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Efektifitas Antibiotik Azelaic Acid Terhadap Propioni-Baktterium Acne Dengan Metode Difusi Pada Pasien Acne Vulgaris Eka Silvia; Ringgo Alfarisi; Arief Effendi; Muhammad Alva Rizqy
MAHESA : Malahayati Health Student Journal Vol 2, No 3 (2022): Volume 2 Nomor 3 (2022)
Publisher : Universitas Malahayati

ABSTRACT Acne vulgaris is a form of chronic inflammation of the hair follicles of the sebaceous glands in the form of multifactorial and clinical manifestations of acne, papules, pustules, lymph nodes, and cysts. Propionibacterium acnes is a bacterium involved in acne inflammation and Azelaic acid is one of the acne vulgaris treatments that have antimicrobial and anti-inflammatory effects. Know the degree of effectiveness of Azelaic Acid antibiotic against propionibacterium acne by in vitro diffusion method and compare it with several antibiotics (clindamycin, erythromycin, benzoyl peroxide, tetracycline) and Lactobacillus acidophilus. The study tested the effectiveness of Azelaic acid antibiotics against propionibacterium acne by in vitro diffusion method and analyzed the data using Shapiro-Wilk for data normality. After being declared to be normally distributed (p>0.05), an unpaired T-test was performed. If the data were not normally distributed, the Mann-Whitney test was performed to test the comparison of 1 and 2. Results: The average effectiveness of the antibiotics Azelaic acid is 33,589 mm and Vaseline 0 mm against Propionibacterium acnes in vitro. Based on the unpaired T-Test, Sig. (2-Tailed) = 0.000, which means that there is a significant difference in each variable. Conclusion: There is a difference in the effectiveness of Azelaic acid with Vaseline on the growth of Propionibacterium acnes by diffusion method in vitro and ranks third highest, including a very strong inhibition zone Keywords: Acne Vulgaris, Azelaic Acid, Propionibacterium Acnes ABSTRAK Acne vulgaris adalah suatu bentuk peradangan kronis pada folikel rambut kelenjar sebaceous berupa multifaktor dan manifestasi klinis berupa jerawat, papula, pustula, kelenjar getah bening dan kista. Propionibacterium acnes merupakan bakteri yang terlibat dalam peradangan jerawat dan Azelaic acid salah satu pengobatan akne vulgaris yang memiliki efek antimikroba dan anti-inflamasi. Tujuan penelitian ini untuk mengetahui derajat keefektivitasan antibiotik Azelaic Acid terhadap propionibacterium acne dengan metode difusi secara in vitro dan membandingkan dengan beberapa antibiotik (klindamisin, eritromisin, benzoil peroksida, tetrasiklin) serta Lactobacillus achidopilus. Penelitian uji efektifitas antibiotik Azelaic acid terhadap propinibacterium acnes dengan metode difusi secara in vitro dan menganalisis data menggunakan Shapiro-wilk untuk normalitas data. Setelah dinyatakan berdistribusi normal (p>0,05) maka dilakukan uji T-Tidak berpasangan jika data tidak berdistribusi normal maka dilakukan uji MannWhitney untuk menguji perbandingan 1 dan 2. Didapatkan rata-rata efektifias antibiotik Azelaic acid 33,589 mm dan Vaseline 0 mm terhadap Propionibacterium acnes secara in vitro. Berdasarkan uji T-Test tidak berpasangan di peroleh Sig.(2-Tailed) = 0,000 yang berarti terdapat perbedaan yang bermakna pada setiap variabel. Terdapat perbedaan efektivitas antibiotik Azelaic acid dengan vaseline terhadap pertumbuhan Propionibacterium acnes dengan metode difusi secara in vitro dan menempati urutan ke ketiga tertinggi, termasuk zona hambat sangat kuat. Kata Kunci: Acne Vulgaris, Azelaic Acid, Propionibacterium Acnes

Hubungan Antara Jenis Kelamin Dengan Angka Kejadian Kondiloma Akuminata Di Poliklinik Kulit Dan Kelamin RSUD Dr. H. Abdoel Moeloek Bandar Lampung Periode 2018-2020 Arif Efendi; Eka Silvia; Abdurrohman Izuddin; Wisnu Galih Prayoga
MAHESA : Malahayati Health Student Journal Vol 2, No 1 (2022): Volume 2 Nomor 1 (2022)
Publisher : Universitas Malahayati

ABSTRACT Condyloma acuminate (CA) is a sexually transmitted disease caused by infection of Human Papilloma Virus (HPV) type 6 and type 11 with clinical manifestations in the form of papules or papillomatous nodules but can be asymptomatic. CA generally occurs in anogenital areas through micro-trauma to the skin or mucosa with risk factors such as high-risk sexual practices, multi-partner, and poor personal hygiene. The prevalence of HPV infection in the world is reported to continue to increase with a prevalence ranging from 160-289 per 100,000 people per year. In Indonesia, the prevalence of KA ranges from 5-19% among total sexually transmitted diseases. To determine the relationship between gender and the incidence rate of condyloma acuminate in the Dermatovenerology Polyclinic of Dr. H. Abdul Moeloek Bandar Lampung in 2018 - 2020. This type of research used in this study is a quantitative analytic study with a cross-sectional design. The samples were 102 patients who meet the inclusion criteria. Data were collected from January 2020 to February 2021. The data used in this study were secondary data from medical records. The data were evaluated by using the Chi-Square test. Among 102 samples, 71 patients diagnosed with condyloma acuminate, gender frequency distribution was 41 (58%) women and 30 (42%) men. Statistical test results with the chi-square test obtained p = 0.008 (p <0.05), which means that there is a significant relationship between sex and the incidence of condyloma acuminate. There is a significant relationship between gender and the incidence of CA in the Dermatovenerology Polyclinic of RSUD DR. H. Abdul Moeloek, Lampung Province in 2018-2020 with p = 0.008 (p <0.05). Keywords: Condyloma Acuminate, Gender, Incidence ABSTRAK Kondiloma akuminata (KA) merupakan penyakit infeksi menular seksual yang disebabkan oleh infeksi Human Papilloma Virus (HPV) tipe 6 dan tipe 11 dengan manifestasi klinis berupa papul atau nodul papilomatus namun dapat asimtomatis. KA umumnya terjadi pada daerah anogenital melalui mikro-trauma pada kulit atau mukosa dengan faktor risiko seperti, praktik seksual berisiko tinggi, multipartner dan kebersihan personal yang buruk. Pravelensi infeksi HPV di dunia dilaporkan terus meningkat dengan prevalensi berkisar antara 160-289 per 100.000 orang per tahun. Di Indonesia pravelensi KA berkisar antara 5-19% dari total penyakit menular seksual. Tujuan penelitian ini untuk mengetahui hubungan antara jenis kelamin dengan angka kejadian kondiloma akuminata di Poliklinik Kulit dan Kelamin RSUD Dr. H. Abdul Moeloek Bandar Lampung pada Tahun 2018 - 2020. Jenis Penelitian ini adalah analitik kuantitatif dengan metode cross sectional menggunakan total sampling sebanyak 102 sampel pasien yang memenuhi kriteria inklusi. Pengambilan data dilakukan dari bulan Januari 2020 hingga Februari 2021. Data yang digunakan yaitu data sekunder berupa rekam medik. Data dievaluasi dengan uji Chi-Square. Didapatkan sampel penelitian berjumlah 102 pasien dengan 71 pasien terdiagnosis dengan Kondiloma Akuminata dengan distribusi frekuensi jenis kelamin yaitu sebanyak 41 orang (58%) perempuan dan 30 orang (42%) laki-laki. Pada hasil uji statistik dengan chi-square diperoleh p=0,008 (p<0,05) yang berarti adanya hubungan yang signifikan antara jenis kelamin dengan angka kejadian kondiloma akuminata. Terdapat hubungan yang yang signifikan antara jenis kelamin dengan angka kejadian KA di Poliklinik Kulit dan Kelamin RSUD.DR.H. Abdul Moeloek Provinsi Lampung tahun 2018-2020 dengan hasil p=0,008 (p<0,05). Kata Kunci: Kondiloma Akuminata, Jenis kelamin, Angka Kejadian

Penyuluhan Tentang Penanganan Dan Pencegahan Covid-19 Anggunan Anggunan; Muh Abu Hanifah Albar Maki; Aswan Jhonet; Neno Fitriyani Hasbie; Eka Silvia; Mardheni Wulandari
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) Volume 4 Nomor 2 April 2021
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v4i2.3679

ABSTRAK Coronavirus Disease 2019 (Covid-19) merupakan penyakit jenis baru yang belum teridentifikasi sebelumnya dan saat ini telah menyerang manusia. Untuk angka kejadiannya sampai tanggal 2 September 2020, COVID-19 sudah ditemukan di 216 negara, dengan total kasus konfirmasi sebesar 25.602.665 kasus. Untuk mencegah penyebaran COVID-19: cuci tangan anda secara rutin, gunakan sabun dan air, atau cairan pembersih tangan berbahan alkohol, selalu jaga jarak aman dengan orang yang batuk atau bersin, kenakan masker jika pembatasan fisik tidak dimungkinkan, jangan sentuh mata, hidung, atau mulut anda. Tujuan kegiatan penyuluhan ini adalah untuk memberikan edukasi dan pemahanan kepada masyarakat umum tentang bagaimana cara memutus rantai penularan COVID-19 serta memberi pengetahuan tentang cara memperkuat imunitas tubuh dengan upaya pola perilaku hidup sehat, serta menyediakan vitamin tambahan sebagai upaya untuk meningkatkan imunitas tubuh dan juga selalu memakan makanan yang sehat dan bergizi. Kegiatan ini diawali dengan pembukaan oleh moderator, kemudian dilanjutkan dengan pemaparan materi tentang pencegahan dan penanganan COVID-19, terakhir kita berikan sesi tanya jawab kepada masyarakat. Kata Kunci : Penyuluhan, COVID 19, Masyarakat ABSTRACT Coronavirus Disease 2019 (Covid-19) is a new type of disease that has not been previously identified and is currently attacking humans. For the number of incidents until September 2, 2020, COVID-19 has been found in 216 countries, with a total of 25,602,665 confirmed cases. To prevent the spread of COVID-19: wash your hands regularly, use soap and water, or an alcohol-based hand sanitizer, always keep a safe distance from people who are coughing or sneezing, wear a mask if physical restrictions are not possible, do not touch eyes, nose, or your mouth. The purpose of this outreach activity is to provide education and understanding to the general public about how to break the chain of transmission of COVID-19 and provide knowledge about how to strengthen the body's immunity with healthy lifestyle habits, and provide additional vitamins as an effort to increase body immunity and always eat a healthy and nutritious diet. This activity began with an opening by the moderator, then continued with the presentation of material on the prevention and handling of COVID-19, finally we gave a question and answer session to the public. Keywords: Counseling, COVID 19, Community

Profil Pasien Eritroderma di Rumah Sakit Pertamina Bintang Amin Periode Januari 2016 – Desember 2019 Arif Effendi; Eka Silvia; M. Syafei Hamzah; M. Ridho Noverliansyah
ARTERI : Jurnal Ilmu Kesehatan Vol 2 No 1 (2020): November
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v2i1.138

Erythroderma is an inflammation of the skin that affects 90% or more of the skin surface area, and can be accompanied by squama. Several case reports found the incidence of erythroderma in men is greater than in women, with cases 2:1 to 4:1, and an average age of 41–61 years. Erythrodermic therapy must be adapted to the conditions of the disease. The mortality rate depends on the cause of erythroderma. Due to the lack of research data on erythroderma, researchers want to see more of the characteristics of the disease. Objectives To determine the profile of Erythroderma patients at Pertamina Bintang Amin Hospital in the period 2 January 2016 - 31 December 2019. Method This study used an observational descriptive method with a retrospective design, sampling with total sampling. Results This study showed that the highest incidence of erythroderma occurred in 2016 many as 11 people (50.0%). The majority of erythrodermic patients were male many as 13 people (59.1%). Erythrodermic patients >60 years of age occupy the highest position in the age distribution many as 14 people (63.6%). The highest cause of erythroderma was the expansion of the disease by 11 people (50.0%). Management mostly given to erythrodermic patients was oral corticosteroids + moisturizers + antihistamines as many as 12 people (54.5%).Conclusion: Highest incidence in 2016, Erythrodermic patients >60 years of age occupy the highest ,The majority of erythrodermic patients were male, cause of erythroderma was the expansion of the disease, Management mostly given to erythrodermic patients was oral corticosteroids + moisturizers + antihistamines.

Penelitian Retrospektif Pasien Skabies Berdasarkan Faktor Usia dan Jenis Kelamin di Poliklinik RS Pertamina Bintang Amin Periode 02 Januari 2016- 31 Desember 2018 Retno Oktavia; Arif Effendi; Eka Silvia
ARTERI : Jurnal Ilmu Kesehatan Vol 2 No 2 (2021): Februari
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v2i2.144

Scabies is a skin disease caused by infestation and sensitization to Sarcoptes scabiei var hominis. Scabies characterized by night itching, affecting a group of people, with a predilection spot in the skin folds that are thin, warm, and moist. Clinical symptoms can be seen polymorphy spread throughout the body. Scabies disease can be prevented by educating patients about scabies which are: disease course, transmission, how to eradicate scabies mites, maintaining personal hygiene, and procedures for applying drugs. Objective: To determine the prevalence of the incidence of scabies and the factors that influence the incidence of scabies based on age and sex at Pertamina Bintang Amin Hospital for January 2, 2016 - December 31, 2018. The type of research used in this research is a descriptive retrospective study by looking at the medical records of scabies patients at the Polyclinic of Skin and Venereal Diseases at Pertamina Bintang Amin Hospital, Bandar Lampung, 2 January 2016-31 December 2018. In this study, the results of the prevalence of scabies were 261 cases (9%) of 2924 patients with skin and venereal diseases for the period of January 2, 2016-31 December 2018 with the highest prevalence, namely in 2018 as many as 108 cases (11%) of 963 patients with skin and venereal diseases. Scabies can occur in women or men and children or adults. The results of this study indicate that most people who suffer from scabies are in the age group of 20-59 years as many as 128 cases (49%), and the most sexes suffer from scabies. Scabies, namely male, as many as 163 cases (62.5%).

Pola Penyakit Infeksi Menular Seksual di Poliklinik Kulit dan Kelamin RSP Bintang Amin Periode 2 Januari 2016 – 31 Desember 2020 Arif Effendi; Eka Silvia; Syafei Hamzah; Muhammad Alkabir Ridhwan
ARTERI : Jurnal Ilmu Kesehatan Vol 2 No 2 (2021): Februari
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v2i2.145

Sexually Transmitted Infections (STIs) are infections that are spread primarily through sexual contact. More than 30 types of microorganisms are known to be transmitted through sexual contact. The most common infections include gonorrhea, chlamydia, syphilis, trichomoniasis, hepatitis B, genital herpes, and human papillomavirus (HPV) infection. Some of the factors that may contribute to the incidence of STIs are sociodemographic and behavioral factors. Purpose: To find out the pattern of sexually transmitted infections at the Skin and Venereal Polyclinic of Bintang Amin Hospital for the period of January 2, 2016 - December 31, 2020. Research Methods: Quantitative descriptive study and cross sectional design and total sampling technique using a questionnaire. Results: The number of samples was 51 from 51 populations, the pattern of sexually transmitted infections in the Polyclinic of Skin and Sex at RSP Bintang Amin, namely condyloma acuminata as many as 28 people (54.9%), candidiasis as many as 16 people (31.4%), Herpes simplex as many as 4 people (7.8%), syphilis as much as 2 people (3.9%) and the lowest was Gonorrhea 1 person (2.0%). Conclusion: The prevalence of sexually transmitted infections that most often occurred in the Skin and Gender Polyclinic of Bintang Amin Hospital for the period January 2, 2016 - December 31, 2020, was obtained the most, namely condyloma acuminata as many as 28 patients (54.9%), with the most female sex being 40 patients ( 78.4%). Age 25-49 years were 36 patients (70.6%), and those who were married were 46 patients (90.2%).

Hubungan Tingkat Pendidikan dengan Angka Kejadian Kondiloma Akuminata Eka Silvia; Tusy Triwahyuni; M. Syafei Hamzah; Rian Hazni
ARTERI : Jurnal Ilmu Kesehatan Vol 2 No 2 (2021): Februari
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v2i2.152

Condyloma acuminata or what is often referred to as or genital warts caused by certain types of human papilloma virus (HPV) especially types 6 and 11. The level of education is one of the social factors that play a role in supporting a person to receive knowledge and information about condyloma acuminata disease, where the higher the level of education of a person usually has a greater understanding of health problems and their prevention, as well as the lower the level of one's education causes the more limited knowledge about the dangers of unhealthy behavior, so that they are not motivated to set a healthy lifestyle The purpose of this research is to determine the correlation between education level and the incidence of condyloma acuminata in dermatovenerology polyclinic of regional general hospital DR. H. Abdul Moeloek Lampung Province 2020. type of this research is analytic observational, with a cross-sectional study design, and with secondary data collection of condyloma acuminata and education level. The education level classification is adjusted according to the Law of the Republic of Indonesia Number 20 of 2003 concerning the National Education System. The technical of collecting the sample is total sampling. Data was collected by looking at medical record data and analyzed using the Spearman test. Results Obtained from 102 people according to the sample obtained. In patients with condyloma acuminata, the highest education level was 49.3%. The results of the Sperman statistical test obtain p = 0.009 (p <0.05) with a value of r = 0.256. Conclusion The final results showed that there was a significant relationship between the level of education and condyloma acuminata, the higher the level of education is lower, the higher the incidence of condyloma acuminata

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