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PENGARUH EKSTRAK MENGKUDU TERHADAP KADAR MALONDIALDEHID DARAH DAN AKTIVITAS KATALASE TIKUS DM YANG DIINDUKSI ALOKSAN Rauza Sukma Rita; Eti Yerizel; Nursal Asbiran; Husnil Kadri
Majalah Kedokteran Andalas Vol 33, No 1: April 2009
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.126 KB) | DOI: 10.22338/mka.v33.i1.p%p.2009

Abstract

AbstrakPenelitian yang menyimpulkan bahwa stres oksidatif meningkat pada penyakit diabetes mellitus telah cukup banyak. Stres oksidatif tersebut dapat diartikan sebagai suatu ketidakseimbangan antara prooksidan (radikal bebas) dengan antioksidan, karena antioksidan tidak mampu meredam peningkatan prooksidan. Penelitian ini bertujuan mengkaji pengaruh asupan ekstrak mengkudu (Morinda citrifolia linn) yang berfungsi sebagai antioksidan terhadap kadar malondialdehid (penanda prooksidan) dan enzim katalase (penanda antioksidan) pada tikus diabetes karena induksi aloksan.Penelitian eksperimental ini dilakukan pada 12 ekor tikus putih dengan berat badan 200-250 gram yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol negatif (hanya diberi makan dan minum), kelompok kontrol positif (makan dan minum,serta diinduksi aloksan), kelompok perlakuan (makan dan minum, diinduksi aloksan, dan diberi ekstrak mengkudu (500 mg/kg BB/hari) selama 12 hari. Data yang diperoleh dianalisa secara statistik dengan uji Anova dengan derajat kepercayaan 95%.Hasil penelitian menunjukkan terdapat perbedaan bermakna antar kelompok (p<0,05), dimana rerata kadar MDA darah kelompok kontrol negatif (4,2610,427 nmol/ml), kelompok kontrol positif (5,6050,391 nmol/ml), kelompok perlakuan (4,2610,427 nmol/ml) dan rerata aktivitas katalase kelompok kontrol negatif (6,5800,277 unit/mg), kelompok kontrol positif (4,9540,485 unit/mg), kelompok perlakuan (6,3140,651 unit/mg).Kesimpulan dari penelitian ini adalah pemberian ekstrak mengkudu dapat menu-runkan kadar MDA darah dan meningkatkan aktivitas enzim katalase tikus DM yang diinduksi aloksan.Kata kunci: ekstrak mengkudu – kadar MDA – aktivitas katalase – aloksan – tikus diabetesAbstractThere were so many study concluded that oxidative stress increased in diabetes mellitus. Oxidative stress can be defined as an imbalance between prooxidants and antioxidants, because antioxidants could not quench overARTIKEL PENELITIAN55production of prooxidants. This study investigated the effect of mengkudu extract (Morinda citrifolia linn) as antioxidant on malondialdehyde (MDA) level (prooxidant marker) and catalase (antioxidant marker) in alloxan induced diabetic rats.This experimental study had been carried out to 12 rats with 200-250 gram weight which divided into three group of four rats each, i.e. negative control, positive control (alloxan induced), and the group was treated by alloxan induced which followed by mengkudu extract oral (500mg/weight/day) for 12 days. The result was analyzed by using one way Anova with confidence interval 95%.There were significantly different in groups (p<0,05). The MDA level in negative control group is 4,2610,427 nmol/ml, positive control group is 5,6050,391 nmol/ml, and the group was treated by alloxan induced which followed by mengkudu extract oral is 4,2610,427 nmol/ml. Catalase activity in negative control group is 6,5800,277 unit/mg, positive control group is 4,9540,485 unit/mg, and the last group is 6,3140,651 unit/mg.The conclusion is mengkudu extract has capability to quench MDA level and increasing catalase activity in alloxan induced diabetic rats.Keywords : mengkudu extract – MDA level – catalase activity – aloksan – diabetic rats
ANALISIS IMPLEMENTASI KEBIJAKAN STANDAR PELAYANAN FISIOTERAPI BERDASARKAN PERMENKES NOMOR 65 TAHUN 2015 DI PUSKESMAS WILAYAH KERJA DINAS KESEHATAN KOTA PADANG PANJANG Rindu Febriyeni Utami; Nursal Asbiran; Siti Khadijah
HUMAN CARE JOURNAL Vol 5, No 1 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i1.799

Abstract

Permasalahan kesehatan masyarakat masih banyak yang belum terselesaikan, ditandai dengan meningkatnya penyakit tidak menular. Upaya pencegahan penyakit tersebut dimulai dari fasilitas kesehatan tingkat pertama. Dalam Permenkes Nomor 65 Tahun 2015 fisioterapi terlibat dalam pelayanan tingkat pertama. Penelitian ini bertujuan untuk memberikan gambaran tentang implementasi kebijakan Permenkes Nomor 65 Tahun 2015 di Puskesmas Kota Padang Panjang. Jenis penelitian ini adalah kualitatif dengan pendekatan fenomenologi yang dilakukan pada bulan April sampai Juli 2019, pengumpulan data dilakukan menggunakan pedoman wawancara, observasi, dan studi dokumen melalui wawancara mendalam dengan kepala dinas, kasi pelayanan kesehatan, ketua IFI dan seluruh kepala Puskesmas Kota Padang Panjang. Hasil penelitian diketahui input seperti kebijakan tentang Permenkes Nomor 65 Tahun 2015 belum pernah disosialisasikan, tenaga fisioterapi belum ada, ketersediaan dana, sarana prasarana belum memadai. Proses implementasi kebijakan pelayanan fisioterapi di Puskesmas, belum ada tenaga fisioterapi yang terlibat dalam program Puskesmas. Dan Output yang diperoleh, Permenkes Nomor 65 Tahun 2015 belum pernah disosialisasikan oleh Pemerintah sehingga belum ada perencanaan dan penerapan tenaga, dana, sarana dan prasarana untuk melakukan pelayanan Fisioterapi di Puskesmas. Kesimpulan penelitian ini adalah seluruh Puskesmas di Kota Padang Panjang belum pernah mendapatkan sosialisasi kebijakan tentang Permenkes Nomor 65 Tahun 2015 sehingga belum ada implementasi pelayanan fisioterapi di Puskesmas.
ANALISIS FAKTOR YANG MEMPENGARUHI RENDAHNYA PARTISIPASI LANSIA DALAM PEMANFAATAN POSYANDU LANSIA DI PUSKESMAS PAUH KEMBAR KABUPATEN PADANG PARIAMAN TAHUN 2019 Eva Susanti; Nursal Asbiran; Nur Hayati
HUMAN CARE JOURNAL Vol 5, No 4 (2020): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i4.616

Abstract

Elderly Integrated Service Post (Posyandu) is one of the efforts to improve the health status and quality of health care for the elderly in the community, happy and efficient for the family and communication between the elderly. This study aims to determine the factors that influence the low participation of the elderly in the use of Posyandu Elderly in Pauh Kembar Health Center, Padang Pariaman Regency in 2019. The research method used is a cross sectional approach. The study was conducted at the Pauh Kembar Health Center in Padang Pariaman Regency from May 14 to June 31, 2019. The analysis found that there was a significant relationship between work with a p value of 0,000 and OR = 6.3. p value of elderly motivation with p value 0.003 and OR = 3.661, cadre role with p value 0.041 and OR = 2,464, distance of home from Posyandu with p value 0,000 and OR = 7,837, and health condition p value 0.022 and OR = 2,981 with participation elderly to Posyandu Elderly. It can be concluded that the distance between home and Posyandu has the greatest risk among other variables. It is suggested the need for holistic and integrated efforts to utilize the posyandu for the elderly in order to improve the health status of the elderly.
THE INFLUENCE OF FAMILY-BASED SURVEILLANCE METHODS ON THE DISCOVERY OF SUSPECTED PULMONARY TUBERCULOSIS IN PADANG PARIAMAN DISTRICTS IN 2017 Destri Suari; Nursal Asbiran; Sukarsi Rusti
HUMAN CARE JOURNAL Vol 6, No 2 (2021): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The discovery of suspect is one effort to cope with pulmonary tuberculosis. Active findings that have been done such as home visits, empowerment of cadres, and counseling has not been maximized. The problem in this study is whether the influence of family-based surveillance method to the discovery of suspect tuberculosis lung in padang pariaman district in 2017. This study aims to see the picture and the influence of independent variables on the dependent variable in Padang Pariaman district in 2017.This type of research is quantitative with pre experimental design research design conducted in December 2017 until the month of Januari 2018. The sample in this study is the head of the family in the village Pungguang Kasiak which amounted to 50 families head . The results of this study indicate that family-based surveillance methods have an effect on the discovery of suspected pulmonary tuberculosis because there is a difference between the number of suspects before and after family-based surveillance methods (mean = - 0,380). Therefore, the family is expected to play a more active role, and can be more concerned about the health of themselves and family members so that if you experience symptoms of pulmonary tuberculosis immediately checked into health services
Co-Authors Destri Suari Eti Yerizel Eva Susanti Husnil Kadri Nur Hayati Rauza Sukma Rita Rindu Febriyeni Utami Siti Khadijah Sukarsi Rusti