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All Journal Majalah Kedokteran Bandung Althea Medical Journal Medical Journal of Indonesia Global Medical and Health Communication Sari Pediatri Paediatrica Indonesiana Jurnal Keperawatan Padjadjaran
Djatnika Setiabudi
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr. Hasan Sadikin, Bandung
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Clinical and laboratory features of pediatric Typhoid fever at the Department of Child Health, Hasan Sadikin General Hospital Bandung Setiabudi, Djatnika; Azhali, M.S.; Garna, Herry; Chairulfatah, Alex
Medical Journal of Indonesia Vol 7 (1998): Supplement 1
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.139 KB) | DOI: 10.13181/mji.v7iSupp1.1145

Abstract

[no abstract available]
Antibiotic resistance patterns of pediatric Typhoid fever at the Department of Child Health, Hasan Sadikin General Hospital, Bandung Setiabudi, Djatnika; Azhali, M.S.; Garna, Herry; Chairulfatah, Alex
Medical Journal of Indonesia Vol 7 (1998): Supplement 1
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.452 KB) | DOI: 10.13181/mji.v7iSupp1.1146

Abstract

[no abstract available]
Clinical Presentation and Laboratory Features in Pediatric Typhoid Fever Patient Susceptibility to First-line Antibiotic Therapy Ratnasari, Dewi; Setiabudi, Djatnika; Rakhmilla, Lulu Eva
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.585 KB)

Abstract

Background: RTyphoid fever remainsa serious health problem in the world. The main cause of this disease is Salmonella enterica serovar Typhi. These microbes have developed resistance to first-line antibiotics (chloramphenicol, ampicillin, and co-trimoksazol) since 1950. Clinical presentation and laboratory features conducted in children infected with resistant strains tend to be more severe. The objective of this study was to determine the differences of clinical presentation and laboratory features in pediatric typhoid fever patient susceptibility to first-line antibiotics.Methods: This was an analytical cross-sectional study of total 119 typhoid fever children with positive blood culture of Salmonella Typhi based on medical data in Department of Child Health Dr. Hasan Sadikin General Hospital, Bandung during 2008–2012. Inclusion criteria included 76 patients with age range 1–15 years old, given an antibiotic, and had susceptibility test done. Numerical variable was the duration of fever in patients after given an antibiotic. Categorical variable included hepatomegaly, diarrhea, platelet count at admission, and leukocyte count at admission. Data were analyzed using a Mann-Whitney and Chi-square test.Results: There was no statistically significant difference in the duration of fever, leucocyte count at admission, and thrombocyte count at admission between sensitive and resistant response to chloramphenicol, ampicillin, and co-trimoksazol (p>0.05). Leucocyte count at admission in children with sensitive and resistant strain to ampicillin almost showed a difference (p=0.07) but still not statistically significant difference.Conclusions: There is no difference of clinical presentation and laboratory features in pediatric typhoid fever patient susceptible to first-line antibiotics. [AMJ.2015;2(4):584–90] DOI: 10.15850/amj.v2n4.653
Validity of Immunoglobulin M Anti Salmonella typhi Serologic Test in Childhood Typhoid Fever Marsela, Hilda; Setiabudi, Djatnika; Indrati, Agnes Rengga
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.598 KB)

Abstract

Background: Typhoid fever, which mostly affects children, remains a major health problem in developing countries. Early diagnosis will help the management and thus, reduce morbidity and mortality. However, a rapid diagnostic test that detects the presence of immunoglobulin M (IgM) directed towards Salmonella typhi (S. typhi) antigen remains controversial despite its popularity. This study was aimed to assess the validity of IgM anti S. typhi serologic test in childhood typhoid fever. Methods: This retrospective diagnostic test, used blood culture as gold standard. Forty-one typhoid fever children with fever of 1–14 days admitted to Dr. Hasan Sadikin General Hospital Bandung from 2013 to 2015 were recruited. Diagnosis of typhoid fever is made clinically. Data were analyzed by Receiver Operating Characteristic (ROC) curve and diagnostic test.Results: Forty one children diagnosed with typhoid fever, 37 were positive for IgM anti S. typhi, but only 18 were positive for S. typhi in blood culture. IgM anti S. typhi (cut-off ≥4) test had an Area Under the Curve (AUC) of 59%, sensitivity of 100% and specificity of 17.39%. IgM anti S. typhi with cut-off >8 showed the highest AUC with sensitivity of 55.56% and specificity of 73.68%.Conclusions: IgM anti S. typhi test of cut-off >8 performs better than cut-off ≥4 in terms of AUC..[AMJ.2017;4(1):138–42] DOI: 10.15850/amj.v4n1.1035
Perbedaan Kadar Platelet Activating Factor Plasma antara Penderita Demam Berdarah Dengue dan Demam Dengue Setiabudi, Djatnika; Setiabudiawan, Budi; Parwati, Ida; Garna, Herry
Majalah Kedokteran Bandung Vol 45, No 4 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1240.077 KB)

Abstract

Manifestasi klinis infeksi virus dengue dapat berupa demam dengue atau keadaan yang lebih berat yaitu demam berdarah dengue. Patogenesis yang menerangkan hal tersebut belum jelas. Teori yang sering dikemukakan yaitu pada penyakit dengue berat terjadi peningkatan kadar mediator proinflamasi. Tujuan penelitian ini untuk melihat perbedaan kadar platelet activating factor plasma penderita demam berdarah dengue dengan demam dengue. Penelitian observasional dengan rancangan potong lintang dilakukan pada Januari–Februari 2013. Subjek penelitian adalah penderita dengue usia 1–14 tahun yang dirawat di Rumah Sakit Dr. Hasan Sadikin Bandung, RSUD Kota Bandung (Ujungberung), dan RSUD Kota Cimahi (Cibabat). Diagnosis dengue dikonfirmasi dengan pemeriksaan antigen nonstruktural-1 dan atau pemeriksaan serologis imunoglobulin M dan G. Sampel darah fase demam, kritis dan pemulihan diambil untuk pemeriksaan kadar platelet activating factor plasma menggunakan metode enzymelinked immunosorbent assay. Selama kurun waktu penelitian didapat 26 penderita dengue, terdiri atas 14 kasus demam dengue dan 12 demam berdarah dengue. Kadar platelet activating factor plasma pada fase kritis penderita demam berdarah dengue [541,45 (239,30–2.449,00)] pg/mL lebih tinggi secara bermakna dibandingkan dengan penderita demam dengue [289,55 (149,50–961,50)] pg/mL; p=0,007. Simpulan, kadar platelet activating factor plasma pada fase kritis penderita demam berdarah dengue lebih tinggi daripada penderita demam dengue. [MKB. 2013;45(4):251–6]Kata kunci: Demam berdarah dengue, demam dengue, platelet activating factor The Difference of Platelet Activating Factor Plasma Level between Dengue Hemorrhagic Fever and Dengue Fever patientsDengue virus infection can manifest as dengue fever and, more severely, as dengue hemorrhagic fever. Their pathogenesis until now is not fully understood. One of the most favorable theories stated the presence of increasing titer of pro-inflammatory mediator in severe dengue. The aim of this study was to determine the difference of plasma platelet activating factor titer between dengue hemorrhagic fever and dengue fever patients. This observational study with cross sectional design was conducted during January–February 2013. Subjects were dengue patients, 1 to 14 years old, hospitalized at Dr. Hasan Sadikin General Hospital, Bandung District Hospital (Ujungberung), and Cimahi District Hospital (Cibabat). Dengue cases were confirmed based on nonstructural-1 antigen and/or immunoglobulin M and G rapid test. Blood samples from febrile, critical and recovery phase were drawn for the examination of platelet activating factor titer using the enzyme-linked immunosorbent assay method. There were 26 dengue cases (14 as dengue fever and 12 as dengue hemorrhagic fever). Plasma platelet activating factor titer at the critical phase was significantly higher in dengue hemorrhagic fever patients [541.45 (239.30–2,449.00)] pg/mL compared to dengue fever patients [289.55 (149.50–961.50)] pg/mL; p=0.007. In conclusion, plasma platelet activating factor titer at the critical phase is higher in dengue hemorrhagic fever patients than in dengue fever patients. [MKB. 2013;45(4):251–6]Key words: Dengue hemorrhagic fever, dengue fever, platelet activating factor DOI: http://dx.doi.org/10.15395/mkb.v45n4.172
Clinical Presentation and Laboratory Features in Pediatric Typhoid Fever Patient Susceptibility to First-line Antibiotic Therapy Dewi Ratnasari; Djatnika Setiabudi; Lulu Eva Rakhmilla
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.585 KB)

Abstract

Background: RTyphoid fever remainsa serious health problem in the world. The main cause of this disease is Salmonella enterica serovar Typhi. These microbes have developed resistance to first-line antibiotics (chloramphenicol, ampicillin, and co-trimoksazol) since 1950. Clinical presentation and laboratory features conducted in children infected with resistant strains tend to be more severe. The objective of this study was to determine the differences of clinical presentation and laboratory features in pediatric typhoid fever patient susceptibility to first-line antibiotics.Methods: This was an analytical cross-sectional study of total 119 typhoid fever children with positive blood culture of Salmonella Typhi based on medical data in Department of Child Health Dr. Hasan Sadikin General Hospital, Bandung during 2008–2012. Inclusion criteria included 76 patients with age range 1–15 years old, given an antibiotic, and had susceptibility test done. Numerical variable was the duration of fever in patients after given an antibiotic. Categorical variable included hepatomegaly, diarrhea, platelet count at admission, and leukocyte count at admission. Data were analyzed using a Mann-Whitney and Chi-square test.Results: There was no statistically significant difference in the duration of fever, leucocyte count at admission, and thrombocyte count at admission between sensitive and resistant response to chloramphenicol, ampicillin, and co-trimoksazol (p>0.05). Leucocyte count at admission in children with sensitive and resistant strain to ampicillin almost showed a difference (p=0.07) but still not statistically significant difference.Conclusions: There is no difference of clinical presentation and laboratory features in pediatric typhoid fever patient susceptible to first-line antibiotics. [AMJ.2015;2(4):584–90] DOI: 10.15850/amj.v2n4.653
Validity of Immunoglobulin M Anti Salmonella typhi Serologic Test in Childhood Typhoid Fever Hilda Marsela; Djatnika Setiabudi; Agnes Rengga Indrati
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.598 KB)

Abstract

Background: Typhoid fever, which mostly affects children, remains a major health problem in developing countries. Early diagnosis will help the management and thus, reduce morbidity and mortality. However, a rapid diagnostic test that detects the presence of immunoglobulin M (IgM) directed towards Salmonella typhi (S. typhi) antigen remains controversial despite its popularity. This study was aimed to assess the validity of IgM anti S. typhi serologic test in childhood typhoid fever. Methods: This retrospective diagnostic test, used blood culture as gold standard. Forty-one typhoid fever children with fever of 1–14 days admitted to Dr. Hasan Sadikin General Hospital Bandung from 2013 to 2015 were recruited. Diagnosis of typhoid fever is made clinically. Data were analyzed by Receiver Operating Characteristic (ROC) curve and diagnostic test.Results: Forty one children diagnosed with typhoid fever, 37 were positive for IgM anti S. typhi, but only 18 were positive for S. typhi in blood culture. IgM anti S. typhi (cut-off ≥4) test had an Area Under the Curve (AUC) of 59%, sensitivity of 100% and specificity of 17.39%. IgM anti S. typhi with cut-off >8 showed the highest AUC with sensitivity of 55.56% and specificity of 73.68%.Conclusions: IgM anti S. typhi test of cut-off >8 performs better than cut-off ≥4 in terms of AUC..[AMJ.2017;4(1):138–42] DOI: 10.15850/amj.v4n1.1035
The Effect of Parent Distraction Coaching Used The Toy on Pain Intensity of 1-5 Year-Old Children During Iv (Intravenous) Insertion Afrida Ristia; Djatnika Setiabudi; Ai Mardiyah
Jurnal Keperawatan Padjadjaran Vol. 6 No. 2 (2018): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1520.191 KB) | DOI: 10.24198/jkp.v6i2.391

Abstract

intravenous insertion is the cause of pain that the children most commonly experience when children are being hospitalised. Repeated and insurmountable in early childhood, it will impact trauma to the child, so that pain management is a main priority for nurses. However, nurses have barrier to implement pain management effectively. Therefore, involvement of the parents in pain management was so important. One of the non-pharmacological pain management involving parents is distraction by the parent (Parent Distraction Coaching).  The purpose of this research was to examined the difference intensity of pain children from ages 1-5 years old between intervention group and control group during intravenous insertion. This research uses quasi experimental methode by applying the pre-experimental design which is called the intact group comparison. Through the consecutive sampling, the data has been collected from 17 children in each group, both control and intervention groups. Respondents in the intervention group were the children undergoing the intravenous insertion and they were accompanied by their parents' distraction after the parents got the parental distraction coaching, while respondents in the control group were the children undergoing the intravenous insertion in accordance with the hospital procedures but they were not accompanied by their parents' distraction. The assessment of pain intensity was done by using FLACC instruments (Face, Legs, Activity, Cry, and Consolability). The data were analyzed descriptively and tested by using inferential t test-independent where the value of p < 0.05. From the results of the statistical tests using t test-independent test, the value of p obtained is 0.005 (p value <0.05). This value indicates that there is a significant difference between the intensity of pain experienced by children in the control group and in the intervention group during the intravenous insertion. Based on these results, nurses are expected to be aware of the importance of parents or family involvement in reducing the pain experienced by children during intravenous insertion, so that the implementation of pain management in children becomes more effective.
Hubungan Kadar Aspartat Aminotransferase (AST) dan Alanin Aminotransferase (ALT) Serum dengan Spektrum Klinis Infeksi Virus Dengue pada Anak Agus Darajat; Nanan Sekarwana; Djatnika Setiabudi
Sari Pediatri Vol 9, No 5 (2008)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp9.5.2008.359-62

Abstract

Latar belakang. Infeksi dengue memiliki spektrum klinis yang luas, yaitu dapat asimtomatis maupunbermanifestasi klinis sebagai demam dengue (DD), demam berdarah dengue (DBD) maupun sindromsyok dengue (SSD). Pada infeksi dengue didapatkan peningkatan kadar aspartat aminotransferase (AST)dan alanin aminotransferase (ALT) serum. Kadar AST dan ALT serum diduga berperan sebagai indikatortingkat keparahan penyakit.Tujuan. Mengetahui hubungan kadar AST dan ALT serum dengan spektrum klinis infeksi dengue pada anak.Metode. Penelitian observasional dengan rancangan cross sectional dilakukan pada 1 Maret-30 April 2007di Bagian Ilmu Kesehatan Anak RS Dr. Hasan Sadikin Bandung. Subjek penelitian kasus infeksi dengue,berusia < 14 tahun secara berurutan memenuhi kriteria klinis DD, DBD, dan SSD menurut WHO (1997)yang disertai bukti serologis infeksi dengue. Uji ANOVA digunakan untuk menilai hubungan kadar ASTdan ALT serum dengan spektrum klinis infeksi dengue pada anak. Kemaknaan ditentukan berdasarkan nilaip<0,05. Seluruh perhitungan statistik dikerjakan dengan piranti lunak SPSS versi 13,0 for Windows.Hasil. Terdapat 60 subjek penelitian terdiri dari 25 (41,7%) laki-laki dan 35 (58,3%) perempuan, denganusia termuda 6 bulan dan tertua 14 tahun. Berdasarkan spektrum klinis subjek terdiri dari kelompok DD17 (28,3%), DBD 21 (35%), dan SSD 22 (36,3%) anak. Nilai rerata AST pada DD 63,2±6,6, DBD267,5±116,1, SSD 1491,5±492,4. Nilai rerata ALT pada DD 29,4±2,4, DBD 78,0±25,3, SSD 435,0±122,1.Hasil uji ANOVA menunjukkan terdapat hubungan kadar AST dan ALT serum dengan spektrum klinisinfeksi dengue pada anak (F=6,018; p=0,000).Kesimpulan. Pada anak dengan infeksi dengue semakin tinggi kadar AST dan ALT serum, semakin beratderajat penyakit 
Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus Aulia Fitri Swity; Djatnika Setiabudi; Herry Garna
Sari Pediatri Vol 15, No 2 (2013)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.914 KB) | DOI: 10.14238/sp15.2.2013.81-6

Abstract

Latar belakang.Epidemi infeksi human immunodeficiency virus (HIV) merupakan tantangan besar dalam permasalahan kesehatan di dunia. Di Indonesia, jumlah kasus HIV/AIDS anak semakin meningkat tiap tahunnya. Pemantauan jumlah CD4 dapat membantu memutuskan dimulainya pemberian terapi anti- CD4 dapat membantu memutuskan dimulainya pemberian terapi antiretroviral/ARV, tetapi pemeriksaannya mahal dan tidak selalu tersedia di sarana kesehatan. Total lymphocyte count (TLC) diajukan sebagai panduan alternatif selain jumlah CD4 pada keadaan sarana kesehatan yang terbatas. Tujuan. Menentukan korelasi TLC dengan jumlah CD4, dan menentukan jumlah CD4 berdasarkan pemeriksaan TLC pada anak HIV.Metode. Penelitian potong lintang berupa observasional analitik, pengambilan data secara retrospektif rekam medis anak HIV yang dirawat inap di Departemen/SMF Ilmu Kesehatan Anak dan rawat jalan di Klinik Teratai Rumah Sakit Dr. Hasan Sadikin, Bandung. Dilakukan analisis regresi linier pada faktor-faktor yang berhubungan bermakna dengan CD4 untuk menentukan korelasi TLC dengan CD4, serta nilai hitung CD4 dari TLC. Kemaknaan ditentukan berdasarkan nilai p<0,05. Hasil.Subjek penelitian 67 anak HIV, terdiri dari 35 (52%) laki-laki dan 32 (48%) perempuan. Rentang jumlah CD4 berkisar antara 6–3.094 mm3, rerata 444,3 mm3(SD 536,3), median 241 mm3,dan rentang jumlah TLC antara 525–10.738, rerata 3.352,4 (SD 2.020,4), median 2.898. Analisis regresi menunjukkan hubungan linier antara jumlah CD4 sebagai variabel tergantung (Y) dan TLC sebagai variabel bebas (X) menggunakan persamaan Y= -158,209+0,180X. Didapatkan korelasi kuat antara TLC dan jumlah CD4 (r=0,68; p<0,001). Kesimpulan.Terdapat hubungan positif antara jumlah limfosit dan jumlah CD4. Jumlah CD4 pada pasien HIV anak dapat diperkirakan dari jumlah limfosit. Diperlukan penelitian lebih lanjut untuk menentukan cut off point TLC dalam inisiasi ARV
Co-Authors Adri Zamany Anwary Afrida Ristia Agnes Rengga Indrati Agus Darajat Ai Mardiyah Alex Chairulfatah Almira Aliyannissa Aulia Fitri Swity Bonnie Arseno Budi Setiabudiawan Cesilia, Citra Dadang Hudaya Somasetia Dedi Rachmadi Desak Gede Arie Yudhantari Devi Andarwati Roboth Dewi Ratnasari DEWI RATNASARI Dzulfikar Djalil Lukmanul Hakim Eddy Fadlyana Elsa Aliyya Harsanti Elsa Pudji Setiawati Heda Melinda Nataprawira Heda Melinda Nataprawira Herri S. Sastramihardja Herry Garna Hilda Marsela Ida Parwati Jujun Junia Kiki Madiapermana Lily Cahyani Tandililing Lionardus Edward Lulu Eva Rakhmilla Lulu Eva Rakhmilla, Lulu Eva M.S. Azhali Marsela, Hilda Meita Dhamayanti Merry Wijaya Nanan Sekarwana Nelly Amalia Risan Qurota Ayuni Silvia Sudarmaji Sjarif Hidajat Effendi Sri Endah Rahayuningsih Susi Susanah Triasta Triasta Tubagus Ferdi Fadilah Wida Purbaningsih