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All Journal e-GIGI Jurnal Pembangunan Wilayah dan Kota SAINS DAN MATEMATIKA Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Urology Journal of Biomedicine and Translational Research Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Media Medika Muda Bioscientia Medicina : Journal of Biomedicine and Translational Research TheJournalish: Social and Government Bioscientia Medicina : Journal of Biomedicine and Translational Research Generics: Journal of Research in Pharmacy
Indah Saraswati
Department Of Medical Biology And Biochemistry, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Konsep Revitalisasi Pelabuhan Juwana Kabupaten Pati Saraswati, Indah; Buchori, Imam
JURNAL PEMBANGUNAN WILAYAH & KOTA Vol 13, No 1 (2017): JPWK Vol 13 No 1 March 2017
Publisher : Magister Pembangunan Wilayah dan Kota,Undip

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1300.721 KB) | DOI: 10.14710/pwk.v13i1.15150

Abstract

Juwana ports is a national port, harbors between islands in the river ofsilugangga which is the gateway to the economy in Pati Regency.The concepts of revitalization of the harbor UPP class III Juwana is necessary because during the reign of the Dutch, this port is an international port with traffic of goods, people and voyage is also very crowded; unfortunately the condition does not continue at this time. The port that should have been a modem port are lagging and lacking in economi meaning to the surrounds community and the development of Pati. Therefore, the formulation of the issue in accordance with the background of the research is why and how the process of revitalization. Juwana port will be done as efforts to improve the economy of surrounding community PATI regency.This analysis is using analytical techniques of Importance Performance Analysis (1PA) and the focusing the technique mix method is a method of qualitative analysis and quantitative analysis methods with analize the performance service, government policies and decreased vitality. From the analysis, it is known that a decrease in the vitality of the port of juwana due to geographic factors, physical factors and factors of Juwana port activity, so that it is necessary to do drafting the revitalization of the Juwana port, they are: ,1) Revitalize the shipping Juwana lines so that ships do not lean or mooring in harbor entrance Juwana resulting rapid silting, 2) Revitalize unloading infrastructure and port infrastruktur, 3) The concept of relocation is greater port positioned to deal with the open sea so that ships with gross tonnage could large mooring or dock in ports.
Zeolite-A Synthesis from Glass Saraswati, Indah
JURNAL SAINS DAN MATEMATIKA Volume 23 Issue 4 Year 2015
Publisher : JURNAL SAINS DAN MATEMATIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.791 KB)

Abstract

Zeolite can be used as ion exchanger, catalyst, and adsorbent.  One type of synthetic zeolites is zeolite-A which being developed to overcome the weakness of natural zeolites for their difference of pore size. This research is aimed to study the synthesized of zeolite-A from wasted glasses as silica source. Hydrogel method was used by reacting sodium aluminate into a sodium silicate solution. The gel formed was heated at 80°C for 8 hours and to produce a white solid. The solid result were characterized by XRD, FTIR, and AAS. The XRD analysis shown that the yield which formed closest to zeolite-A structure was in concentrate variation of sodium silicate and sodium aluminate of 1.05 : 1. This result also can be confirmed by FTIR analysis.
Pengaruh Variasi Waktu Perendaman dalam Ekstrak Daun Teh Hijau (Camellia sinensis) terhadap Stabilitas Dimensi Alginat Prabowo, Yoghi B.; Ibrahim, Natalia P.; Saraswati, Indah
e-GiGi Vol 9, No 1 (2021): E-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.9.1.2021.32307

Abstract

Abstract: Alginate has an imbibition property if it comes in contact with water that will affect the dimensional stability. Green tea (Camellia sinensis) contains phenolic compounds which can minimize the imbibition process while it is used in disinfection of alginate impression. This study was aimed to analyze the differences in the dimensional stability of alginate impressions after immersion in green tea leaf extract based on time variation. This was an experimental post-test laboratory study only. The one way Anova test on the anteroposterior and mediolateral dimensions showed that variation of immersion time in 50% green tea leaf extract could affect the dimensional stability. Moreover, the post hoc Games Howell test on the anteroposterior dimension and the post hoc LSD test on the mediolateral dimension resulted that there were significant differences between the control group and the groups of 5 minutes, 15 minutes, 30 minutes, and 50 minutes of immersion. Among all alginate impressions, the one immersed for 15 minutes was still in accordance with the standard of the American Dental Association. In conclusion, 15-minute immersion of alginate impression in 50% green tea leaf extract was the best time variation.Keywords: alginate, dimensional stability, green tea leaf extract 50% Abstrak: Alginat memiliki sifat imbibisi bila berkontak dengan air yang akan memengaruhi stabilitas dimensi alginat. Teh hijau (Camellia sinensis) mengandung senyawa fenol yang mampu meminimalkan terjadinya proses imbibisi. Penelitian ini bertujuan untuk menganalisis perbedaan stabilitas dimensi alginat setelah direndam berdasarkan variasi waktu dalam ekstrak daun teh hijau. Jenis penelitian ialah eksperimental laboratorik post-test only. Stabilitas dimensi diketahui melalui selisih jarak anteroposterior (A’-B’) dan mediolateral (B’-C’) master die dengan die stone. Hasil uji one way Anova terhadap dimensi anteroposterior dan mediolateral mendapatkan adanya pengaruh variasi waktu perendaman dalam ekstrak daun teh hijau 50% terhadap stabilitas dimensi. Selanjutnya hasil uji post hoc Games Howell terhadap dimensi anteroposterior dan uji post hoc LSD terhadap dimensi mediolateral mendapatkan perbedaan bermakna antara kelompok kontrol dengan kelompok perendaman 5 menit, 15 menit, 30 menit, dan 50 menit. Hasil perendaman cetakan alginat yang masih sesuai dengan standar American Dental Association ialah perendaman selama 15 menit. Simpulan penelitian ini ialah perendaman cetakan alginat dalam ekstrak daun teh hijau 50% yang terbaik ialah selama 15 menit.Kata kunci: alginat, stabilitas dimensi, ekstrak daun teh hijau 50%
THE EFFECT OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA L) AGAINST MOTILITY OF SPERMATOZOA MICE EXPOSED TO MONOSODIUM GLUTAMATE Ilham Saptia Nugraha; Wibisono, Dimas Sindhu; Saraswati, Indah; Juniarto, Achmad Zulfa
Indonesian Journal of Urology Vol 29 No 1 (2022)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v29i1.731

Abstract

Objective: Excessive use of MSG in everyday life can cause infertility to men. Exposure to MSG can cause cells to experience oxidative stress which subsequently triggers the generation of free radicals. Free radicals can be resisted with antioxidants. Material & Methods: This research was a laboratory experimental test with a post-test only control group design using male mice as the experimental object. The statistical test used the One Way ANOVA test. Results: In this research, 5 male mice were assigned into 4 groups and 1 control group. Using the One Way ANOVA test, it was found that there were significant differences in ≥ 2 treatment groups in the motility group of spermatozoa with active movement (p < 0.001) and the motility group of spermatozoa with weak movement (p = 0.036). The two groups showed significant differences. The Post hoc LSD test in the motility group with active movement showed significant differences between the control group with MSG treatment (p < 0.001) and the treatment group given Moringa leaves extract of 600 mg/kgW (p < 0.001) and 1200 mg/kgW (p < 0.001). Conclusion: Moringa leaves extract can effect the improvement of the motility of spermatozoa exposed to monosodium glutamate at a given dose of 300 mg/kgW and 600 mg/kgW.
Effect of kelor (Moringa oleifera Lam) ethanolic leaves extract on uterus of pregnant mice and its teratogenicity Desy Armalina; Neni Susilaningsih; Indah Saraswati; Eva Annisa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202102

Abstract

Moringa oleifera Lam (Moringaceae) is a source of additional dietary. It contains 9 essential amino acids, calcium, iron, potassium, magnesium, zinc and vitamins A, C, E and B which have a major role in the immune system. Previous study reported that M. oleifera Lam can increase the hemoglobin of breastfeeding mothers. In contrast, M. oleifera Lam is well known as abortifacient plant, therefore it is not recommended to use during pregnancy. The aim of this study was to evaluate the effect of M. oleifera Lam ethanolic leaves extract M. oleifera Lam on uterus of pregnant mice and its teratogenic effect. Twenty pregnant female Balb/c mice were used in this experimental study. Mice were randomized divided into four groups with five mice in each group. Group C as control, mice were not given anything. Group T1-T3 were given M. oleifera Lam ethanolic leaves extract during pregnancy age 7-18 days with doses of 10, 20 and 30 mg/kg BW, respectively.  Phytochemical analysis was performed quantitatively and qualitatively. On day 19, a caesarean section was performed to take the uterus, count the number of living foetus, dead foetus, disability, and other morphological abnormalities. No significant difference between all groups was observed. The abortifacient effect was not also observed in the uterus. Qualitative phytochemical analysis results showed that alkaloids, flavonoids, phenols, steroids, and tannins are identified in this extract. Quantitative steroids analysis results showed that the extract contained steroids of 1057.6 ppm. In conclusion, the M. oleifera Lam ethanolic leaves extract at dose of 30 mg/kg BW does not show any effect on the uterus of pregnant mice. Further study concerning the effects on other organs and hormones is recommended.
Vitamin D Deficiency Linked To Depression (Systematic Review: Meta Synthesis) Talitha Salsabila; Indranila Kustarini Samsuria; Dwi Retnoningrum; Indah Saraswati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30058

Abstract

Background: Depression is a mood disorder that is marked by a persistent feeling of sadness, loss of interest; reduced energy and vitality; feelings of low self-worth or guilt; loss of appetite; disturbed sleep or insomnia; and slowness of thought or action. Vitamin D deficiency has been associated with depression. When the level of Vitamin D and serotonin is low, that leads to depression.Objective: To analyze whether vitamin D deficiency or insufficiency is associated with depression.Method: This is a Systematic Review Report. Samples were gathered from two journals – PubMed and Science Direct with specific search terms used were 'vitamin D' and 'depression', then were adjusted based on the inclusion criteria and research question. After that, the findings are combined in order to reach a conclusion so that the research question is well answered.Results: There are eleven journals that describe a link between low level of Vitamin D and symptoms of depression. The connection between the two is formed due to the neuroprotector and immunomodulatory effects of Vitamin D.Conclusion: Previous studies have shown that Vitamin D deficiency linked to depression. Keywords : Depression, level of vitamin D, vitamin D serum.
THE EFFECT OF ROSELLA DRIED CALYX INFUSION (HIBISCUS SABDARIFFA) IN LOWERING LDL CHOLESTEROL SERUM LEVEL ON CIGARETTE SMOKE EXPOSED MALE SPRAGUE DAWLEY RATS Gabriela Rolanda; Lusiana Batubara; Indah Saraswati; Kusmiyati Tjahjono DK
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.31224

Abstract

Background: Cigarettes increase cardiovascular risks by modifying lipid profiles through oxidation, alternating lipoprotein composition, and fat metabolizing enzyme activity. Vascular dysfunction can primarily identified by LDL cholesterol composition shift, one of atherosclerosis predictor. Rosella is a multifunctional herb that widely used as a pleasant tea. Aside from its rich components, anthocyanin, pectin, PCA and hibiscus acid are playing the role keys in lowering LDL cholesterol through lipid metabolism enzyme activity modification. Rosella is easy to find, relatively cheap, tasteful and also categorized as food-grade FDA approved.Aim:  To investigate the effect of rosella infusion in decreasing LDL cholesterol serum on cigarettes exposed male Sprague dawley rat.Methods: This study is a true experimental study design with post-test only controlled group design. After 7 days of adaptation, a total of 30 male Sprague dawley rats were randomly divided into 5 groups (n=6 per group); KN received no special treatment; KP exposed to 4 rods of cigarette smoke/day; experimental groups (P1, P2, P3) exposed to 4 rods of cigarette smoke/day and rosella dried calyx infusion with 250, 500 and 1000 mg/kg respectively for 30 consecutive days. LDL cholesterol levels are measured using the CHOD-PAP method. Collected data were analyzed statistically using One Way ANOVA Test.Results: There is a significant difference between all experimental groups (p=0,00) in the post-hoc test.Conclusion: These lines of evidence suggest that rosella infusion significantly decreases LDL Cholesterol serum level in cigarettes exposed Sprague dawley rats in a dose-dependent manner.Keywords: Cigarettes smoke, LDL cholesterol, Rosella calyx infusion
Macrophage Activity Test of Pulmonary Tuberculosis Patients with Diabetes Mellitus (TB-DM) Arlita Leniseptaria Antari; Indah Saraswati; David Pakaya; Aryoko Widodo
Journal of Biomedicine and Translational Research Vol 2, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (15.528 KB) | DOI: 10.14710/jbtr.v2i2.833

Abstract

Background: Control of pulmonary TB is getting more and more complicated as the number of patients with diabetes mellitus (DM) is increasing. The increasing prevalence of DM is followed by the increasing prevalence of pulmonary TB. Diabetes Mellitus patients have 4,7 times higher risk to develop pulmonary TB compared to patients without DM, since DM can increase the frequency and severity of an infection, including pulmonary TB.Aim: To analyze macrophage activity (phagocytosis, intracellular killing, and TNF-α synthesis) of TB-DM patients.Method: The research is an experimental study using a PBMC cultured sample from TB-DM patient's which undergo observation of macrophage activity (phagocytic, intracellular killing and TNF-α synthesis). The data were taken from microscopic observation of TB-DM patients, colony growth of viable Mycobacterium tuberculosis and the TNF-α level secreted by macrophages.Result: Microscopic observation showed that there are less amount of phagocytosed M. tuberculosis (in macrophage/intracellular level) and there is a little amount of formed vacuoles and giant cells. Furthermore, macrophages in TB-DM patients secrete low level of TNF- α, and there are more viable M. tuberculosis from this macrophage.Conclusions: Macrophages of TB-DM patients are less activated, with reduced phagocytic activity (due to the intrinsic defect of PMN) and reduced antigen presenting activity of phagocytes toward M. tuberculosis. Therefore, there is a need for a further study focused on macrophage activity enhancement on TB-DM patients against M. tuberculosis infection in DM patients.Keywords: macrophage, TB-DM, phagocytosis, intracellular killing, TNF- α. 
Ekstrak Hibiscus rosa-sinensis L. Memperbaiki Kadar Glukosa Darah Puasa dan Jumlah Sel Mast pada Model Tikus Diabetes Terinfeksi Mycobacterium tuberculosis: Hibiscus rosa-sinensis L. Extract Improves Fasting Blood Glucose Levels and Number of Mast Cells in Diabetic Rat Model that Infected with Mycobacterium tuberculosis David Pakaya; Marzela Dewi; Arlita Leniseptaria Antari; Indah Saraswati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.89 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13930

Abstract

Background: The condition of hyperglycemia in Diabetes mellitus (DM) causes a disruption of the function of phagocytes that can facilitate M. tuberculosis infection. Immunostimulant from natural ingredients can help improve the condition of hyperglycemia an immune function. Objective: To analyze the effect of Hibiscus rosa-sinensis L. extract on fasting blood glucose level and the number of mast cell in TB-DM mouse model. Methods: This experimental study used 27 male Wistar rats, 8 weeks of age, 200-230 g weight, divided into 3 groups, K: Normal control group, P1: TB-positive mouse group P2: Group rat TB-DM + Hibiscus rosa-sinensis L extract dose 250 mg/kgBW and 3 time measurement of H + 7 DM, H + 14 DM and H + 21 DM. TB-DM model mice were prepared with the administration of nicotinamide (NA) 100 mg/kgBW and streptozotocin (STZ) 65 mg/Kg BW, TB agent 1.5 x 105 CFU. Fasting blood glucose levels were measured by GOD-PAP method and Pulmonary tissue is excised, made in paraffin blocks and stained with blue Toluidine to count the mast cells. Results: There was an improvement in the mean fasting blood glucose levels in the group treated with the Hibiscus rosa-sinensis L. extract of 250 mg/kgBW compared to the TB-DM group without extract therapy followed by decreased the number of mast cell. Conclusion: Hibiscus rosa-sinensis L. extract. improves fasting blood glucose levels and decreases the number of mast cell of TB-DM rat model.
PENGARUH NILAI pH TERHADAP WARNA DARI KAYU SECANG (Caesalpinia Sappan L.) SEBAGAI INDIKATOR ALAMI BARU Indah Saraswati
Media Medika Muda Vol 1, No 3 (2016)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Zat warna telah dikenal sejak beberapa abad yang lalu. Dalam upaya isolasi zat warna alami, dilakukan kajian mengenai zat warna alami kayu secang (Caesalpinia sappan L.). Beberapa penelitian terdahulu hanya melaporkan aktivitas kayu secang sebagai obat tradisional. Penelitian ini ditujukan untuk mempelajari warna dari kayu secang (Caesalpinia Sappan L.) dalam berbagai variasi nilai pH yaitu dalam larutan asam, netral, dan basa.Metode: Preparasi sampel secang dilakukan dengan mengekstraksi bubuk kayu secang dengan pelarut air menggunakan metode Soxhlet.Hasil: Larutan kayu secang pada larutan asam, netral, dan basa menunjukkan warna yang berbeda. Secang sebagai larutan dianalisis dengan spektrofotometer UV-Vis. Spektra UV-Vis menunjukkan bahwa larutan secang memiliki dua puncak pada panjang gelombang 440 nm dan 540 nm, dengan intensitas yang bervariasi dengan variasi pH. Secara fisik, hal ini ditunjukkan dengan perbedaan warna dari larutan secang tersebut.Simpulan: Larutan secang pada larutan asam menunjukkan warna kuning-jingga, pada larutan netral menunjukkan warna merah, dan pada larutan basa menunjukkan warna ungu-violet. Kata kunci: secang, Caesalpinia sappan L., variasi pH
Co-Authors Achmad Zulfa Juniarto Anfa Adnia Fatma Antari Arlita Leniseptaria Arlita Leniseptaria Antari Aryoko Widodo David Pakaya Desi Kristina Gultom Desy Armalina Dimas Sindhu Wibisono Dwi Retnoningrum Endang Mahati Eva Annisa Eva Annisaa Gabriela Rolanda Hermawan Istiadi Ibrahim, Natalia P. Ilham Saptia Nugraha Imam Buchori Indranila Kustarini Samsuria Kusmiyati Tjahjono DK Lusiana Batubara Marzela Dewi Muflihatul Muniroh Muhammad Avicenna Abdul Syukur Najatullah Neni Susilaningsih Prabowo, Yoghi B. Talitha Salsabila Vega Karlowee Widyandani Sasikirana