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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Riset Kimia IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Jurnal Zarah Indonesian Journal of Chemistry Akta Kimia Indonesia Borneo Journal of Pharmacy Molekul: Jurnal Ilmiah Kimia JFIOnline Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Molekul: Jurnal Ilmiah Kimia
Adlis Santoni
Jurusan Kimia, Universitas Andalas, Padang, 25163, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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KAJIAN BIOAKTIFITAS DAN ANALISA KANDUNGAN SENYAWA METABOLIT SEKUNDER DARI TUMBUHAN Hornstedtia scyphifera var. fusiformis DENGAN HPLC (High Performance Liquid Chrimatography) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Zarah Vol 5 No 2 (2017): Jurnal Zarah
Publisher : Program Studi Pendidikan Kimia, Fakultas Keguruan dan Ilmu Pendidikan Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.33 KB)

Abstract

Hornstedtia scyphifera var. fusiformis merupakan tumbuhan endemik dari famili Zingiberaceae yang tersebar di Sumatera. Tumbuhan ini  mengandung beberapa metabolit sekunder seperti fenolik, flavonoid, saponin, triterpenoid, steroid dan alkaloid. Pengujian Bioaktifitas meliputi uji antioksidan dan antibakteri. Aktivitas antioksidan ditentukan dengan metoda DPPH. Sedangkan aktivitas antibakteri diuji dengan metode difusi cakram terhadap bakteri Staphylococcus aureus (bakteri gram positif) dan Escherichia coli (bakteri gram negatif). Hasil analisa aktitifitas antioksidan dari ketiga ekstrak, diperoleh bahwa ekstrak metanol menunjukkan aktifitas antioksidan yang paling aktif dengan IC50 = 51,8943 mg/L dibandingkan dua ekstrak lainnya. Ketiga esktrak Hornstedtia scyphifera var. fusiformis memberikan aktivitas antibakteri, selanjutnya esktrak n-heksan dan etil asetat pada konsentrasi 500 ppm memiliki zona hambat 10 mm terhadap bakteri Escherichia coli  dan Staphylococcus aureus memiliki zona hambat 10,3 mm. Untuk mengetahui jumlah senyawa metabolit sekunder  yang terkandung dalam  tumbuhan ini dilakukan analisa dengan HPLC.
ISOLASI DAN ELUSIDASI STRUKTUR TRITERPENOID KULIT BATANG SURIAN Toona sinensis DAN UJI TERHADAP HAMA Crosidolomia pavonana Santoni, Adlis; Nurdin, Hazli; Manjang, Yunazar; Achma, Sjamsul A
Jurnal Riset Kimia Vol 3, No 2 (2010): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v3i2.22

Abstract

 ABSTRACT Tryterpenoid compound (3-hydroxyeupha-7-ene) were isolated from hexane fraction the steam bark of Toona sinensis (Meliaceae). The structures of these compounds were established base on spectroscopic evidence, including UV, IR, 3C-NMR, 1H-NMR, HMBC, HMQC and COSY spectra and literature survey this is new compound in family Meliaceae. Insect activity of the hexane fraction (1.0%) and against Crosidolomia pavonana were tested. The activity of hexane were mortality (37.5%), antifeeding (75.5%). The activity of the 3-hydroxyeupha-7-ene showed mortality (52.0%), Lc50; 0.39847 and Lt50; 5.53931. Keywords: Toona sinensis (Meliaceae), 3-hydroxyeupha-7-ene, Crosidolomia pavonana, Antifeeding, Mortality Lc50 and Lt50
MINYAK ATSIRI DARI Toona sinensis DAN UJI AKTIVITAS INSEKTISIDA Santoni, Adlis; Nurdin, Hazli; Manjang, Yunazar; Achmad, Sjamsul A.
Jurnal Riset Kimia Vol 2, No 2 (2009): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v2i2.142

Abstract

ABSTRACT Volatile components from leafs of Toona sinensis (Meliaceae) were isolated by distillation water-vapour method and analyzed using GC/MS. Forty-eight component were identified, and eight major components are Germacrene-D, Germacrene-B, α-Terpinene, α-Humulene, β-Caryophyllene,  α-Elemene, Bicyclogermacrene and α-copaene. Insect activity of the essential oil against Crosidolomia pavonana were tested. The activity of the essential oil with concentration 25% (mortality 73.3%), concentration 50% (mortality 83.3%) and concentration 75% (mortality 90%). Keywords : Toona sinensis (Meliaceae), essential oil, Crosidolomia pavonana, and mortality.    
ISOLASI DAN ELUSIDASI STRUKTUR SENYAWA TRITERPENOID DARI KULIT BATANG AMBACANG (Mangifera foetida L.) SERTA UJI BRINE SHRIMP LETALITY TEST (BSLT) Santoni, Adlis; -, Sabariah; Efdi, Mai
Jurnal Riset Kimia Vol 9, No 1 (2015): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v9i1.252

Abstract

A brine shrimp toxic compound has been isolated from Mangifera foetida L. steam bark. Based on spectroscopic data (IR,1H- NMR, 13C-NMR 1D and 2D), the structure of this compound was identified as mangiferenes B, C30H47O2. In this study, the n-hexane, ethyl acetate, methanol extracts and isolated compound showed toxic effects (LC50 471.9543; 534.5209, 678.4421, and 22.1615 μg/mL, respectively). The toxicity degree among the three extracts and isolated compound is isolated compound > n-hexane extract > ethyl acetate extract > methanol extract.
Teknik Isolasi Antosianin Utama dari Ekstrak Buah Ficus padana Burm.f dengan KCKT Tipe Standar Syukri, Daimon; Darwir, Djaswir; Santoni, Adlis
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.106 KB)

Abstract

Preparative High Performance liquid chromatography (HPLC) today is one of the popular methods to isolate anthocyanin from extract containing anthocyanins. The working principle of preparative-HPLC can be applied to the laboratory standard tupe of HPLC, so it can be used also to isolate the main anthocyanin compounds from anthocyanin mixtures. The function of fraction collector on preparative HPLC equipment were replaced by opening the mobile phase line after the exit of the detector and hold out the solution manually on the standard type of HPLC. Resolution value between the peaks and the computation time when cuts in the chromatogram peak collection mobile phase containing the analyte is of concern in these activities. The appearace of a single peak in the chromatogram of the isolates showed that the technique can be applied for the simple and fast technique of anthocyanins isolation.Keywords : isolation, anthocyanin, Ficus padana Burm.f, Preparative-HPLC, standar type of HPLC.
KAJIAN BIOAKTIFITAS DAN ANALISA KANDUNGAN SENYAWA METABOLIT SEKUNDER DARI TUMBUHAN Hornstedtia scyphifera var. fusiformis DENGAN HPLC (High Performance Liquid Chrimatography) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Zarah Vol 5 No 2 (2017): Jurnal Zarah
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.33 KB) | DOI: 10.31629/zarah.v5i2.205

Abstract

Hornstedtia scyphifera var. fusiformis merupakan tumbuhan endemik dari famili Zingiberaceae yang tersebar di Sumatera. Tumbuhan ini mengandung beberapa metabolit sekunder seperti fenolik, flavonoid, saponin, triterpenoid, steroid dan alkaloid. Pengujian Bioaktifitas meliputi uji antioksidan dan antibakteri. Aktivitas antioksidan ditentukan dengan metoda DPPH. Sedangkan aktivitas antibakteri diuji dengan metode difusi cakram terhadap bakteri Staphylococcus aureus (bakteri gram positif) dan Escherichia coli (bakteri gram negatif). Hasil analisa aktitifitas antioksidan dari ketiga ekstrak, diperoleh bahwa ekstrak metanol menunjukkan aktifitas antioksidan yang paling aktif dengan IC50 = 51,8943 mg/L dibandingkan dua ekstrak lainnya. Ketiga esktrak Hornstedtia scyphifera var. fusiformis memberikan aktivitas antibakteri, selanjutnya esktrak n-heksan dan etil asetat pada konsentrasi 500 ppm memiliki zona hambat 10 mm terhadap bakteri Escherichia coli dan Staphylococcus aureus memiliki zona hambat 10,3 mm. Untuk mengetahui jumlah senyawa metabolit sekunder yang terkandung dalam tumbuhan ini dilakukan analisa dengan HPLC.
ISOLASI SENYAWA TRITERPENOID DAN UJI ANTIBAKTERI EKSTRAK n-HEKSAN DAUN KAYU ARA (Ficus aurata (Miq.) Miq) Santoni, Adlis; Efdi, Mai; Bumali, Restu
Jurnal Riset Kimia Vol 10, No 1 (2019): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.268

Abstract

Triterpenoid isolation from n-hexane extract of kayu ara leaves (Ficus aurata (Miq.) Miq) has been performed. The Isolation has been done by column chromatography method using silica gel as a stationary phase and n-hexane and ethyl acetate as mobile phase with isocratic method and it is continued by trituration method. Isolated compound has white amorphous shape, decomposed at 86-87ºC and gives single spot with reddish brown violet in LB reagent and in H2SO4 reagent on TLC test. UV spectra indicate the presence of double bonds in the isolated compound at 204 nm λmax and IR spectra showed -OH functional group at 3290 cm-1, -CH stretching at 2912,90 cm-1, C=C at 1676 cm-1, C-O stretching at 1054,93 cm-1, and at 1374 cm-1 is spectra of geminal dimethyl compound that are characteristic of triterpenoids which supports ultraviolet spectroscopic data. Antibacterial activity test showed that isolated compound is active in inhibiting the growth of gram-positive bacteria Staphyloccocus aureus and gram-negative bacteria Escherichia coli.
Identifikasi Senyawa Metabolit Sekunder, Uji Antimikroba dan Antioksidan Ekstrak Akar Gantung Hornstedtia Scyphifera Var. Fusiformis Holttum (Sijangkang) Santoni, Adlis; Efdi, Mai; Suhada, Akmel
Jurnal Riset Kimia Vol 10, No 2 (2019): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v10i2.264

Abstract

Hornstedtia scyphifera var. fusiformis Holttum is endemic plant of Zingiberaceae family that distributed in Sumatera. Hornstedtia scyphifera var. fusiformis Holttum contained some secondary metabolite such as phenolic, saponin, triterpenoid and alkaloid. The biological activity of methanol, ethyl acetate, and n-hexane extracts from Hornstedtia scyphifera var. fusiformis Holttum suspended roots was tested for antibacterial and antioxydant activity. Antioxidant activity was analized by DPPH method. The antibacterial activity  was tested by used disk difussion method againts Staphylococcus aureus bacteria (gram-positive bacteria) and Escherichia coli (gram-negative bacteria). Almost all of Hornstedtia scyphifera var. fusiformis Holttum suspended roots extract were given antibacterial activity, nonetheless the biggest inhibition zone of Escherichia coli that was inhibited by n-hexane and ethyl acetate extracts which have inhibtion zone 10 mm at  concentration 500 mg/L and also againts Staphylococcus aureus, the biggest inhibition by ethyl acetate and n-hexane extracts which have inhibition zone 10.30 mm at concentration 500 mg/L. Among all extracts tested, methanol extract of the possessed moderate free radical scavenging activity with IC50 = 51.89 mg/L.
Teknik Isolasi Antosianin Utama dari Ekstrak Buah Ficus padana Burm.f dengan KCKT Tipe Standar Syukri, Daimon; Darwir, Djaswir; Santoni, Adlis
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.106 KB) | DOI: 10.35617/jfi.v7i1.151

Abstract

Preparative High Performance liquid chromatography (HPLC) today is one of the popular methods to isolate anthocyanin from extract containing anthocyanins. The working principle of preparative-HPLC can be applied to the laboratory standard tupe of HPLC, so it can be used also to isolate the main anthocyanin compounds from anthocyanin mixtures. The function of fraction collector on preparative HPLC equipment were replaced by opening the mobile phase line after the exit of the detector and hold out the solution manually on the standard type of HPLC. Resolution value between the peaks and the computation time when cuts in the chromatogram peak collection mobile phase containing the analyte is of concern in these activities. The appearace of a single peak in the chromatogram of the isolates showed that the technique can be applied for the simple and fast technique of anthocyanins isolation.Keywords : isolation, anthocyanin, Ficus padana Burm.f, Preparative-HPLC, standar type of HPLC.
ISOLASI DAN ELUSIDASI STRUKTUR TRITERPENOID KULIT BATANG SURIAN Toona sinensis DAN UJI TERHADAP HAMA Crosidolomia pavonana Adlis Santoni; Hazli Nurdin; Yunazar Manjang; Sjamsul A Achma
Jurnal Riset Kimia Vol. 3 No. 2 (2010): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v3i2.22

Abstract

 ABSTRACT Tryterpenoid compound (3-hydroxyeupha-7-ene) were isolated from hexane fraction the steam bark of Toona sinensis (Meliaceae). The structures of these compounds were established base on spectroscopic evidence, including UV, IR, 3C-NMR, 1H-NMR, HMBC, HMQC and COSY spectra and literature survey this is new compound in family Meliaceae. Insect activity of the hexane fraction (1.0%) and against Crosidolomia pavonana were tested. The activity of hexane were mortality (37.5%), antifeeding (75.5%). The activity of the 3-hydroxyeupha-7-ene showed mortality (52.0%), Lc50; 0.39847 and Lt50; 5.53931. Keywords: Toona sinensis (Meliaceae), 3-hydroxyeupha-7-ene, Crosidolomia pavonana, Antifeeding, Mortality Lc50 and Lt50
Co-Authors -, Sabariah Afrizal Afrizal Akmel Suhada Asri Amelia Bumali, Restu Bustanul Arifin BUSTANUL ARIFIN Daimon Syukri Darwir, Djaswir Darwir, Djaswir Djaswir Darwis Elisabet Elisabet Hazli Nurdin Hazli Nurdin Hermansyah Aziz Indah Putri Lestari Intania Permata Khoiriah Khoiriah Leidina Zein Mai Efdi Matlal Fajri Alif Nindi Antika Febriana Norman Ferdinal Norman Ferdinal Novesar Jamarun Olly Norita Tetra Rahmi Vika Ulia Ria Januarti Sabariah - Safni Safni Salim, Emil Sari Ramadhani Silfani Mairanti Sjamsul A Achma Sjamsul A. Achmad Sjamsul A. Achmad Suhada, Akmel Suhada, Akmel Suryati Suryati Syukri Syukri Trisno Afandi Vanny Yulia Safitri Wellia, Diana Vanda Yayan Rabbani Kurniawan Yayan Rabbani Kurniawan Yelfira Sari Yulizar Yusuf Yunazar Manjang Yunazar Manjang