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Muhartono Muhartono
Fakultas Kedokteran Universitas Lampung

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Pengaruh Ekstrak Kulit Manggis (Garcinia mangostana L.) TERHADAP Testis Tikus Putih yang Diberi Paparan Gelombang Elektromagnetik Handphone Muhartono Muhartono; Andrian Rivanda; Anggraeni Janar Wulan; Susianti Susianti
Jurnal Kesehatan Vol 8, No 1 (2017): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.112 KB) | DOI: 10.26630/jk.v8i1.391

Abstract

Mobile phone electromagnetic waves will induce elevated reactive oxygen species (ROS) that may cause testicle histopathological changes. Resolving this condition, the antioxidants contained in mangosteen peel are needed. This study was to determine the effects of ethanol extract  from mangosteen peel (Garcinia mangostana L.) in order to repair testicle histopathological changes, specifically spermatozoa and spermatogenic cells on Sprague dawley strain white male rats (Rattus norvegicus) that had been exposed by handphone electromagnetic waves. This study were used 25 Sprague dawley strain white male rats with 200-300 gram body weight, then the samples were divided into 5 groups which consist of Control Group 1 (K1) with no treatments were given in rats, Control 2 (K2) were given Nacl 0,9 % and mobile phone electromagnetic waves exposures. The Treatment group (P1), (P2), and (P3) were given ethanol extract from mangosteen peel with multilevel dosage of 50, 100, 200 mg / kgBW and exposure to mobile phone electromagnetic wave for 3 hours per day along for 28 days. The result of this study showed mean of sperm cells on K1=173.75±SD 16.978, K2=101.75±7.455 SD, P1=148.50±SD 10.149, 10.247 P2=162.50± SD, P3=180.75 7.365 ± SD and mean of spermatogenic cells on K1=306.75±SD 11.955, K2= 157.00±7.303 SD, P1=243.50±SD 21.672 10.340 P2=266.75±SD P3=294.75±13.150 SD. One Way Anova test (p<0.005), sperm cells and spermatogenic cells showed significant results with p=0.000. The conclusion is ethanol extract of mangosteen peel (Garcinia mangostana L.) can repair testicle histopathological changes by inducing total  testicular sperm cells and spermatogenic cells of Sprague dawley strain white male rats (Rattus norvegicus) exposed by mobile phone electromagnetic waves.
Pengaruh Herbisida Paraquat Diklorida Oral terhadap Hati Tikus Putih Muhartono Muhartono; Yolanda Fratiwi; Indri Windarti; Susianti Susianti
Jurnal Kesehatan Vol 6, No 2 (2015): JURNAL KESEHATAN
Publisher : Politeknik Kesehatan Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.061 KB) | DOI: 10.26630/jk.v6i2.89

Abstract

Penggunaan herbisida paraquat diklorida oleh para petani sebagai salah satu upaya untuk meningkatkan hasil produksi pada sektor pertanian. Herbisida paraquat diklorida sering digunakan secara sembarangan dan tidak memperhatikan label peringatan. Herbisida yang masuk ke dalam tubuh melalui oral dapat menyebabkan kerusakan berbagai organ, salah satunya adalah hati. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian herbisida paraquat diklorida per−oral terhadap pembengkakan hepatosit dan kongesti sinusoid hati. Penelitian ini bersifat eksperimental dengan menggunakan 25 ekor tikus putih jantan galur Sprague dawley yang dibagi menjadi 5 kelompok. Masing-masing kelompok terdiri dari 5 ekor tikus yang diberi perlakuan selama 2 hari dengan dosis yang berbeda, yaitu K1 merupakan kelompok kontrol, K2, K3, K4, dan K5 diberi herbisida paraquat diklorida 25 mg/kgBB, 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Hasil penelitian menunjukkan rerata skor pembengkakan hepatosit dan kongesti sinusoid mengalami peningkatan. Hasil uji Kruskal Wallis yang dilanjutkan uji Post Hoc Mann Whitney menunjukkan perbedaan yang bermakna antar kelompok perlakuan p=0,001. Pemberian herbisida paraquat diklorida per-oral dapat menyebabkan pembengkakan hepatosit dan kongesti sinusoid hati tikus. Kata Kunci: Hati Tikus Putih, herbisida paraquat diklorida, kongesti sinusoid, pembengkakan hepatosit.
Papilloma dan Karsinoma Sinonasal Rizki Hanriko; Muhartono Muhartono
Jurnal Kesehatan Vol 8, No 1 (2017): Jurnal Kesehatan
Publisher : Politeknik Kesehatan Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.508 KB) | DOI: 10.26630/jk.v8i1.405

Abstract

Sinonasal papilloma is rare, only 0.5-4% of sinonasal tumors with aetiopathogenesis has not known yet. Sinonasal carcinoma is a rare malignancy, and the most common types are squamous cell carcinoma (SCC). Malignant transformation of papilloma is very low, which inverted type were reported about 2-27%, with the development of papilloma into carcinoma was approximately 63 months (6 months-13 years). Prior study showed the malignant transformation in 11% of recurrences inverted papilloma, which were 7%syncronous and 3.6% metachronous SCC. The unilateral inverted papilloma with sinonasal squamous cell carcinoma were usually occured in the elderly. Some factors to consider in malignant transformation of papilloma were recurrence, atypical features and HPV. Smoker, large tumor and lesion in the frontal sinus area were had a tendency to recurrence. Malignancy were associated with bone invasion, bilateral inverted papilloma, squamous cell hyperplasia, presence of three types of epithelial cells (squamous metaplasia, squamous mature and cylindrical cell), heavy hyperkeratosis, mitotic index ≥2/HPF, the absence of polyps inflammation, the number of plasma cells, low of eosinophils and neutrophils absent.