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Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut Auzal Halim; Reni Daniati; Rina Wahyuni
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Microencapsulation of metronidazole using HPMC as a polymer by solvent evaporation method had been studied. Microcapsulhad been made into3formulation with 3 ratio variation between Metronidazole and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were analyzed by SEM, DTA, FT-IR, particle sized distribution and dissolution profile. Microcapsules were white to slightly yellow and almost perfectly spherical.Disolution profiles of microcapsules showed that the greater amount of HPMC gave the slower release ofMetronidazole. Dissolution kinetics of microcapsule allowedHiguchi equation, where the realese of Metronidazole from microcapsules were controlled by diffution process.

Penentuan Cemaran Mikroba Pada Jamu Pelangsing Yang Beredar Di Pasar Tarandam Padang Rina Wahyuni; Vonda Perdana Lase; Harrizul Rivai
Jurnal Farmasi Higea Vol 5, No 2 (2013)
Publisher : STIFARM Padang

Research about microbial countamination on slimming herbals powders, pills, capsules and caplets circulating in Tarandam market, Padang, has been evaluated. Powders had total plate count 0 x 106 CFU/g for PP (standard quality of powder was ≤ 1 x 106 CFU/g for total plate count). Pills had total plate count ≤ 0.5 x 105 CFU/g for MR (standard quality of pill was ≤ 1 x 105 CFU/g for total plate count). Capsules had total plate count 1.1 x 105 CFU/g for LM and 1.6 x 105 CFU/g for SA (standard quality of capsule was ≤ 1 x 104 CFU/g for total plate count) and Caples had total plate count 0.2 x 105 CFU/g for SC (standard quality of caplet was ≤ 1 x 104 CFU/g for total plate count). The total plate count calculation showed that only powders and pills were observed the BPOM standard quality of herbal drugs.The fungal count from all of samples were not observed the standard quality of herbal drugs. Powders had total fungal count 9 x 104 CFU/g for PP (standard quality of powder was ≤ 1 x 104 CFU/g for total fungal count). Pills had total fungal count 3.1 x 104 CFU/g for MR (standard quality of pill was ≤ 1 x 103 CFU/g for total fungal count). Capsules had total fungal count 2,3 x 104 CFU/g for LM and 2.6 x 104 CFU/g for SA (standard quality of capsule was ≤ 1 x 103 CFU/g for total fungal count) and caplets had total fungal count 2.1 x 104 CFU/g for SC (standard quality of caplet was ≤ 1 x 103 CFU/g for total fungal count).

Pembuatan dan Karakterisasi Dispersi Padat Nifedipin dengan Poloxamer 188 Menggunakan Metode Peleburan Rina Wahyuni; Auzal Halim; Sri Oktavia; Rahmi Purwaningsih
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Nifedipin is a poorly water soluble calcium channel blocking agent. Solid dispersion is one of several pharmaceutical technologies that enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to prepare and characterize nifedipin-poloxamer 188 solid dispersion by fusion method. Combination of nifedipin and poloxamer 188 for F1, F2 and F3 were 1:9, 2:8 and 3:7 respectively. The physical mixture and solid dispersions were characterized for particles size distribution, drug-carrier interaction, drug content and dissolution rate. The physicochemical characterization showed a specific characterized of solid dispersion. As indicated from X Ray Diffractograms, DTA thermograms and SEM photographs, nifedipin was in the amorphous form and entrapped in polymer matrix. FTIR results proved no chemical interaction between nifedipin and poloxamer 188. SEM images showed a new morphology of solid dispersions compare with pure drug and physical mixture. The dissolution rate was increased with increasing polymer concentrations. F1 showed the highest dissolution rate among all formulas. Statistic analysis showed a significant differences (P<0.05) of dissolution efficiency among all formulas.

Isolasi Mikroba Endofit Dari Kulit Batang, Daun, dan Kulit Buah Manggis (Garcinia mangostana L.) Pengkulturan Serta Uji Aktivitas Antimikrobanya Akmal Djamaan; Asia Asia; Rina Wahyuni
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The antimicrobial activity of endophytes microbe that symbiosis with mangosteen had been carried out. There were 12 fungal’s isolates and 14 bacterial’s isolates had been isolated from cortex, lief, and pericarp of Garcinia mangostana L. Each fungal’s isolates were fermented in Soybean Extract Broth liquid medium for 1 week at on a rotary shaker incubator at a 25-270 C and 90 rpm speed. Each bacterial’s isolates were fermented in water corn soaked medium for 24 hours on a rotary shaker incubator at 300C and 120 rpm speed. Fermented fungal’s and bacterial’s were tested their antimicrobial’s activity against Staphylococcus aureus, Escherichia coli and Candida albicans with agar diffusion methode. The result showed that J-G1 (Candida sp) and J-T1 (Candida sp) were fungal’s isolates that ware active against Escherichia coli with inhibition diameter 10 mm. J-H1 (Curvularis sp), J-G2 (Candida sp), J-T1 (Candida sp) were fungal’s isolates that were active against Staphylococcus aureus with inhibition diameter 9 mm, 11 mm and 13 mm respectively. B-T2 (Klebsiella sp)and B-K51 (Bacillus sp1) were bacterial’s isolates that were active againts Escherichia coli with inhibition diameter 13 mm and 18 mm respectively. B-H (Bacillus sp2), B-G (Bacillus sp2), B-P1 (Bacillus sp1), B-K101(Bacillus sp1) and B-K102 (Bacillus sp1) were bacterial’s isolates that were active againts Staphylococcus aureus with inhibition diameter 11 mm, 14 mm, 15 mm, 16 mm and 15 mm respectively.

Uji Pengaruh Surfaktan Tween 80 Dan Span 80 Terhadap Solubilisasi Dekstrometorfan Hidrobromida Rina Wahyuni; Auzal Halim; Rina Trifarmila
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The solubilization of dextromethorphan hydrobromide using Tween 80 and Span 80 has been studied. CMC’s value of Tween 80 and Span 80 are determined by surface tension method using Du Nouy Tensiometer and refractive index method using ABBE refractometer. The solubility of dextromethorphan hydrobromide using Tween 80 and Span 80 was evaluated at concentrations below the CMC point, above the CMC point and at CMC point. CMC’s value of Tween 80 and Span 80 respectively are 5,9 µg/mL and 6,3µg/mL. The solubility of dextromethorphan hydrobromide using Tween 80 was greater than Span 80 at concentration above the CMC’s value.

Ekstraksi Asam Lemak Dari Daging Buah Alpukat Zulharmita Zulharmita; Reni Afrina; Rina Wahyuni
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

The fatty acid content analysis of avocados pulp taken from Batusangkar (Sumatra Barat) area had researched. Avocado were divided into 2 groups, that are group A : broaded in 3 days, group B : broaded in 5 days. Group A produced 149.274 g oils, whereas group B produced 169.598 g oils, analysis of avocado oil of group A by GC-MS showed the avocado oil components, namely acid miristat (2.44%), acid behenat (2.22%) and acid isopalmitat (10.97%), whereas the avocado oil components of group B are acid nonanoat (1.20%), acid miristat (2.80%), acid behenat (2.23%), acid palmitoleainat (7.91%), acid oleat (10.95%), acid oleat (28.69%), acid isopalmitat (4.77%).

Pemanfaatan Ekstrak Etanol Daun Murbai (Morus alba L.) Sebagai Bahan Aktif Pasta Gigi Dan Uji Aktivitas Anti Bakteri Terhadap Plak Gigi Akmal Djamaan; Fatimah Saidah; Rina Wahyuni
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

The formulation of leaf´s murbey ethanol extract´s toothpaste and its activities against dental plaque´s bacteries had been done. Pre test showed the leaf´s murbey ethanol extracts at 4% of concentration gave an optimal diameter of inhibition against dental plague. Based that fact, this research would have made 3 formulas at toothpaste from leaf´s murbey extract at 1%, 2%, and 4% of concentration. All of formulas would have wade with the same base of toothpaste. All of formulas would be characterized of pharmaceutic´s properties and antibacteria´s activities, that would be compared with toothpaste “S” and “P” as a standard. The result shawed all formulas gave a good characteristic of pharmaceutic properties. F3 had gave a good diameter of inhibition, that was 21.875 mm, where as the “S” and “P” of toothpaste had gave a diameter of inhibition respectively 23.875 mm and 22.75mm. There was a significant difference of inhibition´s diameter of all formulas at 0.05 level of confidence.

Mikroenkapsulasi Karbamazepin dengan Polimer Hpmc Menggunakan Metoda Emulsifikasi Penguapan Pelarut Rina Wahyuni; Yustina Susi Irawati; Auzal Halim
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Microencapsulation of Carbamazepine using HPMC as a polymer by emulsification solvent evaporation method had been studied. Microcapsules had been made into 3 formulation with 3 ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content and dissolution profile. The evaluation result showed that HPMC as a polymer of sustained release was influence characteristic microcapsules of Carbamazepine. Microcapsules were white to slightly yellow and almost perfectly spherical. Disolution profiles of microcapsules showed that the formula containing the greatest amount of HPMC gave the slower release of Carbamazepine. Resistance release of biggest drug shown by formula 3 giving disolution during 6 hour counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi equation, where the realese of Carbamazepine from microcapsules were controlled by diffution process.

Mikroenkapsulasi Karbamazepin dengan Polimer HPMC Menggunakan Metoda Emulsifikasi Penguapan Pelarut Rina Wahyuni; Auzal Halim; Yustina Susi Irawati
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Microencapsulation of Carbamazepine using HPMC as a polymer by emulsification solvent evaporation method had been studied. Microcapsules had been made into 3 formulation with 3 ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content and dissolution profile. The evaluation result showed that HPMC as a polymer of sustained release was influence characteristic microcapsules of Carbamazepine. Microcapsules were white to slightly yellow and almost perfectly spherical. Disolution profiles of microcapsules showed that the formula containing the greatest amount of HPMC gave the slower release of Carbamazepine. Resistance release of biggest drug shown by formula 3 giving disolution during 6 hour counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi equation, where the realese of Carbamazepine from microcapsules were controlled by diffution process.

Formulasi Dan Evaluasi Stabilitas Fisik Suspensi Ibuprofen Menggunakan Kombinasi Polimer Serbuk Gom Arab Dan Natrium Karboksimetilselulosa Rina Wahyuni; Syofyan Syofyan; Septa Yunalti
Jurnal Farmasi Higea Vol 9, No 1 (2017)
Publisher : STIFARM Padang

The research about formulation and evaluation of physical stability of ibuprofen suspension using arabic gom and natrium carboxymethylcelulose as suspending agent had been done. Concentration of arabic gom and natrium carboxymethylcelulose were 2.5 : 0.25, 5 : 0.5, 2.5 : 0.75 and 5 : 1 % for F1, F2, F3 and F4 respectinely. Evaluation of physical stability had been done for 8 weeks, ie organoleptic, density, viscosity, volume of sedimentation, redispresion, pH, freeze thaw cycling, crystal growth and particle size distribution. Concentration of arabic gom and natrium carboxymethylcelulose had been influenced the physical stability of suspension.

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