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All Journal Jurnal Keperawatan Jurnal Kedokteran Brawijaya Journal of Islamic Medicine JSMARTech : Journal of Smart Bioprospecting and Technology Malang Respiratory Journal Cermin Dunia Kedokteran
Djanggan Sargowo
Pascasarjana Fakultas Kedokteran, Universitas Brawijaya, Malang
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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GAGAL JANTUNG KIRI DAN HIPERTENSI PULMONAL Sargowo, Djanggan
Journal of Islamic Medicine Vol 1, No 1 (2017): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.232 KB) | DOI: 10.18860/jim.v1i1.4118

Abstract

In patients with left heart failure, pulmonary hypertension and right ventricular dysfunction is a common condition and has important implications in the development of disease, disability and death, so it required special attention. Pulmonary hypertension is the most common form with approximately 65-80% of cases. Although today is already highly developed understanding of the pathophysiology and clinical assessment, as well as setting the hemodynamic definition and classification of pulmonary hypertension in left heart failure, but the interrelation hemodynamics in pulmonary hypertension combination of pre- and post-capillary is still very complex, and there is no evidence-based recommendations the handling of pulmonary hypertension is left heart failure. Here, we will discuss the prevalence and significance of pulmonary hypertension and cardiac dysfunction Right in patients with both heart failure with ejection fraction decreased, as well as heart failure with ejection fraction, as well as provides an overview of the pathophysiology of the complex due to the interaction of cardiopulmonary left heart failure, which can supports the evolution of the phenotype of the left ventricle into the right ventricle phenotype through the travel history of heart failure. Next, we will discuss fenoitp pulmonary hypertension by combining the clinical context, the assessment of non-invasive and invasive hemodynamic variables in a structured diagnostic assessment.
HUBUNGAN TIM DINAMIS DENGAN KEMAMPUAN PERAWAT IGD MELAKUKAN CPR DI RUMAH SAKIT RUJUKAN PERTAMA NUSA TENGGARA BARAT Suharsono, Tony; Aries Fahrozi, Lalu; Sargowo, Djanggan
Jurnal Keperawatan Vol 6, No 2 (2015): Juli
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.065 KB) | DOI: 10.22219/jk.v6i2.2870

Abstract

Latar Belakang Peran penting perawat dalam penanganan cardiac arrest dan kemampuan kemampuan melakukan high quality CPR adalah kemampuan yang wajib dimiliki oleh perawat.Tujuan penelitian ini adalah untuk mengetahui hubungan antara tim dinamis dengan kemampuan perawat IGD dalam melakukan CPR. Metode observasional analitik dengan pendekatan cross sectional menggunakan purposive sampling. Jumlah sampel 52 perawat IGD dari tiga rumah sakit rujukan pertama di NTB. Alat ukur lembar observasi dan manequin GD/CPR180S, untuk mengetahui kemampuan CPR dan parameter tim dinamis. Hasil penelitian menunjukkan bahwa rata-rata responden hanya melakukan 4 hal dari indikator CPR yang berkualitas dan 5 dari 6 indikator tim dinamis dalam proses CPR. Hasil analisa bivariat dengan menggunakan korelasi pearson menunjukkan Pv 0,000 dan r 0,637. Tim dinamis mempunyai hubungan yang erat dengan kemampuan perawat melakukan CPR. Berdasar dari penelitian ini, sebaiknya pelatihan CPR dilakukan dengan pendekatan tim.
IDENTIFIKASI MUTASI GEN CYSTATIONINE-β SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI Muliartha, I Ketut Gede; Sargowo, Djanggan; Iskandar, Abdillah
Jurnal Kedokteran Brawijaya Vol 24, No 3 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.881 KB) | DOI: 10.21776/ub.jkb.2008.024.03.3

Abstract

ABSTRACT Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels of  plasma  total  homocysteine  (tHcy)  was  caused  by  genetic  or  nutrient-related  disturbances  in  the transsulfuration  or  remethylation  pathways  for  homocysteine  metabolism.  This  study  observed  premature myocard  infarct  acute  patients  with  hyperhomocysteinemia.The  aim  of  the  research  was  to  determine Cystarhionine-β  Synthase  and  Methylenetetrahydrofolate  Reductase  genes  mutations  in  premature  acute myocard  infarct  patients  with  hyperhomocysteinemia.This  study  was  a  cross  sectional  study  in  premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and normal  folic  acid,  vitamin  B6,  vitamin  B12  levels  and  lipid  profile.  Five  patients  were  assayed  for Cystathionine-β  Synthase  and  gen  Methylenetetrahydrofolate  Reductase  genese  mutations  by  Polymerase Chain  Reactions  (PCR).  Five  from  23  patients  (  21,7%  )  plasma  total
PENGHAMBATAN AKTIFASI NFκ κκ κB OLEH CAPE (CAFFEIC ACID PHENETHYL ESTER), KOMPONEN AKTIF MADU LEBAH (HONEYBEE HIVES),PADA HUVEC’S (HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS) YANG DIPAPAR LDL TEROKSIDASI Rohman, Mohammad Saifur; Rastini, Endah Kusuma; Sarbini, Dwi; A W, Titi; Widodo, Widodo; Sargowo, Djanggan
Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (948.806 KB) | DOI: 10.21776/ub.jkb.2006.022.01.1

Abstract

The high prevalence of cardiovascular morbidity and  mortality caused by complication of atherosclerosisneeds an optimal effort to prevent the atherosclerosis progression and complication. Atherogenesis is a chronicinflammatory process which could be prevented via the inhibitionof NF?B, a known key transcription factor involved in inflammatory process. An active component of honeybee hives, CAPE (Caffeic Acid Phenethyl Ester), is believed to inhibit inflammatory process via the inhibition of NF?B activation. However, it remains uncertain whetherCAPE inhibits NF?B activation in endothelial cells. This study therefore was aimed to examine the molecular mechanism of CAPE mediated NF?B inactivation in OxLDL-treated HUVEC?s. Immunohistochemistry using p50 antibody was applied to detectthe migration of NF?B (p50-p65 complex) from inactive form in cytoplasmto active form in nucleus.
Polimorfisme Gen Penyandi Reseptor Adrenergik β3 pada Remaja dengan Sindroma Metabolik Andarini, Sri; Sargowo, Djanggan
Jurnal Kedokteran Brawijaya Vol 28, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.397 KB) | DOI: 10.21776/ub.jkb.2014.028.02.13

Abstract

Sindroma metabolik telah menjadi permasalahan dunia termasuk di Indonesia dengan obesitas sebagai salah satu komponennya. Obesitas pada remaja dapat mengarah pada obesitas saat dewasa, yang dapat disebabkan faktor genetik dan lingkungan. Faktor genetic yang mempengaruhi obesitas adalah gen penyandi reseptor adrenergic yang berperan dalam thermogenesis. Penelitian ini dilakukan untuk menjelaskan peran gen penyandi reseptor adrenergik β3  pada remaja dengan sindroma metabolik. Penelitian dilakukan dengan menggunakan desain case control. Kriteria sindroma metabolik menggunakan batasan dari IDF (International Diabetes Federation). Hasil penelitian mengidentifikasi adanya polimorfisme pada gen penyandi reseptor adrenergik β3 pada 13,3% remaja dengan sindroma metabolik. Polimorfisme yang terjadi adalah pada rantai basa 212 missense timin menjadi adenin, guanin dan adenin pada rantai basa 213 serta delesi rantai basa 244 pada 2 remaja dengan SM dan rantai basa 354 pada satu remaja dengan SM. Didapatkan hubungan antara adanya polimorfisme dan terjadinya sindroma metabolik. Dapat disimpulkan bahwa terjadinya polimorfisme pada gen penyandi reseptor adrenergik β3 berhubungan dengan terjadinya sindroma metabolik pada remaja.Kata Kunci: Gen penyandi reseptor adrenergic β 3, polimorfisme, remaja, sindroma metabolik
Akurasi Fibrinogen dan Hs-CRP sebagai Biomarker pada Sindroma Koroner Akut Setiawan, Ivan; Wardhani, Viera; Sargowo, Djanggan
Jurnal Kedokteran Brawijaya Vol 26, No 4 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.915 KB) | DOI: 10.21776/ub.jkb.2011.026.04.10

Abstract

Peran fibrinogen dan Hs-CRP menunjukkan potensinya sebagai biomarker pada sindrom koroner akut. Penelitian ini adalah observasional dengan pendekatan potong lintang yang berlangsung dari bulan Februari dampai dengan Juli 2011. Jumlah subjek untuk tiap kelompok kasus maupun kontrol adalah 76, berusia antara 35 sampai dengan 80 tahun. Kedua kelompok diukur kadar fibrinogen dan Hs-CRP. Cut off masing-masing biomarker diukur dengan Receiver Operating Curve. Akurasi dr nilai diukur dengan sensitivitas, spesifitas, rasio kemungkinan, nilai duga positif dan nilai duga negatif, baik secara kombinasi maupun terpisah. Umur rerata pada kedua kelompok 57,5 tahun. Kadar fibrinogen pada kelompok kasus (5,8±1,56 g/L) berbeda bermakna dibandingkan dengan kelompok kontrol (3,78±1,78 g/L). Kadar Hs-CRP pada kelompok kasus (4,04±1,94 mg/L) berbeda bermakna dibanding kelompok kontrol (1,98±1,25 mg/L). Kedua biomarker baik secra kombinasi atau terpisah dapat dipakai sebagai alat diagnostik pada sindrom koroner akut. Fibrinogen dan Hs-CRP mempunyai nilai diagnostik terbaik dibanding bila digunakan secara terpisah.Kata Kunci: Atherosklerosis, biomarker, fibrinogen, Hs-CRP, inflamasi, sindrom koroner akut
Developing Herbal Medicine, The Role of β-1,3/1,6-D-Glucan Forms of Polysaccharide Peptide (PsP) from Mycelia Ganoderma lucidum Extracts for Lowering Elevated Total Cholesterol Level in Patients with Heart Failure in Ischaemic Heart Disease Sargowo, Djanggan; Wihastuti, Titin Andri; Dewi, Elvira Sari; Saputri, Diana Nanda
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.40

Abstract

High levels of total cholesterol can worsen the condition of ischemic heart failure. Polysaccharide peptide (PsP) is a capsule of Ganoderma lucidum extract. This study aims to measure changes in total cholesterol levels in patients with ischemic heart failure before and after the administration of PSP and Placebo and to analyze differences in decreases in total cholesterol levels between PSP and Placebo group. This research is a true experiment with a prospective double-blind randomized control method through pre-post test design. The sample consisted of 26 patients, divided into 2 groups and given PSP or placebo capsules per oral interventions carried out every day for 90 days. Venipuncture blood was taken before and after the intervention to measure total cholesterol levels by spectrophotometry methods. Paired T Test was used to determine the average reduction in total cholesterol levels for each group. Independent T Test was used to determine the difference of reduction in total cholesterol average between the two groups. The decrease of total cholesterol average level in PsP group was 24.3 mg/dl (p value 0.001) and an increase of Placebo group was 8.3 mg/dl (p value 0.099). Comparison of the average reduction in total cholesterol levels in PsP : Placebo group was 24.31: -8.31 mg/dl (p value 0.000). There was significant decrease total cholesterol levels in PsP group and neither was of the Placebo group. In addition, there was significant difference in the reduction of total cholesterol levels between PSP and Placebo group.
Lung Adenocarcinoma Metastases to Mediastinal with Malignant Pericardial Effusion Andri, Andri; Parsama Putra, Ngakan Putu; Sargowo, Djanggan; Erawati, Dini Rachma; Retnani, Diah Prabawati
Malang Respiratory Journal Vol 3, No 2 (2021): Vol. 3 No. 2
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.362 KB) | DOI: 10.21776/ub.mrj.2021.003.02.4

Abstract

Lung adenocarcinoma with malignant pericardial effusion and also metastases to mediastinum has great impact on morbidity and mortality of patient and it is rare case. Most adenocarcinoma in the mediastinum are metastases from the lung, gastrointestinal tract, pancreas, kidney or even the pituitary gland. Cardiac metastases in lung cancer may occur due to retrograde lymphatic spread or by hematogenous dissemination of tumour cells. Pericardium is frequently involved in direct cardiac invasion by adjacent lung cancer. Pericardial effusion, pericarditis, and tamponade are common and life threatening presentation in such cases. A 42-years-old male with superior mediastinal mass has malignant pericardial effusion, cytology shows adenocarcinoma. The patient undergo transthoracic fine needle aspiration biopsy. The result from biopsy is adenocarcinoma. This is a rare case, patient with primary lung adenocarcinoma and malignant pericardial effusion also metastases to mediastinum. To determine the diagnosis requires a comprehensive clinical evaluation and multidisciplinary approach.
Peningkatan Kesintasan Pasca Henti Jantung-Di Luar Rumah Sakit Memerlukan Alat Baru Sargowo, Djanggan
Cermin Dunia Kedokteran Vol 44, No 9 (2017): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (824.596 KB) | DOI: 10.55175/cdk.v44i9.730

Abstract

Saat ini, identifikasi pasien kandidat ICD masih sulit. Memperbaiki keluaran resusitasi merupakan satu–satunya cara untuk menurunkan kematian karena henti jantung mendadak. Salah satu caranya adalah memperpendek selang waktu antara henti jantung dan defibrilasi antara lain dengan alat deteksi henti jantung yang secara otomatis memperingatkan orang sekitar dan EMS. Merancang algoritma deteksi dengan positive predictive accuracy yang tinggi akan menjadi tantangan teknis tersendiriPotential ICD candidate is still difficult to be identified. The only method to lower sudden cardiac death is to improve the outcome of resuscitation; i.e by reducing the time-lag between cardiac arrest and defibrillation attempt through the use of automatic detector that can alert EMS and surrounding people. There is still a challenge to set up an algorithm with high positive predictive accuracy.
Karakteristik Pasien Gagal Jantung di RS BUMN di Kota Malang Sidarta, Erdo Puncak; -, Vidyawati; Sargowo, Djanggan
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.949 KB) | DOI: 10.55175/cdk.v45i9.609

Abstract

Penelitian ini merupakan studi observatif deskriptif dengan purposive sampling sejak Februari 2017 hingga Oktober 2017 di RS BUMN di Kota Malang. Data diperoleh dari wawancara, pemeriksaan klinis, pemeriksaan penunjang pada pasien IGD RS dengan diagnosis gagal jantung oleh spesialis jantung. Jumlah responden sebanyak 33 orang. Hasil: Dari 33 pasien, 19 (57,6%) pria. Kelompok usia terbanyak <60 tahun (17 - 51,5%). Sumber pembiayaan terutama asuransi pemerintah (BPJS) (27 - 82%). Sejumlah 24 (72,7%) pasien memiliki riwayat penyakit jantung, 14(42,4%) memiliki riwayat merokok, 7 (21,2%) memiliki riwayat konsumsi alkohol, 10 (30,3%) memiliki riwayat diabetes mellitus, dan 20 (60,6%) memiliki riwayat rawat inap akibat gagal jantung. Rehospitalisasi terutama <6 bulan (10 - 30,3%). Penyebab terbanyak kardiomiopati terdilatasi (13 - 39,4%). Sebanyak 15 pasien (45,4%) datang dengan NYHA III dan gejala fisik terutama edema perifer (22 - 66,7%). Kardiomegali pada x-ray dada didapat pada 31(93,9%), irama sinus pada elektrokardiogram pada 28 (84,9%). Pada ekokardiografi, 17 pasien (51,5%) memiliki ejeksi fraksi ≥40%. Simpulan: Sebagian besar responden pria, berusia < 60 tahun, kardiomiopati terdilatasi merupakan penyebab paling banyak gagal jantung.A descriptive observational study with purposive sampling was done at BUMN hospital in Malang city. Data were collected from interview, clinical examination and diagnostics on 33 patients diagnosed as heart failure in ER by cardiologist from February 2017 to October 2017. Results: Of all 33 patients recorded, 19 (57.6%) were men, dominant age group was <60 years old (17/33 - 51.5%). The largest source of funding is government insurance (BPJS) (27/33 - 82%). Previous heart disease found in 24/33 (72.7%) patients, 14/33 (42.4%) had smoking history, 7/33 (21.2%) had history of alcohol consumption, 10/33 (30.3%) had diabetes mellitus, and 20/33 (60.6%) had family history of heart failure. Rehospitalization within <6 months was in 10/33 (30,3%) patients. The most common cause of heart failure was dilated cardiomyopathy (13/33 - 39.4%); 15/33 (45.4%) came with NYHA III. Most patients had peripheral edema (22/33 - 66.7%). Cardiomegaly findings in chest x-ray was in 31/33 (93.9%) patients and 28/33 (84.9%) had sinus rhythm in electrocardiogram. On echocardiography, 17/33 (51.5%) had an ejection fraction of ≥40%. Conclusion: The majority of respondents were male, less than 60 years old with dilated cardiomyopathy.
Co-Authors -, Vidyawati Abdillah Iskandar Achdiat Agoes, Achdiat Andri Andri Dwi Sarbini Elvira Sari Dewi Endah Kusuma Rastini Erawati, Dini Rachma I Ketut Gede Muliartha Ivan Setiawan Lalu Aries Fahrozi, Lalu Mohammad Saifur Rohman Parsama Putra, Ngakan Putu Retnani, Diah Prabawati Saputri, Diana Nanda Satuman Satuman Sidarta, Erdo Puncak Sri Andarini Teuku Heriansyah, Teuku Titi A W Titin A Wihastuti, Titin A Titin Andri Wihastuti Tony Suharsono, Tony Viera Wardhani Widodo Widodo