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Kombinasi Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.) dan Daun Pepaya (Carica papaya L.) sebagai Hepatoprotektif selama Pengobatan Tuberkulosis TITIK SUNARNI; RINI PRASTIWI; MARDIYONO MARDIYONO; YUDI RINANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.614 KB)

Abstract

Hepatoprotective activity of Morinda citrifolia L. fruits and Carica papaya L. leaves ethanolic extract have been investigated in antituberculosis-induced rats. Forty rats were divided into following eight groups: normal control group was treated with normal feed and water; negative control group was treated with isoniazid and rifampicin, positive control group was treated with isoniazid, rifampicin and Methicol®, and the last five groups were treated with isoniazid, rifampicin and combination of M. citrifolia L. fruits and C. papaya L. leaves extract on various doses. All groups were treated daily for 27 days. Serum levels of bilirubin, alanine aminotransferase (ALT) as well as aspartate aminotransferase (AST) were determined on day -0, 14, 21 and 28 to monitor the liver function. All rats were sacrified on day-28 for liver histology observation. Combination of M. citrifolia extract 20 mg/200 g bw and C. papaya extract 120 mg/200 g bw significantly decreased the serum level of ALT, AST as well as bilirubin. The histology study showed that this combination could prevent the liver damaged based on the lower percentage of necrosis (27.83%), as compared to that of negative control (47.47%).
Dagusibu, P3K (Pertolongan Pertama Pada Kecelakaan) di Rumah dan Penggunaan Antibiotik yang Rasional di Kelurahan Nusukan Ika Purwidyaningrum; Jason Merari Peranginangin; Mardiyono Mardiyono; Jamilah Sarimanah
Journal of Dedicators Community Vol 3, No 1 (2019)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.582 KB) | DOI: 10.34001/jdc.v3i1.782

Abstract

The purpose of the service activity is to provide information and education to the public about dagusibu, P3K at home and rational use of antibiotics. Health counseling is needed by the community because it is known that the community. The GKSO Movement (Conscious Family Movement) is a program launched by the Indonesian Pharmacists Association (IAI) which is an effort to improve public understanding of medicines through dissemination of medicines, Dagusibu (Get, Use, Save and Dispose) medical equipment, medicine first aid treatment, and knowledge of antibiotics. The service partner, a resident of RT 08 RW 14, lacks awareness in maintaining cleanliness and still does not know the symptoms caused by an illness. The results of dedication show that citizens gain new knowledge and understand the material provided as a purpose of service