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All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Farmasi Indonesia Borneo Journal of Pharmacy PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA

Sondang Khairani

Universitas Pancasila

Author-ID : 3682470

Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Articles

Efek Sari Buah Terong Belanda (Solanum betaceum Cav.) terhadap Perubahan Profil Lipid pada Mencit Dislipidemia Ni Made Dwi Sandhiutami; Sondang Khairani; Moordiani Moordiani; Ira Ningtiyas Purpranoto
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.10302

Buah terong belanda (Solanum betaceum Cav.) mengandung antosianin, isoflavon, karotenoid, serat, vitamin-vitamin seperti vitamin E, vitamin A, vitamin C dan vitamin B6, banyak digunakan secara empiris untuk tekanan darah tinggi, aterosklerosis, membantu metabolisme, meningkatkan imunitas, sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui efek perubahan profil lipid dari pemberian sari buah terong belanda terhadap mencit dislipidemia. Pengujian efek perubahan profil lipid dilakukan dengan cara mengiduksi mencit dengan pemberian kuning telur, sukrosa dan lemak hewan sehingga mencit mengalami dislipidemia. Setelah 14 hari, penginduksian dihentikan dan dilanjutkan dengan pemberiaan sediaan uji setiap hari selama 7 hari (i) kontrol positif (atorvastatin dosis 2,6 mg/kgBB), sari buah terong belanda (ii) dosis 14 g/kgBB, (iii) dosis 21 g/kgBB dan (iv) dosis 28 g/kgBB, (v) kontrol normal dan (vi) kontrol negatif. Pemeriksaan kadar kolesterol total, trigliserida, LDL dan HDL pada darah mencit dilakukan dengan metode kalorimetri enzimatik pada hari ke-0, ke-14, dan ke-21. Sari buah terong belanda dosis 14, 21, 28 g/kgBB dapat menurunkan kadar kolesterol total dengan persentase penurunan secara berturut-turut sebesar 21,08; 25,50; dan 29,94%. menurunkan kadar trigliserida sebesar 20,28; 31,69; dan 38,54%; menurunkan kadar LDL sebesar 28,43; 28,76; dan 42,83%; dan meningkatkan kadar HDL sebesar 16,67; 17,50; 30,13%. Sari buah terong belanda dengan dosis 28 g/kgBB perhari efektif menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan kadar HDL mencit dislipidemia.

Pengaruh Pemberian Aspartam secara Oral terhadap Kadar AST dan ALT Serum serta Gambaran Histopatologi Hati Tikus Putih Ros Sumarny; Sondang Khairani; Mohamad Rega Satria Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Aspartame is low calorie sweetener metabolized into aspartic acid, phenylalanine and methanol, methanol cause damage to the liver. The purpose this study to determine the effect rats of oral aspartame administration for 90 days on biochemical parameters AST, ALT and liver histopathology. Rats were divided randomly into four groups: normal control, dose groups 126, 252, 504 mg/kgBW. Blood samples were taken on the 0th, 30th, 60th and 90th days to measure AST, ALT levels and 90th day to see liver histopathology. AST and ALT measurements using UV-VIS spectrophotometry with a wavelength of 340 nm. The levels of AST and ALT on the 90th day in the normal group 41,55 and 48,40 UI/L. Dose groups 126, 252, and 504 mg / kgBW were low doses 54,62 and 57,72 UI/L, 66,88 and 70,47 UI/L, 77,50 and 80,03 UI/L. Rats histopathology liver of aspartame showed hemorrhage. Concluded aspartame can increase of AST and ALT levels in rats blood serum and liver damage.

Evaluasi Switch Therapy Antibiotik pada Pasien Pneumonia di RSUP Dr. M. Djamil Padang Sondang Khairani S.Farm., M.Farm., Apt
Jurnal Penelitian Farmasi Indonesia Vol. 4 No. 2 (2015): jpfi
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.285 KB)

The ideal route of administration for any medication is one that achieves serum concentration sufficient to produce the desired effect withoutproducing undesired effect. Patients may be concidered candidates for switching from intravenous to oral therapy once the patient has shown clinicalimprovement and is medically stable. Purpose of this study is the evaluation of selection antibiotics and timeliness to switch therapyfrom iv to oralantibiotics therapy.A prospective observation study, data were collected from all hospitalized patients with community-acquired pneumonia at internal medicinedepartment and respiratory care department at Dr. M. Djamil Public Hospital in Padang Indonesia from September until November 2013receivedantibioticswitchtherapy. Objective criteria were used to define time to switch therapy. Result showed, 49 patients fulfill inclusive criteria in thisresearch, 41 patients from internal medicine department and 8 patients from respiratory care department. All use ceftriaxone intravena, but 32 (65%)patients wrong in switched to oral therapy antibiotics, where 23 to cefixime, 7 to azithromycin, 1 to cefadroxyl and 1 to amoxcillin + clavulanic acid.Only 17 patients (35%) with prompt conversion of intravena antibiotic therapy to oral, 12 to ciprofloxacin and 5 to levofloxacin, only 12 patients rightin time to conversion intravena to oral antibiotics, with time to switch therapy was the fifth days. 49 patients have been discharged in goodconditionand doctor's approval.

Evaluasi Efek Samping OBat Kemoterapi terhadap Quality of Life (QOL) Pasien Kanker Payudara di Rumah Sakit X Jakarta Sondang Khairani; Sesilia A Keban; Meyke Afrianty
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Breast cancer is the number one cancer type discovered at women in the world. Most causes are genetic factors and hormonal factors. One cancer treatments with chemotherapy. Chemotherapy drugs active in cells dividing and reproducing, but cells normally to be affected by chemotherapy and side effects from chemotherapy drugs affect quality of life. The aim of the study to evaluate side effects of chemotherapy drugs on the quality of life of breast cancer patients. Sampling technique observational prospective breast cancer patients with completed the chemotherapy cycle from September 2017 to April 2018 with descriptive analysis and statistics by looking correlation between drug side effects and Quality of Life (QoL). Results of the study were side effects of fatigue 100%, nausea 67,5%, vomiting 60%, no appetite 63,75%, fever 42,5%, joint pain 43,75%, diarrhea 16,25%, difficulty swallowing 16,25%, allergies 5%, itching 1,25%, mouth sores 3,75%, swollen right hand 1,25%, constipation 3,75%. QoL results are physical 6,2%; psychology 5,3%; social 4,9%; spiritual 6,8%. Results of Sperman test showed no correlation between the side effects of chemotherapy and QoL P> 0,05. This study shows that there is no relationship between the side effects drug chemotherapy and QoL in breast cancer patients.

Edukasi dan Aplikasi Pengelolaan Sampah Berbasis Pemilahan Sampah di Lingkungan Fakultas Farmasi Universitas Pancasila Nurita Andayani; Esti Mulatsari; Moordiani Moordiani; Sondang Khairani; Gressty F Swandiny
Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 1 (2022): Februari 2022
Publisher : LPPM Universitas Bina Sarana Informatika

Fakultas Farmasi Universitas Pancasila (FFUP) merupakan salah satu fakultas yang ada di Universitas Pancasila yang memiliki jumlah mahasiswa cukup banyak. Selain itu, di Fakultas Farmasi Universitas Pancasila terdapat 9 kios kantin yang sehari-harinya melayani kebutuhan makanan dan minuman dari sivitas akademika FFUP serta fakultas lain di Universitas Pancasila yang berdampingan langsung dengan Fakultas Farmasi. Kondisi ini berpotensi menimbulkan suatu masalah yaitu penumpukan sampah. Secara umum kesadaran sivitas akademika dan orang-orang yang beraktivitas di lingkungan FFUP mengenai sampah masih kurang. Oleh karena itu edukasi, sosialisasi dan aplikasi mengenai pemilahan sampah sangat diperlukan di lingkungan FFUP yang berguna dalam mengurangi frekuensi sampah. Edukasi dan aplikasi telah dilakukan melalui kegiatan penyuluhan, pengadaan fasilitas pemilahan sampah, dan pelatihan aplikasi pemanfaatan sampah. Program ini cukup berhasil meningkatkan pengetahuan civitas akademika tentang pengelolaan sampah berbasis pemilahan sampah dengan kenaikan pemahaman dan kepedulian tentang pengelolaan sampah sebesar 4,58%, dan 8,94% secara berturut – turut dan telah diterapkan nya sistem pemilahan sampah di FFUP

Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo Ni Made Dwi Sandhiutami; Sondang Khairani; Rika Sari Dewi; Zainur Rahman Hakim; Anita Rahmi Pradani
Borneo Journal of Pharmacy Vol 5 No 2 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i2.3169

Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.

Evaluasi Perencanaan dan Pengadaan Obat di Era Jaminan Kesehatan Nasional (JKN) di Puskesmas Kabupaten Cianjur Yusi Anggriani; Rina Rosdiana; Sondang Khairani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.8673

Perencanaan diperlukan untuk menentukan jenis dan jumlah obat yang sesuai dengan kebutuhan. Pengadaan merupakan tahapan selanjutnya untuk merealisasikan kebutuhan obat, sehingga obat dapat tersedia dengan efektif dan efisien. Tujuan penelitian untuk mengetahui kesesuaian perencanaan dan pengadaan obat dengan rencana kebutuhan obat, e-catalogue dan Fornas di Puskesmas Kabupaten Cianjur. di Puskesmas Kabupaten Cianjur. Desain penelitian kuantitatif non eksperimental observasional. Data kuantitatif diambil secara retrospektif dari dokumen perenacanan, pengadaaan, dan laporan penggunaan obat di Puskesmas obat tahun 2019. Penelitian dilakukan di 23 Puskesmas yang disampling berdasarkan wilayah secara proporsional, dipilih berdasarkan tipe puskesmas dan jumlah kapitasi pertahun Hasil dari penelitian menunjukkan; rata-rata kesesuaian jenis obat di RKO dengan pengadaan obat sebesar 85,90%, kesesuaian jumlah obat di RKO dengan pengadaan sebesar 70,55%, kesesuaian antara pengadaan obat dengan Fornas sebesar 77,01%. Kesesuaian dana obat yang terdapat dalam RKO dengan pengadaan obat sebesar 95,77%, alokasi dana pengadaan yang terserap sebesar 93,86%, alokasi dana obat sebesar 20,35% dari total dana pelayanan Kesehatan di Puskesmas. Pengadaan obat berdasarkan e-catalogue sistem sebesar 32,44%. Pengadaan obat di Puskesmas Kabupaten Cianjur belum sesuai dengan perencanaan, penggunaan dana JKN yang belum optimal, dan pengadaan obat berdasarkan e-catalogue masih perlu ditingkatkan.

Co-Authors Anggriani, Yusi Anita Rahmi Pradani Esti Mulatsari Gressty F Swandiny Ira Ningtiyas Purpranoto Meyke Afrianty Mohamad Rega Satria Ramadhan Moordiani Moordiani Ni Made Dwi Sandhiutami Nurita Andayani RIKA SARI DEWI Rina Rosdiana ROS SUMARNY Sesilia A Keban Zainur Rahman Hakim

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