tersering pada pria. Prostatektomi radikal merupakan terapi pilihan pada kanker prostat yang masih organ confined. Tindakan ini merupakan tindakan operatif dengan derajat kesulitan tinggi, sehingga risiko morbiditas atau mortalitas harus menjadi perhatian. Tujuan penelitian ini adalah mengevaluasi morbiditas, mortalitas pasien, dan faktor yang berperan.Penelitian ini dilakukan secara retrospektif dengan mengumpulkan data dari rekam medis dan status khusus pasien kanker prostat yang telah menjalani operasi prostatektomi radikal dari 2005 sampai 2011 di RS Hasan Sadikin. Analisis univariat dilakukan dengan Chi-square untuk menilai faktor yang berperan terhadap morbiditas dan mortalitas.Sebanyak 90 pasien sebagai subjek penelitian. Usia rerata subjek 62,99 + 5,32 tahun, nilai PSA 31,89 + 29,13 ng/ml, volume prostat 53,24 + 29,13 ml, skor Gleason paling banyak ditemukan pada rentang 2-6 sebesar 58,9%. Rerata lama operasi 236,74 + 89,78 menit dengan jumlah perdarahan sebanyak 874,22 + 573,46 ml dan transfusi 318,11 ml.Morbiditas mayor ditemukan pada 8 kasus (0,08%); 6 kasus termasuk klasifikasi modikasi Clavien derajat 3 dan 2 kasus derajat 5. Analisis statistik tidak menunjukkan adanya kaitan antara usia, PSA, volume prostat, skor Gleason, dan stadium T terhadap terjadinya morbiditas dan mortalitas.Kesimpulannya, morbiditas pada penelitian ini sebesar 0,06% dan mortalitas 0,02%. Faktor usia, PSA, volume prostat, skor Gleason, dan stadium T tidak bermakna secara statistik. Penapisan pra-operasi yang baik akan mencegah terjadinya morbiditas dan mortalitas, selain faktor pengalaman operator.Kata kunci: kanker prostat, prostatektomi radikal, morbiditas, mortalitas.
Penanganan Metastasis Tulang dan Bone Loss pada Penderita Kanker Prostat SAFRIADI, FERRY
Indonesian Journal of Cancer Vol 6, No 3 (2012): Jul - Sep 2012
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.115 KB)

Abstract

Kanker prostat merupakan keganasan non-kulit terbanyak di negara barat atau keganasan keempat terbanyak pada pria setelah kanker kulit, paru, dan usus besar.Di negara maju, stadium awal ditemukan pada 75% penderita. Di Rumah Sakit Hasan Sadikin, Bandung, pada periode 2004-2010 ditemukan 57% kasus masih terbatas di organ dan locally advanced. Sedangkan sisanya, 43% termasuk stadium lanjut dari 320 kasus kanker prostat.Kanker prostat adalah keganasan di bidang urologi yang paling sering bermetastasis ke tulang sampai 70% kasus. Penyulitnya berupa nyeri hebat, fraktur patologis, sindrom kompresi tulang belakang, dan hiperkalsemia. Insidensi penyulit sekitar 46,1% mengakibatkan peningkatan biaya perawatan dan memperburuk prognosis pasien.Androgen Deprivation Therapy merupakan terapi kanker prostat yang telah bermetastasis. Terapi ini sendiri menyebabkan osteopenia atau osteoporosis.Bifosfonat merupakan obat yang paling banyak dipakai saat ini untuk terapi metastasis tulang. Bifosfonat menghambat secara langsung aktivitas osteoclast dan secara tidak langsung melalui osteoblast. Denosumab merupakan opsi terapi terkini pada kasus metastasis tulang dan lebih baik dari asam zoledronat.Kata kunci: kanker prostat, metastasis tulang, bone loss, terapi.
PROSTATE CANCER RISK CALCULATOR COMPARISON: IPCRC vs KPCRC vs PCPT-RC vs ERSPC-RC IN PREDICTING PROSTATE CANCER AT HASAN SADIKIN HOSPITAL Tansol, Christiano; Safriadi, Ferry
Indonesian Journal of Urology Vol 24 No 2 (2017)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v24i2.368

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Objective: To compare the validated calculators of Indonesian Prostate Cancer Risk Calculator  (IPCRC) vs Korean Prostate Cancer Risk Calculator (KPCRC) vs Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) vs European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in predicting prostate cancer in our patients at Hasan Sadikin Hospital Bandung. Material & methods: This study is a prospective study conducted from August 2014 – December 2015 at Urology Clinic at Hasan Sadikin Hospital that included all patients with BPH or suspected PCa who have been undergoing prostate biopsy. Variables such as age, PSA level, prostate volume (transabdominal or transrectal ultrasound) and digital rectal examination (DRE) finding were recorded. Risk calculation was generated using each risk calculator. Data were analyzed using Chi-square analysis, Kolmogorov-Smirnov, and finally receiver operating characterisitic (ROC) curve. All statistical analyses were performed with SPSS version 20.  Results: There were 89 BPH and 43 PCa patients between August 2014 – December 2015. The mean age, PSA and prostate volume are 65.78 ± 8.33 years; 121.16 ± 375.76ng/ml; 55.86 ± 31.9ml respectively. Abnormal DRE was found in 27 PCas and 4 BPHs. Receiver operator curve analysis of IPCRC showed AUC 0.861 vs KPCRC (AUC=0.779) vs ERSPC-RC (AUC=0.745) vs PCPT-RC (AUC=0.794) vs PSA (AUC 0.794), sensitivity 81.4% and specificity 71.9% with cut-off point 19.67 for the IPCRC in predicting the prostate cancer in our center. Conclusion: IPCRC is better than KPCRC, PCPT-RC and ERSPC-RC in predicting prostate cancer in our center.
ULTRASONOGRAFI UNTUK PREDIKSI LASERASI PARENKIM GINJAL DAN HEMATOMA PERIRENAL PADA PASIEN TRAUMA TUMPUL ABDOMEN DENGAN KECURIGAAN TRAUMA GINJAL Richata, Galuh; Sugandi, Suwandi; Haroen, Zulhardi; E, Mumuh M; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati; Safriadi, Ferry
Indonesian Journal of Urology Vol 15 No 1 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i1.366

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Objective: To evaluate the sensitivity and the specificity of the ultrasound in predicting renal parenchyma laceration and perirenal hematoma in patients with abdominal blunt trauma with suspicion of renal trauma, as confirmed by operative findings in the explorative laparotomy. Material & methods: From March 2005 to March 2006, we found 28 patients admitted to the emergency department with abdominal blunt trauma with suspicion of renal trauma. Every patient was scanned sonografically to detect the presence of the renal parenchyma laceration and perirenal hematoma. All those patients underwent laparotomy for any certain indication, but not because of ultrasound findings. The ultrasound findings then were checked with the operative findings. Results: The sensitivity of the ultrasound in predicting renal parenchyma laceration is 53.8%, while its sensitivity in predicting perirenal hematoma is 75%. The specificity of ultrasound in predicting both renal parenchyma laceration and perirenal hematoma is 100%. Conclusion: Ultrasound for kidney trauma is sensitive in predicting the presence of perirenal hematoma, but not sensitive in predicting the presence of a renal parenchyma laceration. Ultrasound is very specific in predicting if both perirenal hematoma and renal parenchyma laceration are present.
PENGETAHUAN, TINGKAH LAKU, DAN TINDAKAN KLINIS DOKTER UMUM PADA PENATALAKSANAAN BPH Adi, Kuncoro; Safriadi, Ferry; Sugandi, Suwandi; Haroen, Zulhardi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati
Indonesian Journal of Urology Vol 15 No 1 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i1.362

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Objective: To evaluate the Primary Care Physician’s (PCPs) knowledge, attitude and clinical behavior in managing patients with BPH, as an input in the review of BPH guideline of Indonesian Urology Association. Material & method: The mailing included a cover letter, questioner consist of 10 questions survey, survey instrument and a post-paid envelope. A 10-questions survey were validated according to BPH guideline by Indonesian Urology Association (IUA). PCPs who work in district health offices and registered in district health office of Indonesian Health Ministry in Bandung, were selected as respondents. Results: 75% of sampled primary care physician working in 71 district health offices responded. 83% of respondent did not know the BPH guideline that had been published by Indonesian Urology Association. Although 88% of PCP’s knew about the symptoms of BPH, only 32% heard about of International Prostate Symptoms score. However, only 13 % were reported applying the symptoms score. Regarding to mandatory examination by the guideline, 64% of PCPs reported performing digital rectal examination, and 47% reported ordering urinalysis test. The recommended test such as PSA and serum creatinine level only asked 24% and 60% by PCPs. Only 21% of PCPs knew about the uroflowmetry but never ordering the test. 47% of PCPs reported using α blockers and 2% using finasteride for treating BPH. The referral was conducted by PCPs mostly due to urinary retention and hematuria. 70% of PCPs would refer the patients to urologist and the others to general surgeon and general internist. Conclusion: Although PCPs play role up to certain extent in diagnosing and managing of BPH, most of them are not interested in looking for reference.
LITOTRIPSI LASER HOLMIUM YAG UNTUK TERAPI BATU URETER Adi, Kuncoro; Safriadi, Ferry; Sugandi, Suwandi; Haroen, Zulhardi; Noegroho, Bambang S; Tjahjodjati, Tjahjodjati
Indonesian Journal of Urology Vol 15 No 2 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i2.352

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Objective: To assess the efficacy of pulsed holmium:YAG laser lithotripsy for ureteral stone therapy. Material and method: Ninety-one patients (70 males and 21 females) with age range 20 – 76 years underwent 93 ureteroscopic procedures for 101 ureteral stones. A preoperative diagnosis was established by ultrasound scanning and intravenous urography. An 8 F rigid Karl-Storz ureteroscope was used for a holmium:YAG laser (OmniPulse MaxTM 80 watt Holmium Laser System Model 1210-VHP, Trimedyne,Inc. Irvine CA, USA) as energy source for laser lithotripsy. The stone localization was mostly at the lower third of the ureter. The mean stone size was 9,6 mm, mean duration of procedure was 48,1 minutes, and the mean hospital stay was 2,1 days. Results: The overall stone clearance rate was 95,6% with the best results for stones in the middle third of the ureter (100%). At follow up we noted two patients with residual stones and two patients with a perforation of the ureteral wall. Conclusion: The Holmium:YAG laser is effective for ureteral stone treatment with a high success rate. Special attention and care should be afforded in impacted ureteral stones. 
ESTROGEN EFFECT ON WISTAR'S VAGINAL EPITHELIUM Surur, Abu; Sugandi, Suwandi; Haroen, Zulhardi; Noegroho, Bambang S; Tjahjodjati, Tjahdjojati; Safriadi, Ferry; Siregar, Safendra; Adriansjah, Ricky; Adi, Kuncoro; Hernowo, Betthy S
Indonesian Journal of Urology Vol 17 No 2 (2010)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v17i2.349

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Objective: To evaluate the effect of estrogen on wistar’s vaginal epithelium. Material & method: We divided 30 female wistars into three groups, ten wistars underwent bilateral ovariectomy, 10 wistars underwent bilateral ovariectomy, and estrogen replacement and 10 wistars as control. The second group received estradiol 1 mg/kg/day, directly after ovariectomy. After 4 weeks the vagina was then harvested and stained with hematoxylin-eosin to evaluate the thickness of epithelial layer of vagina. A pair T-test was use for statistical analysis. Results: Estrogen ablation decreased the thickness of epithelial layer in wistar’s vagina. The mean thickness of epithelial layer in vagina were 3, 5, and 10 for each group respectively. The mean epithelial layer of the first group as well as the second group showed significant difference compared to control group (p>0,05), while the first group showed insignificant difference compared to the second group. Conclusion: Estrogen ablation seems to decrease the thickness of vaginal epithelium, while estrogen replacement revealed insignificant effect.