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Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): November 2020
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.02 KB)

Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

Kombinasi relaksasi otot progresif dan terapi musik tradisional Bali efektif menurunkan stres kerja petani Cristin Wiyani; Ririn Wahyu Widayati; Ni Kadek Rai Nining Sonia Dewi; Siti Fadlilah
Jurnal Kebidanan dan Keperawatan Aisyiyah Vol 17, No 2 (2021): Desember
Publisher : Universitas Aisyiyah Yogyakarta

Penelitian ini menggunakan desain quasy experiment pre-posttest nonequivalent control group. Responden terdiri 2 kelompok masing-masing 18 orang, diambil dengan consecutive sampling. Instrumen berupa standar operasional prosedur, lembar observasi, dan kuesioner International Stress Management Association (ISMA). Uji statistik menggunakan Wilcoxon. Terdapat penurunan mean skor stres di kelompok kontrol dan intervensi yaitu 0,50 dan 1,50. Uji bivariat pre-posttest kelompok kontrol dan itervensi yaitu p-value 0,015 dan 0,000. Uji beda posttest antar kelompok didapatkan p-value 0,630. Ada pengaruh kombinasi relaksasi otot progresif dan terapi musik tradisional Bali terhadap stress kerja petani di Tabanan Bali.

Rapid Diagnostic Test (RDT) untuk Mencegah Penularan Covid-19 di Kabupaten Sleman Yogyakarta Siti Fadlilah; Ariyanto Nugroho; Ririn Wahyu Widayati; Cristin Wiyani
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 4 (2022): November
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v6i4.5379

Corona Virus Disease 19 (Covid-19) masih menjadi sebuah penyakit pandemi di dunia. Jumlah positif Covid-19 di seluruh dunia 8 Juli 2020 mencapai 11.939.555, sembuh 6.841.773 dan meninggal 545.586. Jumlah kasus di Indonesia per tanggal 8 Juli 2020 sebanyak 68.079, dengan angka kesembuhan 31.585, dan kematian 3.359. Angka kejadian di DI Yogyakarta dikonfirmasi sebanyak 349, dengan kesembuhan 285 orang, dan kematian 8 orang (2,3%). Untuk mencegah penularan Covid-19 diperlukan adanya tes massal untuk penapisan awal pada orang yang dicurigai. penapisan awal dilakukan oleh Dinas Kesehatan Kabupaten Sleman dengan melibatkan relawan dari perawat anggota DPD PPNI Kabupaten Sleman. Penapisan awal dengan metode rapid diagnostic test (RDT) antibodi. Relawan perawat bertugas mengambil sampel darah vena yang digunakan untuk pemeriksaan. Pemeriksaan dilakukan dengan peserta kluster salah satu swalayan di Jalan Magelang Yogyakarta. Pemeriksaan RDT dilaksanakan sebanyak 3 tahap dan masing-masing tahap dibagi dua shift petugas. Pemeriksaan RDT didapatkan hasil dari 1.324 peserta, sebanyak 53 orang (4.0%) dinyatakan reaktif (positif). Peserta dengan hasil RDT reaktif kemudian menjalani tes diagnostik lanjutan.

Upregulation of MRNA TNF-α in Skeletal Muscle Tissue of Streptozotocin-Induced Diabetic RAT Akbar Satria Fitriawan; Christin Wiyani; Endang Nurul Syafitri; Ririn Wahyu Widayati
Proceedings of the International Conference on Nursing and Health Sciences Vol 1 No 1 (2020): July-December 2020
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar

Inflammation is a molecular mechanism that linking obesity and ageing with insulin resistance in type 2 diabetes mellitus (DM). Although type 1 DM is primarily caused by insulin deficiency, but insulin resistance also prominent feature in this disease. It is not fully understood whether inflammation also contribute in insulin resistance phenotype in type 1 DM. This study aimed to assess mRNA TNF-α expression in the skeletal muscle tissue of type 1 diabetes mellitus rat model.This in-vivo study used 18 adults male wistar rats. The study conducted at Department of Anatomy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada from July to October 2020. Male Wistar rats divided into control group (CDM, n=6), and diabetes mellitus group which is divided into 1-month DM group (DM1M, n=6), and 2-month DM group (DM2M, n=6). The DM model was conducted through single intraperitoneal injection of Streptozotocin 60 mg/kg Body Weight (BW). At the end of study, rats were sacrificed and the gastrocnemius muscle was harvested. The expression of mRNA TNF-α was measured by RT-PCR. Statistical analysis was conducted using One Way ANOVA test. Blood glucose level were significantly higher in DM groups compared to control group (p<0.05). The body weight of DM groups was significantly lower after 1 month and 2 months DM period compared to control group (p<0.05). DM groups demonstrated upregulation of mRNA TNF-α compared to control group (p<0.05). Type 1 diabetes mellitus model demonstrated upregulation of mRNA TNF-α in skeletal muscle tissue.

Optimalisasi Promosi Kesehatan Melalui Inovasi Media Visual Bagi Atlet Sepak Bola Remaja Desty Ervira Puspaningtyas; Sri Kadaryati; Yuni Afriani; Ririn Wahyu Widayati; Siska Puspita Sari; Andika Setiawan; Cindy Nur Elityasari; Ellysha Anggreini Heryanto; Dea Puarisa Sugian Putri
MEDIA ILMU KESEHATAN Vol 12 No 1 (2023): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v12i1.845

Background: The inconsistency of performance for adolescent soccer athletes is caused by inappropriate nutrition practices. The study on U-14 to U-18 soccer athletes showed 20% of athletes lacked fluid intake and 87% of athletes had low energy and protein intake. Objective: This study aims to develop health promotion media for youth soccer athletes. Methods: This study assessed the feasibility of the developed media which consists of two stages. The first stage is the media feasibility assessment conducted by experts who focused on developing health promotion media. Results: The feasibility of sports nutrition pyramid poster, meal plate poster, and infographic is 3.2; 3.4; and 3.3. The sports nutrition pyramid poster has scores of 3 (layout); 3.5 (design); 3.2 (content). The meal plate poster has scores of 3.25 (layout); 3 (design); 3.7 (content). The infographic has scores of 3 (layout); 3 (design); 3.7 (content). There was an increase in the athlete's knowledge score from 65 to 79 (p=0.001). Conclusion: All media are feasible to be used as athletes’ health promotion media.

Health Promotion Through Audio Visual and Simulation Effectively Reduces Children's Anxiety Due to Hospitalization Fadlilah, Siti; Damayanti, Santi; Wijayanthi, Rachma Sukma; Widayati, Ririn Wahyu
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Preschool-aged children who are hospitalized are prone to anxiety. This anxiety, if not treated, can hinder the treatment process, and the length of treatment will increase. This study aims to determine the effect of health promotion using audio-visual media and simulations on the anxiety of hospitalized children in Mimika, Papua, Indonesia. The research used a quasi-experimental with a pretest-posttest control group. The sample used the control and intervention groups with 24 people in each group, the sampling technique used consecutive sampling. The instruments used were animated videos about medical devices and procedures, medical devices for simulation, standard operating procedures, observation sheets, and the Modified Yale Preoperative Anxiety Scale (mYPAS) anxiety questionnaire. Bivariate analysis is Paired T-Test and Independent T-Test: The intervention group decreased the average posttest anxiety score more than the control group (30.0 more than 5.4). Bivariate test between gender and age with anxiety showed p less than 0.05. The pretest-posttest comparison in the control and intervention groups was p=0.343 and p=0.000. At the same time, the comparison of posttest between the control and intervention groups showed p=0.002. Age and gender are related to the anxiety of pediatric patients. Health promotion and simulation of health tools and measures effectively reduce anxiety in pediatric patients.Abstrak: Anak usia prasekolah yang dirawat di rumah sakit rentan terhadap kecemasan. Kecemasan ini jika tidak diobati dapat menghambat proses pengobatan, dan lamanya pengobatan akan bertambah. Penelitian ini bertujuan untuk mengetahui pengaruh promosi kesehatan menggunakan media audio visual dan simulasi terhadap kecemasan anak rawat inap di Mimika, Papua, Indonesia. Penelitian menggunakan eksperimen semu dengan pretest-posttest control group. Sampel menggunakan kelompok kontrol dan intervensi dengan jumlah masing-masing 24 orang, teknik pengambilan sampel menggunakan consecutive sampling. Instrumen yang digunakan adalah video animasi tentang alat dan prosedur medis, alat simulasi medis, prosedur operasi standar, lembar observasi, dan kuesioner kecemasan Modified Yale Preoperative Anxiety Scale (mYPAS). Analisis bivariat adalah Paired T-Test dan Independent T-Test: Kelompok intervensi mengalami penurunan rata-rata skor kecemasan posttest lebih besar dibandingkan kelompok kontrol (30,0 lebih dari 5.4). Uji bivariat antara jenis kelamin dan usia dengan kecemasan menunjukkan p kurang dari 0,05. Perbandingan pretest-posttest pada kelompok kontrol dan intervensi adalah p=0,343 dan p=0,000. Sementara itu, perbandingan posttest antara kelompok kontrol dan intervensi menunjukkan p=0,002. Usia dan jenis kelamin berhubungan dengan kecemasan pasien anak. Promosi kesehatan dan simulasi alat dan tindakan kesehatan secara efektif mengurangi kecemasan pada pasien anak.

Pengaruh Relaksasi Nafas Dalam Terhadap Pola Tidur Lansia di BPSTW Yogyakarta Unit Budhi Luhur Yuda Prawinata; Thomas Aquino Erjinyuare Amigo; Ririn Wahyu Widayati
Jurnal Ilmiah Wahana Pendidikan Vol 5 No 2 (2019): JURNAL ILMIAH WAHANA PENDIDIKAN
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.8122595

This aim of this study is to find out deep breathing relaxation technique can affect on the elderly sleep patterns at BPSTW of Budhi Luhur Unit Yogyakarta. The reseach used a quantitative research method. It was quasi experimental research using a pre-test and post-test with a non-equivalent control group design. A convinience sampling technique was used to collect data from as many as 20 elderly people in each group. The wilcoxon analysis was applied to the intervention and control groups before and after practicing the deep breathing exercise. Meanwhile, the Mann-Whitney test was applied to the intervention and control groups after practicing the deep breathing exercise. The results indicate that the sleep patterns in the control group before and after practicing the deep breathing exercise show a p-value of 0.296, while the intervention group shows a p-value of 0.000. the bivariate analysis on the intervention and control groups after practicing the deep breathing relaxation techniques shows a p-value of 0.000. since the results indicate a p-value of less than 0.005 (p<0.05), it is concluded that there is a difference in the sleep patterns scores of the groups with the deep breathing relaxation treatment and the groups without the deep breathing relaxation treatment.

Pengaruh Terapi Yoga Terhadap Stres Pada Lanjut Usia Yang Mengalami Penurunan Fungsi Pendengaran Di BPSTW Yogyakarta Unit Abiyoso Dewi Pransisca Surya; Suwarsi Suwarsi; Ririn Wahyu Widayati
Jurnal Keperawatan Respati Yogyakarta Vol 5 No 3 (2018): SEPTEMBER 2018
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35842/jkry.v5i3.257

Hasil studi pendahuluan yang telah dilakukan di BPSTW Yogyakata Unit Abiyoso didapatkan 26 lansia mengalami penurunan fungsi pendengaran, dari 26 lansia tersebut didapatkan hasil sebanyak 10 lansia mengalami stres ringan dan 16 lansia mengalami stres dalam rentang normal. Tujuan penelitian ini adalah untuk mengetahui pengaruh Terapi Yoga terhadap stres pada lanjut usia yang mengalami penurunan fungsi pendengaran di BPSTW Yogyakarta Unit Abiyoso. Penelitian ini menggunakan jenis penelitian kuantitatif, tehnik sampling Consecutive Sampling, desain penelitian menggunakan quasi experiment, rancangan one group pretest posttest, alat ukur yang digunakan kuesioner DASS, responden penelitian lansia yang tinggal di BPSTW Yogyakarta Unit Abiyoso, jumlah responden 20, Terapi Yoga diberikan sebanyak 3 kali, dan analisa yang digunakan Wilcoxon. Hasil penelitian menunjukkan terjadi penurunan tingkat stres pada lansia yang mengalami penurunan fungsi pendengaran di BPSTW Yogyakarta Unit Abiyoso dengan hasil yang bermakna P-Value 0,000. Kesimpulannya adalah Ada Pengaruh yang signifikan terapi Yoga terhadap stres pada lansia yang mengalami penurunan fungsi pendengaran di BPSTW Yogyakarta Unit Abiyoso.

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