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All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia Borneo Journal of Pharmacy PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA

Sondang Khairani

Universitas Pancasila

Author-ID : 3682470

Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

Published : 8 Documents Claim Missing Document

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Title

Evaluasi Efek Samping OBat Kemoterapi terhadap Quality of Life (QOL) Pasien Kanker Payudara di Rumah Sakit X Jakarta Sondang Khairani; Sesilia A Keban; Meyke Afrianty
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Breast cancer is the number one cancer type discovered at women in the world. Most causes are genetic factors and hormonal factors. One cancer treatments with chemotherapy. Chemotherapy drugs active in cells dividing and reproducing, but cells normally to be affected by chemotherapy and side effects from chemotherapy drugs affect quality of life. The aim of the study to evaluate side effects of chemotherapy drugs on the quality of life of breast cancer patients. Sampling technique observational prospective breast cancer patients with completed the chemotherapy cycle from September 2017 to April 2018 with descriptive analysis and statistics by looking correlation between drug side effects and Quality of Life (QoL). Results of the study were side effects of fatigue 100%, nausea 67,5%, vomiting 60%, no appetite 63,75%, fever 42,5%, joint pain 43,75%, diarrhea 16,25%, difficulty swallowing 16,25%, allergies 5%, itching 1,25%, mouth sores 3,75%, swollen right hand 1,25%, constipation 3,75%. QoL results are physical 6,2%; psychology 5,3%; social 4,9%; spiritual 6,8%. Results of Sperman test showed no correlation between the side effects of chemotherapy and QoL P> 0,05. This study shows that there is no relationship between the side effects drug chemotherapy and QoL in breast cancer patients.

Pengaruh Pemberian Aspartam secara Oral terhadap Kadar AST dan ALT Serum serta Gambaran Histopatologi Hati Tikus Putih Ros Sumarny; Sondang Khairani; Mohamad Rega Satria Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Aspartame is low calorie sweetener metabolized into aspartic acid, phenylalanine and methanol, methanol cause damage to the liver. The purpose this study to determine the effect rats of oral aspartame administration for 90 days on biochemical parameters AST, ALT and liver histopathology. Rats were divided randomly into four groups: normal control, dose groups 126, 252, 504 mg/kgBW. Blood samples were taken on the 0th, 30th, 60th and 90th days to measure AST, ALT levels and 90th day to see liver histopathology. AST and ALT measurements using UV-VIS spectrophotometry with a wavelength of 340 nm. The levels of AST and ALT on the 90th day in the normal group 41,55 and 48,40 UI/L. Dose groups 126, 252, and 504 mg / kgBW were low doses 54,62 and 57,72 UI/L, 66,88 and 70,47 UI/L, 77,50 and 80,03 UI/L. Rats histopathology liver of aspartame showed hemorrhage. Concluded aspartame can increase of AST and ALT levels in rats blood serum and liver damage.

Co-Authors Anggriani, Yusi Anita Rahmi Pradani Esti Mulatsari Gressty F Swandiny Ika Permata Sari Ira Ningtiyas Purpranoto Meyke Afrianty Mohamad Rega Satria Ramadhan Moordiani Moordiani Ni Made Dwi Sandhiutami Ni Made Dwi Sandhiutami Nurita Andayani RIKA SARI DEWI Rina Rosdiana ROS SUMARNY Sesilia A Keban Zainur Rahman Hakim

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