Antioxidant is an essential compound to keep manââ¬â¢s health due to its function as radical scavenging. Curcumin analogàcompounds can function as antioxidant (Sardjiman, 2000). The aim of the experiment was to find out the antioxidant activity of 2,.6-bis-(2ââ¬â¢-furilidin)-cyclohexanone, 2,.5-bis-(2ââ¬â¢furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one compounds, and the antioxidant activity of each compound against DPPHàradical with IC50 parameter as well as the correlation of compounds structureââ¬â¢s activities against antioxidant.àThe antioxidant activity of curcumin analog compounds wereas tested against DPPH freeàradical. The test was conducted in 5 series of concentrations by adding 4.0àml test solutions with 1.0 ml DPPH. The antioxidant activity against free radical was measured usingwith spectrophotometer at 517 nm wavelength and determined for the IC50 value. The experiment employed rutin as positive control. The result of the experiment showed that curcumin analog compounds have antioxidantàactivity with IC50 of rutin, 2,.6-bis-(2ââ¬â¢-furilidin)-cyclohexanone, 2,.5-bis-(2ââ¬â¢furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one as follows: 4.93 ppm, 22.73 ppm, 20.67 ppm, and 18.80 ppmàrespectively. The highest antioxidant activity belonged toà1,.5-difuril-1.4-pentadien-3-one compound which is 18.80 ppm . Correlation of activity structure of the 3 compounds can be seen from the log p parameter and energy space of HOMO-LUMO.ÃÂ