EDI DHARMANA
UNIVERSITAS DIPONEGORO

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Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata NUGRAHANINGSIH NUGRAHANINGSIH; SARJADI SARJADI; EDI DHARMANA; HERTANTO WAHYU SUBAGIO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.677 KB)

Abstract

Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.
EFEK SELF EFFICACY TRAINING TERHADAP SELF EFFICACY DAN KEPATUHAN DIET DIABETESI Ainul Yaqin; Safitri Niken; Edi Dharmana
JI-KES (Jurnal Ilmu Kesehatan) Vol 1, No 1 (2017): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : STIKes Hafshawaty Pesantren Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.583 KB) | DOI: 10.33006/ji-kes.v1i1.45

Abstract

AbstrakPasien diabetes melllitus (DM) seringkali tidak patuh terhadap pola diet yang dianjurkan. Banyak pasien DM yang mengalami berat badan berlebih atau kurus. Ketidakpatuhan diet menyebabkan rendahnya kontrol glikemik, dan meningkatkan komplikasi, disability and mortality. Kepatuhan dipengaruhi oleh keyakinan diri/self efficacy (SE), di sisi lain program peningkatan SE terkait dietDM belum banyak diteliti. Self efficacy training (SET)mampu meningkatkan SEsehingga kepatuhan diet meningkat. Tujuan penelitian untuk menganalisis efek SET terhadap SE dan kepatuhan diet diabetesi. Metode menggunakan quasy experiment dengan rancangan post test nonequivalent control group. Sampel kelompok intervensi dan kontrol masing-masing 48 dan 51 orang. Intervensi dilakukan sebanyak 6 sesi selama 12 hari. Hasil menunjukkan mayoritas responden adalah perempuan dengan usia 58-67 tahun. SE diukur dengan kuisioner DIET-SE dan kepatuhan dengan PDAQ Selisih nilai mean SE kelompok intervensi dan kontrol setelah perlakuan adalah 4,27 dengan p=0,000 dan selisih mean kepatuhan diet kelompok intervensi dan kontrol adalah 5,94 dengan p=0,000. Hasil uji multivariat dengan MANOVA didapatkan ada efek SETpada kedua variabel dependen yang sangat bermakna (p=0,000), namun jika dilihat dari hasil selisih mean dengan kelompok kontrol, variabel kepatuhan memiliki peningkatan nilai mean yang lebih besar dibandingkan variabel SE. Kesimpulan penelitian SET dapat meningkatkan kepatuhan diet pasien DM melalui peningkatan SE. Kata kunci: sef efficacy training; self efficacy; kepatuhan  AbstractDiabetic Mellitus (DM) patients are often not adherent to the recommended dietary patterns. Many DM patients are overweight or underweight. Dietary adherence leads to lower glycemic control, and increases complications, disability and mortality. Adherence is influenced by self-efficacy (SE), on the other hand SE improvement programs related to DM diet has not been much studied. Self efficacy training (SET) is able to improve SE so that diet compliance increases. The objective of the study was to analyze the effects of SET on SE and adherence to the diabetic diet. The method used quasy experiment with post tes nonequivalent control group design. The sample of the intervention and control groups were each 48 1 person. Intervention conducted as much as 6 sessions for 12 days. Results showed the majority of respondents were women aged 58-67 years. SE is measured by a DIET-SE questionnaire and compliance with PDAQ. The mean difference of SE values of the intervention and control groups after treatment was 4.27 with p = 0,000 and the mean difference of dietary intervention group and intervention was 5.94 p = 0,000. The result of multivariate test with MANOVA showed that there was a SET effect on both highly significant dependent variables (p = 0.000_, but if seen from the result of mean difference with the control group, the compliance variable had higher mean value than the SE variable. Improving DM patient's compliance through SE enhancement. Keywords: self efficacy training; self efficacy; obedience